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1. 发明授权

US08946426B2 Substituted bicyclic heterocyclic compounds as gamma secretase modulators 有权
标题翻译：取代的双环杂环化合物作为γ分泌酶调节剂
公开(公告)号：US08946426B2
公开(公告)日：2015-02-03
申请号：US13144554
申请日：2010-02-02
申请人： Henricus Jacobus Maria Gijsen , Adriana Ingrid Velter , Gregor James MacDonald , François Paul Bischoff , Tongfei Wu , Sven Franciscus Anna Van Brandt , Michel Surkyn , Mirko Zaja , Serge Maria Aloysius Pieters , Didier Jean-Claude Berthelot , Michel Anna Jozef De Cleyn , Daniel Oehlrich
发明人： Henricus Jacobus Maria Gijsen , Adriana Ingrid Velter , Gregor James MacDonald , François Paul Bischoff , Tongfei Wu , Sven Franciscus Anna Van Brandt , Michel Surkyn , Mirko Zaja , Serge Maria Aloysius Pieters , Didier Jean-Claude Berthelot , Michel Anna Jozef De Cleyn , Daniel Oehlrich
IPC分类号： A61K31/437 , C07D471/04 , C07D487/04 , C07D403/10 , C07D413/10
CPC分类号： C07D487/04 , C07D401/12 , C07D403/10 , C07D403/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D471/04
摘要： The present invention is concerned with substituted bicyclic heterocyclic compounds of Formula (I) wherein Het1, Het2, A1, A2, A3 and A4 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译：本发明涉及其中Het1，Het2，A1，A2，A3和A4具有权利要求中限定的含义的式（I）的取代双环杂环化合物。根据本发明的化合物可用作γ-分泌酶调节剂。本发明还涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。

2. 发明授权

US08946266B2 Substituted triazole and imidazole derivatives as gamma secretase modulators 有权
标题翻译：取代的三唑和咪唑衍生物作为γ分泌酶调节剂
公开(公告)号：US08946266B2
公开(公告)日：2015-02-03
申请号：US13382659
申请日：2010-07-13
申请人： Tongfei Wu , Henricus Jacobus Maria Gijsen , Frederik Jan Rita Rombouts , François Paul Bischoff , Didier Jean-Claude Berthelot , Daniel Oehlrich , Michel Anna Jozef De Cleyn , Serge Maria Aloysius Pieters , Garrett Berlond Minne , Adriana Ingrid Velter′ , Sven Franciscus Anna Van Brandt , Michel Surkyn
发明人： Tongfei Wu , Henricus Jacobus Maria Gijsen , Frederik Jan Rita Rombouts , François Paul Bischoff , Didier Jean-Claude Berthelot , Daniel Oehlrich , Michel Anna Jozef De Cleyn , Serge Maria Aloysius Pieters , Garrett Berlond Minne , Adriana Ingrid Velter′ , Sven Franciscus Anna Van Brandt , Michel Surkyn
IPC分类号： A61K31/4439 , C07D401/14 , C07D233/60 , C07D403/10 , C07D405/14 , C07D471/04 , C07D487/04 , C07D498/04
CPC分类号： C07D233/60 , C07D401/14 , C07D403/10 , C07D405/14 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present invention is concerned with novel substituted triazole and imidazole derivatives of Formula (I) wherein R1, R2, A1, A2, A3, A4, X, and Het1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译：本发明涉及式（I）的新型取代三唑和咪唑衍生物，其中R1，R2，A1，A2，A3，A4，X和Het1具有权利要求中限定的含义。根据本发明的化合物可用作γ-分泌酶调节剂。本发明还涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。

