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1. 发明申请

US20060246034A1 Interferon-beta composite 有权
标题翻译：干扰素-β复合物
公开(公告)号：US20060246034A1
公开(公告)日：2006-11-02
申请号：US10569211
申请日：2004-08-24
申请人： Hideki Narumi , Yoshiaki Tsushima , Koji Yamashita , Saburou Sone , Miyuki Sato
发明人： Hideki Narumi , Yoshiaki Tsushima , Koji Yamashita , Saburou Sone , Miyuki Sato
IPC分类号： A61K38/21 , C07K14/56 , C08G63/91
CPC分类号： C07K14/565 , A61K38/215 , A61K47/60
摘要： The present invention relates to a complex between interferon-β and polyethylene glycol, which has high biological activity, and to a method for producing the complex at high efficiency. Namely, the present invention relates to a method for producing an interferon-β complex comprising binding interferon-β to polyethylene glycol in the presence of at least one additive selected from the group consisting of oligosaccharides having 5 or less sugar units, monosaccharides, their corresponding sugar alcohols, and C2-6 polyhydric alcohols, and to an interferon-β complex produced by the method, which has polyethylene glycol specifically bound with lysine located at the 19th or 134th position in the amino acid sequence of interferon-β.
摘要翻译：本发明涉及具有高生物活性的干扰素-β和聚乙二醇之间的复合物，以及一种高效生产复合物的方法。即，本发明涉及一种生产干扰素-β复合物的方法，包括在至少一种添加剂的存在下将干扰素-β与聚乙二醇结合，所述添加剂选自具有5个或更少糖单位的寡糖，单糖，它们相应的糖醇和C 2-6个多元醇，以及通过该方法制备的干扰素-β复合物，其具有与位于氨基酸序列中第19位或第134位的赖氨酸特异性结合的聚乙二醇的干扰素-β。

2. 发明申请

US20100145017A1 METHOD OF PRODUCING INTERFERON-B COMPLEX 有权
标题翻译：生产干扰素B复合物的方法
公开(公告)号：US20100145017A1
公开(公告)日：2010-06-10
申请号：US12579438
申请日：2009-10-15
申请人： Hideki Narumi , Yoshiaki Tsushima , Koji Yamashita , Saburou Sone , Miyuki Sato
发明人： Hideki Narumi , Yoshiaki Tsushima , Koji Yamashita , Saburou Sone , Miyuki Sato
IPC分类号： C07K14/565
CPC分类号： C07K14/565 , A61K38/215 , A61K47/60
摘要： A method for producing an interferon-β complex includes binding interferon-β to polyethylene glycol in the presence of at least one additive selected from the group consisting of oligosaccharides having 5 or less sugar units, monosaccharides, sugar alcohols thereof, and C2-6 polyhydric alcohols.
摘要翻译：干扰素的制造方法复合物包括结合性干扰素在至少一种选自由5个或更少糖单元的寡糖，单糖，其糖醇和C2-6多元醇组成的组的存在下存在的聚乙二醇。

3. 发明授权

US07691975B2 Interferon-β complex 有权
标题翻译：干扰素复杂
公开(公告)号：US07691975B2
公开(公告)日：2010-04-06
申请号：US10569211
申请日：2004-08-24
申请人： Hideki Narumi , Yoshiaki Tsushima , Koji Yamashita , Saburou Sone , Miyuki Sato
发明人： Hideki Narumi , Yoshiaki Tsushima , Koji Yamashita , Saburou Sone , Miyuki Sato
IPC分类号： C07K14/00 , A61K38/21 , A61K38/00
CPC分类号： C07K14/565 , A61K38/215 , A61K47/60
摘要： The present invention relates to a complex between interferon-β and polyethylene glycol, which has high biological activity, and to a method for producing the complex at high efficiency. Namely, the present invention relates to a method for producing an interferon-β complex comprising binding interferon-β to polyethylene glycol in the presence of at least one additive selected from the group consisting of oligosaccharides having 5 or less sugar units, monosaccharides, their corresponding sugar alcohols, and C2-6 polyhydric alcohols, and to an interferon-β complex produced by the method, which has polyethylene glycol specifically bound with lysine located at the 19th or 134th position in the amino acid sequence of interferon-β.
摘要翻译：本发明涉及干扰素与复合物之间的复合物。和具有高生物活性的聚乙二醇，以及高效制备络合物的方法。即，本发明涉及一种干扰素的制造方法。复合物包含结合干扰素在至少一种添加剂的存在下，使用聚乙二醇，所述添加剂选自具有5个或更少糖单元的寡糖，单糖，它们相应的糖醇和C 2-6多元醇，以及至干扰素-bgr; 通过该方法制备的复合物，其具有与位于干扰素-bgr的氨基酸序列中的第19位或第134位的赖氨酸特异性结合的聚乙二醇。

