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1. 发明授权

US06479298B1 Device and method for separating components of a fluid sample 有权
标题翻译：用于分离流体样品组分的装置和方法
公开(公告)号：US06479298B1
公开(公告)日：2002-11-12
申请号：US09454988
申请日：1999-12-03
申请人： Henry F. Miller , Fu-Chung Lin , Robert J. Losada , Jeffrey P. Radziunas , Jeffrey Karg
发明人： Henry F. Miller , Fu-Chung Lin , Robert J. Losada , Jeffrey P. Radziunas , Jeffrey Karg
IPC分类号： G01N118
CPC分类号： B01L3/50215 , G01N33/491 , Y10T436/25 , Y10T436/25375
摘要： A device and method for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents comprising a container and a composite element in the container. The composite element is a separator comprising at least two components and more particularly, a bellows with a seal body, a low-density float and a high-density ballast. A fluid sample is delivered to the container and the device is subjected to centrifugation whereby the centrifugal load causes the seal body of the separator to deform so that the separator migrates through the fluid sample and then stabilizes between the heavier and lighter fractions of the fluid sample. The seal body of the separator will resiliently return to its initial configuration upon termination of the centrifugal load such that the seal body sealingly engages the container and the composite element separates the heavier and lighter fractions of the fluid sample.
摘要翻译：用于分离流体样品的较重和较轻馏分的装置和方法。该装置包括多个构件，其包括容器中的容器和复合元件。复合元件是包括至少两个部件的分离器，更具体地，具有密封体，低密度浮子和高密度压载物的波纹管。将流体样品输送到容器并且使装置进行离心，由此离心负荷使得分离器的密封体变形，使得分离器通过流体样品移动，然后在流体样品的较重和较轻部分之间稳定。当离心负载终止时，分离器的密封体将弹性地返回到其初始构型，使得密封体密封地接合容器，并且复合元件分离流体样品的较重和较轻的部分。

2. 发明授权

US06516953B1 Device for separating components of a fluid sample 有权
标题翻译：用于分离流体样品的组分的装置
公开(公告)号：US06516953B1
公开(公告)日：2003-02-11
申请号：US09452981
申请日：1999-12-02
申请人： Paul C. DiCesare , Jeffrey Karg , Fu-Chung Lin , Jeffrey P. Radziunas
发明人： Paul C. DiCesare , Jeffrey Karg , Fu-Chung Lin , Jeffrey P. Radziunas
IPC分类号： B01D2126
CPC分类号： G01N33/491 , A61B5/15003 , A61B5/150221 , A61B5/150236 , A61B5/150251 , A61B5/150351 , A61B5/150572 , A61B5/150755 , A61B5/154 , B01D21/0003 , B01D21/26 , B01D21/262 , B01D2221/10 , B01L3/50215 , B01L2300/042
摘要： A device and method is provided for separating components of a fluid sample. The device includes a plurality of constituents comprising a container, a liner in the container, a closure for the container and a composite element. The composite element is a seal plug with a density between the densities of the components of the fluid sample is releasably engaged with the container closure and with the liner. A needle cannula is used to deposit a fluid sample in the liner and the entire device is placed in a centrifuge. The centrifugal load causes the seal plug to separate from the closure and causes the liner to expand outwardly against the container. The seal plug migrates into the fluid sample and stabilizes between the densities of the components of the fluid sample. The liner will resiliently return to its initial configuration upon termination of centrifugal load such that the liner sealingly engages the seal plug and separates the components of the fluid sample.
摘要翻译：提供了用于分离流体样品的组分的装置和方法。该装置包括多个构件，其包括容器，容器中的衬垫，用于容器的封闭件和复合元件。复合元件是密封塞，其密度在流体样品的部件的密度之间与容器封闭件和衬套可释放地接合。使用针插管将流体样品沉积在衬垫中，并将整个装置放置在离心机中。离心载荷使得密封塞与封闭件分离并使衬套朝向容器向外扩张。密封塞移动到流体样品中并且在流体样品的组分的密度之间稳定。当离心负载终止时，衬套将弹性地返回到其初始构型，使得衬套密封地接合密封塞并分离流体样品的部件。

3. 发明授权

US06497325B1 Device for separating components of a fluid sample 有权
标题翻译：用于分离流体样品的组分的装置
公开(公告)号：US06497325B1
公开(公告)日：2002-12-24
申请号：US09454267
申请日：1999-12-03
申请人： Paul DiCesare , Jeffrey Karg , Fu-Chung Lin
发明人： Paul DiCesare , Jeffrey Karg , Fu-Chung Lin
IPC分类号： B01D2126
CPC分类号： B01L3/50215
摘要： A device and method is provided for separating heavier and lighter fractions of a fluid sample. The device includes a plurality of constituents. The constituents include a container, a liner in the container and a composite element in the liner for separating the fractions of a fluid sample. The separator comprises a specific density at a target density range as defined by separable fluid components densities. A fluid sample is delivered to the liner and then the device is subjected to centrifugation whereby the centrifugal load causes the liner to deform and the composite element migrates into the fluid sample and stabilizes between the heavier and lighter fractions of the fluid sample. The liner will resiliently return to its initial configuration upon termination of the centrifugal load such that the liner sealingly engages the composite element and separates the heavier and lighter fractions of the fluid sample.
摘要翻译：提供了用于分离流体样品的较重和较轻馏分的装置和方法。该装置包括多个成分。组分包括容器，容器中的衬垫和用于分离流体样品的级分的衬垫中的复合元件。分离器包括由可分离的流体组分密度所限定的目标密度范围的特定密度。将流体样品输送到衬套，然后使装置进行离心，由此离心负载导致衬套变形，并且复合元件迁移到流体样品中并且在流体样品的较重和较轻部分之间稳定。衬垫将在离心负载终止时弹性地返回到其初始构型，使得衬套密封地接合复合元件并分离流体样品的较重和较轻的部分。