3. 发明申请

US20120135981A1 NOVEL SUBSTITUTED TRIAZOLE AND IMIDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS 有权
标题翻译：作为GAMMA秘密调节剂的新型三唑并咪唑衍生物
公开(公告)号：US20120135981A1
公开(公告)日：2012-05-31
申请号：US13382659
申请日：2010-07-13
申请人： Tongfei Wu , Henricus Jacobus Maria Gijsen , Frederik Jan Rita Rombouts , François Paul Bischoff , Didier Jean-Claude Berthelot , Daniel Oehlrich , Michel Anna Jozef De Cleyn , Serge Maria Aloysius Pieters , Garrett Berlond Minne , Adriana Ingrid Velter' , Sven Franciscus Anna Van Brandt , Michel Surkyn
发明人： Tongfei Wu , Henricus Jacobus Maria Gijsen , Frederik Jan Rita Rombouts , François Paul Bischoff , Didier Jean-Claude Berthelot , Daniel Oehlrich , Michel Anna Jozef De Cleyn , Serge Maria Aloysius Pieters , Garrett Berlond Minne , Adriana Ingrid Velter' , Sven Franciscus Anna Van Brandt , Michel Surkyn
IPC分类号： A61K31/553 , C07D403/10 , C07D413/14 , A61K31/5377 , A61K31/4439 , A61K31/4196 , A61P25/28 , A61P25/00 , A61P25/16 , C07D471/04 , C07D487/04 , C07D498/04 , C07D405/14 , A61K31/437 , A61K31/55 , A61K31/519 , A61K31/4985 , A61K31/5383 , C07D401/14
CPC分类号： C07D233/60 , C07D401/14 , C07D403/10 , C07D405/14 , C07D471/04 , C07D487/04 , C07D498/04
摘要： The present invention is concerned with novel substituted triazole and imidazole derivatives of Formula (I) wherein R1, R2, A1, A2, A3, A4, X, and Het1 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译：本发明涉及式（I）的新型取代三唑和咪唑衍生物，其中R1，R2，A1，A2，A3，A4，X和Het1具有权利要求中限定的含义。根据本发明的化合物可用作γ-分泌酶调节剂。本发明还涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。

4. 发明申请

US20110281881A1 NOVEL SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS GAMMA SECRETASE MODULATORS 有权
标题翻译：新的取代双环杂环化合物作为GAMMA分泌酶调节剂
公开(公告)号：US20110281881A1
公开(公告)日：2011-11-17
申请号：US13144554
申请日：2010-02-02
申请人： Henricus, Jacobus, Maria Gijsen , Adriana Ingrid Velter , Gregor James MacDonald , Francois Paul Bischoff , Tongfei Wu , Sven, Franciscus, Anna Van Brandt , Michel Surkyn , Mirko Zaja , Serge, Maria, Aloysius Pieters , Didier Jean-Claude Berthelot , Michel, Anna, Josef De Cleyn , Daniel Oehlrich
发明人： Henricus, Jacobus, Maria Gijsen , Adriana Ingrid Velter , Gregor James MacDonald , Francois Paul Bischoff , Tongfei Wu , Sven, Franciscus, Anna Van Brandt , Michel Surkyn , Mirko Zaja , Serge, Maria, Aloysius Pieters , Didier Jean-Claude Berthelot , Michel, Anna, Josef De Cleyn , Daniel Oehlrich
IPC分类号： A61K31/437 , C07D403/12 , C07D413/14 , C07D403/14 , C07D487/04 , C07D413/12 , C07D417/12 , C07D401/14 , A61K31/4184 , A61K31/4439 , A61K31/506 , A61K31/5025 , A61K31/4985 , A61K31/4245 , A61K31/427 , A61K31/4192 , A61K31/4196 , A61K31/444 , A61K31/501 , A61P25/28 , A61P25/00 , A61P25/16 , C07D471/04
CPC分类号： C07D487/04 , C07D401/12 , C07D403/10 , C07D403/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D471/04
摘要： The present invention is concerned with substituted bicyclic heterocyclic compounds of Formula (I) wherein Het1, Het2, A1, A2, A3 and A4 have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
摘要翻译：本发明涉及其中Het1，Het2，A1，A2，A3和A4具有权利要求中限定的含义的式（I）的取代双环杂环化合物。根据本发明的化合物可用作γ-分泌酶调节剂。本发明还涉及制备这种新化合物的方法，包含所述化合物作为活性成分的药物组合物以及所述化合物作为药物的用途。

