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1. 发明授权

US07264923B2 Norovirus infected cell cultures and uses therefor 有权
标题翻译：诺如病毒感染细胞培养物及其用途
公开(公告)号：US07264923B2
公开(公告)日：2007-09-04
申请号：US10839211
申请日：2004-05-05
申请人： Herbert W. Virgin , Christiane Wobus , Stephanie Karst
发明人： Herbert W. Virgin , Christiane Wobus , Stephanie Karst
IPC分类号： C12Q1/70 , C12N5/00 , C12N5/02 , C12N7/00 , C12N7/02 , C12N5/06 , C12P21/04
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N2770/30021 , C12N2770/30022
摘要： A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a deficiency in a cellular anti-viral pathway such as a STAT-1-dependent pathway, an interferon receptor-dependent pathway, or a PKR-dependent pathway. Also disclosed are methods of screening anti-viral compounds against norovirus-permissive cells infected with norovirus, and norovirus adapted to grow in fibroblasts as well as macrophages that are not deficient in a cellular anti-viral pathway. Methods of making a norovirus vaccine are also disclosed.
摘要翻译：公开了用诺如病毒感染的诺如病毒允许细胞培养物，以及培养诺如病毒的方法。诺如病毒允许细胞包括树突状细胞谱系细胞和巨噬细胞谱系细胞，例如树突细胞和在细胞抗病毒途径中缺乏的巨噬细胞，例如STAT-1-依赖性途径，干扰素受体依赖性途径，或PKR依赖性途径。还公开了筛选针对诺如病毒感染的诺如病毒允许细胞的抗病毒化合物的方法，以及适于在成纤维细胞以及细胞抗病毒途径中不缺陷的巨噬细胞生长的诺如病毒。还公开了制备诺如病毒疫苗的方法。

2. 发明授权

US07794928B2 Norovirus detection, methods and compositions therefor 有权
标题翻译：诺如病毒检测，其方法和组合物
公开(公告)号：US07794928B2
公开(公告)日：2010-09-14
申请号：US12025327
申请日：2008-02-04
申请人： Herbert W. Virgin , Christiane Wobus , Stephanie Karst
发明人： Herbert W. Virgin , Christiane Wobus , Stephanie Karst
IPC分类号： C12Q1/70 , C12P21/04 , C12N5/00 , C12N7/00 , G01N33/567
CPC分类号： C12N7/00 , C07K14/005 , C07K16/10 , C07K2317/76 , C12N15/1131 , C12N2310/32 , C12N2310/321 , C12N2310/52 , C12N2770/16022 , C12N2770/16051 , C12N2310/3521
摘要： A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a deficiency in a cellular anti-viral pathway such as a STAT-1-dependent pathway, an interferon receptor-dependent pathway, or a PKR-dependent pathway. Also disclosed are methods of screening anti-viral compounds against norovirus-permissive cells infected with norovirus, and norovirus adapted to grow in fibroblasts as well as macrophages that are not deficient in a cellular anti-viral pathway. Methods of making a norovirus vaccine are also disclosed. A replicative form of norovirus as well as its use in the development of an anti-viral agent and a polypeptide expression system are also described. Further disclosed are methods of detecting norovirus in a sample.
摘要翻译：公开了用诺如病毒感染的诺如病毒允许细胞培养物，以及培养诺如病毒的方法。诺如病毒允许细胞包括树突状细胞谱系细胞和巨噬细胞谱系细胞，例如树突细胞和在细胞抗病毒途径中缺乏的巨噬细胞，例如STAT-1-依赖性途径，干扰素受体依赖性途径，或PKR依赖性途径。还公开了筛选针对诺如病毒感染的诺如病毒允许细胞的抗病毒化合物的方法，以及适于在成纤维细胞以及细胞抗病毒途径中不缺陷的巨噬细胞生长的诺如病毒。还公开了制备诺如病毒疫苗的方法。还描述了诺如病毒的复制形式及其在开发抗病毒剂和多肽表达系统中的用途。还公开了检测样品中的诺如病毒的方法。

