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1. 发明授权

US08697094B2 Stable solid preparations 有权
标题翻译：稳固的固体制剂
公开(公告)号：US08697094B2
公开(公告)日：2014-04-15
申请号：US10530785
申请日：2003-10-15
申请人： Muneo Nonomura , Hiroki Ito , Hideo Hashimoto , Tadashi Urai
发明人： Muneo Nonomura , Hiroki Ito , Hideo Hashimoto , Tadashi Urai
IPC分类号： A61K9/00 , A61K31/44
CPC分类号： A61K9/1676 , A61K9/209 , A61K9/4808 , A61K31/4439 , A61K47/02
摘要： It is intended to provide a process for producing unstable amorphous benzimidazole compounds having a proton pump inhibitor function, and stable solid preparations for medicinal use containing these compounds which are produced by blending such an amorphous benzimidazole compound with a nontoxic base such as a basic inorganic salt, forming an intermediate coating layer on the layer containing the active ingredient and further forming an enteric coating layer or a release-controlling coating layer.
摘要翻译：旨在提供一种制备具有质子泵抑制剂功能的不稳定无定形苯并咪唑化合物的方法，以及含有这些化合物的稳定的固体制剂，其通过将无定形苯并咪唑化合物与无毒碱如碱性无机盐在包含活性成分的层上形成中间涂层，并进一步形成肠溶衣层或释放控制涂层。

2. 发明申请

US20110020410A1 STABLE SOLID PREPARATIONS 有权
标题翻译：稳定的固体制剂
公开(公告)号：US20110020410A1
公开(公告)日：2011-01-27
申请号：US12821717
申请日：2010-06-23
申请人： Muneo Nonomura , Hiroki Ito , Hideo Hashimoto , Tadashi Urai
发明人： Muneo Nonomura , Hiroki Ito , Hideo Hashimoto , Tadashi Urai
IPC分类号： A61K31/4439 , A61K31/4184 , A61K9/00
CPC分类号： A61K9/1676 , A61K9/209 , A61K9/4808 , A61K31/4439 , A61K47/02
摘要： It is intended to provide a process for producing unstable amorphous benzimidazole compounds having a proton pump inhibitor function, and stable solid preparations for medicinal use containing these compounds which are produced by blending such an amorphous benzimidazole compound with a nontoxic base such as a basic inorganic salt, forming an intermediate coating layer on the layer containing the active ingredient and further forming an enteric coating layer or a release-controlling coating layer.
摘要翻译：旨在提供一种制备具有质子泵抑制剂功能的不稳定无定形苯并咪唑化合物的方法，以及含有这些化合物的稳定的固体制剂，其通过将无定形苯并咪唑化合物与无毒碱如碱性无机盐在包含活性成分的层上形成中间涂层，并进一步形成肠溶衣层或释放控制涂层。

3. 发明授权

US07692505B2 Crystal oscillator 失效
标题翻译：水晶振荡器
公开(公告)号：US07692505B2
公开(公告)日：2010-04-06
申请号：US11500433
申请日：2006-08-08
申请人： Hideo Hashimoto
发明人： Hideo Hashimoto
IPC分类号： H03B5/32
CPC分类号： H03B5/368 , H03L1/022 , H03L1/023 , H03L1/028
摘要： A crystal oscillator in which phase noise is reduced includes: a resonance circuit having a crystal unit and split capacitors connected to the crystal unit; a transistor for oscillation having a base connected to the connection node of the crystal unit and the split capacitors; an output line for connecting the node for connecting together the split capacitors and the emitter of the transistor; a crystal resonator inserted in the output line; and a resistor connected in parallel to the crystal resonator.
摘要翻译：相位噪声减小的晶体振荡器包括：具有晶体单元的谐振电路和与晶体单元连接的分离电容器; 用于振荡的晶体管，其具有连接到晶体单元的连接节点的基极和分离电容器; 用于连接用于将分离电容器和晶体管的发射极连接在一起的节点的输出线; 插入输出线的晶体谐振器; 以及与晶体谐振器并联连接的电阻器。

