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    • 3. 发明申请
    • Methods and Compositions for Preserving the Viability of Photoreceptor Cells
    • 保护感光细胞活力的方法和组合物
    • US20070287756A1
    • 2007-12-13
    • US11587022
    • 2005-04-22
    • Toru Nakazawa
    • Toru Nakazawa
    • A61K47/00A61P27/02
    • A61K9/0048A61K9/0051A61K38/06A61K38/1793A61K38/1825A61K38/19A61K38/2006A61K45/06A61K2039/505C07K16/241
    • Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering a neuroprotective agent, for example, a substance capable of suppressing endogenous MCP-1, a MCP-1 antagonist, a substance capable of suppressing endogenous TNF-alpha, a TNF-alpha antagonist, a substance capable of suppressing endogenous IL-1 beta, an IL-1 beta antagonist, a substance capable of inducing endogenous bFGF, exogenous bFGF, a bFGF mimetic, and combinations thereof, to a mammal having an eye with retinal detachment. The neuroprotective agent maintains the viability of the photoreceptor cells until such time that the retina becomes reattached to the underlying retinal pigment epithelium and choroid. The treatment minimizes the loss of vision, which otherwise may occur as a result of retinal detachment.
    • 提供了用于维持视网膜脱离后感光细胞活力的方法和组合物。 可以通过给予神经保护剂,例如能够抑制内源性MCP-1的物质,MCP-1拮抗剂,能够抑制内源性TNF-α的物质,TNF-α拮抗剂, 能够抑制内源性IL-1β的物质,能够诱导内源性bFGF的物质,外源性bFGF,bFGF模拟物及其组合的物质,其具有视网膜脱离的眼睛的哺乳动物。 神经保护剂维持光感受器细胞的活力,直到视网膜再次附着于下面的视网膜色素上皮和脉络膜。 治疗可以最大限度地减少由于视网膜脱离而导致的视力丧失。
    • 6. 发明授权
    • Electrophotographic process including controlling applied current values
    • 电子照相过程包括控制施加的电流值
    • US4629674A
    • 1986-12-16
    • US625536
    • 1984-06-28
    • Toru Nakazawa
    • Toru Nakazawa
    • G03G15/02G03G13/02G03G13/22G03G13/16
    • G03G13/22Y10S430/102
    • An electrophotographic process includes performing removal of electricity or pre-charging by direct current corona discharge and main charging by direct current corona discharge of a polarity reverse to the polarity for removal of electric charge or pre-charging on an organic photoconductive photosensitive layer chargeable at both the positive and negative polarities. Then is performed imagewise exposure, development with a toner and transfer of the toner image. Such operations are repeated to form plural images. Main charging is carried out with an applied current such that the photosensitive layer surface potential is saturated at 500 to 700 volts (absolute value) and removal of electric charge or pre-charging is carried out with at an applied current lower than the saturation injected current value and corresponding to 40 to 90% thereof.
    • 电子照相方法包括通过直流电晕放电进行电除电或预充电,并通过直流电晕放电,其极性与极性相反,以消除电荷或预充电在有两层可带电的感光层上 正负极性。 然后进行图像曝光,用调色剂显影和转印调色剂图像。 重复这样的操作以形成多个图像。 以施加的电流进行主充电,使得感光层表面电位在500至700伏特(绝对值)下饱和,并且以低于饱和注入电流的施加电流进行电荷或预充电的去除 值,相当于其40〜90%。