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1. 发明申请

US20110159016A1 HEMOGLOBIN-BASED METHODS FOR PROPHYLAXIS, DIAGNOSIS AND/OR TREATMENT OF RETINAL DISORDERS 审中-公开
标题翻译：基于HEMOGLOBIN的预防性疾病的方法，诊断和/或治疗反应性疾病
公开(公告)号：US20110159016A1
公开(公告)日：2011-06-30
申请号：US13035272
申请日：2011-02-25
申请人： Tongalp H. Tezel , Henry J. Kaplan , Jon Klein
发明人： Tongalp H. Tezel , Henry J. Kaplan , Jon Klein
IPC分类号： A61K39/395 , G01N33/72 , A61K38/18 , A61P27/02
CPC分类号： G01N33/723 , G01N2800/164
摘要： The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels and activities in the retinal tissue.
摘要翻译：目前公开的主题提供了通过测量受试者中的血红蛋白和修饰的血红蛋白来诊断受试者的视网膜疾病的方法。目前公开的主题还提供了通过调节血红蛋白水平和视网膜组织中的活性来减少受试者的视网膜组织中的缺氧来治疗受试者的视网膜疾病的方法。

2. 发明授权

US09155790B2 Methods and compositions for modulating ocular damage 有权
标题翻译：用于调节眼部损伤的方法和组合物
公开(公告)号：US09155790B2
公开(公告)日：2015-10-13
申请号：US13698518
申请日：2011-05-20
申请人： Tongalp H. Tezel , Henry J. Kaplan , Robert A. Mitchell , John O. Trent
发明人： Tongalp H. Tezel , Henry J. Kaplan , Robert A. Mitchell , John O. Trent
IPC分类号： A61K31/517 , A61K39/395 , A61K31/505 , A61K31/53 , A61K45/06
CPC分类号： A61K39/3955 , A61K31/505 , A61K31/53 , A61K45/06 , A61K2300/00
摘要： Methods for modulating eye damage associated with a disease or disorder, and/or damage incident to trauma including but not limited to trauma associated with ocular surgery are provided. In some embodiments, the methods include administering an effective amount of a modulator of a migration inhibitory factor (MIF) polypeptide biological activity to a subject. Also provided are methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of an ocular disease, and methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of scarring and/or other consequence of wound healing incident to ocular surgery, as well as modulating the survival, function, and/or differentiation of engrafted cells that can be employed as part of tissue engineering procedures to correct structural, functional, and/or cellular defects of the eye.
摘要翻译：提供了用于调节与疾病或病症相关的眼睛损伤和/或损伤事件的方法，包括但不限于与眼部手术相关的创伤。在一些实施方案中，所述方法包括向受试者施用有效量的迁移抑制因子（MIF）多肽生物活性的调节剂。还提供了用于调节延缓发作和/或预防眼部疾病发展的严重性的方法，以及调节延缓发作和/或抑制和/或预防眼部疾病的发生的严重性的方法伤口愈合和/或眼部手术引起的伤口愈合的其他结果，以及调节可以用作组织工程程序的一部分以修正结构，功能和/或细胞的移植细胞的存活，功能和/或分化眼睛的缺陷。

3. 发明申请

US20090053816A1 HEMOGLOBIN-BASED METHODS FOR PROPHYLAXIS, DIAGNOSIS AND/OR TREATMENT OF RETINAL DISORDERS 审中-公开
标题翻译：基于HEMOGLOBIN的预防性疾病的方法，诊断和/或治疗反应性疾病
公开(公告)号：US20090053816A1
公开(公告)日：2009-02-26
申请号：US12294409
申请日：2007-03-26
申请人： Tongalp H. Tezel , Henry J. Kaplan , Jon Klein
发明人： Tongalp H. Tezel , Henry J. Kaplan , Jon Klein
IPC分类号： G01N33/72 , C12Q1/00 , A61K38/00 , A61K39/395 , A61P27/00 , A61B5/05 , A61B17/20
CPC分类号： G01N33/723 , G01N2800/164
摘要： The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels and activities in the retinal tissue.
摘要翻译：目前公开的主题提供了通过测量受试者中的血红蛋白和修饰的血红蛋白来诊断受试者的视网膜疾病的方法。目前公开的主题还提供了通过调节血红蛋白水平和视网膜组织中的活性来减少受试者的视网膜组织中的缺氧来治疗受试者的视网膜疾病的方法。

4. 发明申请

US20130177552A1 METHODS AND COMPOSITIONS FOR MODULATING OCULAR DAMAGE 有权
标题翻译：调节眼损伤的方法和组合物
公开(公告)号：US20130177552A1
公开(公告)日：2013-07-11
申请号：US13698518
申请日：2011-05-20
申请人： Tongalp H. Tezel , Henry J. Kaplan , Robert A. Mitchell , John O. Trent
发明人： Tongalp H. Tezel , Henry J. Kaplan , Robert A. Mitchell , John O. Trent
IPC分类号： A61K39/395 , A61K31/505
CPC分类号： A61K39/3955 , A61K31/505 , A61K31/53 , A61K45/06 , A61K2300/00
摘要： Methods for modulating eye damage associated with a disease or disorder, and/or damage incident to trauma including but not limited to trauma associated with ocular surgery are provided. In some embodiments, the methods include administering an effective amount of a modulator of a migration inhibitory factor (MIF) polypeptide biological activity to a subject. Also provided are methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of an ocular disease, and methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of scarring and/or other consequence of wound healing incident to ocular surgery, as well as modulating the survival, function, and/or differentiation of engrafted cells that can be employed as part of tissue engineering procedures to correct structural, functional, and/or cellular defects of the eye.
摘要翻译：提供了用于调节与疾病或病症相关的眼睛损伤和/或损伤事件的方法，包括但不限于与眼部手术相关的创伤。在一些实施方案中，所述方法包括向受试者施用有效量的迁移抑制因子（MIF）多肽生物活性的调节剂。还提供了用于调节延缓发作和/或预防眼部疾病发展的严重性的方法，以及调节延缓发作和/或抑制和/或预防眼部疾病的发生的严重性的方法伤口愈合和/或眼部手术引起的伤口愈合的其他结果，以及调节可以用作组织工程程序的一部分以修正结构，功能和/或细胞的移植细胞的存活，功能和/或分化眼睛的缺陷。