5. 发明授权

US08778919B2 Cyclic anilino—pyridinotriazines 有权
标题翻译：环状苯胺基 - 吡啶并三嗪
公开(公告)号：US08778919B2
公开(公告)日：2014-07-15
申请号：US11993237
申请日：2006-06-26
申请人： Frederik Jan Rita Rombouts , Christopher John Love , Kristof Van Emelen , Sven Franciscus Anna Van Brandt , Tongfei Wu
发明人： Frederik Jan Rita Rombouts , Christopher John Love , Kristof Van Emelen , Sven Franciscus Anna Van Brandt , Tongfei Wu
IPC分类号： A61K31/33 , C07D487/00 , C07D255/02
CPC分类号： C07D487/18 , C07D251/16 , C07D401/04 , C07D471/18 , C07D471/22 , C07D487/08
摘要： The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents 1, n represents 1, Z represents N or C, in particular N; —X1— represents C1-4alkyl, in particular methyl; —X2— represents —C1-4alkyl- or —C1-4alkyl-NR7—, in particular propyl, -ethyl-NR7— or -propyl-NR7—; —Y— represents —NR2—C1-6alkyl-CO—NR4—, -Het1-C1-6alkyl-CO—NR5— or -Het2-CO—NR6— and wherein the —C1-6alkyl-linker of —NR2—C1-6alkyl-CO—NR4— or -Het1-C1-6alkyl-CO—NR5— is optionally substituted with one or where possible two or more substituents selected from hydroxy, halo and phenyl; R1 represents hydrogen, chloro, fluoro or bromo; R2 represents —C1-4alkyl-, in particular ethyl or methyl; R7 represents hydrogen; R8 represents hydrogen; R4, R5 and R6 represent hydrogen; Het1 is selected from piperazinyl or piperidinyl, in particular -piperazinyl; Het2 selected from pyrrolidinyl or piperidinyl, in particular pyrrolidinyl wherein said pyrrolidinyl is optionally substituted with hydroxy.
摘要翻译：本发明涉及式（I）化合物，N-氧化物形式，其药学上可接受的加成盐和立体化学异构形式，其中m表示1，n表示1，Z表示N或C，特别是N; -X1-表示C1-4烷基，特别是甲基; -X2-表示-C 1-4烷基 - 或-C 1-4烷基-NR 7 - ，特别是丙基， - 乙基-NR 7 - 或 - 丙基-NR 7 - ; -Y-代表-NR2-C1-6烷基-CO-NR4-，-Het1-C1-6烷基-CO-NR5-或-Het2-CO-NR6-，其中-NR2-C1- C 1-6烷基-CO-NR 4 - 或-Het 1 -C 1-6烷基-CO-NR 5 - 任选被一个或其中可能的两个或更多个选自羟基，卤素和苯基的取代基取代; R1代表氢，氯，氟或溴; R 2表示-C 1-4烷基，特别是乙基或甲基; R7代表氢; R8代表氢; R4，R5和R6代表氢; Het1选自哌嗪基或哌啶基，特别是哌嗪基; Het2选自吡咯烷基或哌啶基，特别是吡咯烷基，其中所述吡咯烷基任选被羟基取代。

