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1. 发明申请

US20150119469A1 Formulations and kit for biometric deposition of apatite on teeth 审中-公开
标题翻译：磷灰石生物沉积在牙齿上的配方和试剂盒
公开(公告)号：US20150119469A1
公开(公告)日：2015-04-30
申请号：US14481127
申请日：2014-09-09
申请人： Heraeus Kulzer GmbH
发明人： Susanne BUSCH , Andreas UTTERODT , Michael GERLACH
IPC分类号： A61C19/06 , A61D5/00 , A61K6/033
CPC分类号： A61C19/063 , A61D5/00 , A61K6/0017 , A61K6/0082 , A61K6/033 , A61K8/042 , A61K8/20 , A61K8/24 , A61K8/65 , A61K2800/87 , A61Q11/00
摘要： The invention proposes a kit and formulations for biomimetic deposition of apatite on teeth from a partially elastic shaped body comprising an envelope, whereby the shaped body a) comprises at least one mineralization matrix containing a gel that comprises water-soluble phosphates or phosphates that can be hydrolysed to form water-soluble phosphate ions and has a pH value of 2 to 8, optionally fluorides, and b) the at least one or a second mineralization matrix comprises a second gel having a pH value of 3.5 to 14 comprising calcium ions or compounds releasing calcium ions. Moreover, the method for producing the formulation and the use thereof for the deposition of apatite, in particular of needle-shaped fluorapatite crystallites, is claimed. Using the formulations according to the invention, it is feasible to deposit more than or equal to 1 μm apatite, in particular fluorapatite, on tooth surfaces in order to seal or brighten porous tooth surfaces.
摘要翻译：本发明提出了一种用于从包含外壳的部分弹性形状的主体在牙齿上仿生沉积磷灰石的试剂盒和配方，其中成形体a）包括至少一个含有凝胶的矿化基质，该凝胶包含水溶性磷酸盐或磷酸盐，其可以是水解形成水溶性磷酸盐离子，pH值为2-8，任选氟化物，和b）至少一种或第二种矿化基质包含pH值为3.5至14的包含钙离子或化合物的第二凝胶释放钙离子。此外，要求保护磷灰石，特别是针状氟磷灰石微晶沉积制剂的方法及其用途。使用根据本发明的制剂，在牙齿表面上沉积多于或等于1μm的磷灰石，特别是氟磷灰石是可行的，以便密封或增亮多孔牙齿表面。

2. 发明申请

US20150072315A1 Formulations and kit for biometric deposition of apatite on teeth 审中-公开
标题翻译：磷灰石生物沉积在牙齿上的配方和试剂盒
公开(公告)号：US20150072315A1
公开(公告)日：2015-03-12
申请号：US14481429
申请日：2014-09-09
申请人： Heraeus Kulzer GmbH
发明人： Susanne BUSCH , Andreas UTTERODT , Michael GERLACH
IPC分类号： A61C19/06 , A61K6/00 , A61L24/02
CPC分类号： A61C19/063 , A61K6/0017 , A61K6/0082 , A61L24/02
摘要： The invention proposes formulations for biomimetic deposition of apatite from a partially elastic shaped body on teeth, whereby the shaped body a) contains at least one mineralization matrix containing a gel that comprises water-soluble phosphates or phosphates that can be hydrolyzed to form water-soluble phosphate ions and has a pH value of 2 to 8, optionally fluorides, and b) the at least one or a second mineralization matrix comprises a second gel having a pH value of 3.5 to 14 comprising calcium ions or compounds releasing calcium ions. Moreover, the method for producing the formulation for the deposition of apatite, in particular of needle-shaped fluorapatite crystals, is claimed. Using the formulations according to the invention, it is feasible to deposit more than or equal to 1 μm apatite, in particular fluorapatite, on tooth surfaces in order to seal or brighten porous tooth surfaces.
摘要翻译：本发明提出了用于从牙齿上部分弹性成形体的磷灰石仿生沉积的制剂，其中成形体a）包含至少一个含有凝胶的矿化基质，该凝胶包含水溶性磷酸盐或磷酸盐，其可水解形成水溶性磷酸根离子，pH值为2-8，任选氟化物，和b）至少一种或第二种矿化基质包含pH值为3.5至14的第二种凝胶，其包含钙离子或释放钙离子的化合物。此外，要求保护磷灰石，特别是针状氟磷灰石晶体的沉积配方的方法。使用根据本发明的制剂，在牙齿表面上沉积多于或等于1μm的磷灰石，特别是氟磷灰石是可行的，以便密封或增亮多孔牙齿表面。

