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1. 发明授权

US06736646B2 Electromagnetic induction-type connector 有权
标题翻译：电磁感应式连接器
公开(公告)号：US06736646B2
公开(公告)日：2004-05-18
申请号：US10157811
申请日：2002-05-31
申请人： Hideo Takahashi , Yasuhiro Suzuki , Naoya Kojima
发明人： Hideo Takahashi , Yasuhiro Suzuki , Naoya Kojima
IPC分类号： H01R1130
CPC分类号： H01F38/14 , H01R13/6633
摘要： A first connector includes a first core member, and a first positioning-purpose fitting portion for the second connector. A second connector includes a second core member, in which an induction electromotive force is produced by the first core member, and a second positioning-purpose fitting portion for fitting in the first fitting portion. The first fitting portions, as well as the second fitting portions, may be arranged at opposite sides of the first core member in such a manner that the first core member are interposed between the first fitting portions. A shock-absorbing elastic member, which can be elastically deformed upon contact, may be provided at the first fitting portion (35) and/or the second fitting portion (44).
摘要翻译：第一连接器包括第一芯部件和用于第二连接器的第一定位用配件部分。第二连接器包括第二芯构件，其中由第一芯构件产生感应电动势，以及用于装配在第一装配部分中的第二定位用配合部。第一装配部分以及第二装配部分可以以第一芯体插入在第一装配部之间的方式设置在第一芯构件的相对侧。可以在第一装配部分（35）和/或第二装配部分（44）处设置可以在接触时弹性变形的减震弹性部件。

2. 发明申请

US20080020029A1 Drug Delivery System Using an Immune Response System 审中-公开
标题翻译：使用免疫反应系统的药物输送系统
公开(公告)号：US20080020029A1
公开(公告)日：2008-01-24
申请号：US10598916
申请日：2005-03-17
申请人： Naoya Kojima , Yoshitaka Shimizu , Yuzuru Ikehara , Hayao Nakanishi
发明人： Naoya Kojima , Yoshitaka Shimizu , Yuzuru Ikehara , Hayao Nakanishi
IPC分类号： A61K9/127
CPC分类号： A61K47/36 , A61K9/1271
摘要： The object of the present invention is to provide a drug delivery composition which allows efficient accumulation of an administered substance such as an anti-cancer drug and the like in a target site. The present invention provides a drug delivery liposome composition for delivering a substance to be administered to a target site, which comprises an oligosaccharide coated liposome and a substance to be administered.
摘要翻译：本发明的目的是提供一种药物递送组合物，其能够将靶向部位等抗癌药等被给药物有效积聚。本发明提供一种药物递送脂质体组合物，其用于将待施用的物质输送到包含寡糖包被的脂质体和待施用物质的靶位点。

3. 发明授权

US08821882B2 Vaccine preparation for neospora caninum infection 有权
标题翻译：新孢子虫感染疫苗的制备
公开(公告)号：US08821882B2
公开(公告)日：2014-09-02
申请号：US13119629
申请日：2009-09-11
申请人： Yoshifumi Nishikawa , Naoaki Yokoyama , Naoya Kojima
发明人： Yoshifumi Nishikawa , Naoaki Yokoyama , Naoya Kojima
IPC分类号： A61K39/00 , A61K39/38
CPC分类号： A61K39/012 , A61K9/127 , A61K2039/552 , A61K2039/55555 , A61K2039/55583
摘要： A vaccine preparation characterized in that Neospora caninum-derived dense granule protein 7 or apical membrane antigen 1 or an immunologically active variant or derivative thereof is included in liposomes each having an oligosaccharide capable of binding to a carbohydrate recognition molecule on the surface of antigen-presenting cells on the surface of the liposome.
摘要翻译：一种疫苗制剂，其特征在于新生孢子囊源于致密颗粒蛋白7或顶端膜抗原1或其免疫学活性变体或衍生物包括在每个具有能够结合抗原呈递的表面上的碳水化合物识别分子的寡糖的脂质体中脂质体表面上的细胞。