4. 发明授权

US5388573A Dry powder inhalator medicament carrier 失效
标题翻译：干粉吸入器药物载体
公开(公告)号：US5388573A
公开(公告)日：1995-02-14
申请号：US161230
申请日：1993-12-02
申请人： Paul Mulhauser , Jeffrey Karg
发明人： Paul Mulhauser , Jeffrey Karg
IPC分类号： A61J1/03 , A61M15/00 , A61M16/00 , B05D7/14 , B65D83/06
CPC分类号： A61M15/0045 , A61M15/0048 , A61M2202/064
摘要： A carrier impregnated at spaced locations along its circumference with a dose of powdered medicament. The carrier is selectively indexed so as to present the impregnated doses of medicament seriatim between a pair of holes in an upper and lower pressure plate in an inhalator. Air is forced through the holes in the pressure plates and the encapsulated dose on the carrier to entrain a dose of the powdered medicament, which is then inhaled through a mouthpiece, by the patient-user. The powdered medicament is embedded in and across interstices in the carrier formed by intersecting and sometimes offset depressions on each surface of the carrier, providing corners and surfaces to cause the medicament entrained in the air stream to break up as it is pressed up against and passed through the carrier infrastructure to aerosol or atomize the same so that the medicament is presented in appropriate particle sizes for maximum benefit when inhaled.
摘要翻译：一种载体，其沿着其圆周与间隔开的位置用一定剂量的粉末状药物浸渍。载体被选择性地分级，以便在吸入器中的上压力板和下压板中的一对孔之间存在浸渍剂量的药物。空气被迫通过压力板中的孔和载体上的包封剂量，以夹带剂量的粉末药物，然后由患者使用者通过吸口吸入。粉末状药物嵌入载体中并穿过载体形成的间隙，通过在载体的每个表面上相交并有时抵消凹陷形成，提供拐角和表面，以使夹带在空气流中的药物在被压靠和通过时分解通过载体基础设施进行气溶胶或雾化，使得药物以适当的粒度呈现，以便在吸入时获得最大的益处。

5. 发明申请

US20050181519A1 Metering doses of sample liquids 有权
标题翻译：样品液体的计量剂量
公开(公告)号：US20050181519A1
公开(公告)日：2005-08-18
申请号：US10911845
申请日：2004-08-05
申请人： Jeffrey Karg , Douglas Kroncke
发明人： Jeffrey Karg , Douglas Kroncke
IPC分类号： B01L3/02 , G01N1/10 , G01N1/38 , G01N35/10
CPC分类号： B01L3/021 , B01F3/0865 , B01F15/0454 , B01F2003/0896 , B01L3/0275 , B01L3/0293 , B01L3/5027 , B01L2300/06 , B01L2300/0858 , G01N1/38 , G01N2035/1032 , Y10T436/2575
摘要： A method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample liquid, and to retain the collected dose by capillary force when the channel is emptied. The sample liquid is then removed from the channel under conditions that enable retention of the collected, metered dose of the sample liquid in the pocket. Following a cleaning step, a volume of diluent liquid is introduced into the channel to induce diffusion and mixing of the diluent liquid with the dose of sample liquid to form a mixture.
摘要翻译：计量和混合样品液体与稀释液体的方法包括将样品液体引入限定在壳体中的通道中。壳体限定了通向通道的口袋，其尺寸适于收集计量剂量的样品液体，并且当通道排空时通过毛细管力保持收集的剂量。然后在允许将收集的计量剂量的样品液体保留在口袋中的条件下，将样品液体从通道中除去。在清洁步骤之后，将一定体积的稀释液引入通道中以诱导稀释液与样品液体的剂量的扩散和混合以形成混合物。