4. 发明授权

US07915386B2 Method of producing an interferon-β complex 有权
标题翻译：生产干扰素的方法复杂
公开(公告)号：US07915386B2
公开(公告)日：2011-03-29
申请号：US12579438
申请日：2009-10-15
申请人： Hideki Narumi , Yoshiaki Tsushima , Koji Yamashita , Saburou Sone , Miyuki Sato
发明人： Hideki Narumi , Yoshiaki Tsushima , Koji Yamashita , Saburou Sone , Miyuki Sato
IPC分类号： A61K38/21
CPC分类号： C07K14/565 , A61K38/215 , A61K47/60
摘要： A method for producing an interferon-β complex includes binding interferon-β to polyethylene glycol in the presence of at least one additive selected from the group consisting of oligosaccharides having 5 or less sugar units, monosaccharides, sugar alcohols thereof, and C2-6 polyhydric alcohols.
摘要翻译：干扰素的制造方法复合物包括结合性干扰素在至少一种选自由5个或更少糖单元的寡糖，单糖，其糖醇和C2-6多元醇组成的组的存在下存在的聚乙二醇。

5. 发明申请

US20090081284A1 THERAPEUTIC AGENT FOR ALLERGY CONTAINING LIPOSOME HAVING OLIGOSACCHARIDE ON ITS SURFACE 审中-公开
标题翻译：用于含有低密度脂蛋白在其表面上含有脂质过氧化物质的治疗剂
公开(公告)号：US20090081284A1
公开(公告)日：2009-03-26
申请号：US12297714
申请日：2006-10-20
申请人： Naoya Kojima , Hideki Narumi , Hajime Masumoto , Tomokatsu Iwamura , Akihito Kaneda
发明人： Naoya Kojima , Hideki Narumi , Hajime Masumoto , Tomokatsu Iwamura , Akihito Kaneda
IPC分类号： A61K39/36 , A61K9/127 , A61P37/08 , A61K39/35
CPC分类号： A61K39/36 , A61K9/0019 , A61K9/0043 , A61K9/1271 , A61K47/549 , A61K47/6911 , A61K2039/55555 , A61K2039/57 , A61K2039/6018
摘要： An object of the present invention is to provide a therapeutic agent for allergy which realizes enhancement of therapeutic efficacy and improvement in side effects such as anaphylaxis in a method for treating allergy by allergen administration (hyposensitization therapy).That is, the present invention provides the therapeutic agent for allergy comprising a liposome having on its surface an oligosaccharide capable of binding to a lectin derived from an antigen presenting cell and composed of 2 to 11 sugar residues, wherein an allergen is encapsulated in said liposome.
摘要翻译：本发明的目的是提供一种过敏治疗剂，其通过变应原给药（低敏感治疗）治疗过敏的方法，其实现了治疗功效的提高和副作用的改善，例如过敏反应。也就是说，本发明提供了包含脂质体在其表面上具有能够结合衍生自抗原呈递细胞并由2至11个糖残基组成的凝集素的寡糖的过敏治疗剂，其中变应原包封在所述脂质体中。

