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1. 发明申请

US20120022356A1 IMPLANTABLE MRI COMPATIBLE MEDICAL LEAD WITH A ROTATABLE CONTROL MEMBER 审中-公开
标题翻译：可植入MRI兼容医疗引导与可旋转的控制成员
公开(公告)号：US20120022356A1
公开(公告)日：2012-01-26
申请号：US13262179
申请日：2009-10-30
申请人： Linn Olsen , Mikael Forslund , Henrik Djurling , Patrik Forsström , Leda Henriquez , Kenneth Dahlberg , Olof Stegfeldt , Åke Sivard
发明人： Linn Olsen , Mikael Forslund , Henrik Djurling , Patrik Forsström , Leda Henriquez , Kenneth Dahlberg , Olof Stegfeldt , Åke Sivard
IPC分类号： A61N1/05 , A61B5/04
CPC分类号： A61N1/057 , A61N1/3752
摘要： A medical implantable lead is adapted to be implanted into a human or animal body for monitoring and/or controlling of an organ inside the body. The lead has in a distal end, a combined fixation means and electrode member in form of a helix, which is connected to a rotatable tubular member being connected to a rotatable member at a proximal end of the lead, and which is rotatable in relation to the lead and extendable out from the distal end, by rotation of the control member and the tubular torque transferring member, to be able to fixate the distal end of the lead to the organ by being screwed into the tissue. The helix is electrically connected to a connector at the proximal end by means of at least one electrically conducting wire formed as an electrically conducting coil, which is separate from the tubular torque transferring member and unrotatable in relation to the lead and that has one or more individual wires, each including an electrically conducting wire core and a surrounding electrically insulating layer, wherein the rotatable control member is rotatable within the connector.
摘要翻译：医用可植入引线适于植入人体或动物体内，用于监测和/或控制体内器官。引线具有远端，组合的固定装置和螺旋形式的电极构件，其连接到可旋转的管状构件，该可旋转的管状构件在引线的近端处连接到可旋转构件，并且其可相对于引线并且通过控制构件和管状扭矩传递构件的旋转从远端可伸出，以能够通过拧入组织而将引线的远端固定到器官。螺旋线通过至少一个形成为导电线圈的导电线电连接到近端处的连接器，导电线圈与管状扭矩传递构件分离并且相对于引线不可旋转，并且具有一个或多个各个电线各自包括导电线芯和周围的电绝缘层，其中可旋转控制构件可在连接器内旋转。

2. 发明授权

US08521307B2 Implantable MRI compatible medical lead 有权
标题翻译：可植入MRI兼容医用铅
公开(公告)号：US08521307B2
公开(公告)日：2013-08-27
申请号：US13262551
申请日：2009-07-10
申请人： Henrik Djurling , Kenneth Dahlberg , Mikael Forslund , Patrik Forsström , Leda Henriquez , Linn Olsen , Olof Stegfeldt , Åke Sivard
发明人： Henrik Djurling , Kenneth Dahlberg , Mikael Forslund , Patrik Forsström , Leda Henriquez , Linn Olsen , Olof Stegfeldt , Åke Sivard
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/3752
摘要： A medical implantable lead is adapted to be implanted into a human or animal body for monitoring and/or controlling of an organ inside the body, and has in a distal end, a combined fixation means and electrode member in form of a helix, which is rotatable in relation to the lead and extendable out from the distal end by rotation of a tubular torque transferring member. The helix is electrically connected to a connector in the proximal end by at least one electrically conducting wire, which is formed as an electrically conducting coil, which is separate from the tubular torque transferring member and that includes one or more individual wires each having an electrically conducting wire core and a surrounding electrically insulating layer. The tubular torque transferring member has no electrically conducting function to or from the helix. The lead is arranged such that the electrical connection between the helix and the conducting wire is always maintained regardless of the rotational position of the helix while no electrical connection is present between the helix and the tubular torque transferring member although the helix is rotatable by the tubular torque transferring member.
摘要翻译：医用可植入引线适于植入人体或动物体内，用于监测和/或控制体内器官，并且在远端具有组合的固定装置和螺旋形式的电极部件可相对于引线旋转，并通过管状扭矩传递构件的旋转从远端伸出。螺旋线通过至少一个导电线电连接到近端的连接器，导电线形成为导电线圈，其与管状扭矩传递构件分离，并且包括一个或多个单独的导线，每个导线导线芯和周围的电绝缘层。管状转矩传递部件不具有与螺旋之间的导电功能。导线被布置成使得螺旋和导线之间的电连接总是保持，而不管螺旋的旋转位置如何，同时螺旋和管状扭矩传递构件之间没有电连接，尽管螺旋可由管状扭矩传递构件。

