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1. 发明授权

US08518923B2 Treatment or prevention of hypertensive disorders of pregnancy or fetal growth retardation 有权
标题翻译：治疗或预防妊娠高血压疾病或胎儿发育迟缓
公开(公告)号：US08518923B2
公开(公告)日：2013-08-27
申请号：US12669778
申请日：2008-07-14
申请人： Monique Visser , Herman Jan Tijmen Coelingh Bennink
发明人： Monique Visser , Herman Jan Tijmen Coelingh Bennink
IPC分类号： A61K31/56
CPC分类号： A61K31/565
摘要： The present invention relates to the use of a steroid in the manufacture of a pharmaceutical composition for use in the therapeutic or prophylactic treatment of a hypertensive disorder of pregnancy (HDP) or fetal growth retardation, said treatment comprising administering to a female mammal a steroid selected from the group consisting of: substances represented by the following formula (formula I) in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors of such substances; and mixtures of one or more of the aforementioned substances and/or precursors.
摘要翻译：本发明涉及类固醇在制备用于治疗或预防性治疗妊娠高血压疾病（HDP）或胎儿生长迟缓的药物组合物中的用途，所述治疗包括向雌性哺乳动物施用选择的类固醇由下式（式I）表示的物质，其中式R1，R2，R3，R4独立地为氢原子，羟基或具有1-5个碳原子的烷氧基; R5，R6，R7各自为羟基; 不超过3个R 1，R 2，R 3，R 4为氢原子; 这些物质的前体; 和一种或多种上述物质和/或前体的混合物。

2. 发明申请

US20120015917A1 Use of Estrogenic Compounds in Combination with Progestogenic Compounds in Hormone-Replacement Therapy 审中-公开
标题翻译：在激素替代治疗中使用雌激素化合物与孕激素化合物的组合
公开(公告)号：US20120015917A1
公开(公告)日：2012-01-19
申请号：US13242034
申请日：2011-09-23
申请人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
发明人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
IPC分类号： A61K31/57 , A61K31/58 , A61K31/575
CPC分类号： A61K45/06 , A61K31/568 , A61K31/569 , A61K2300/00
摘要： The present invention relates to a pharmaceutical kit comprising a plurality of oral dosage units which comprise a progestogen. The progestogen is levonorgestrel, norgestimate, norethisterone, drospirenone, dydrogesterone, trimegestone, dienogest, precursors thereof and mixtures thereof. The kit comprises an amount of progestogen equivalent to 30-500 mg of levonorgestrel, 1-40 mg of ethinyl estradiol and 02-100 mg dehydroepiandrosterone.
摘要翻译：本发明涉及药物试剂盒，其包含多个包含孕激素的口服剂量单位。孕激素是左炔诺孕酮，诺孕酯，炔诺酮，屈螺酮，地屈孕酮，曲美孕酮，依诺孕酮，其前体及其混合物。试剂盒包含相当于30-500mg左炔诺孕酮，1-40mg乙炔雌二醇和02-100mg脱氢表雄甾酮的孕激素。

3. 发明申请

US20080280861A1 Method of Female Contraception and a Kit For Use Therein 审中-公开
标题翻译：女性避孕方法及其使用的一套
公开(公告)号：US20080280861A1
公开(公告)日：2008-11-13
申请号：US11663814
申请日：2004-09-27
申请人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
发明人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
IPC分类号： A61K31/57 , A61P15/18
CPC分类号： A61K31/565 , A61K31/57 , A61K2300/00
摘要： The invention is concerned with a method of contraception in a female mammal of childbearing capability. The method has two alternating phases—a preservation phase and a shedding phase—and has at least two sequences of (a) a preservation phase of 3-12 months involving continuous oral administration to the female of dosage units containing: (i) an estrogen selected from 17β-estradiol, esters of 17β-estradiol and combinations thereof, in an amount equivalent to a daily oral dosage of 2.2-5 mg 17β-estradiol, and (ii) a progestogen in an amount equivalent to a daily oral dosage of 30-750 μg levonorgestrel; and (b) a shedding phase of 4-12 days during which no progestogen is administered. The invention also relates to a contraceptive kit having one or more packaging units that are separately packaged, individually removable oral dosage units for use in the aforementioned contraceptive method.
摘要翻译：本发明涉及一种女性哺乳动物避孕方法。该方法具有两个交替阶段 - 保存阶段和脱落阶段 - 并且具有至少两个序列（a）3-12个月的保存期，其连续口服给予含有以下的剂量单位的雌性：（i）雌激素选自17β-雌二醇，17β-雌二醇的酯和其组合，其量相当于2.2-5mg17β-雌二醇的每日口服剂量，和（ii）相当于每日口服剂量30的量的孕激素 -750杯左炔诺孕酮; 和（b）4-12天的脱落期，在此期间不服用孕激素。本发明还涉及具有单独包装的一个或多个包装单元的避孕套件，用于上述避孕方法的单独可移除的口服剂量单元。