5. 发明授权

US5722428A Method for producing a posterior vitreous detachment 失效
标题翻译：后玻璃体脱离的方法
公开(公告)号：US5722428A
公开(公告)日：1998-03-03
申请号：US740430
申请日：1996-10-29
申请人： Henry J. Kaplan , Tongalp H. Tezel
发明人： Henry J. Kaplan , Tongalp H. Tezel
IPC分类号： A61F9/007 , A61K9/00 , A61K38/48 , A61B19/00
CPC分类号： A61F9/00736 , A61K38/48 , A61K9/0048
摘要： Methods for enzymatic production of a posterior vitreous detachment are provided. In preferred methods, dispase is used to cleave type IV collagen and fibronectin at the vitreoretinal junction to promote the posterior vitreous detachment. The methods provide for enzymatic treatment in conjunction with intraocular surgery as well as treatments to relieve the blinding complications of certain eye disorders without the need for surgery. Also disclosed are kits for production of a posterior vitreous detachment and devices containing the enzymes useful in the methods.
摘要翻译：提供了用于酶促生产后玻璃体脱离的方法。在优选的方法中，分泌酶用于在玻璃体视网膜结处切割IV型胶原和纤连蛋白以促进玻璃体后脱离。所述方法提供了结合眼内手术的酶处理以及用于减轻某些眼睛疾病的致盲并发症而不需要手术的治疗。还公开了用于生产后玻璃体分离的试剂盒和含有可用于该方法的酶的装置。

6. 发明申请

US20130084262A1 REPAIRING BRUCH'S MEMBRANE WITH HYDROGELS 审中-公开
标题翻译：用HYDROGEL修复布氏膜
公开(公告)号：US20130084262A1
公开(公告)日：2013-04-04
申请号：US13642063
申请日：2011-04-19
申请人： Andrea S. Gobin , Tongalp H. Tezel
发明人： Andrea S. Gobin , Tongalp H. Tezel
IPC分类号： A61K45/06 , A61K38/18 , A61K31/78
CPC分类号： A61K31/78 , A61K9/0048 , A61K9/06 , A61K38/07 , A61K38/08 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1858 , A61K38/30 , A61K45/06 , A61K47/60 , A61K47/6903 , A61L27/18 , A61L27/227 , A61L27/52 , A61L27/54 , A61L2300/414 , A61L2300/416 , A61L2300/426 , A61L2430/16 , C08L71/02 , A61K2300/00
摘要： The invention provides hydrogels and methods for their use in treating disorders of the retina such as age-related macular degeneration (AMD).
摘要翻译：本发明提供水凝胶及其用于治疗视网膜病变的方法，例如年龄相关性黄斑变性（AMD）。

7. 发明申请

US20130204245A1 Surface Modification of Surgical Instruments for Selective Manipulation of Biological Tissues 审中-公开
标题翻译：手术器械的表面改性用于生物组织的选择性操纵
公开(公告)号：US20130204245A1
公开(公告)日：2013-08-08
申请号：US13577427
申请日：2011-02-07
申请人： Albena Ivanisevic , Tongalp H. Tezel
发明人： Albena Ivanisevic , Tongalp H. Tezel
IPC分类号： A61B18/00
CPC分类号： A61B18/00 , A61B17/28 , A61B2017/00858 , A61B2017/320004 , A61B2017/320008 , A61F9/007 , A61F9/00736 , A61L31/10 , A61L2400/12 , A61L2400/18 , A61L2420/04 , A61L2420/08 , A61L2430/16
摘要： Surgical instruments having at least one surface modified through formation of polyelectrolyte films and/or nanoparticle deposition thereon to increase adhesion between the surgical instrument and a patient's inner limiting membrane while reducing trauma during surgery are provided. The instrument includes a proximate end operable to be grasped by a surgeon and a distal tip operable to interface with a selected tissue, the distal tip comprising: i. first surface operable to receive at least one electrolyte film; ii. at least one layer of a polyelectrolyte film substantially coating the first surface, the polyelectrolyte film having at least one functional group displaying a charge.
摘要翻译：提供具有通过形成聚电解质膜和/或其上的纳米颗粒沉积而修饰的至少一个表面的外科器械，以增加手术器械与患者的内部限制膜之间的粘附，同时减少手术期间的创伤。仪器包括可操作以由外科医生掌握的近端，以及可操作以与选定组织相接的远端，所述远端包括：i。第一表面可操作以接收至少一个电解质膜; ii。至少一层聚电解质膜基本上涂覆第一表面，该聚电解质膜具有至少一个显示电荷的官能团。

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