4. 发明授权

US5754021A Load control system for vehicle 失效
标题翻译：车载负荷控制系统
公开(公告)号：US5754021A
公开(公告)日：1998-05-19
申请号：US687923
申请日：1996-07-26
申请人： Naoya Kojima
发明人： Naoya Kojima
IPC分类号： B60R16/02 , B60R16/03 , H02J13/00 , H04Q9/00 , H02J1/00
CPC分类号： H02J13/0003 , B60R16/0315
摘要： An improved load control system for controlling loads such as electric motors in a vehicle is disclosed. The system includes switching circuits, each associated with particular loads and placed in close proximity to the loads' respective switches. The system also includes several load control units which are placed in various locations inside the car, so as to minimize the possibility that all the control units will be damaged in a collision. Each of the switching circuits is capable of sending commands to each of the control units, and each of the control units is capable of controlling each of the loads in the car. Thus, when a failure occurs in a particular switching circuit, the associated loads can be controlled using another switching circuit.
摘要翻译：公开了一种用于控制车辆中的电动机的负载的改进的负载控制系统。该系统包括切换电路，每个切换电路与特定负载相关联并且被放置在紧靠负载的相应开关的位置。该系统还包括放置在汽车内部各种位置的多个负载控制单元，以便最小化所有控制单元在碰撞中将被损坏的可能性。每个开关电路能够向每个控制单元发送命令，并且每个控制单元能够控制轿厢中的每个负载。因此，当在特定开关电路中发生故障时，可以使用另一个开关电路来控制相关联的负载。

5. 发明授权

US06218161B1 Sugar-chain synthetase and process for producing the same 有权
标题翻译：糖链合成酶及其制备方法
公开(公告)号：US06218161B1
公开(公告)日：2001-04-17
申请号：US09143438
申请日：1998-08-28
申请人： Shuichi Tsuji , Nobuyuki Kurosawa , Toshiro Hamamoto , Young-Choon Lee , Takashi Nakaoka , Naoya Kojima
发明人： Shuichi Tsuji , Nobuyuki Kurosawa , Toshiro Hamamoto , Young-Choon Lee , Takashi Nakaoka , Naoya Kojima
IPC分类号： C12N1554
CPC分类号： C12N9/1081
摘要： Novel GalNAc&agr;2,6-sialyltransferases P-B1 and P-B3; GalNAc&agr;2,6-sialyltransferase genes encoding the above GalNAc&agr;2,6-sialyltransferases P-B1 and P-B3; and an extracellularly releasable protein catalyzing GalNAc&agr;2,6-sialic acid transfer which comprises a polypeptide portion as being an active domain of the GalNAc&agr;2,6-sialyltransferase P-B1 or P-B3 together with a signal peptide are provided. Also provided is a process for preparing a sialyltransferases which enables efficient recovery of a sialyltransferase expressed in a large quantity in microorganisms.
摘要翻译：新型GalNAcalpha2,6-sialyltransferases P-B1和P-B3; 编码上述GalNAcalpha2,6-唾液酸转移酶P-B1和P-B3的GalNAcalpha2,6-sialyltransferase基因; 以及催化GalNAcalpha2,6-唾液酸转移的细胞外可释放蛋白，其包含作为GalNAcalpha2,6-唾液酸转移酶P-B1或P-B3的活性结构域的多肽部分与信号肽。还提供了一种制备唾液酸转移酶的方法，其能够有效地回收在微生物中大量表达的唾液酸转移酶。

6. 发明申请

US20090238863A1 LIPOSOME COMPOSITION FOR INDUCTION OF IMMUNITY 审中-公开
标题翻译：用于诱导免疫的脂质体组合物
公开(公告)号：US20090238863A1
公开(公告)日：2009-09-24
申请号：US11909912
申请日：2006-03-29
申请人： Naoya Kojima , Yuzuru Ikehara , Kunio Tsujimura
发明人： Naoya Kojima , Yuzuru Ikehara , Kunio Tsujimura
IPC分类号： A61K9/127 , A61P35/00
CPC分类号： A61K39/39 , A61K9/127 , A61K2039/55555
摘要： It is an object of the present invention to provide a liposome composition which is able to allow the MHC class I and class II molecules of antigen-presenting cells to efficiently present an antigen substance. The present invention provides a liposome composition, which comprises an oligosaccharide-coated liposome and an antigen substance and is used to cause the MHC class I and class II molecules of an antigen-presenting cell to present an antigen peptide.
摘要翻译：本发明的目的是提供能够使抗原呈递细胞的MHC I类和II类分子有效地呈递抗原物质的脂质体组合物。本发明提供脂质体组合物，其包含寡糖包被的脂质体和抗原物质，并且用于使抗原呈递细胞的MHC I类和II类分子呈递抗原肽。