3. 发明申请

US20120035693A1 IMPLANTABLE MRI COMPATIBLE MEDICAL LEAD 有权
标题翻译：可植入MRI兼容医用引线
公开(公告)号：US20120035693A1
公开(公告)日：2012-02-09
申请号：US13262551
申请日：2009-07-10
申请人： Henrik Djurling , Kenneth Dahlberg , Mikael Forslund , Patrik Forsström , Leda Henriquez , Linn Olsen , Olof Stegfeldt , Åke Sivard
发明人： Henrik Djurling , Kenneth Dahlberg , Mikael Forslund , Patrik Forsström , Leda Henriquez , Linn Olsen , Olof Stegfeldt , Åke Sivard
IPC分类号： A61N1/00
CPC分类号： A61N1/057 , A61N1/3752
摘要： A medical implantable lead is adapted to be implanted into a human or animal body for monitoring and/or controlling of an organ inside the body, and has in a distal end, a combined fixation means and electrode member in form of a helix, which is rotatable in relation to the lead and extendable out from the distal end by rotation of a tubular torque transferring member. The helix is electrically connected to a connector in the proximal end by at least one electrically conducting wire, which is formed as an electrically conducting coil, which is separate from the tubular torque transferring member and that includes one or more individual wires each having an electrically conducting wire core and a surrounding electrically insulating layer. The tubular torque transferring member has no electrically conducting function to or from the helix. The lead is arranged such that the electrical connection between the helix and the conducting wire is always maintained regardless of the rotational position of the helix while no electrical connection is present between the helix and the tubular torque transferring member although the helix is rotatable by the tubular torque transferring member.
摘要翻译：医用可植入引线适于植入人体或动物体内，用于监测和/或控制体内器官，并且在远端具有组合的固定装置和螺旋形式的电极部件可相对于引线旋转，并通过管状扭矩传递构件的旋转从远端伸出。螺旋线通过至少一个导电线电连接到近端的连接器，导电线形成为导电线圈，其与管状扭矩传递构件分离，并且包括一个或多个单独的导线，每个导线导线芯和周围的电绝缘层。管状转矩传递部件不具有与螺旋之间的导电功能。引线被布置成使得螺旋和导线之间的电连接总是保持，而不管螺旋的旋转位置如何，同时螺旋和管状扭矩传递构件之间没有电连接，尽管螺旋可由管状扭矩传递构件。

4. 发明申请

US20110245646A1 MEDICAL IMPLANTABLE LEAD AND METHOD FOR THE MANUFACTURE THEREOF 有权
标题翻译：医用可植入式铅及其制造方法
公开(公告)号：US20110245646A1
公开(公告)日：2011-10-06
申请号：US13132125
申请日：2008-12-02
申请人： Hans Strandberg , Åke Sivard , Åsa Broomé , Kenneth Dahlberg , Gustav Pellijeff , Leda Henriquez
发明人： Hans Strandberg , Åke Sivard , Åsa Broomé , Kenneth Dahlberg , Gustav Pellijeff , Leda Henriquez
IPC分类号： A61B5/04 , A61N1/36 , H05K13/00
CPC分类号： A61N1/05 , A61N1/056 , A61N1/086 , A61N1/3718 , Y10T29/49002
摘要： A medical implantable lead adapted to be implanted into a human or animal body for monitoring and/or controlling of an organ inside the body has a fixation in a distal end, which is adapted to fix a distal end of the lead to the organ, an electrode member in the distal end adapted to be in contact with tissue of the organ and receive and/or transmit electrical signals from and/or to the organ, and at least one electrically conducting coil, which includes one or more electrically conducting helical wires and that is adapted to connect the electrode member in the distal end with a monitoring and/or controlling device in a proximal end of the lead. One or more of the individual wires of the coil has a wire core that is provided with a surrounding electrically insulating layer, which in turn is provided with a surrounding electrically conducting shield layer, and the coil is close lapped such that electrically conducting shield layers of adjacent loops of the coil are in electrical contact with each other.
摘要翻译：适于植入人体或动物体内的用于监测和/或控制体内器官的医用可植入引线具有在远端固定，其适于将引线的远端固定到器官，远端中的电极构件适于与器官的组织接触并且接收和/或传送来自器官和/或器官的电信号，以及至少一个导电线圈，其包括一个或多个导电螺旋线和其适于将远端中的电极构件与引线的近端中的监视和/或控制装置连接。线圈的一条或多条单独的线具有线芯，该芯线设置有环绕的电绝缘层，该电绝缘层又设置有环绕的导电屏蔽层，并且线圈被紧密地重叠，使得导电屏蔽层线圈的相邻环彼此电接触。