4. 发明授权

US07650659B2 Washing method 有权
标题翻译：洗涤方法
公开(公告)号：US07650659B2
公开(公告)日：2010-01-26
申请号：US10591171
申请日：2006-03-09
申请人： Hideo Hashimoto
发明人： Hideo Hashimoto
IPC分类号： D06F35/00
CPC分类号： D06F37/02 , D06F33/02 , D06F35/00 , D06F37/06 , D06F2204/065
摘要： It is intended to provide a washing method for reliably cleaning water-soluble contaminations such as sweat without damaging fabrics.A frame body 18 is disposed horizontally in a casing. The frame body 18 is rotated by a drive motor 23 in the casing. The casing and the frame body 18 are filled with water, and then clothes are placed in the frame body 18. A plurality of protrusions 40 are formed in order that an inner periphery 39 of the frame body 18 has a wavy pattern. A height of the protruding parts is set to from 3.0 to 6.0% of the inner diameter of the frame body 18. A surfant contained in cleaning liquid permeates deep into the clothes.
摘要翻译：旨在提供一种用于可靠地清洁诸如汗水等水溶性污染而不损坏织物的洗涤方法。框架体18水平地设置在壳体中。框体18由壳体内的驱动马达23旋转。壳体和框体18填充有水，然后将衣物放置在框架体18中。形成多个突起40，以使框体18的内周39具有波状图案。突出部的高度设定为框体18的内径的3.0〜6.0％。清洗液中所含的冲洗物深入衣服。

5. 发明授权

US07271182B2 Salts of benzimidazole compound and use thereof 有权
公开(公告)号：US07271182B2
公开(公告)日：2007-09-18
申请号：US10343142
申请日：2001-08-03
申请人： Keiji Kamiyama , Hideo Hashimoto
发明人： Keiji Kamiyama , Hideo Hashimoto
IPC分类号： A61K31/4439 , C07D401/12
CPC分类号： C07D401/12 , A61K31/4439
摘要： A sodium salt, magnesium salt, lithium salt, potassium salt, calcium salt or barium salt of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole, and a pharmaceutical composition comprising the salt. The novel salt is useful as an excellent antiulcer agent.

6. 发明申请

US20070030083A1 Crystal oscillator 失效
标题翻译：水晶振荡器
公开(公告)号：US20070030083A1
公开(公告)日：2007-02-08
申请号：US11500433
申请日：2006-08-08
申请人： Hideo Hashimoto
发明人： Hideo Hashimoto
IPC分类号： H03B5/32
CPC分类号： H03B5/368 , H03L1/022 , H03L1/023 , H03L1/028
摘要： A crystal oscillator in which phase noise is reduced includes: a resonance circuit having a crystal unit and split capacitors connected to the crystal unit; a transistor for oscillation having a base connected to the connection node of the crystal unit and the split capacitors; an output line for connecting the node for connecting together the split capacitors and the emitter of the transistor; a crystal resonator inserted in the output line; and a resistor connected in parallel to the crystal resonator.
摘要翻译：相位噪声减小的晶体振荡器包括：具有晶体单元的谐振电路和与晶体单元连接的分离电容器; 用于振荡的晶体管，其具有连接到晶体单元的连接节点的基极和分离电容器; 用于连接用于将分离电容器和晶体管的发射极连接在一起的节点的输出线; 插入输出线的晶体谐振器; 以及与晶体谐振器并联连接的电阻器。

7. 发明授权

US06433309B1 Oscillator that uses thermostatic oven 有权
公开(公告)号：US06433309B1
公开(公告)日：2002-08-13
申请号：US09795104
申请日：2001-03-01
申请人： Hideo Hashimoto , Takeshi Uchida
发明人： Hideo Hashimoto , Takeshi Uchida
IPC分类号： H05B100
摘要： An oven-controlled oscillator includes a thermostatic oven having a heat source, a vibrator provided in the thermostatic oven, an oscillation circuit for generating an oscillation signal in response to an action of the vibrator, and a heat source control circuit. The heat source control circuit includes a sensor for detecting an internal temperature of the thermostatic oven, an operational amplifier for controlling current to flow through the heat source in response to a resistance value of the sensor so that the internal temperature of the thermostatic oven may be maintained at a predetermined preset temperature, and a feedback resistor for the operational amplifier. The feedback resistor includes a thermistor whose resistance value drops as the temperature rises, and the thermistor is thermally coupled to the thermostatic oven. Preferably, a quartz-crystal element is used as the vibrator.

