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1. 发明授权

US5034188A Artificial lung 失效
标题翻译：人造肺
公开(公告)号：US5034188A
公开(公告)日：1991-07-23
申请号：US154638
申请日：1988-02-09
申请人： Hikaru Nakanishi , Katsuyuki Kuwana , Shuichi Ishii
发明人： Hikaru Nakanishi , Katsuyuki Kuwana , Shuichi Ishii
IPC分类号： A61M1/18 , A61M1/14 , A61M1/16 , A61M1/36 , B01D63/02
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1629 , A61M1/3627 , Y10S128/03 , Y10S261/28
摘要： An artificial lung comprises a venous blood reservoir to receive and store venous blood. A heat exchanger communicating with the venous blood reservoir receives the venous blood so the blood temperature is regulated by heat exchange through a wall between flowing water and the venous blood. A blood oxygenator concentrically disposed within a hollow space of said heat exchanger comprises a cylindrical body defining a cylindrical space and at least one gas permeable membrane separating said cylindrical space into a first space and a second space. The first space receives the venous blood from the heat exchanger and the second space communicates with an oxygenating gas feed line so that the blood is oxygenated through the gas permeable membrane.
摘要翻译：人造肺包括用于接收和存储静脉血的静脉血液储存器。与静脉血液储存器连通的热交换器接收静脉血，从而通过流动的水和静脉血之间的壁进行热交换来调节血液温度。同心地设置在所述热交换器的中空空间内的血液充氧器包括限定圆柱形空间的圆柱形主体和将所述圆柱形空间分隔成第一空间和第二空间的至少一个气体可渗透膜。第一空间从热交换器接收静脉血，第二空间与氧合气供给管路连通，使得血液通过透气膜进行氧合。

2. 发明授权

US4808378A Blood oxygenator 失效
标题翻译：血液充氧器
公开(公告)号：US4808378A
公开(公告)日：1989-02-28
申请号：US37117
申请日：1987-04-10
申请人： Hikaru Nakanishi , Masahiro Kamiya , Katsuyuki Kuwana , Hiroaki Ishizuka
发明人： Hikaru Nakanishi , Masahiro Kamiya , Katsuyuki Kuwana , Hiroaki Ishizuka
IPC分类号： B01D63/02 , B01D63/04 , A61M1/14
CPC分类号： B01D63/025 , B01D63/043 , B01D2313/025 , Y10S128/03 , Y10S261/28
摘要： A blood oxygenator includes an elongated hollow housing having an elongated chamber therein, an elongated fiber assembly disposed within the chamber along an axis thereof and including a bundle of hollow fibers of a microporous membrane. The opposite ends of the fiber bundle are sealingly secured to the inner peripheral surface of the housing by a potting material. Gas inlet and outlet members are connected respectively to the opposite ends of the housing and communicate respectively with the opposite ends of the hollow fibers. Blood inlet and outlet are formed on the housing and communicate with the chamber intermediate the opposite ends of the hollow fibers. The fiber assembly includes a plurality of layers of spirally-wound fiber bundles arranged one upon another. Each turn of one of each adjacent spirally-wound bundles is disposed in a plane intersecting the plane in which each turn of the other fiber bundle is disposed. The outer periphery of the outermost layer of the spirally-wound bundle is held in contact with the inner peripheral surface of the housing.
摘要翻译：血液充氧器包括其中具有细长室的细长中空壳体，细长纤维组件，其沿轴线设置在腔室内，并且包括微孔膜的中空纤维束。纤维束的两端通过灌封材料密封地固定在壳体的内周面上。气体入口和出口构件分别连接到壳体的相对端并且分别与中空纤维的相对端连通。血液入口和出口形成在壳体上并与中空纤维的相对端之间的腔室连通。纤维集合体包括多个彼此相互排列的螺旋卷绕的纤维束层。每个相邻的螺旋缠绕束中的每一个的每一圈设置在与其中设置另一纤维束的每个匝的平面交叉的平面中。螺旋卷绕的束的最外层的外周保持与壳体的内周面接触。

3. 发明授权

US4240796A Method of treating capillary fibers 失效
标题翻译：治疗毛细血管纤维的方法
公开(公告)号：US4240796A
公开(公告)日：1980-12-23
申请号：US933612
申请日：1978-08-14
申请人： Hikaru Nakanishi
发明人： Hikaru Nakanishi
IPC分类号： B01D65/02 , B01D67/00 , B05D5/00
CPC分类号： B01D67/0095 , B01D65/02 , B01D2321/168
摘要： Novel method of treating capillary fibers comprising introducing into the capillary fibers a carbon chloride fluoride or a mixture of the carbon chloride fluoride with a material capable of forming an azeotrope therewith to remove selectively octyl alcohol, isopropyl myristate and the like from the capillary fibers, retaining glycerol within the wall of said capillary fibers.
摘要翻译：新颖的处理毛细管纤维的方法包括将毛细管纤维中的氯化碳氟化物或氟化碳与能够形成共沸物的物质的混合物从毛细管纤维中导入辛醇，肉豆蔻酸异丙酯等，保留甘油在所述毛细管纤维的壁内。