5. 发明授权

US08437863B2 Electrode lead 有权
标题翻译：电极铅
公开(公告)号：US08437863B2
公开(公告)日：2013-05-07
申请号：US13140729
申请日：2008-12-19
申请人： Åke Sivard , Gustav Pellijeff , Hans Strandberg , Leda Henriquez , Åsa Broomé , Kenneth Dahlberg
发明人： Åke Sivard , Gustav Pellijeff , Hans Strandberg , Leda Henriquez , Åsa Broomé , Kenneth Dahlberg
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/086 , A61N1/3688 , A61N1/3718
摘要： An implantable electrode lead for tissue stimulation adapted to be attached to an implantable tissue stimulator provided with a pulse generator, has at least two stimulation electrodes to apply stimulation pulses to said tissue and arranged close to the distal end of the electrode lead, and at least two electrical conductors to connect said electrodes to said pulse generator. The electrode lead further has a switching unit arranged close to the distal end of the electrode lead and adapted to switch the electrode lead between a local pacing mode and a normal pacing mode, the switching unit being controlled by a mode control signal. Further, a pacing module is arranged close to the distal end of the electrode lead and in relation to the switching unit and being connectable to said at least two stimulation electrodes, the pacing module includes a pulse generating unit to generate stimulating pulses to be applied to the tissue by the stimulation electrodes. When the electrode lead is in the local pacing mode the electrical conductors are disconnected from said stimulation electrodes which instead are connected to the pacing module, and when the electrode lead is in the normal pacing mode the electrical conductors are connected to the stimulation electrodes.
摘要翻译：一种用于组织刺激的可植入电极引线，其适用于连接到具有脉冲发生器的可植入组织刺激器，具有至少两个刺激电极，以将刺激脉冲施加到所述组织并且靠近电极引线的远端布置，并且至少两个电导体将所述电极连接到所述脉冲发生器。电极引线还具有靠近电极引线的远端布置的开关单元，并且适于在局部起搏模式和正常起搏模式之间切换电极引线，开关单元由模式控制信号控制。此外，起搏模块靠近电极引线的远端设置，并且相对于开关单元设置并且可连接到所述至少两个刺激电极，所述起搏模块包括脉冲产生单元，用于产生刺激脉冲以施加到由刺激电极组织。当电极引线处于局部起搏模式时，电导体与所述刺激电极断开，代替地连接到起搏模块，并且当电极引线处于正常起搏模式时，电导体连接到刺激电极。

