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1. 发明授权

US5688931A Polysaccharide derivatives and drug carriers 失效
标题翻译：多糖衍生物和药物载体
公开(公告)号：US5688931A
公开(公告)日：1997-11-18
申请号：US325296
申请日：1994-12-28
申请人： Hideo Nogusa , Hiroshi Hamana , Toshiro Yano , Masahiro Kajiki , Keiji Yamamoto , Satoshi Okuno , Shuichi Sugawara , Nobukazu Kashima , Kazuhiro Inoue
发明人： Hideo Nogusa , Hiroshi Hamana , Toshiro Yano , Masahiro Kajiki , Keiji Yamamoto , Satoshi Okuno , Shuichi Sugawara , Nobukazu Kashima , Kazuhiro Inoue
IPC分类号： A61K47/48 , C08B37/00 , C08B37/02 , C07H13/02 , C07K5/00 , C08B37/08
CPC分类号： C08B37/0063 , A61K47/48338 , C08B37/00 , C08B37/0006
摘要： A novel polysaccharide derivative, a drug carrier comprising a novel polysaccharide derivative, and a drug complex are disclosed. The polysaccharide derivative according to the present invention comprises a polysaccharide having a carboxyl group in which a peptide chain is introduced at a part or all of the carboxyl groups of the polysaccharide. The peptide chain comprises 1-8 amino acids which may be the same or different. A part or all of the amino groups in the peptide chain which are not involved in the linkages with the carboxyl groups of the polysaccharide or the carboxyl groups in the peptide chain may form an acid amide linkage or an ester linkage with a carboxyl group, an amino group or a hydroxyl group of a third compound such as drugs. The polysaccharide derivative has a property of accumulating in a high amount at a tumor, and thus can deliver efficiently a drug which has a side-effect or a limited sustainment of the drug efficacy to the tumor.
摘要翻译： PCT No.PCT / JP94 / 00322 Sec。 371日期1994年12月28日第 102（e）日期1994年12月28日PCT 1994年2月28日PCT PCT。第WO94 / 19376号公报日期1994年9月1日公开了一种新型多糖衍生物，包含新型多糖衍生物的药物载体和药物复合物。本发明的多糖衍生物含有在多糖的一部分或全部羧基上引入肽链的具有羧基的多糖。肽链包含1-8个氨基酸，其可以相同或不同。不参与与肽链中的多糖或羧基的羧基的连接的肽链中的一部分或全部氨基可以与羧基形成酸酰胺键或酯键，氨基或第三化合物如药物的羟基。多糖衍生物具有在肿瘤中高度积累的性质，因此能够有效地递送对肿瘤具有药效的副作用或有限维持性的药物。

2. 发明授权

US06458347B1 Drug complex 有权
标题翻译：药物复合体
公开(公告)号：US06458347B1
公开(公告)日：2002-10-01
申请号：US09172085
申请日：1998-10-14
申请人： Shuichi Sugawara , Masahiro Kajiki , Hiroshi Kuriyama , Nobuya Kitaguchi
发明人： Shuichi Sugawara , Masahiro Kajiki , Hiroshi Kuriyama , Nobuya Kitaguchi
IPC分类号： A61K3177
CPC分类号： A61K47/61 , A61K47/60
摘要： Disclosed is a drug complex of a drug having a hydroxyl group, which is capable of controlling the rate of the release of the drug therefrom in blood, the drug complex being represented by the following formula (1): A—B—C (1) wherein A represents at least one carrier selected from the group consisting of saccharides each having a carboxyl group, polyethylene glycols each having a carboxyl group, aliphatic carboxylic acids each having a carboxyl group, and derivatives thereof each having a carboxyl group; B represents at least one spacer comprised of a compound having a amino group and a carboxyl group; C represents at least one drug having a hydroxyl group, wherein the carrier A is bonded to the spacer B through an amide bond formed between the carboxyl group of the carrier A and the amino group of the spacer B; and the spacer B is bonded to the drug C through an ester bond formed between the carboxyl group of the spacer B and the hydroxyl group of the drug C.
摘要翻译：公开了具有羟基的药物的药物复合物，其能够控制药物在血液中的释放速率，药物复合物由下式（1）表示：其中A表示至少一种载体选自具有羧基的糖类，各自具有羧基的聚乙二醇，各自具有羧基的脂肪族羧酸，以及各自具有羧基的衍生物; B表示至少一个由具有氨基和羧基的化合物组成的间隔物; C表示至少一种具有羟基的药物，其中载体A通过形成在载体A的羧基和间隔基B的氨基之间的酰胺键与间隔基B结合; 并且间隔物B通过在间隔物B的羧基和药物C的羟基之间形成的酯键与药物C结合。

