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1. 发明授权

US08980914B2 Therapeutic agent for chronic obstructive pulmonary disease and method for treatment for chronic obstructive pulmonary disease with the same 有权
标题翻译：慢性阻塞性肺疾病治疗剂及慢性阻塞性肺疾病治疗方法相同
公开(公告)号：US08980914B2
公开(公告)日：2015-03-17
申请号：US10565828
申请日：2004-07-27
申请人： Hidetsugu Takagaki , Yasuo Aoki , Mitsuteru Ishiwara , Nobuaki Mizutani
发明人： Hidetsugu Takagaki , Yasuo Aoki , Mitsuteru Ishiwara , Nobuaki Mizutani
IPC分类号： A61K31/00 , A61K31/4704 , C07D215/38
CPC分类号： A61K31/4704 , C07D215/38
摘要： This therapeutic agent for chronic obstructive pulmonary disease comprises, an active ingredient, at least one of a 7-aminoquinolinone derivative represented by the general formula (I): wherein R1 represents a hydrogen atom or an alkyl group; R2 and R3 each represents a group selected from a hydrogen atom, an acyl group, an alkyl group and an alkenyl group; and R4 and R5 each represents a group selected from a hydrogen atom, an acyl group, an alkyl group, an alkenyl group and an aralkyl group, and its physiologically acceptable salt.
摘要翻译：该慢性阻塞性肺疾病治疗剂包含活性成分，由通式（I）表示的7-氨基喹啉酮衍生物中的至少一种：其中R1表示氢原子或烷基; R2和R3各自表示选自氢原子，酰基，烷基和烯基的基团; R 4和R 5各自表示选自氢原子，酰基，烷基，烯基和芳烷基的基团及其生理学上可接受的盐。

2. 发明申请

US20060235045A1 Therapeutic agent for chronic obstructive pulmonary disease and method for treatment for chronic obstructive pulmonary disease with the same 有权
标题翻译：慢性阻塞性肺疾病治疗剂及慢性阻塞性肺疾病治疗方法相同
公开(公告)号：US20060235045A1
公开(公告)日：2006-10-19
申请号：US10565828
申请日：2004-07-27
申请人： Hidetsugu Takagaki , Yasuo Aoki , Mitsuteru Ishiwara , Nobuaki Mizutani
发明人： Hidetsugu Takagaki , Yasuo Aoki , Mitsuteru Ishiwara , Nobuaki Mizutani
IPC分类号： A61K31/4704
CPC分类号： A61K31/4704 , C07D215/38
摘要： This therapeutic agent for chronic obstructive pulmonary disease comprises, an active ingredient, at least one of a 7-aminoquinolinone derivative represented by the general formula (I): wherein R1 represents a hydrogen atom or an alkyl group; R2 and R3 each represents a group selected from a hydrogen atom, an acyl group, an alkyl group and an alkenyl group; and R4 and R5 each represents a group selected from a hydrogen atom, an acyl group, an alkyl group, an alkenyl group and an aralkyl group, and its physiologically acceptable salt.
摘要翻译：用于慢性阻塞性肺疾病的治疗剂包含活性成分，由通式（I）表示的7-氨基喹啉酮衍生物中的至少一种：其中R 1表示氢原子或烷基 ; R 2和R 3各自表示选自氢原子，酰基，烷基和烯基的基团; R 4和R 5各自表示选自氢原子，酰基，烷基，烯基和芳烷基的基团，其生理上可接受的盐。

