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1. 发明申请

US20110081445A1 FEED ADDITIVE COMPOSITION FOR RUMINANTS CONTAINING ACIDIC OR NEUTRAL AMIN ACID, AND METHOD FOR PRODUCTION THEREOF 审中-公开
标题翻译：含有酸或中性氨基酸的发酵剂的饲料添加剂组合物及其生产方法
公开(公告)号：US20110081445A1
公开(公告)日：2011-04-07
申请号：US12896305
申请日：2010-10-01
申请人： Hidetsugu NAKAZAWA , Hiroyuki Sato , Yuki Miyazawa , Susumu Shibahara , Sachiko Oka , Yumi Goto
发明人： Hidetsugu NAKAZAWA , Hiroyuki Sato , Yuki Miyazawa , Susumu Shibahara , Sachiko Oka , Yumi Goto
IPC分类号： A23K1/16 , A23K1/18
CPC分类号： A23K40/35 , A23K20/142 , A23K20/158 , A23K50/10
摘要： A feed additive composition includes a protective agent, lecithin, an acidic or neutral amino acid, and water. A method of producing a feed additive composition includes preparing a molten mixture of a protective agent, lecithin, and an acidic or neutral amino acid, and immersing the molten mixture in water or an aqueous liquid to obtain a solidified mixture. Feed additives may be obtained by such method. The protective agent may include a hydrogenated vegetable oil or hydrogenated animal oil having a melting point of higher than 50° C. and lower than 90° C.
摘要翻译：饲料添加剂组合物包括保护剂，卵磷脂，酸性或中性氨基酸和水。制备饲料添加剂组合物的方法包括制备保护剂，卵磷脂和酸性或中性氨基酸的熔融混合物，并将熔融混合物浸入水或含水液体中以获得固化的混合物。饲料添加剂可以通过这种方法获得。保护剂可以包括熔点高于50℃且低于90℃的氢化植物油或氢化动物油。

2. 发明授权

US09204660B2 Feed additive composition for ruminants and method of producing the same 有权
标题翻译：反刍动物饲料添加剂组合物及其制备方法
公开(公告)号：US09204660B2
公开(公告)日：2015-12-08
申请号：US12896264
申请日：2010-10-01
申请人： Hidetsugu Nakazawa , Hiroyuki Sato , Yuki Miyazawa , Susumu Shibahara , Sachiko Oka , Yumi Goto
发明人： Hidetsugu Nakazawa , Hiroyuki Sato , Yuki Miyazawa , Susumu Shibahara , Sachiko Oka , Yumi Goto
IPC分类号： A23K1/18 , A23K3/00 , A23L1/00 , A23K1/16 , A23K1/00
CPC分类号： A23K1/1634 , A23K20/142 , A23K20/158 , A23K40/35 , A23K50/10
摘要： A feed additive composition includes a protective agent, lecithin in an amount of 0.05 to 6% by weight relative to a total weight of the composition, a basic amino acid in an amount of at least 40% by weight and less than 65% by weight relative to the total weight of the composition, and water. A method of producing a feed additive composition includes preparing a molten mixture of at least one protective agent, lecithin and at least one basic amino acid, and solidifying the molten mixture by immersing the molten mixture in water or an aqueous liquid. The protective agent includes hydrogenated vegetable oils and/or hydrogenated animal oils having melting points of greater than 50° C. and less than 90° C.
摘要翻译：饲料添加剂组合物包含相对于组合物总重量为0.05至6重量％的保护剂卵磷脂，至少40重量％且小于65重量％的碱性氨基酸相对于组合物的总重量和水。制备饲料添加剂组合物的方法包括制备至少一种保护剂，卵磷脂和至少一种碱性氨基酸的熔融混合物，并将熔融混合物浸入水或含水液体中来固化熔融混合物。保护剂包括熔点大于50℃且小于90℃的氢化植物油和/或氢化动物油。