4. 发明授权

US08367647B2 Treatment of meconium aspiration syndrome with estrogens 有权
标题翻译：用雌激素治疗胎粪吸入综合征
公开(公告)号：US08367647B2
公开(公告)日：2013-02-05
申请号：US12664982
申请日：2008-06-20
申请人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
发明人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
IPC分类号： A61K31/56
CPC分类号： A61K31/565 , A61K9/0031 , A61K9/0053
摘要： One aspect of the present invention relates to the use of an estrogen in the treatment of Meconium Aspiration Syndrome (MAS) in a newborn infant, said treatment comprising administering an effective amount of estrogen to said newborn infant within 7 days after birth. The present treatment offers the advantage that estrogens can be administered using non-invasive modes of administration, e.g. oral or rectal administration. Other aspects of the present invention relate to a suppository for use in newborn infants comprising at least 1 μg of estrogen and to an oral applicator comprising a container holding an aqueous liquid containing micronised estetrol and a metering dispenser for metering the liquid into the oral cavity of a newborn infant.
摘要翻译：本发明的一个方面涉及雌激素在新生儿中治疗胎粪综合征（MAS）中的用途，所述治疗包括在出生后7天内对所述新生儿施用有效量的雌激素。本治疗提供的优点是可以使用非侵入性给药模式来施用雌激素，例如，口服或直肠给药。本发明的其它方面涉及用于包含至少1μg雌激素的新生儿的栓剂和口服施用器，其包含容纳含有微粉化estetrol的含水液体的容器和用于将液体计量到口腔内的计量分配器新生儿

5. 发明授权

US08071576B2 Method of preventing or treating benign gynaecological disorders 有权
标题翻译：预防或治疗良性妇科疾病的方法
公开(公告)号：US08071576B2
公开(公告)日：2011-12-06
申请号：US10495708
申请日：2002-11-14
申请人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
发明人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
IPC分类号： A61K31/56 , A61K31/57
CPC分类号： A61K45/06 , A61K31/568 , A61K31/569 , A61K2300/00
摘要： The present invention relates to a method of preventing or treating benign estrogen sensitive gynecological disorders in a female mammal, wherein the method comprises the administration to said female mammal of a combination of progestogen and androgen in an amount that is therapeutically effective to prevent or reduce the symptoms of these disorders. The present method is particularly suitable for preventing or treating disorders selected from the group consisting of endrometriosis, adenomyosis, uterine fibroids, dysmenorrhoea, menorrhagia and metrorrhagia. Another aspect of the invention relates to a pharmaceutical kit comprising a plurality of oral dosage units which comprise a progestogen in an amount equivalent to 3-500 μg levonorgestrel and either 5 to 250 mg dehydroepiandrosterone or 1 to 50 mg testosterone undecanoate.
摘要翻译：本发明涉及一种在雌性哺乳动物中预防或治疗良性雌激素敏感性妇科疾病的方法，其中所述方法包括给予所述雌性哺乳动物孕激素和雄激素的组合，其量可以有效地预防或减少这些疾病的症状。本发明的方法特别适合于预防或治疗选自由气血病，子宫腺肌症，子宫肌瘤，痛经，月经过多和月经过度组成的组的疾病。本发明的另一方面涉及药物试剂盒，其包含多个口服剂量单位，其包含相当于3-500μg左炔诺孕酮的量的孕激素和5至250mg脱氢表雄酮或1至50mg十一酸睾酮。

6. 发明授权

US07968514B2 Pharmaceutical composition for treating or preventing ovarian cancer 有权
标题翻译：用于治疗或预防卵巢癌的药物组合物
公开(公告)号：US07968514B2
公开(公告)日：2011-06-28
申请号：US12093908
申请日：2006-11-16
申请人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
发明人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
IPC分类号： A61K38/18 , C07K14/49 , C07K14/48 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： A61K39/0011 , A01K2267/0331
摘要： The invention relates to therapeutic and prophylactic treatment of ovarian cancer and metastases thereof. More specifically, the invention relates to immunogenic polypeptides comprising at least a portion of an ovarian tissue cell-associated protein or immunologically active variants thereof and to nucleic acids encoding such polypeptides and to the use thereof in immunotherapeutic methods of treatment. Said immunogenic polypeptides are provided by the zona pellucida (ZP) glycoproteins. ZP glycoproteins and fragments thereof that can induce a CD8+ and/or CD4+ T cell response as well as nucleic acid sequences encoding them can suitably be used in the present immunotherapeutic strategies.
摘要翻译：本发明涉及卵巢癌及其转移的治疗和预防性治疗。更具体地，本发明涉及包含卵巢组织细胞相关蛋白或其免疫活性变体的至少一部分和编码这些多肽的核酸的免疫原性多肽及其在免疫治疗性治疗方法中的用途。所述免疫原性多肽由透明带（ZP）糖蛋白提供。可诱导CD8 +和/或CD4 + T细胞应答的ZP糖蛋白及其片段以及编码它们的核酸序列可适用于本发明的免疫治疗策略。