7. 发明申请

US20090081284A1 THERAPEUTIC AGENT FOR ALLERGY CONTAINING LIPOSOME HAVING OLIGOSACCHARIDE ON ITS SURFACE 审中-公开
标题翻译：用于含有低密度脂蛋白在其表面上含有脂质过氧化物质的治疗剂
公开(公告)号：US20090081284A1
公开(公告)日：2009-03-26
申请号：US12297714
申请日：2006-10-20
申请人： Naoya Kojima , Hideki Narumi , Hajime Masumoto , Tomokatsu Iwamura , Akihito Kaneda
发明人： Naoya Kojima , Hideki Narumi , Hajime Masumoto , Tomokatsu Iwamura , Akihito Kaneda
IPC分类号： A61K39/36 , A61K9/127 , A61P37/08 , A61K39/35
CPC分类号： A61K39/36 , A61K9/0019 , A61K9/0043 , A61K9/1271 , A61K47/549 , A61K47/6911 , A61K2039/55555 , A61K2039/57 , A61K2039/6018
摘要： An object of the present invention is to provide a therapeutic agent for allergy which realizes enhancement of therapeutic efficacy and improvement in side effects such as anaphylaxis in a method for treating allergy by allergen administration (hyposensitization therapy).That is, the present invention provides the therapeutic agent for allergy comprising a liposome having on its surface an oligosaccharide capable of binding to a lectin derived from an antigen presenting cell and composed of 2 to 11 sugar residues, wherein an allergen is encapsulated in said liposome.
摘要翻译：本发明的目的是提供一种过敏治疗剂，其通过变应原给药（低敏感治疗）治疗过敏的方法，其实现了治疗功效的提高和副作用的改善，例如过敏反应。也就是说，本发明提供了包含脂质体在其表面上具有能够结合衍生自抗原呈递细胞并由2至11个糖残基组成的凝集素的寡糖的过敏治疗剂，其中变应原包封在所述脂质体中。

8. 发明授权

US6017743A Sia.alpha. 2,3, Gal.beta. 1, 4Glc NAc.alpha. 2,8-sialyltransferase 失效
标题翻译： Siaα2,3，Galβ1，4Glc NAcα2,8-唾液酸转移酶
公开(公告)号：US6017743A
公开(公告)日：2000-01-25
申请号：US957742
申请日：1997-10-24
申请人： Shuichi Tsuji , Yukiko Yoshida , Naoya Kojima , Nobuyuki Kurosawa , Toshiro Hamamoto
发明人： Shuichi Tsuji , Yukiko Yoshida , Naoya Kojima , Nobuyuki Kurosawa , Toshiro Hamamoto
IPC分类号： C12N15/09 , C07H21/04 , C12N5/10 , C12N9/10 , C12N15/54 , C12P21/02 , C12R1/91 , C12N15/63
CPC分类号： C12N9/1081 , C07K2319/02
摘要： The present invention provides a nucleotide sequence encoding Sia.alpha.2,3Gal.beta.1,4GlcNAc .alpha.2,8-sialyltransferase and an enzymatically active fragment thereof. The present invention also provides a nucleotide sequence encoding an extracellularly releasable protein capable of catalyzing Sia.alpha.2,3Gal.beta.1,4GlcNAc .alpha.2,8-sialyltransfer which comprises an enzymatically active fragment of the Sia.alpha.2,3Gal.beta.1,4GlcNAc .alpha.2,8-sialyltransferase together with a nucleotide sequence encoding at least one signal peptide. The present invention also provides recombinant vectors comprising nucleotide sequences encoding Sia.alpha.2,3Gal.beta.1,4GlcNAc .alpha.2,8-sialyltransferase. Processes for preparing extracellularly releasable polypeptide fragments of Sia.alpha.2,3Gal.beta.1,4GlcNAc .alpha.2,8-sialyltransferase are provided as well.
摘要翻译：本发明提供编码Siaα2,3Galβ1,4GlcNAcα2,8-唾液酸转移酶的核苷酸序列及其酶活性片段。本发明还提供编码能够催化Siaα2,3Galβ1,4GlcNAcα2,8-唾液酸转移酶的细胞外可释放蛋白质的核苷酸序列，其包含Siaα2,3Galβ1,4GlcNAcα2的酶促活性片段，8-唾液酸转移酶以及编码至少一种信号肽的核苷酸序列。本发明还提供了包含编码Siaα2,3Galβ1,4GlcNAcα2,8-唾液酸转移酶的核苷酸序列的重组载体。还提供了用于制备Siaα2,3Galβ1,4GlcNAcα2,8-唾液酸转移酶的细胞外可释放多肽片段的方法。