6. 发明授权

US5388572A Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same 失效
标题翻译：具有吸入活化活塞的干粉药物吸入器，以雾化剂量并输送相同剂量
公开(公告)号：US5388572A
公开(公告)日：1995-02-14
申请号：US143182
申请日：1993-10-26
申请人： Paul Mulhauser , Jeffrey Karg , Thomas Foxen , Christopher J. Brooks
发明人： Paul Mulhauser , Jeffrey Karg , Thomas Foxen , Christopher J. Brooks
IPC分类号： B65D83/04 , A61M11/00 , A61M13/00 , A61M15/00 , B05B11/00 , B05B11/06 , B65D83/06 , A61M16/00 , B05D7/14 , B05D83/06
CPC分类号： B05B11/3091 , A61M11/02 , A61M15/0026 , A61M15/0045 , A61M15/0048 , A61M15/0075 , A61M15/0091 , B05B11/061 , A61M2202/064 , A61M2205/073
摘要： A dry powder inhalator for delivering a precise dose of a medicament contains a mesh disc impregnated with a series of spaced, medicament doses about the disc periphery. The inhalator is armed by manually retracting a finger pull extending downwardly from the bottom of the inhalator housing or rotating the bottom of the housing. The user inserts a mouthpiece on the housing into the mouth and inhales. This causes a chamber in the housing under a diaphragm to evacuate, thereby pulling the diaphragm down onto a knock out lever. The pivoting of the lever enables release of a piston into a cylinder which first compresses, and then dispenses a reduced volume of air at high pressure in a burst up through the medicament disc. When the burst of air hits the impregnated disc, the dose is forced out of the mesh's interstices, producing a cloud of the drug in its powdered form, which is inhaled by the user.
摘要翻译：用于递送精确剂量的药物的干粉吸入器包含浸渍有围绕盘周边的一系列间隔的药物剂量的网片盘。通过手动收回从吸入器壳体的底部向下延伸的或者旋转壳体的底部的手指拉力来吸入吸入器。用户将口罩插入外壳进入口腔并吸入。这使得在隔膜下的壳体中的腔室被排出，从而将隔膜向下拉到敲击杆上。杠杆的枢转使得活塞能够释放到气缸中，该气缸首先压缩，然后在高压下通过药物盘突发地分配减小体积的空气。当爆裂的空气撞击浸渍的盘时，剂量被迫离开网状物的间隙，产生由粉末形式的药物的云，其由用户吸入。

7. 发明申请

US20080302178A1 Method and system for dispensing precise reagent volumes 审中-公开
标题翻译：用于分配精确试剂体积的方法和系统
公开(公告)号：US20080302178A1
公开(公告)日：2008-12-11
申请号：US12157357
申请日：2008-06-10
申请人： Jeffrey Karg
发明人： Jeffrey Karg
IPC分类号： G01F15/00 , G01F13/00
CPC分类号： G01F13/006 , G01N35/1016
摘要： A method and system for dispensing small volumes of liquid reagents is provided. The system includes a sequence of one, two, or three or more sensors, attached to a conduit, which send an electronic signal indicating the presence or lack of fluid in the conduit. The sensors can sense the leading edge of a fluid in a conduit, often called the leading meniscus. The sensors are connected to a microprocessor capable of recording the time the leading meniscus passes each sensor. The microprocessor can also calculate the time difference between the sensors, and at a constant flow rate, determine the speed of the fluid in the conduit and proportionally, depending on the diameter of the conduit, calculate the flow rate within the conduit. The microprocessor can also control the pump to cause the fluid to flow for a specific period of time so that a known discrete volume can be dispensed from the conduit. The microprocessor can also control a pump allowing the leading meniscus to be positioned accurately within the conduit.
摘要翻译：提供了用于分配小体积液体试剂的方法和系统。该系统包括连接到导管的一个，两个或三个或更多个传感器的序列，其传送指示管道中存在或缺少流体的电子信号。传感器可以感测导管中的流体的前缘，通常称为主导半月板。传感器连接到能够记录主要弯月面通过每个传感器的时间的微处理器。微处理器还可以计算传感器之间的时间差，并且以恒定的流速，根据导管的直径，根据导管的直径，确定导管中流体的速度并计算出流量。微处理器还可以控制泵以使流体流动一段特定的时间，从而可以从导管分配已知的离散体积。微处理器还可以控制一个允许引导弯液面准确地定位在导管内的泵。

8. 发明授权

US5267964A Fluid control device including automatic valve 失效
标题翻译：流体控制装置包括自动阀
公开(公告)号：US5267964A
公开(公告)日：1993-12-07
申请号：US855909
申请日：1992-03-23
申请人： Jeffrey Karg
发明人： Jeffrey Karg
IPC分类号： A61M5/00 , A61M5/142 , A61M5/168 , A61M39/00 , F16K7/17 , A61M1/00
CPC分类号： A61M5/1424
摘要： A fluid delivery device and method of delivering fluid is provided. The device comprises a delivery member including a member for creating a vacuum pressure, to suck fluid into a reservoir, and for expelling fluid from the reservoir. A body is provided including a first opening, a second opening, and a third opening, the interior of the body defining a first fluid pathway from the first opening to the second opening and a second fluid pathway from the second opening and a second fluid pathway from the second opening to the third opening. The delivery member is coupled to the second opening. A fluid source is coupled to the first opening. A fluid conduit is coupled to the third opening for allowing the device to deliver product to a patient. The first and second fluid pathways are defined in part by walls that define a central cavity and a diaphragm located therein. The diaphragm closing both the first and second fluid pathways when it is in a first, static position and opening the first pathway when the delivery member creates a vacuum pressure, while maintaining the second pathway in a closed position. When the delivery member creates a positive pressure, the second pathway is opened while the first fluid pathway is maintained in a closed position.

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