8. 发明授权

US08222422B2 Crystal of benzimidazole compound 有权
标题翻译：苯并咪唑化合物的晶体
公开(公告)号：US08222422B2
公开(公告)日：2012-07-17
申请号：US12921682
申请日：2009-03-09
申请人： Hideo Hashimoto , Tadashi Urai
发明人： Hideo Hashimoto , Tadashi Urai
IPC分类号： C07D401/00 , A61K31/44
CPC分类号： C07D401/12
摘要： Provided is a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole showing an X-ray powder diffraction pattern having characteristic peaks at interplanar spacings (d) of 10.06±0.2, 8.70±0.2, 6.57±0.2, 5.59±0.2 and 4.00±0.2 Angstroms. The present invention provides a stable antiulcer drug superior in the absorbability.
摘要翻译：提供了（R）-2 - [[3-甲基-4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基] -1H-苯并咪唑的结晶，其显示X射线粉末衍射图在d = 10.06±0.2,8.70±0.2,6.57±0.2,5.59±0.2和4.00±0.2埃的面间距处具有特征峰。本发明提供了在吸收性方面优异的稳定的抗溃疡药。

9. 发明授权

US08061163B2 Washing apparatus 有权
标题翻译：洗衣机
公开(公告)号：US08061163B2
公开(公告)日：2011-11-22
申请号：US12890418
申请日：2010-09-24
申请人： Hideo Hashimoto
发明人： Hideo Hashimoto
IPC分类号： D06F21/04 , D06F33/02 , D06F37/06
CPC分类号： D06F37/06 , D06F35/005 , D06F37/04 , D06F39/087 , D06F43/02 , D06F2204/065
摘要： The washing apparatus has a frame body to be filled with a cleaning liquid. The frame body is rotated within a casing by a drive motor. The frame body has an inner periphery having a wavy patterned surface. An inner diameter D of the frame body is set to more than or equal to 600 mm and less than or equal to 850 mm. The frame body is rotated so that a peripheral speed of the inner periphery is more than or equal to 28 m/min and less than or equal to 57 m/min. A height h of the wave form is set to more than or equal to 2.0% and less than or equal to 9.0% of the inner diameter D, and a pitch p of the wave form is set to more than or equal to 2.0% and less than or equal to 9.0% of a peripheral length L of an imaginary circle having a diameter of the inner diameter D.
摘要翻译：洗涤装置具有要填充有清洁液体的框体。框架主体通过驱动马达在壳体内旋转。框架体具有带有波状图案表面的内周边。框体的内径D设定为600mm以上且小于等于850mm。框架体旋转使得内周的圆周速度大于或等于28m / min且小于或等于57m / min。波形的高度h被设定为大于或等于内径D的2.0％且小于或等于9.0％，并且波形的间距p被设定为大于或等于2.0％，并且小于或等于具有内径D的直径的假想圆的周长L的9.0％

10. 发明授权

US07994332B2 Process for producing crystal 有权
标题翻译：水晶生产工艺
公开(公告)号：US07994332B2
公开(公告)日：2011-08-09
申请号：US12492735
申请日：2009-06-26
申请人： Hideo Hashimoto , Hideaki Maruyama
发明人： Hideo Hashimoto , Hideaki Maruyama
IPC分类号： C07D401/00
CPC分类号： C07D401/12 , A61K31/4439 , C30B7/00
摘要： The present invention relates to a production method of a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]benzimidazole.n′H2O (wherein n′ is about 0 to about 0.1) or a salt thereof, which characteristically includes crystallization from an organic solvent solution or suspension in which (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-benzimidazole.nH2O (wherein n is about 0.1 to about 1.0) or a salt thereof has been dissolved or suspended, and the like, and provides a convenient method for efficiently producing an optically active sulfoxide derivative having an extremely high enantiomer excess in high yield at an industrial large scale.
摘要翻译：本发明涉及（R）-2 - [[[3-甲基-4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基]苯并咪唑的溶液的制备方法。（其中n'为约0至约0.1）或其盐，其特征在于包括从有机溶剂溶液或悬浮液中结晶，其中（R）-2 - [[[3-甲基-4-（2,2,2' - 三氟乙氧基）-2-吡啶基]甲基]亚磺酰基] - 苯并咪唑·nH 2 O（其中n为约0.1至约1.0）或其盐已经溶解或悬浮等，并且提供了有效地制造光学活性亚砜衍生物在工业规模上以高产率具有极高的对映体过量。

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