3. 发明申请

US20080072338A1 Animal for Drug Efficacy Evaluation, Method for Developing Chronic Obstructive Pulmonary Disease in Animal for Drug Efficacy Evaluation, and Method for Evaluating Drug Efficacy Using the Animal 审中-公开
标题翻译：用于药物功效评估的动物，用于药物功效评估的动物中慢性阻塞性肺疾病发展的方法和使用动物评价药物功效的方法
公开(公告)号：US20080072338A1
公开(公告)日：2008-03-20
申请号：US11576137
申请日：2005-09-26
申请人： Nobuaki Mizutani , MItsuteru Ishiwara
发明人： Nobuaki Mizutani , MItsuteru Ishiwara
IPC分类号： A01K67/00
CPC分类号： A61K49/0008 , A01K2267/035
摘要： The present invention provides an animal for drug efficacy evaluation produced by administering an aqueous solution, in which cigarette smoke is dissolved in water or physiological saline, directly to a lower airway of an animal except a human so as to develop chronic obstructive pulmonary disease; a method for developing chronic obstructive pulmonary disease in an animal for drug efficacy evaluation including administering an aqueous solution, in which cigarette smoke is dissolved in water or physiological saline, directly to a lower airway of an animal except a human; and a method for evaluating drug efficacy including administering a drug to the animal for drug efficacy evaluation and then evaluating the effect of the drug.
摘要翻译：本发明提供一种用于药物功效评价的动物，其通过将香烟烟雾溶解在水或生理盐水中的水溶液直接施用于除了人以外的动物的下呼吸道而产生慢性阻塞性肺疾病; 一种用于药物功效评估的用于在动物中发展慢性阻塞性肺疾病的方法，包括将香烟烟雾溶于水或生理盐水的水溶液直接施用于除人之外的动物的下呼吸道; 以及评价药物功效的方法，包括向动物施用药物用于药物功效评价，然后评价药物的效果。

4. 发明授权

US09023751B2 Method for producing catalyst 有权
标题翻译：催化剂生产方法
公开(公告)号：US09023751B2
公开(公告)日：2015-05-05
申请号：US13640100
申请日：2010-04-20
申请人： Nobuaki Mizutani
发明人： Nobuaki Mizutani
IPC分类号： H01M4/90 , H01M4/92 , B01J37/16 , B01J23/52 , B01J35/00
CPC分类号： H01M4/921 , B01J23/52 , B01J35/0033 , B01J35/0046 , B01J37/16 , H01M4/925 , H01M4/926 , Y02E60/50
摘要： This invention is intended to improve the coverage of a platinum or platinum alloy surface with gold when producing a catalyst comprising carrier particles that support gold-modified platinum or platinum alloys. The invention provides a method for producing a catalyst comprising carrier particles that support gold-modified platinum or platinum alloys comprising a step of gold reduction comprising adding carrier particles that support platinum or platinum alloys, a reducing agent, and a gold precursor to a liquid medium and mixing the same, wherein the reducing agent is added to adjust the ORP value (i.e., an oxidation-reduction potential with reference to the silver-silver chloride electrode) of the liquid medium to −630 to +230 mV upon completion of addition.
摘要翻译：本发明旨在在制备包含支持金改性铂或铂合金的载体颗粒的催化剂时，改善铂或铂合金表面与金的覆盖。本发明提供了一种制备催化剂的方法，其包含载体金属的载体颗粒，所述载体颗粒支持金改性的铂或铂合金，其包括金还原步骤，包括将支持铂或铂合金的载体颗粒，还原剂和金前体添加到液体介质并将其混合，其中加入还原剂以在加入完成时将液体介质的ORP值（即，参考银 - 氯化银电极的氧化还原电位）调节至-630至+ 230mV。

5. 发明申请

US20100203428A1 Supported Catalyst for Fuel Cell and Fuel Cell 审中-公开
标题翻译：燃料电池和燃料电池的支持催化剂
公开(公告)号：US20100203428A1
公开(公告)日：2010-08-12
申请号：US12761303
申请日：2010-04-15
申请人： Toshiharu TABATA , Tomoaki Terada , Takahiro Nagata , Mikihiro Kataoka , Hiroaki Takahashi , Nobuaki Mizutani , Yousuke Horiuchi
发明人： Toshiharu TABATA , Tomoaki Terada , Takahiro Nagata , Mikihiro Kataoka , Hiroaki Takahashi , Nobuaki Mizutani , Yousuke Horiuchi
IPC分类号： H01M4/92 , B01J23/42 , B01J21/18
CPC分类号： H01M4/92 , H01M4/8842 , H01M4/926 , H01M2008/1095
摘要： A supported catalyst for fuel cell includes a conductive carrier and platinum supported on the conductive carrier. A 90% particle diameter D90 on a cumulative particle size curve obtained by determining a particle size distribution of the supported catalyst by a light scattering method is 28 μm or less.
摘要翻译：用于燃料电池的载体催化剂包括导电载体和负载在导电载体上的铂。通过使用光散射法测定负载型催化剂的粒度分布得到的累积粒径曲线上的90％粒径D90为28μm以下。