3. 发明授权

US07714096B2 Resin composition, cured product and optical parts 失效
标题翻译：树脂组合物，固化产品和光学部件
公开(公告)号：US07714096B2
公开(公告)日：2010-05-11
申请号：US12057815
申请日：2008-03-28
申请人： Mitsuru Ueda , Shinji Ando , Jin-gang Liu , Yuzi Shibasaki , Yasuhiro Nakamura , Shuichi Sugawara , Miwa Ariyuki , Yuichi Eriyama , Keisuke Kuriyama , Hideaki Takase
发明人： Mitsuru Ueda , Shinji Ando , Jin-gang Liu , Yuzi Shibasaki , Yasuhiro Nakamura , Shuichi Sugawara , Miwa Ariyuki , Yuichi Eriyama , Keisuke Kuriyama , Hideaki Takase
IPC分类号： C08K3/10 , C08K3/22 , C08G69/48 , C08G69/42 , C08G75/00 , C08G79/02 , C08G69/26 , C08F283/04 , C09K19/00
CPC分类号： C08L79/08 , C08G73/1064 , C08J5/18 , C08J2379/08 , C08K3/22 , Y10T428/1023
摘要： It is provided for a resin composition including (A) at least one polyamic acid having the structure represented by the following formula (1): wherein R1 is independently an alkyl group having 1 to 3 carbon atoms or a cyano group; a is independently an integer of 0 to 4; R is a tetravalent organic group; n is an integer of 1 to 4; and m is an integer of 1 to 100,000, and (E) an organic solvent.
摘要翻译：提供一种树脂组合物，其包含（A）至少一种具有由下式（1）表示的结构的聚酰胺酸：其中R 1独立地为具有1至3个碳原子的烷基或氰基; a独立地为0〜4的整数; R是四价有机基团; n为1〜4的整数， m为1〜100的整数，（E）有机溶剂。

4. 发明申请

US20080255284A1 RESIN COMPOSITION, CURED PRODUCT AND OPTICAL PARTS 失效
标题翻译：树脂组合物，固化产品和光学部件
公开(公告)号：US20080255284A1
公开(公告)日：2008-10-16
申请号：US12057815
申请日：2008-03-28
申请人： Mitsuru Ueda , Shinji Ando , Jin-gang Liu , Yuzi Shibasaki , Yasuhiro Nakamura , Shuichi Sugawara , Miwa Ariyuki , Yuichi Eriyama , Keisuke Kuriyama , Hideaki Takase
发明人： Mitsuru Ueda , Shinji Ando , Jin-gang Liu , Yuzi Shibasaki , Yasuhiro Nakamura , Shuichi Sugawara , Miwa Ariyuki , Yuichi Eriyama , Keisuke Kuriyama , Hideaki Takase
IPC分类号： C08G69/00 , C08K3/22
CPC分类号： C08L79/08 , C08G73/1064 , C08J5/18 , C08J2379/08 , C08K3/22 , Y10T428/1023
摘要： It is provided for a resin composition including (A) at least one polyamic acid having the structure represented by the following formula (1): wherein R1 is independently an alkyl group having 1 to 3 carbon atoms or a cyano group; a is independently an integer of 0 to 4; R is a tetravalent organic group; n is an integer of 1 to 4; and m is an integer of 1 to 100,000, and (E) an organic solvent.
摘要翻译：提供了一种树脂组合物，其包含（A）至少一种具有由下式（1）表示的结构的聚酰胺酸：其中R 1独立地为具有1至3个碳原子的烷基或氰基; a独立地为0〜4的整数; R是四价有机基团; n为1〜4的整数， m为1〜100,000的整数，（E）有机溶剂。

