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    • 7. 发明授权
    • Preparation of N-substituted pyrrolidin-2-ones
    • N-取代的吡咯烷-2-酮的制备
    • US5101044A
    • 1992-03-31
    • US577589
    • 1990-09-04
    • Ludwig SchusterUlrich Koehler
    • Ludwig SchusterUlrich Koehler
    • B01J23/44B01J23/889B01J25/00C07B61/00C07D207/26C07D207/267C07D207/38
    • C07D207/267C07D207/38
    • A process for the preparation of N-substituted pyrrolidin-2-ones of the general formula I ##STR1## where R.sup.1 is C.sub.1 - to C.sub.20 -alkyl, C.sub.6 - to C.sub.10 aryl or C.sub.7 - to C.sub.12 -aralkyl comprises hydrogenolytically cleaving 5-iminopyrrolidin-2-ones of the general formula II ##STR2## in which the R.sup.1 radicals are identical or different C.sub.1 - to C.sub.20 -alkyl, C.sub.6 - to C.sub.10 -aryl or C.sub.7 - to C.sub.12 -aralkyl, at super-atmospheric pressure and elevated temperature in the presence of a hydrogenation catalyst to give the pyrrolidin-2-ones I; specifically, the 5-iminopyrrolidin-2-ones of the formula II are obtained by reacting .beta.-cyanopropionic acid esters of the general formula III ##STR3## where R.sup.2 is C.sub.1 - to C.sub.20 -alkyl, C.sub.7 - to C.sub.12 -aralkyl or C.sub.6 - to C.sub.10 -aryl, with an amine of the general formula IVR.sup.1 --NH.sub.2 IVwhere R.sup.1 is as defined above.
    • 制备通式I的N-取代吡咯烷-2-酮的方法,其中R 1是C 1 -C 20烷基,C 6至C 10芳基或C 7 -C 12芳烷基包括氢解裂解5-亚氨基吡咯烷 其中R 1基团是相同或不同的C 1〜C 20 - 烷基,C 6〜C 10 - 芳基或C 7〜C 12 - 芳烷基,在超大气压下和升高的 在加氢催化剂存在下,得到吡咯烷-2-酮I; 具体地,式II的5-亚氨基吡咯烷-2-酮通过使通式III的β-氰基丙酸酯反应获得,其中R 2是C 1 -C 20烷基,C 7到C 12 - 芳烷基或C 6 - 至C10-芳基,与通式IV的R 1 -NH 2 IV的胺反应,其中R1如上定义。