6. 发明申请

US20100222574A1 CYCLIC ANILINO - PYRIDINOTRIAZINES 有权
标题翻译： CYCLIC ANILINO - PYRIDINOTRIAZINES
公开(公告)号：US20100222574A1
公开(公告)日：2010-09-02
申请号：US11993237
申请日：2006-06-26
申请人： Frederik Jan Rita Rombouts , Christopher John Love , Kristof Van Emelen , Sven Franciscus Anna Van Brandt , Tongfei Wu
发明人： Frederik Jan Rita Rombouts , Christopher John Love , Kristof Van Emelen , Sven Franciscus Anna Van Brandt , Tongfei Wu
IPC分类号： C07D471/14
CPC分类号： C07D487/18 , C07D251/16 , C07D401/04 , C07D471/18 , C07D471/22 , C07D487/08
摘要： The present invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents 1, n represents 1, Z represents N or C, in particular N; —X1— represents C1-4alkyl, in particular methyl; —X2— represents —C1-4alkyl- or —C1-4alkyl-NR7—, in particular propyl, -ethyl-NR7— or -propyl-NR7—; —Y— represents-NR2—C1-6alkyl-CO—NR4—, -Het1-C1-6alkyl-CO—NR5— or -Het2-CO—NR6— and wherein the —C1-6alkyl-linker of —NR2—C1-6alkyl-CO—NR4— or -Het1-C1-6alkyl-CO—NR5— is optionally substituted with one or where possible two or more substituents selected from hydroxy, halo and phenyl; R1 represents hydrogen, chloro, fluoro or bromo; R2 represents —C1-4alkyl-, in particular ethyl or methyl; R7 represents hydrogen; R8 represents hydrogen; R4, R5 and R6 represent hydrogen; Het1 is selected from piperazinyl or piperidinyl, in particular -piperazinyl; Het2 selected from pyrrolidinyl or piperidinyl, in particular pyrrolidinyl wherein said pyrrolidinyl is optionally substituted with hydroxy.
摘要翻译：本发明涉及式（I）化合物，N-氧化物形式，其药学上可接受的加成盐和立体化学异构形式，其中m表示1，n表示1，Z表示N或C，特别是N; -X1-表示C1-4烷基，特别是甲基; -X2-表示-C 1-4烷基 - 或-C 1-4烷基-NR 7 - ，特别是丙基， - 乙基-NR 7 - 或 - 丙基-NR 7 - ; -Y-表示-NR2-C1-6烷基-CO-NR4-，-Het1-C1-6烷基-CO-NR5-或-Het2-CO-NR6-，其中-NR2-C1- C 1-6烷基-CO-NR 4 - 或-Het 1 -C 1-6烷基-CO-NR 5 - 任选被一个或其中可能的两个或更多个选自羟基，卤素和苯基的取代基取代; R1代表氢，氯，氟或溴; R 2表示-C 1-4烷基，特别是乙基或甲基; R7代表氢; R8代表氢; R4，R5和R6代表氢; Het1选自哌嗪基或哌啶基，特别是哌嗪基; Het2选自吡咯烷基或哌啶基，特别是吡咯烷基，其中所述吡咯烷基任选被羟基取代。

7. 发明申请

US20120108531A1 PHOSPHONATE NUCLEOSIDES USEFUL AS ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS, AND INTERMEDIATES FOR THEIR PRODUCTION 失效
标题翻译：用于治疗病毒感染的药物组合物中的主要成分的磷酸盐核苷酸及其生产中间体
公开(公告)号：US20120108531A1
公开(公告)日：2012-05-03
申请号：US13291781
申请日：2011-11-08
申请人： Piet Herdewijn , Christophe Pannecouque , Tongfei Wu , Erik De clercq
发明人： Piet Herdewijn , Christophe Pannecouque , Tongfei Wu , Erik De clercq
IPC分类号： A61K31/7076 , C07H23/00 , A61P31/18 , A61K31/7068 , A61P31/14 , C07H19/16 , A61K31/7072
CPC分类号： C07H19/20 , C07F7/0812 , C07H1/00 , C07H15/04 , C07H17/02 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/16
摘要： Disclosed herein are novel phosphonate nucleosides and thiophosphonate nucleosides comprising a phosphonalkoxy-substituted or phosphonothioalkyl-substituted five-membered, saturated or unsaturated, oxygen-containing or sulfur-containing ring coupled to a heterocyclic nucleobase such as a pyrimidine or purine base. The invention further relates to compounds having HIV (Human Immunodeficiency Virus) replication inhibiting properties and to compounds having antiviral activities with respect to other viruses. The invention also relates to methods for preparation of all such compounds and pharmaceutical compositions comprising them. The invention further relates to the use of said compounds as a medicine and in the manufacture of a medicament useful for the treatment of subjects suffering from HIV infection, as well as for treatment of other viral, retroviral or lentiviral infections and to the treatment of animals suffering from FIV, viral, retroviral or lentiviral infections.
摘要翻译：本文公开了包含与杂环核碱基如嘧啶或嘌呤碱基偶联的膦酰烷氧基取代或膦酰硫代烷基取代的五元饱和或不饱和的含氧或含硫环的新型膦酸酯核苷和硫代膦酸核苷。本发明还涉及具有HIV（人类免疫缺陷病毒）复制抑制性质的化合物和对其它病毒具有抗病毒活性的化合物。本发明还涉及制备所有这些化合物的方法和包含它们的药物组合物。本发明还涉及所述化合物作为药物和制备用于治疗患有HIV感染的受试者以及用于治疗其它病毒，逆转录病毒或慢病毒感染和治疗动物的药物的用途患有FIV，病毒，逆转录病毒或慢病毒感染。