7. 发明申请

US20100184736A1 Treatment of Meconium Aspiration Syndrome with Estrogens 有权
标题翻译：用雌激素治疗胎粪吸入综合征
公开(公告)号：US20100184736A1
公开(公告)日：2010-07-22
申请号：US12664982
申请日：2008-06-20
申请人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
发明人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
IPC分类号： A61K31/566 , A61K31/565 , A61P11/00 , A61M5/00
CPC分类号： A61K31/565 , A61K9/0031 , A61K9/0053
摘要： One aspect of the present invention relates to the use of an estrogen in the treatment of Meconium Aspiration Syndrome (MAS) in a newborn infant, said treatment comprising administering an effective amount of estrogen to said newborn infant within 7 days after birth. The present treatment offers the advantage that estrogens can be administered using non-invasive modes of administration, e.g. oral or rectal administration. Other aspects of the present invention relate to a suppository for use in newborn infants comprising at least 1 μg of estrogen and to an oral applicator comprising a container holding an aqueous liquid containing micronised estetrol and a metering dispenser for metering the liquid into the oral cavity of a newborn infant.
摘要翻译：本发明的一个方面涉及雌激素在新生儿中治疗胎粪综合征（MAS）中的用途，所述治疗包括在出生后7天内向所述新生儿施用有效量的雌激素。本治疗提供的优点是可以使用非侵入性给药模式来施用雌激素，例如，口服或直肠给药。本发明的其它方面涉及用于包含至少1μg雌激素的新生儿的栓剂和口服施用器，其包含容纳含有微粉化estetrol的含水液体的容器和用于将液体计量到口腔内的计量分配器新生儿

8. 发明申请

US20100184731A1 TREATMENT OR PREVENTION OF HYPERTENSIVE DISORDERS OF PREGNANCY OR FETAL GROWTH RETARDATION 有权
标题翻译：治疗或预防妊娠高血压疾病或宫颈生长迟缓
公开(公告)号：US20100184731A1
公开(公告)日：2010-07-22
申请号：US12669778
申请日：2008-07-14
申请人： Monique Visser , Herjan Jan Tijmen Coelingh Bennink
发明人： Monique Visser , Herjan Jan Tijmen Coelingh Bennink
IPC分类号： A61K31/56 , A61P9/12
CPC分类号： A61K31/565
摘要： The present invention relates to the use of a steroid in the manufacture of a pharmaceutical composition for use in the therapeutic or prophylactic treatment of a hypertensive disorder of pregnancy (HDP) or fetal growth retardation, said treatment comprising administering to a female mammal a steroid selected from the group consisting of: substances represented by the following formula (formula I) in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors of such substances; and mixtures of one or more of the aforementioned substances and/or precursors.
摘要翻译：本发明涉及类固醇在制备用于治疗或预防性治疗妊娠高血压疾病（HDP）或胎儿生长迟缓的药物组合物中的用途，所述治疗包括向雌性哺乳动物施用选择的类固醇由下式（式I）表示的物质，其中式R1，R2，R3，R4独立地为氢原子，羟基或具有1-5个碳原子的烷氧基; R5，R6，R7各自为羟基; 不超过3个R 1，R 2，R 3，R 4为氢原子; 这些物质的前体; 和一种或多种上述物质和/或前体的混合物。

9. 发明申请

US20050148559A1 Method of preventing or treating benign gynaecological disorders 有权
标题翻译：预防或治疗良性妇科疾病的方法
公开(公告)号：US20050148559A1
公开(公告)日：2005-07-07
申请号：US10495708
申请日：2002-11-14
申请人： Herman Coelingh Bennink , Monique Visser
发明人： Herman Coelingh Bennink , Monique Visser
IPC分类号： A61K31/568 , A61K31/569 , A61K45/06 , A61P5/30 , A61K31/57 , A61K31/56
CPC分类号： A61K45/06 , A61K31/568 , A61K31/569 , A61K2300/00
摘要： The present invention relates to a method of preventing or treating benign estrogen sensitive gynaecological disorders in a female mammal, wherein the method comprises the administration to said female mammal of a combination of progestogen and androgen in an amount that is therapeutically effective to prevent or reduce the symptoms of these disorders. The present method is particularly suitable for preventing or treating disorders selected from the group consisting of endrometriosis, adenomyosis, uterine fibroids, dysmenorrhoea, menorrhagia and metrorrhagia. Another aspect of the invention relates to a pharmaceutical kit comprising a plurality of oral dosage units which comprise a progestogen in an amount equivalent to 3-500 μg levonorgestrel and either 5 to 250 mg dehydroepiandrosterone or 1 to 50 mg testosterone undecanoate.
摘要翻译：本发明涉及一种在雌性哺乳动物中预防或治疗良性雌激素敏感性妇科疾病的方法，其中所述方法包括给予所述雌性哺乳动物孕激素和雄激素的组合，其量可以有效地预防或减少这些疾病的症状。本发明的方法特别适合于预防或治疗选自由气血病，子宫腺肌症，子宫肌瘤，痛经，月经过多和月经过度组成的组的疾病。本发明的另一方面涉及药物试剂盒，其包含多个口服剂量单位，其包含相当于3-500杯左炔诺孕酮的量的孕激素和5至250mg脱氢表雄酮或1至50mg十一酸睾酮。

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