5. 发明授权

US4730418A Abrasing apparatus using magnetic abrasive powder 失效
标题翻译：使用磁性研磨粉的磨耗装置
公开(公告)号：US4730418A
公开(公告)日：1988-03-15
申请号：US930151
申请日：1986-11-12
申请人： Shuichi Sugawara , Hisatsugu Kaji , Masaaki Shimada
发明人： Shuichi Sugawara , Hisatsugu Kaji , Masaaki Shimada
IPC分类号： B24B31/02 , B24B31/112 , B24B31/03
CPC分类号： B24B31/112 , B24B31/0224
摘要： An abrasing apparatus including an annular barrel having an upper opening. The barrel is rotated around an exciting coil and is filled with magnetic abrasive powder which is arranged by magnetic flux generated by the exciting coil to form magnetic brush. A work is embedded into the magnetic brush. The work is rotated together with a spindle and the barrel is rotated so that the surface of the work is abrased by the magnetic brush. A bottom magnetic pole, a lateral magnetic pole and an upper magnetic pole are disposed in an inner periphery in the barrel in the proximity to the exciting coil and the strong magnetic brush is locally formed therein. The side portion of the work is located in the local magnetic brush, and the bottom, side and upper surfaces of the work are abrased like a mirror surface.
摘要翻译：一种磨损装置，包括具有上部开口的环形筒。桶围绕励磁线圈旋转，并填充有磁性磨料粉末，该磨料粉末由励磁线圈产生的磁通量排列，形成磁刷。一个工作嵌入到磁刷中。工件与主轴一起旋转，并且筒被旋转，使得工件的表面被磁刷磨损。底部磁极，横向磁极和上部磁极设置在枪管内部的靠近励磁线圈的内周中，强磁性电刷局部地形成在其中。工件的侧面部分位于局部磁刷中，工件的底面，侧面和上表面像镜面一样磨损。

6. 发明授权

US07863408B2 Body fluid compatible and biocompatible resin 有权
标题翻译：体液相容性和生物相容性树脂
公开(公告)号：US07863408B2
公开(公告)日：2011-01-04
申请号：US11028185
申请日：2005-01-04
申请人： Shuichi Sugawara
发明人： Shuichi Sugawara
IPC分类号： C08G65/34
CPC分类号： C08G65/48 , A61K47/60 , A61L27/18 , A61L31/18 , A61L33/068 , C08G65/22 , C08G65/329 , C08L71/02 , C08L2203/02
摘要： A body fluid compatible and biocompatible resin for use in a medical treatment involving a contact of said resin with at least one member selected from the group consisting of a body fluid and a biological tissue, which comprises at least one substituted oxyalkylene polymer having a weight average molecular weight of from 1,000 to 1,000,000 and represented by the following formula (1): wherein each of R1, R2 and R3 independently represents a hydrogen atom or a —CH2R4 group, and each R4 independently represents a hydroxyl group or a —OR5 group (wherein R5 represents a group selected from the group consisting of a C1-C10 aliphatic hydrocarbyl group, a C6-C10 aryl group, a —R6COOH group and a derivative thereof, and a —CH2—O—CH2—CH(OH)—CH2—OR7 group, wherein R6 represents a C1-C10 aliphatic hydrocarbylene group and R7 represents a C1-C10 aliphatic hydrocarbyl group or a C6-C10 aryl group), provided that all of R1, R2, and R3 are not simultaneously hydrogen atoms; and 10≦x≦10,000 and 0≦y≦10,000.
摘要翻译：一种体液相容性和生物相容性树脂，用于涉及所述树脂与选自体液和生物组织中的至少一种的接触的药物治疗，其包含至少一种具有重量平均值的取代的氧化烯聚合物分子量为1,000〜1,000,000，由下式（1）表示：其中，R 1，R 2和R 3各自独立地表示氢原子或-CH 2 R 4基，R 4各自独立地表示羟基或-OR 5基（其中R5表示选自C1-C10脂族烃基，C6-C10芳基，-R6COOH基及其衍生物的基团和-CH2-O-CH2-CH（OH）-CH2 -OR7基团，其中R6表示C1-C10脂族亚烃基，R7表示C1-C10脂族烃基或C6-C10芳基），条件是R1，R2和R3全部不同时为氢原子; 和10＆nlE; x＆nlE; 10,000和0＆nlE; y＆nlE; 10,000。