3. 发明申请

US20110081444A1 FEED ADDITIVE COMPOSITION FOR RUMINANTS AND METHOD OF PRODUCING THE SAME 有权
标题翻译：用于造血细胞的饲料添加剂组合物及其生产方法
公开(公告)号：US20110081444A1
公开(公告)日：2011-04-07
申请号：US12896264
申请日：2010-10-01
申请人： Hidetsugu Nakazawa , Hiroyuki Sato , Yuki Miyazawa , Susumu Shibahara , Sachiko Oka , Yumi Goto
发明人： Hidetsugu Nakazawa , Hiroyuki Sato , Yuki Miyazawa , Susumu Shibahara , Sachiko Oka , Yumi Goto
IPC分类号： A23K1/16 , A23K1/18
CPC分类号： A23K1/1634 , A23K20/142 , A23K20/158 , A23K40/35 , A23K50/10
摘要： A feed additive composition includes a protective agent, lecithin in an amount of 0.05 to 6% by weight relative to a total weight of the composition, a basic amino acid in an amount of at least 40% by weight and less than 65% by weight relative to the total weight of the composition, and water. A method of producing a feed additive composition includes preparing a molten mixture of at least one protective agent, lecithin and at least one basic amino acid, and solidifying the molten mixture by immersing the molten mixture in water or an aqueous liquid. The protective agent includes hydrogenated vegetable oils and/or hydrogenated animal oils having melting points of greater than 50° C. and less than 90° C.
摘要翻译：饲料添加剂组合物包含相对于组合物总重量为0.05至6重量％的保护剂卵磷脂，至少40重量％且小于65重量％的碱性氨基酸相对于组合物的总重量和水。制备饲料添加剂组合物的方法包括制备至少一种保护剂，卵磷脂和至少一种碱性氨基酸的熔融混合物，并将熔融混合物浸入水或含水液体中来固化熔融混合物。保护剂包括熔点大于50℃且小于90℃的氢化植物油和/或氢化动物油。

4. 发明申请

US20090232933A1 FEED ADDITIVE COMPOSITION FOR RUMINANTS AND METHOD OF PRODUCING THE SAME 审中-公开
标题翻译：用于造血细胞的饲料添加剂组合物及其生产方法
公开(公告)号：US20090232933A1
公开(公告)日：2009-09-17
申请号：US12409132
申请日：2009-03-23
申请人： Hidetsugu Nakazawa , Hiroyuki Sato , Yuki Miyazawa , Susumu Shibahara , Sachiko Oka , Yumi Goto
发明人： Hidetsugu Nakazawa , Hiroyuki Sato , Yuki Miyazawa , Susumu Shibahara , Sachiko Oka , Yumi Goto
IPC分类号： A23K1/18 , A23D9/00 , A21D13/00
CPC分类号： A23K40/35 , A23K20/142 , A23K20/158 , A23K50/10
摘要： A food additive composition for ruminants of the dispersion type and a method of continuously producing the same. This food additive composition for ruminants, which contains 40% by weight or more but less than 65% by weight of a basic amino acid and has rumen bypass properties, is formulated into granules in an arbitrary shape which are scarcely classified when added to a silage or another feed. Thus, attempts have been made to develop a method of producing granules by which the milk yield of a lactation cow can be increased. Namely, it is intended to provide a food additive composition for ruminants which contains at least one protecting agent selected from among a hardened vegetable oil and a hardened animal oil having a melting point higher than 50° C. but lower than 90° C., 0.05 to 6% by weight of lecithin, water and 40% by weight or more but less than 65% by weight of a basic amino acid. It is also intended to provide a method of producing a food additive composition for ruminants characterized by comprising solidifying a molten mixture, which comprises at least one protecting agent selected from among a hardened vegetable oil and a hardened animal oil having a melting point higher than 50° C. but lower than 90° C., lecithin and a basic amino acid, by dipping in water.
摘要翻译：分散型反刍动物用食品添加剂组合物及其连续制造方法。这种含有40重量％以上但小于65重量％的碱性氨基酸并具有瘤胃旁路性质的反刍动物食品添加剂组合物配制成任意形状的颗粒，当加入青贮饲料时几乎不分类或另一个饲料。因此，已经尝试开发生产可以增加哺乳期母牛的产奶量的颗粒的方法。即，本发明提供一种反刍动物食品添加剂组合物，其含有选自硬化植物油和熔点高于50℃但低于90℃的硬化动物油中的至少一种保护剂， 0.05至6重量％的卵磷脂，水和40重量％以上但小于65重量％的碱性氨基酸。还旨在提供一种生产用于反刍动物的食品添加剂组合物的方法，其特征在于包括固化熔融混合物，所述熔融混合物包含至少一种选自硬化植物油和熔点高于50℃的硬化动物油中的保护剂 ℃，但低于90℃，卵磷脂和碱性氨基酸，通过浸入水中。