3. 发明申请

US20130261218A1 POLYMERIZABLE DENTAL COMPONENTS WITH IMPROVED USAGE PROPERTIES, METHODS FOR ADJUSTING THE USAGE PROPERTIES OF POLYMERIZABLE DENTAL COMPOSITES, AND DENTAL COMPOSITES OPTIMIZED ACCORDING TO SAID METHODS 有权
标题翻译：具有改进使用性质的可聚合牙齿组分，用于调节聚合物牙齿复合材料的使用性能的方法和根据所述方法优化的牙齿复合材料
公开(公告)号：US20130261218A1
公开(公告)日：2013-10-03
申请号：US13799806
申请日：2013-03-13
申请人： HERAEUS KULZER GMBH
发明人： Andreas UTTERODT , Kurt REISCHL , Nelli SCHÖNHOF , Michael ECK , Christine HIERSEKORN , Jutta SCHNEIDER
IPC分类号： A61K6/00 , G01N19/00 , G01N19/04
CPC分类号： A61K6/0091 , A61K6/0047 , A61K6/0073 , G01N19/00 , G01N19/04
摘要： Method for adjusting or improving or optimising the usage properties of filler(s)-containing, flowable dental material, which involves relating to at least one measuring value representing the tackiness to at least one measuring value representing the texturing or plasticity or consistency. Flowable, usage-optimised, usually non-polymerised dental composites contain, as fillers, at least one glass filler and at least one filler from the group of chipped polymers or pre-polymer fillers based on ground polymer that is pre-polymerised together with inorganic particles, and, as additive(s),at least one compound represented through formula H—Y—Z (I), where: Y═—O—, —S—, —CO—, —OSi(OR1)2—, —OE Z═H, OH, SH, NH2, COOH, COOR2 E=—CnHmOp- R1═H, C1-C4-Alkyl R2═C1-C15-Alkyl, interrupted by one or more O atoms. C2-C14-Alkyl, n=2 bis 5 m=4 bis 11 p=n
摘要翻译：用于调节或改善或优化含填料的可流动的牙科材料的使用性质的方法涉及至少一个表示粘性的测量值至少表示纹理或可塑性或一致性的测量值。可流动的，使用优化的通常非聚合的牙科复合材料包含至少一种玻璃填料和至少一种基于与无机物一起预聚合的研磨聚合物的切片聚合物或预聚物填料的至少一种填料颗粒和作为添加剂的至少一种通过式HYZ（I）表示的化合物，其中：Y = -O - ， - S - ， - CO-，-OSi（OR 1）2 - ， - O Z = H，OH，SH，NH 2，COOH，COOR 2 E = -C n H mOp -R 1 = H，C 1 -C 4烷基R 2 = C 1 -C 15 - 烷基，被一个或多个O原子间隔开。 C2-C14-烷基，n = 2双5m = 4双11 p = n

4. 发明申请

US20150125824A1 Application system for facile 3-dimensional application of medical, cosmetic or drug-containing dental care products 审中-公开
标题翻译：适用于医疗，化妆品或含药物的牙科护理产品的轻松三维应用的应用系统
公开(公告)号：US20150125824A1
公开(公告)日：2015-05-07
申请号：US14481268
申请日：2014-09-09
申请人： Heraeus Kulzer GmbH
发明人： Susanne BUSCH , Andreas UTTERODT , Michael GERLACH , Ralf SUFFEL
IPC分类号： A61C19/06 , A61K6/00
CPC分类号： A61C19/063 , A61K6/0017 , A61K8/0216 , A61Q11/00
摘要： The invention discloses a partially elastic shaped body in the form of a negative image of a dental arch containing a matrix based on a gel containing an active substance or a system with a mineralizing effect as well as an application system for the treatment of teeth. The application system comprises an application dental splint that is well-suited for use on the upper and/or lower jaw, whereby the dental splint can accommodate at least one first three-dimensional shaped body that is adapted to the splint and contains a matrix, preferably the dental splint can be deformed by heat. The matrix of the at least one first and optionally further shaped body contains at least one active substance or a system with a mineralizing effect containing phosphates, calcium, and fluorides. The method for producing the application system and a kit comprising the application system are also a subject matter of the invention. According to the invention, the application system and kit are used for depositing apatite, in particular needle-shaped fluorapatite crystals. According to the invention, it is feasible to deposit more than or equal to 1 μm apatite, in particular fluorapatite, on tooth surfaces over one sleeping period or during the day in order to seal or brighten porous tooth surfaces.
摘要翻译：本发明公开了一种牙弓的负像形式的部分弹性成形体，其包含基于含有活性物质或具有矿化作用的系统的凝胶的基质以及用于治疗牙齿的应用系统。所述应用系统包括适用于所述上部和/或下部钳口的适用的牙夹板，由此所述牙夹板可容纳至少一个适于夹板并包含基体的第一立体成形体，优选地，牙夹板可以通过加热而变形。至少一个第一和任选另外成形的主体的基质包含至少一种活性物质或具有含磷酸盐，钙和氟化物的矿化作用的体系。用于生产应用系统的方法和包括应用系统的套件也是本发明的主题。根据本发明，应用系统和试剂盒用于沉积磷灰石，特别是针状氟磷灰石晶体。根据本发明，在一个睡眠期间或白天中，在牙齿表面上沉积多于或等于1μm磷灰石，特别是氟磷灰石是可行的，以便密封或增亮多孔牙齿表面。

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