6. 发明授权

US11139498B2 Electrode catalyst for fuel cells 有权
公开(公告)号：US11139498B2
公开(公告)日：2021-10-05
申请号：US16014941
申请日：2018-06-21
申请人： Toru Yamamoto , Nobuaki Mizutani , Kohei Koyamada , Kotaro Horiai , Mikihiro Kataoka , Kenji Yamamoto
发明人： Toru Yamamoto , Nobuaki Mizutani , Kohei Koyamada , Kotaro Horiai , Mikihiro Kataoka , Kenji Yamamoto
IPC分类号： H01M8/1004 , H01M4/92 , H01M4/88 , H01M4/90 , H01M8/1018 , H01M4/86
摘要： An electrode catalyst for fuel cells that can inhibit an increase in gas diffusion resistance includes a carbon material having a ratio of a peak intensity IA derived from an amorphous structure to a peak intensity IG derived from a graphite structure in an X-ray diffraction spectrum (ratio IA/IG) of 0.90 or less as a catalyst-supporting carrier.

7. 发明授权

US08160882B2 Speech information processing apparatus and method 有权
标题翻译：语音信息处理装置及方法
公开(公告)号：US08160882B2
公开(公告)日：2012-04-17
申请号：US12358660
申请日：2009-01-23
申请人： Nobuaki Mizutani
发明人： Nobuaki Mizutani
IPC分类号： G10L13/06
CPC分类号： G10L15/08 , G10L25/15
摘要： A temporary child set is generated. An elastic ratio of an elastic section of a model pattern is calculated. A temporary typical pattern of the set is generated by combining the pattern belonging to the set with the model pattern having the elastic pattern expanded or contracted. A distortion between the temporary typical pattern of the set and the pattern belonging to the set is calculated, and a child set is determined as the set when the distortion is below a threshold. A typical pattern as the temporary typical pattern of the child set is stored with a classification rule as the classification item of the context of the pattern belonging to the child set.
摘要翻译：生成临时子集。计算模型图案的弹性部分的弹性比。通过将属于集合的模式与具有扩展或收缩的弹性模式的模型模式组合来生成集合的临时典型模式。计算集合的临时典型模式和属于集合的模式之间的失真，并且当失真低于阈值时，将子集确定为集合。将作为子集的临时典型模式的典型模式与分类规则一起存储为属于子集的模式的上下文的分类项。

8. 发明申请

US20100196802A1 Fuel Cell and Supported Catalyst Used Therefor 审中-公开
标题翻译：燃料电池及其所用的催化剂
公开(公告)号：US20100196802A1
公开(公告)日：2010-08-05
申请号：US12761241
申请日：2010-04-15
申请人： Toshiharu TABATA , Tomoaki Terada , Takahiro Nagata , Mikihiro Kataoka , Hiroaki Takahashi , Nobuaki Mizutani , Yousuke Horiuchi
发明人： Toshiharu TABATA , Tomoaki Terada , Takahiro Nagata , Mikihiro Kataoka , Hiroaki Takahashi , Nobuaki Mizutani , Yousuke Horiuchi
IPC分类号： H01M4/92
CPC分类号： H01M4/921 , B22F1/025 , B22F9/26 , B22F2999/00 , C22C5/02 , C22C5/04 , C23C30/00 , H01M4/9083 , H01M4/926 , H01M2008/1095 , B22F2201/013
摘要： A fuel cell having an excellent life property is achieved. A supported catalyst for a fuel cell includes a catalytic particle made of an alloy of platinum and gold, and a conductive carrier supporting the catalytic particle. 50% or more of gold forms a solid solution with platinum.
摘要翻译：实现了具有优异寿命特性的燃料电池。用于燃料电池的载体催化剂包括由铂和金的合金制成的催化剂颗粒和负载催化剂颗粒的导电载体。 50％以上的金与铂形成固溶体。