5. 发明授权

US06806384B2 Production method of &bgr;-amino-&agr;-hydroxycarboxylic acid 失效
标题翻译： β-氨基-α-羟基羧酸的制备方法
公开(公告)号：US06806384B2
公开(公告)日：2004-10-19
申请号：US10118958
申请日：2002-04-10
申请人： Yasuyuki Otake , Tomoyuki Onishi , Sachiko Oka , Daisuke Takahashi
发明人： Yasuyuki Otake , Tomoyuki Onishi , Sachiko Oka , Daisuke Takahashi
IPC分类号： C07C22900
CPC分类号： C07C229/34 , C07C227/32 , C07C269/04 , C07C271/22 , C07D263/24 , Y02P20/55
摘要： The present invention provides a production method of an optically active &bgr;-amino-&agr;-hydroxycarboxylic acid, which includes the following steps (a)-(c): (a) treating an optically active N-carbamate protected &bgr;-amino epoxide with an acid to give an optically active 5-hydroxymethyl-2-oxazolidinone; (b) oxidizing the resulting compound in the presence of 2,2,6,6-tetramethyl-1-piperidinyloxy and hypochlorite to give an optically active 4-benzyl-2-oxo-5-oxazolidinecarboxylic acid; and (c) treating the 4-benzyl-2-oxo-5-oxazolidinecarboxylic acid with a base, and a production method of an optically active N-carbamate protected &bgr;-amino-&agr;-hydroxycarboxylic acid which includes protection of the amino group with a carbamate type protecting group. The industrial production method of the present invention can produce these compounds efficiently.
摘要翻译：本发明提供光学活性β-氨基-α-羟基羧酸的制备方法，其包括以下步骤（a） - （c）：（a）用光学活性N-氨基甲酸酯保护的β-氨基环氧化物酸，得到光学活性的5-羟甲基-2-恶唑烷酮;（b）在2,2,6,6-四甲基-1-哌啶基氧基和次氯酸盐存在下氧化所得化合物，得到光学活性的4-苄基-2 - 氧代-5-恶唑烷羧酸; 和（c）用碱处理4-苄基-2-氧代-5-恶唑烷羧酸，以及光学活性N-氨基甲酸酯保护的β-氨基-α-羟基羧酸的制备方法，其包括保护氨基与氨基甲酸酯型保护基。本发明的工业生产方法可以有效地生产这些化合物。

6. 发明申请

US20050228175A1 Production method of 2-deoxy-L-ribose compound 审中-公开
标题翻译： 2-脱氧-L-核糖化合物的制备方法
公开(公告)号：US20050228175A1
公开(公告)日：2005-10-13
申请号：US11076877
申请日：2005-03-11
申请人： Sachiko Oka , Yutaka Honda , Kunisuke Izawa
发明人： Sachiko Oka , Yutaka Honda , Kunisuke Izawa
IPC分类号： C07D317/22 , C07H1/00
CPC分类号： C07H15/04 , C07D317/22 , C07H1/00 , C07H3/02 , Y02P20/55
摘要： 2-Deoxy-L-ribose may be prepared by reacting a compound represented by formula (1) with an organometallic compound represented by formula (2) to give a compound represented by formula (3), which is then subjected to deprotection of a hydroxyl group and production of aldehyde by acid hydrolysis: wherein R1 and R2 are each independently a hydroxyl-protecting group or R1 and R2 in combination form a hydroxyl-protecting group, R3 and R4 are each independently an alkyl group, an aralkyl group, an aryl group or a silyl group or R3 and R4 in combination form an alkylene group.
摘要翻译： 2-脱氧-L-核糖可以通过使由式（1）表示的化合物与由式（2）表示的有机金属化合物反应得到由式（3）表示的化合物，然后将其脱羟基通过酸水解组合和生产醛：其中R 1和R 2各自独立地是羟基保护基或R 1和R 2， SUP> 2组合形成羟基保护基，R 3和R 4各自独立地为烷基，芳烷基，芳基或甲硅烷基或R 3和R 4组合形成亚烷基。

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