7. 发明申请

US20080287605A1 Curable Liquid Composition, Cured Layer and Coated Optical Fiber 审中-公开
标题翻译：可固化液体组合物，固化层和涂覆光纤
公开(公告)号：US20080287605A1
公开(公告)日：2008-11-20
申请号：US11886088
申请日：2006-03-10
申请人： Shuichi Sugawara , Hiroshi Miyazawa , Masahito Mase , Takeo Shigemoto
发明人： Shuichi Sugawara , Hiroshi Miyazawa , Masahito Mase , Takeo Shigemoto
IPC分类号： C08L75/16 , B05D5/06
CPC分类号： C03C25/1065 , C08K5/3435 , C08K5/5415 , C09D4/00 , C09D7/63
摘要： A curable liquid resin optical fiber coating composition comprising 0.1 to 10 wt %, relative to the total weight of the composition, of an alkoxysilane compound (A) which does not contain a radically polymerizable functional group, and 0.01 to 1 wt %, relative to the total weight of the composition, of a hindered amine compound. (B). This curable liquid resin composition produces a cured product that ensures a high n-value of the coated optical fiber and an excellent fiber strength after coating removal.
摘要翻译：相对于组合物的总重量为0.1〜10重量％的可固化液晶树脂光纤涂层组合物，相对于不含自由基聚合性官能团的烷氧基硅烷化合物（A）为0.01〜1重量％组合物的总重量，受阻胺化合物。（B）。该可固化液体树脂组合物产生确保涂层光纤的n值高，并且在除去涂层后具有优异的纤维强度的固化产物。

8. 发明授权

US08809496B2 Production method of 11-sugar sialylglycopeptide 有权
标题翻译： 11-糖唾液酸糖肽的制备方法
公开(公告)号：US08809496B2
公开(公告)日：2014-08-19
申请号：US13394197
申请日：2010-09-03
申请人： Shuichi Sugawara , Kenji Osumi
发明人： Shuichi Sugawara , Kenji Osumi
IPC分类号： C07K9/00 , C07K1/30 , C07K1/16
CPC分类号： C07K7/06 , C07K9/00 , C08B37/0063
摘要： It is an object of the present invention to provide a method for producing an 11-sugar sialylglycopeptide easily and with good yield and a high degree of purity on an industrial scale from defatted bird egg yolks. The present invention provides a production method of an 11-sugar sialylglycopeptide. More specifically, the present invention provides a production method of an 11-sugar sialylglycopeptide comprising: an extraction step of extracting defatted bird egg yolks with water or a salt solution to obtain a liquid extract of a glycopeptide, a precipitation step of adding the liquid extract to a water-soluble organic solvent to precipitate the glycopeptide, and a desalting step of desalting the precipitate.
摘要翻译：本发明的一个目的是提供一种从脱脂鸟蛋黄制成工业规模的11-糖唾液酸糖肽的方法，其制备方法良好，产率高，纯度高。本发明提供了11-糖唾液酸糖肽的制备方法。更具体地说，本发明提供了11-糖唾液酸糖肽的制造方法，包括：提取步骤，用水或盐溶液提取脱脂鸟蛋黄，得到糖肽的液体提取物，添加液体提取物的沉淀步骤向水溶性有机溶剂中沉淀糖肽，以及脱盐脱盐步骤。