9. 发明授权

US08626510B2 Speech synthesizing device, computer program product, and method 有权
标题翻译：语音合成装置，计算机程序产品和方法
公开(公告)号：US08626510B2
公开(公告)日：2014-01-07
申请号：US12559844
申请日：2009-09-15
申请人： Nobuaki Mizutani
发明人： Nobuaki Mizutani
IPC分类号： G10L13/00
CPC分类号： G10L13/08 , G10L13/07
摘要： An acquiring unit acquires pattern sentences, which are similar to one another and include fixed segments and non-fixed segments, and substitution words that are substituted for the non-fixed segments. A sentence generating unit generates target sentences by replacing the non-fixed segments with the substitution words for each of the pattern sentences. A first synthetic-sound generating unit generates a first synthetic sound, a synthetic sound of the fixed segment, and a second synthetic-sound generating unit generates a second synthetic sound, a synthetic sound of the substitution word, for each of the target sentences. A calculating unit calculates a discontinuity value of a boundary between the first synthetic sound and the second synthetic sound for each of the target sentences and a selecting unit selects the target sentence having the smallest discontinuity value. A connecting unit connects the first synthetic sound and the second synthetic sound of the target sentence selected.
摘要翻译：获取单元获取彼此相似并且包括固定段和非固定段的模式句子，以及替代非固定段的替换字。句子生成单元通过用每个模式句子的替代词替换非固定段来产生目标句子。第一合成声产生单元产生第一合成声音，固定音段的合成声音，第二合成声音产生单元产生用于每个目标句子的第二合成声音，替代词的合成声音。计算单元计算每个目标句子的第一合成声音和第二合成声音之间的边界的不连续值，并且选择单元选择具有最小不连续值的目标语句。连接单元连接所选择的目标句子的第一合成声音和第二合成声音。

10. 发明申请

US20130035226A1 METHOD FOR PRODUCING CATALYST 有权
标题翻译：生产催化剂的方法
公开(公告)号：US20130035226A1
公开(公告)日：2013-02-07
申请号：US13640100
申请日：2010-04-20
申请人： Nobuaki Mizutani
发明人： Nobuaki Mizutani
IPC分类号： H01M4/88
CPC分类号： H01M4/921 , B01J23/52 , B01J35/0033 , B01J35/0046 , B01J37/16 , H01M4/925 , H01M4/926 , Y02E60/50
摘要： This invention is intended to improve the coverage of a platinum or platinum alloy surface with gold when producing a catalyst comprising carrier particles that support gold-modified platinum or platinum alloys. The invention provides a method for producing a catalyst comprising carrier particles that support gold-modified platinum or platinum alloys comprising a step of gold reduction comprising adding carrier particles that support platinum or platinum alloys, a reducing agent, and a gold precursor to a liquid medium and mixing the same, wherein the reducing agent is added to adjust the ORP value (i.e., an oxidation-reduction potential with reference to the silver-silver chloride electrode) of the liquid medium to −630 to +230 mV upon completion of addition.
摘要翻译：本发明旨在在制备包含支持金改性铂或铂合金的载体颗粒的催化剂时，改善铂或铂合金表面与金的覆盖。本发明提供了一种制备催化剂的方法，其包含载体金属的载体颗粒，所述载体颗粒支持金改性的铂或铂合金，其包括金还原步骤，包括将支持铂或铂合金的载体颗粒，还原剂和金前体添加到液体介质并将其混合，其中加入还原剂以在加入完成时将液体介质的ORP值（即，参考银 - 氯化银电极的氧化还原电位）调节至-630至+ 230mV。

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