6. 发明申请

US20110251654A1 ELECTRODE LEAD 有权
标题翻译：电极引线
公开(公告)号：US20110251654A1
公开(公告)日：2011-10-13
申请号：US13140729
申请日：2008-12-19
申请人： Åke Sivard , Gustav Pellijeff , Hans Strandberg , Leda Henriquez , Åsa Broomé , Kenneth Dahlberg
发明人： Åke Sivard , Gustav Pellijeff , Hans Strandberg , Leda Henriquez , Åsa Broomé , Kenneth Dahlberg
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/05 , A61N1/086 , A61N1/3688 , A61N1/3718
摘要： An implantable electrode lead for tissue stimulation adapted to be attached to an implantable tissue stimulator provided with a pulse generator, has at least two stimulation electrodes to apply stimulation pulses to said tissue and arranged close to the distal end of the electrode lead, and at least two electrical conductors to connect said electrodes to said pulse generator. The electrode lead further has a switching unit arranged close to the distal end of the electrode lead and adapted to switch the electrode lead between a local pacing mode and a normal pacing mode, the switching unit being controlled by a mode control signal. Further, a pacing module is arranged close to the distal end of the electrode lead and in relation to the switching unit and being connectable to said at least two stimulation electrodes, the pacing module includes a pulse generating unit to generate stimulating pulses to be applied to the tissue by the stimulation electrodes. When the electrode lead is in the local pacing mode the electrical conductors are disconnected from said stimulation electrodes which instead are connected to the pacing module, and when the electrode lead is in the normal pacing mode the electrical conductors are connected to the stimulation electrodes.
摘要翻译：一种用于组织刺激的可植入电极引线，其适用于连接到具有脉冲发生器的可植入组织刺激器，具有至少两个刺激电极，以将刺激脉冲施加到所述组织并且靠近电极引线的远端布置，并且至少两个电导体将所述电极连接到所述脉冲发生器。电极引线还具有靠近电极引线的远端布置的开关单元，并且适于在局部起搏模式和正常起搏模式之间切换电极引线，开关单元由模式控制信号控制。此外，起搏模块靠近电极引线的远端设置，并且相对于开关单元设置并且可连接到所述至少两个刺激电极，所述起搏模块包括脉冲产生单元，用于产生刺激脉冲以施加到由刺激电极组织。当电极引线处于局部起搏模式时，电导体与所述刺激电极断开，代替地连接到起搏模块，并且当电极引线处于正常起搏模式时，电导体连接到刺激电极。

7. 发明授权

US08442647B2 Medical implantable lead and method for the manufacture thereof 有权
标题翻译：医用植入式铅及其制造方法
公开(公告)号：US08442647B2
公开(公告)日：2013-05-14
申请号：US13132125
申请日：2008-12-02
申请人： Hans Strandberg , Åke Sivard , Åsa Broomé , Kenneth Dahlberg , Gustav Pellijeff , Leda Henriquez
发明人： Hans Strandberg , Åke Sivard , Åsa Broomé , Kenneth Dahlberg , Gustav Pellijeff , Leda Henriquez
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/056 , A61N1/086 , A61N1/3718 , Y10T29/49002
摘要： A medical implantable lead adapted to be implanted into a human or animal body for monitoring and/or controlling of an organ inside the body has a fixation in a distal end, which is adapted to fix a distal end of the lead to the organ, an electrode member in the distal end adapted to be in contact with tissue of the organ and receive and/or transmit electrical signals from and/or to the organ, and at least one electrically conducting coil, which includes one or more electrically conducting helical wires and that is adapted to connect the electrode member in the distal end with a monitoring and/or controlling device in a proximal end of the lead. One or more of the individual wires of the coil has a wire core that is provided with a surrounding electrically insulating layer, which in turn is provided with a surrounding electrically conducting shield layer, and the coil is close lapped such that electrically conducting shield layers of adjacent loops of the coil are in electrical contact with each other.
摘要翻译：适于植入人体或动物体内的用于监测和/或控制体内器官的医用可植入引线具有在远端固定，其适于将引线的远端固定到器官，远端中的电极构件适于与器官的组织接触并且接收和/或传送来自器官和/或器官的电信号，以及至少一个导电线圈，其包括一个或多个导电螺旋线和其适于将远端中的电极构件与引线的近端中的监视和/或控制装置连接。线圈的一条或多条单独的线具有线芯，该芯线设置有环绕的电绝缘层，该电绝缘层又设置有环绕的导电屏蔽层，并且线圈被紧密地重叠，使得导电屏蔽层线圈的相邻环彼此电接触。