3. 发明申请

US20080254443A1 Norovirus detection, methods and compositions therefor 有权
标题翻译：诺如病毒检测，其方法和组合物
公开(公告)号：US20080254443A1
公开(公告)日：2008-10-16
申请号：US12025327
申请日：2008-02-04
申请人： Herbert W. Virgin , Christiane Wobus , Stephanie Karst
发明人： Herbert W. Virgin , Christiane Wobus , Stephanie Karst
IPC分类号： C12Q1/70
CPC分类号： C12N7/00 , C07K14/005 , C07K16/10 , C07K2317/76 , C12N15/1131 , C12N2310/32 , C12N2310/321 , C12N2310/52 , C12N2770/16022 , C12N2770/16051 , C12N2310/3521
摘要： A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a deficiency in a cellular anti-viral pathway such as a STAT-1-dependent pathway, an interferon receptor-dependent pathway, or a PKR-dependent pathway. Also disclosed are methods of screening anti-viral compounds against norovirus-permissive cells infected with norovirus, and norovirus adapted to grow in fibroblasts as well as macrophages that are not deficient in a cellular anti-viral pathway. Methods of making a norovirus vaccine are also disclosed. A replicative form of norovirus as well as its use in the development of an anti-viral agent and a polypeptide expression system are also described. Further disclosed are methods of detecting norovirus in a sample.
摘要翻译：公开了用诺如病毒感染的诺如病毒允许细胞培养物，以及培养诺如病毒的方法。诺如病毒允许细胞包括树突状细胞谱系细胞和巨噬细胞谱系细胞，例如树突细胞和在细胞抗病毒途径中缺乏的巨噬细胞，例如STAT-1-依赖性途径，干扰素受体依赖性途径，或PKR依赖性途径。还公开了筛选针对诺如病毒感染的诺如病毒允许细胞的抗病毒化合物的方法，以及适于在成纤维细胞以及细胞抗病毒途径中不缺陷的巨噬细胞生长的诺如病毒。还公开了制备诺如病毒疫苗的方法。还描述了诺如病毒的复制形式及其在开发抗病毒剂和多肽表达系统中的用途。还公开了检测样品中的诺如病毒的方法。

4. 发明申请

US20060003957A1 RNA virus expression and replication, methods and uses therefor 审中-公开
标题翻译： RNA病毒表达和复制，其方法和用途
公开(公告)号：US20060003957A1
公开(公告)日：2006-01-05
申请号：US11122944
申请日：2005-05-05
申请人： Herbert Virgin , Christiane Wobus , Stephanie Karst
发明人： Herbert Virgin , Christiane Wobus , Stephanie Karst
IPC分类号： A61K48/00 , C07H21/02
CPC分类号： C12N7/00 , C07K14/005 , C07K16/10 , C07K2317/76 , C12N15/1131 , C12N2310/32 , C12N2310/321 , C12N2310/52 , C12N2770/16022 , C12N2770/16051 , C12N2310/3521
摘要： A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a deficiency in a cellular anti-viral pathway such as a STAT-1-dependent pathway, an interferon receptor-dependent pathway, or a PKR-dependent pathway. Also disclosed are methods of screening anti-viral compounds against norovirus-permissive cells infected with norovirus, and norovirus adapted to grow in fibroblasts as well as macrophages that are not deficient in a cellular anti-viral pathway. Methods of making a norovirus vaccine are also disclosed. A replicative form of norovirus as well as its use in the development of an anti-viral agent and a polypeptide expression system are also described.
摘要翻译：公开了用诺如病毒感染的诺如病毒允许细胞培养物，以及培养诺如病毒的方法。诺如病毒允许细胞包括树突状细胞谱系细胞和巨噬细胞谱系细胞，例如树突细胞和在细胞抗病毒途径中缺乏的巨噬细胞，例如STAT-1-依赖性途径，干扰素受体依赖性途径，或PKR依赖性途径。还公开了筛选针对诺如病毒感染的诺如病毒允许细胞的抗病毒化合物的方法，以及适于在成纤维细胞以及细胞抗病毒途径中不缺陷的巨噬细胞生长的诺如病毒。还公开了制备诺如病毒疫苗的方法。还描述了诺如病毒的复制形式及其在开发抗病毒剂和多肽表达系统中的用途。

5. 发明申请

US20050255480A1 RNA virus expression and replication, methods and uses therefor 有权
标题翻译： RNA病毒表达和复制，其方法和用途
公开(公告)号：US20050255480A1
公开(公告)日：2005-11-17
申请号：US10839211
申请日：2004-05-05
申请人： Herbert Virgin , Christiane Wobus , Stephanie Karst
发明人： Herbert Virgin , Christiane Wobus , Stephanie Karst
IPC分类号： A01N43/36 , A61K31/40 , C07K14/08 , C12N5/00 , C12N5/02 , C12N7/00 , C12N7/01 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C12Q1/68 , C12Q1/70
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N2770/30021 , C12N2770/30022
摘要： A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a deficiency in a cellular anti-viral pathway such as a STAT-1-dependent pathway, an interferon receptor-dependent pathway, or a PKR-dependent pathway. Also disclosed are methods of screening anti-viral compounds against norovirus-permissive cells infected with norovirus, and norovirus adapted to grow in fibroblasts as well as macrophages that are not deficient in a cellular anti-viral pathway. Methods of making a norovirus vaccine are also disclosed.
摘要翻译：公开了用诺如病毒感染的诺如病毒允许细胞培养物，以及培养诺如病毒的方法。诺如病毒允许细胞包括树突状细胞谱系细胞和巨噬细胞谱系细胞，例如树突细胞和在细胞抗病毒途径中缺乏的巨噬细胞，例如STAT-1-依赖性途径，干扰素受体依赖性途径，或PKR依赖性途径。还公开了筛选针对诺如病毒感染的诺如病毒允许细胞的抗病毒化合物的方法，以及适于在成纤维细胞以及细胞抗病毒途径中不缺陷的巨噬细胞生长的诺如病毒。还公开了制备诺如病毒疫苗的方法。