4. 发明授权

US5308314A Integrated heart-lung machine 失效
标题翻译：综合心肺机
公开(公告)号：US5308314A
公开(公告)日：1994-05-03
申请号：US944086
申请日：1992-09-11
申请人： Yasuhiro Fukui , Akio Funakubo , Katsumi Takahashi , Hiroshi Sasagawa , Hikaru Nakanishi
发明人： Yasuhiro Fukui , Akio Funakubo , Katsumi Takahashi , Hiroshi Sasagawa , Hikaru Nakanishi
IPC分类号： A61M1/14 , A61M1/10 , A61M1/16 , A61M1/36 , A61M37/00
CPC分类号： A61M1/1698 , A61M1/1006 , A61M1/101 , A61M1/1036 , A61M1/1625 , A61M1/1629 , A61M1/3663 , A61M2205/3666 , Y10S128/03 , Y10S415/90
摘要： An integrated heart-lung machine, which includes a blood pump having a casing of a cup-like shape interiorly defining a pump chamber at an intermediate portion thereof for pumping in and out blood from a blood inlet to a guide flange formed at opposite ends of the casing; a rotor having a rotary member securely fixed to the fore end thereof within the pump chamber and journalled in the guide flange; an artificial lung of a doughnut-like or cylindrical shape connected contiguously to a blood flow passage in the guide flange and concentrically with the rotor; a stator detachably fitted in an intermediate portion between the rotor and the artificial lung; and a pedestal base located at one side of the artificial lung and provided with a blood outlet in communication with the artificial lung. Accordingly, influent blood to the pump chamber is sent into the artificial lung through the blood passage by the pumping action of the rotor, and is refreshed by contact with air or oxygen in the lung, which is maintained in a heated state by the stator, and returned to the patient's body through the blood outlet. This arrangement permits minimizing of the length of the blood circulating passages to and through the machine and permits shortening and minimizing of the blood passages interconnecting the blood pump, artificial lung and blood filter, while preventing blood contamination and leaks as well as blood cell destruction. Easy installation and handling is also permitted in a sanitary region on a bed or on an operating table.
摘要翻译：一种综合的心肺机器，其包括具有杯状形状的壳体的血泵，其内部限定在其中间部分处的泵室，用于将血液从血液入口泵入和输出到形成在相对端的引导凸缘套管转子，其具有在泵室内牢固地固定到其前端的旋转构件，并且轴颈安装在引导凸缘中; 环形或圆柱形的人造肺与引导凸缘中的血流通道连续并与转子同心连接; 可拆卸地安装在转子和人造肺之间的中间部分的定子; 以及位于人造肺的一侧的基座，并具有与人造肺连通的血液出口。因此，通过转子的泵送作用将流入泵室的血液通过血液通道送入人造肺，并且通过与定子保持在加热状态的肺中的空气或氧气接触而被刷新，并通过出血口返回病人的身体。这种布置允许使通过机器的血液循环通道的长度最小化，并且允许缩短和最小化血液通道，连接血液泵，人造肺和血液过滤器，同时防止血液污染和泄漏以及血细胞破坏。在床上或手术台上的卫生区域也允许安装和处理方便。

5. 发明授权

US4501785A Hydrophilized membrane of porous hydrophobic material and process of producing same 失效
标题翻译：多孔疏水材料的亲水膜及其制备方法
公开(公告)号：US4501785A
公开(公告)日：1985-02-26
申请号：US516335
申请日：1983-07-22
申请人： Hikaru Nakanishi
发明人： Hikaru Nakanishi
IPC分类号： C08J9/34 , A61M1/16 , B01D67/00 , B01D69/02 , B01D71/26 , C08J9/42 , B32B3/00
CPC分类号： B01D67/0088 , Y10T428/24802 , Y10T428/249993
摘要： A hydrophilized membrane of a porous hydrophobic material having micropores each defined by a surface at least part of which is coated with polyethylene glycol. Water is allowed to pass through the micropores. There is also disclosed a process for hydrophilizing such a porous hydrophobic membrane.
摘要翻译：多孔疏水材料的亲水化膜，其具有各自由至少一部分涂覆有聚乙二醇的表面限定的微孔。允许水通过微孔。还公开了一种使这种多孔疏水膜亲水化的方法。

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