9. 发明授权

US5854042A Sugar-chain synthetase and process for producing the same 失效
标题翻译：糖链合成酶及其制备方法
公开(公告)号：US5854042A
公开(公告)日：1998-12-29
申请号：US666367
申请日：1996-08-19
申请人： Shuichi Tsuji , Nobuyuki Kurosawa , Toshiro Hamamoto , Young-Choon Lee , Takashi Nakaoka , Naoya Kojima
发明人： Shuichi Tsuji , Nobuyuki Kurosawa , Toshiro Hamamoto , Young-Choon Lee , Takashi Nakaoka , Naoya Kojima
IPC分类号： C12N9/10 , C12N15/54
CPC分类号： C12N9/1081
摘要： Novel GalNAc .alpha. 2,6-sialyltransferases P-B1 and P-B3; GalNAc .alpha. 2,6-sialyltransferase genes encoding the above GalNAc .alpha. 2,6-sialyltransferases P-B1 and P-B3; and an extracellularly releasable protein catalyzing GalNAc .alpha. 2,6-sialic acid transfer which comprises a polypeptide portion as being an active domain of the GalNAc .alpha. 2,6-sialyltransferase P-B1 or P-B3 together with a signal peptide are provided. Also provided is a process for preparing a sialyltransferases which enables efficient recovery of a sialyltransferase expressed in a large quantity in microorganisms.
摘要翻译： PCT No.PCT / JP94 / 02182 Sec。 371日期：1996年8月19日 102（e）日期1996年8月19日PCT 1994年12月22日PCT PCT。公开号WO95 / 18217 日期1995年7月6日新型GalNAcα2,6-唾液酸转移酶P-B1和P-B3; 编码上述GalNAcα2,6-唾液酸转移酶P-B1和P-B3的GalNAcα2,6-唾液酸转移酶基因; 以及催化GalNAcα2-6唾液酸转移的细胞外可释放蛋白，其包含多肽部分作为GalNAcα2,6-唾液酸转移酶P-B1或P-B3与信号肽的活性结构域。还提供了一种制备唾液酸转移酶的方法，其能够有效地回收在微生物中大量表达的唾液酸转移酶。

10. 发明授权

US5798244A Sia.alpha. 2,3Gal.beta. 1,4GlcNAc .alpha. 2,8-sialyltransferase 失效
标题翻译： Sia alpha 2,3Gal beta 1,4GlcNAc alpha 2,8-sialyltransferase
公开(公告)号：US5798244A
公开(公告)日：1998-08-25
申请号：US626994
申请日：1996-04-03
申请人： Shuichi Tsuji , Yukiko Yoshida , Naoya Kojima , Nobuyuki Kurosawa , Toshiro Hamamoto
发明人： Shuichi Tsuji , Yukiko Yoshida , Naoya Kojima , Nobuyuki Kurosawa , Toshiro Hamamoto
IPC分类号： C12N15/09 , C07H21/04 , C12N5/10 , C12N9/10 , C12N15/54 , C12P21/02 , C12R1/91
CPC分类号： C12N9/1081 , C07K2319/02
摘要： The subject invention provides Sia.alpha.2,3 Gal.beta.1,4GlcNAc.alpha.2,8-sialyltransferase and an enzymatically active fragment thereof, and a nucleotide sequence encoding said sialyltransferase. The subject invention also provides an extracellularly releasable protein capable of catalyzing Sia.alpha.2,3Gal.beta.1,4GlcNAc.alpha.2,8-sialyltransfer which comprises the enzymatically active fragment of the Sia.alpha.2,3Gal.beta.1,4GlcNAc.alpha.2,8-sialyltransferase together with a signal peptide.
摘要翻译：本发明提供了Siaα2βGalβ1,4GlcNAcα2,8-唾液酸转移酶及其酶活性片段和编码所述唾液酸转移酶的核苷酸序列。本发明还提供能够催化Siaα2,3Galβ1,4GlcNAcα2,8-唾液酸转移酶的细胞外可释放蛋白，其包含Siaα2,3Galβ1,4GlcNAcα2,8-唾液酸转移酶的酶活性片段以及信号肽。

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