6. 发明授权

US08809377B2 Deubiquitinase inhibitors and methods for use of the same 有权
标题翻译：去泛素酶抑制剂及其使用方法
公开(公告)号：US08809377B2
公开(公告)日：2014-08-19
申请号：US13241802
申请日：2011-09-23
申请人： Nicholas J. Donato , Christiane Wobus , Hollis D. Showalter , Moshe Talpaz , Jeffrey W. Perry , Roderick J. Sorenson , Mary X. O'Riordan , Yafei Jin
发明人： Nicholas J. Donato , Christiane Wobus , Hollis D. Showalter , Moshe Talpaz , Jeffrey W. Perry , Roderick J. Sorenson , Mary X. O'Riordan , Yafei Jin
IPC分类号： A61K31/444 , A61K31/4433 , A61K31/4436 , A61K31/4439
CPC分类号： C07D495/04 , C07C255/43 , C07D213/30 , C07D213/32 , C07D213/61 , C07D213/68 , C07D213/74 , C07D213/75 , C07D231/12 , C07D233/54 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D251/16 , C07D261/08 , C07D271/04 , C07D271/10 , C07D277/30 , C07D285/12 , C07D285/16 , C07D401/12 , C07D417/12 , C12N9/99
摘要： Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds, wherein the compound can have a structure of formula (III):
摘要翻译：本文公开了抑制去泛素酶（DUB），治疗病原体感染（例如病毒，细菌和/或寄生虫）的方法，抑制细胞增殖的方法，治疗神经变性疾病的方法，治疗一种或多种症状的方法的神经变性疾病或遗传性疾病，和化合物，其中所述化合物可以具有式（III）的结构：

7. 发明申请

US20120077806A1 Deubiquitinase Inhibitors and Methods for Use of the Same 有权
标题翻译：去泛素酶抑制剂及其使用方法
公开(公告)号：US20120077806A1
公开(公告)日：2012-03-29
申请号：US13241802
申请日：2011-09-23
申请人： Nicholas J. Donato , Christiane Wobus , Hollis D. Showalter , Moshe Talpaz , Jeffrey W. Perry , Roderick J. Sorenson , Mary X. O'Riordan , Yafei Jin
发明人： Nicholas J. Donato , Christiane Wobus , Hollis D. Showalter , Moshe Talpaz , Jeffrey W. Perry , Roderick J. Sorenson , Mary X. O'Riordan , Yafei Jin
IPC分类号： A61K31/541 , C12N5/02 , A61K31/5377 , A61K31/53 , A61K31/50 , C07D413/12 , A61K31/496 , A61K31/505 , A61K31/454 , A61K31/4439 , A61K31/44 , A61K31/433 , A61K31/4245 , A61K31/426 , A61K31/42 , A61K31/4164 , A61K31/415 , A61K31/165 , C07D417/12 , C07D253/065 , C07D253/04 , C07D237/06 , C07D239/02 , A61K31/4965 , C07D401/12 , C07D213/57 , C07D285/06 , C07D285/12 , C07D271/10 , C07D277/30 , C07D261/06 , C07D233/90 , C07D231/10 , C07C255/32 , A61P25/28 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , C12N9/99
CPC分类号： C07D495/04 , C07C255/43 , C07D213/30 , C07D213/32 , C07D213/61 , C07D213/68 , C07D213/74 , C07D213/75 , C07D231/12 , C07D233/54 , C07D233/64 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/08 , C07D251/16 , C07D261/08 , C07D271/04 , C07D271/10 , C07D277/30 , C07D285/12 , C07D285/16 , C07D401/12 , C07D417/12 , C12N9/99
摘要： Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds.
摘要翻译：本文公开了抑制去泛素酶（DUB），治疗病原体感染（例如病毒，细菌和/或寄生虫）的方法，抑制细胞增殖的方法，治疗神经变性疾病的方法，治疗一种或多种症状的方法的神经变性疾病或遗传性疾病，以及化合物。

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