9. 发明申请

US20100137490A1 RESIN COMPOSITION, CURED PRODUCT AND OPTICAL PARTS 审中-公开
标题翻译：树脂组合物，固化产品和光学部件
公开(公告)号：US20100137490A1
公开(公告)日：2010-06-03
申请号：US12694850
申请日：2010-01-27
申请人： Mitsuru Ueda , Shinji Ando , Jin-gang Liu , Yuzi Shibasaki , Yasuhiro Nakamura , Shuichi Sugawara , Miwa Ariyuki , Yuichi Eriyama , Keisuke Kuriyama , Hideaki Takase
发明人： Mitsuru Ueda , Shinji Ando , Jin-gang Liu , Yuzi Shibasaki , Yasuhiro Nakamura , Shuichi Sugawara , Miwa Ariyuki , Yuichi Eriyama , Keisuke Kuriyama , Hideaki Takase
IPC分类号： C08K3/22 , C08L79/08 , C08G73/10
CPC分类号： C08L79/08 , C08G73/1064 , C08J5/18 , C08J2379/08 , C08K3/22 , Y10T428/1023
摘要： It is provided for a resin composition including (A) at least one polyamic acid having the structure represented by the following formula (1): wherein R1 is independently an alkyl group having 1 to 3 carbon atoms or a cyano group; a is independently an integer of 0 to 4; R is a tetravalent organic group; n is an integer of 1 to 4; and m is an integer of 1 to 100,000, and (E) an organic solvent.
摘要翻译：提供一种树脂组合物，其包含（A）至少一种具有由下式（1）表示的结构的聚酰胺酸：其中R 1独立地为具有1至3个碳原子的烷基或氰基; a独立地为0〜4的整数; R是四价有机基团; n为1〜4的整数， m为1〜100的整数，（E）有机溶剂。

10. 发明申请

US20050113560A1 Body fluid compatible and biocompatible resin 有权
标题翻译：体液相容性和生物相容性树脂
公开(公告)号：US20050113560A1
公开(公告)日：2005-05-26
申请号：US11028185
申请日：2005-01-04
申请人： Shuichi Sugawara
发明人： Shuichi Sugawara
IPC分类号： A61K47/48 , A61L27/18 , A61L31/18 , A61L33/06 , C08G65/22 , C08G65/329 , C08G65/48 , C08L71/02 , C08G65/34
CPC分类号： C08G65/48 , A61K47/60 , A61L27/18 , A61L31/18 , A61L33/068 , C08G65/22 , C08G65/329 , C08L71/02 , C08L2203/02
摘要： A body fluid compatible and biocompatible resin for use in a medical treatment involving a contact of said resin with at least one member selected from the group consisting of a body fluid and a biological tissue, which comprises at least one substituted oxyalkylene polymer having a weight average molecular weight of from 1,000 to 1,000,000 and represented by the following formula (1): wherein each of R1, R2 and R3 independently represents a hydrogen atom or a —CH2R4 group, and each R4 independently represents a hydroxyl group or a —OR5 group (wherein R5 represents a group selected from the group consisting of a C1-C10 aliphatic hydrocarbyl group, a C6-C10 aryl group, a —R6COOH group and a derivative thereof, and a —CH2—O—CH2—CH(OH)—CH2—OR7 group, wherein R6 represents a C1-C10 aliphatic hydrocarbylene group and R7 represents a C1-C10 aliphatic hydrocarbyl group or a C6-C10 aryl group), provided that all of R1, R2, and R3 are not simultaneously hydrogen atoms; and 10≦x≦10,000 and 0≦y≦10,000.
摘要翻译：一种体液相容性和生物相容性树脂，用于涉及所述树脂与选自体液和生物组织中的至少一种的接触的药物治疗，其包含至少一种具有重量平均值的取代的氧化烯聚合物分子量为1,000〜1,000,000，由下式（1）表示：其中R 1，R 2和R 3各自独立地为表示氢原子或-CH 2 R 4 R 4基团，并且每个R 4独立地表示羟基或-OR 5个基团（其中R 5表示选自C 1 -C 10脂肪族烃基的基团， C 6 -C 10芳基，-OR 6 COOH基团及其衍生物，和-CH 2， -O-CH 2 -CH（OH）-CH 2 - ， - 7组，其中R 6， SUP>表示C 1 -C 3 10脂族亚烃基和R 7表示C 1 -C 10脂族烃基或C 6 - / SUB> -C 10芳基），条件是所有的R 1，R 2和R 3均为 >不是同时是氢原子; 并且10 <= x <= 10,000且0 <= y <= 10,000。

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