8. 发明授权

US08224457B2 Medical implantable lead 有权
标题翻译：医用植入式铅
公开(公告)号：US08224457B2
公开(公告)日：2012-07-17
申请号：US12447984
申请日：2006-10-31
申请人： Hans Strandberg , Anna Norlin-Weissenrieder , Leda Henriquez , Eva Harström , Mikael Sjögren , Annika Naeslund , Susanne Nilsson , Olof Stegfeldt
发明人： Hans Strandberg , Anna Norlin-Weissenrieder , Leda Henriquez , Eva Harström , Mikael Sjögren , Annika Naeslund , Susanne Nilsson , Olof Stegfeldt
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/056 , H01B7/0823
摘要： A medical implantable lead has a proximal end and a distal end, and a flexible flat elongate body. The elongate body includes a layer of strip conductors extending along the length of the flat elongate body, a top insulating layer, and a bottom insulating layer. The layer of strip conductors is sealingly enclosed between the top and bottom insulating layers, and at least a major portion of the flat elongate body is twisted into an elongate helical portion having a central cavity extending longitudinally of the helical portion.
摘要翻译：医用可植入引线具有近端和远端，以及柔性扁平细长体。细长主体包括沿扁平细长体的长度延伸的条形导体层，顶部绝缘层和底部绝缘层。带状导体层被密封地封闭在顶部和底部绝缘层之间，并且扁平细长体的至少大部分被扭转成具有沿螺旋部分纵向延伸的中心空腔的细长螺旋部分。

9. 发明申请

US20100114279A1 MEDICAL IMPLANTABLE LEAD 有权
标题翻译：医用植入式铅
公开(公告)号：US20100114279A1
公开(公告)日：2010-05-06
申请号：US12447984
申请日：2006-10-31
申请人： Hans Strandberg , Anna Norlin-Weissenrieder , Leda Henriquez , Eva Harström , Mikael Sjögren , Annika Naeslund , Susanne Nilsson , Olof Stegfeldt
发明人： Hans Strandberg , Anna Norlin-Weissenrieder , Leda Henriquez , Eva Harström , Mikael Sjögren , Annika Naeslund , Susanne Nilsson , Olof Stegfeldt
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/056 , H01B7/0823
摘要： A medical implantable lead has a proximal end and a distal end, and a flexible flat elongate body. The elongate body includes a layer of strip conductors extending along the length of the flat elongate body, a top insulating layer, and a bottom insulating layer. The layer of strip conductors is sealingly enclosed between the top and bottom insulating layers, and at least a major portion of the flat elongate body is twisted into an elongate helical portion having a central cavity extending longitudinally of the helical portion.
摘要翻译：医用可植入引线具有近端和远端，以及柔性扁平细长体。细长主体包括沿扁平细长体的长度延伸的条形导体层，顶部绝缘层和底部绝缘层。带状导体层被密封地封闭在顶部和底部绝缘层之间，并且扁平细长体的至少大部分被扭转成具有沿螺旋部分纵向延伸的中心空腔的细长螺旋部分。

10. 发明授权

US08419716B2 Tissue stimulating device and method 有权
标题翻译：组织刺激装置及方法
公开(公告)号：US08419716B2
公开(公告)日：2013-04-16
申请号：US12445607
申请日：2006-10-31
申请人： Anna Weissenrieder-Norlin , Leda Henriquez , Hans Strandberg , Eva Harström , Mikael Sjögren , Annika Naeslund
发明人： Anna Weissenrieder-Norlin , Leda Henriquez , Hans Strandberg , Eva Harström , Mikael Sjögren , Annika Naeslund
IPC分类号： A61N1/44
CPC分类号： A61N1/44 , A61N1/32 , A61N1/362
摘要： A tissue stimulating device that provides biological stimulation of tissue has a release surface adapted for arrangement adjacent to a tissue to be stimulated. An agent reservoir of the device includes an ionic agent capable of causing a stimulation if present at sufficient high extracellular concentration close to the tissue. An agent releaser is provided in the device for releasing a selected amount of the ionic agent from the agent reservoir to an outside of the release surface at a stimulation occasion for stimulating the tissue. The ionic agent will cause a temporary change in ion permeability of the tissue cell membranes and a depolarization of the tissue cells.
摘要翻译：提供组织的生物刺激的组织刺激装置具有适于布置成邻近要刺激的组织的释放表面。该装置的药剂储存器包括能够在靠近组织足够高的细胞外浓度存在时引起刺激的离子试剂。在用于在用于刺激组织的刺激时刻将选定量的离子试剂从试剂储存器释放到释放表面外部的试剂释放剂。离子剂将导致组织细胞膜的离子渗透性的暂时变化和组织细胞的去极化。

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