6. 发明申请

US20090263413A1 IMMUNOSTIMULATORY OLIGONUCLEOTIDES AND USE THEREOF IN PHARMACEUTICALS 有权
标题翻译：免疫组化寡核苷酸及其在药物中的应用
公开(公告)号：US20090263413A1
公开(公告)日：2009-10-22
申请号：US12301746
申请日：2007-05-31
申请人： Tomokatsu Iwamura , Hideki Narumi , Hajime Masumoto , Akihito Kaneda , Akiko Soneda , Shizuo Akira
发明人： Tomokatsu Iwamura , Hideki Narumi , Hajime Masumoto , Akihito Kaneda , Akiko Soneda , Shizuo Akira
IPC分类号： A61K39/29 , C07H21/04 , A61K31/711 , A61P31/14
CPC分类号： A61K31/711 , A61K2039/55561
摘要： A novel immunostimulatory oligonucleotide by which an IFN-inducing activity is enhanced and an inflammatory cytokine-inducing activity is reduced, and a pharmaceutical containing the same, and an application thereof are provided. That is, the present invention provides the immunostimulatory oligonucleotide composed of a base sequence represented by a formula: 5′-(G)MPXCGYQ(G)N-3′ (X and Y are mutually independent and represent an arbitrary sequence which has a length of 0 to 10 nucleotides and does not contain 4 or more consecutive G residues, and a length of X+Y is 6 to 20 nucleotides; XCGY contains a palindrome sequence having a length of at least 8 nucleotides and has a length of 8 to 22 nucleotides; P and Q are mutually independent and represent one nucleotide other than G; M represents an integer of 6 to 10 and N represents an integer of 0 to 3) wherein a full length thereof is 16 to 37 nucleotides (except for an oligonucleotide composed of a basesequence represented by SEQ ID NO:5), the pharmaceutical application thereof.
摘要翻译：提供了IFN诱导活性增强并且减少炎性细胞因子诱导活性的新型免疫刺激性寡核苷酸，并且提供了含有该诱导活性的药物及其应用。也就是说，本发明提供了由以下通式表示的碱基序列组成的免疫刺激性寡核苷酸：5' - （G）MPXCGYQ（G）N-3'（X和Y相互独立，表示任意序列，其长度 0〜10个核苷酸，不含4个以上连续的G残基，X + Y的长度为6〜20个核苷酸; XCGY含有长度至少为8个核苷酸的长度为8〜22的回文序列核苷酸; P和Q相互独立，表示除G以外的一个核苷酸; M表示6〜10的整数，N表示0〜3的整数），其全长为16〜37个核苷酸（除了构成的寡核苷酸由SEQ ID NO：5表示的碱基序列），其药物应用。

7. 发明授权

US08592566B2 Immunostimulatory oligonucleotides and use thereof in pharmaceuticals 有权
标题翻译：免疫刺激性寡核苷酸及其在药物中的应用
公开(公告)号：US08592566B2
公开(公告)日：2013-11-26
申请号：US12301746
申请日：2007-05-31
申请人： Tomokatsu Iwamura , Hideki Narumi , Hajime Masumoto , Akihito Kaneda , Akiko Soneda , Shizuo Akira
发明人： Tomokatsu Iwamura , Hideki Narumi , Hajime Masumoto , Akihito Kaneda , Akiko Soneda , Shizuo Akira
IPC分类号： A61K31/711 , A61K31/7125 , A61K39/29 , A61K39/35
CPC分类号： A61K31/711 , A61K2039/55561
摘要： A novel immunostimulatory oligonucleotide by which an IFN-inducing activity is enhanced and an inflammatory cytokine-inducing activity is reduced, and a pharmaceutical containing the same, and an application thereof are provided. That is, the present invention provides the immunostimulatory oligonucleotide composed of a base sequence represented by a formula: 5′-(G)MPXCGYQ(G)N-3′ (SEQ ID NO: 118) (X and Y are mutually independent and represent an arbitrary sequence which has a length of 0 to 10 nucleotides and does not contain 4 or more consecutive G residues, and a length of X+Y is 6 to 20 nucleotides; XCGY contains a palindrome sequence having a length of at least 8 nucleotides and has a length of 8 to 22 nucleotides; P and Q are mutually independent and represent one nucleotide other than G; M represents an integer of 6 to 10 and N represents an integer of 0 to 3) wherein a full length thereof is 16 to 37 nucleotides (except for an oligonucleotide composed of a base sequence represented by SEQ ID NO:5), the pharmaceutical application thereof.
摘要翻译：提供了IFN诱导活性增强并且减少炎性细胞因子诱导活性的新型免疫刺激性寡核苷酸，并且提供了含有该诱导活性的药物及其应用。也就是说，本发明提供了由以下通式表示的碱基序列组成的免疫刺激性寡核苷酸：5' - （G）MPXCGYQ（G）N-3'（SEQ ID NO：118）（X和Y相互独立，长度为0〜10个核苷酸且不含4个以上连续G残基的任意序列，X + Y的长度为6〜20个核苷酸; XCGY含有长度至少为8个核苷酸的回文序列，长度为8〜22个核苷酸; P和Q相互独立，表示除G以外的一个核苷酸; M表示6〜10的整数，N表示0〜3的整数），其全长为16〜37 核苷酸（除了由SEQ ID NO：5表示的碱基序列组成的寡核苷酸），其药学应用。

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