8. 发明授权

US08501709B2 Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production 失效
标题翻译：可用作用于治疗病毒感染的药物组合物中的活性成分的膦酸核苷和用于其生产的中间体
公开(公告)号：US08501709B2
公开(公告)日：2013-08-06
申请号：US13291781
申请日：2011-11-08
申请人： Piet Herdewijn , Christophe Pannecouque , Tongfei Wu , Erik De Clercq
发明人： Piet Herdewijn , Christophe Pannecouque , Tongfei Wu , Erik De Clercq
IPC分类号： A61K31/70 , C07H19/00 , C07H19/04 , C07H19/20
CPC分类号： C07H19/20 , C07F7/0812 , C07H1/00 , C07H15/04 , C07H17/02 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/16
摘要： The invention is directed to phosphonate nucleosides comprising a phosphonalkoxy-substituted five-membered, saturated or unsaturated, oxygen-containing ring coupled to a heterocyclic nucleobase such as a pyrimidine or purine base, as well as pharmaceutical compositions thereof. These compounds, which can be described by general formula (II), are useful for the treatment of retroviral infection, e.g., HIV (Human Immunodeficiency Virus) infection in a mammal. The invention also features synthetic intermediates for the preparation of phosphonate nucleosides.
摘要翻译：本发明涉及包含与杂环核碱基如嘧啶或嘌呤碱基偶联的膦酰基烷氧基取代的五元饱和或不饱和的含氧环的膦酸酯核苷，以及其药物组合物。可以通过通式（II）描述的这些化合物可用于治疗哺乳动物中的逆转录病毒感染，例如HIV（人类免疫缺陷病毒）感染。本发明还具有用于制备膦酸酯核苷的合成中间体。

9. 发明授权

US08076310B2 Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production 有权
标题翻译：可用作用于治疗病毒感染的药物组合物中的活性成分的膦酸核苷和用于其生产的中间体
公开(公告)号：US08076310B2
公开(公告)日：2011-12-13
申请号：US10598535
申请日：2005-03-04
申请人： Piet Herdewijn , Christophe Pannecouque , Tongfei Wu , Erik De Clerq
发明人： Piet Herdewijn , Christophe Pannecouque , Tongfei Wu , Erik De Clerq
IPC分类号： A61K31/70 , A01N43/04 , C07H15/00 , C07H17/00 , C07H23/00 , C07H19/20 , C07H19/048 , C07H19/16 , C07H19/06
CPC分类号： C07H19/20 , C07F7/0812 , C07H1/00 , C07H15/04 , C07H17/02 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/16
摘要： Disclosed herein are novel phosphonate nucleosides and thiophosphonate nucleosides comprising a phosphonalkoxy-substituted or phosphonothioalkyl-substituted five-membered, saturated or unsaturated, oxygen-containing or sulfur-containing ring coupled to a heterocyclic nucleobase such as a pyrimidine or purine base. The invention further relates to compounds having HIV (Human Immunodeficiency Virus) replication inhibiting properties and to compounds having antiviral activities with respect to other viruses. The invention also relates to methods for preparation of all such compounds and pharmaceutical compositions comprising them. The invention further relates to the use of said compounds as a medicine and in the manufacture of a medicament useful for the treatment of subjects suffering from HIV infection, as well as for treatment of other viral, retroviral or lentiviral infections and to the treatment of animals suffering from FIV, viral, retroviral or lentiviral infections.
摘要翻译：本文公开了包含与杂环核碱基如嘧啶或嘌呤碱基偶联的膦酰烷氧基取代或膦酰硫代烷基取代的五元饱和或不饱和的含氧或含硫环的新型膦酸酯核苷和硫代膦酸核苷。本发明还涉及具有HIV（人类免疫缺陷病毒）复制抑制性质的化合物和对其它病毒具有抗病毒活性的化合物。本发明还涉及制备所有这些化合物的方法和包含它们的药物组合物。本发明还涉及所述化合物作为药物和制备用于治疗患有HIV感染的受试者以及用于治疗其它病毒，逆转录病毒或慢病毒感染和治疗动物的药物的用途患有FIV，病毒，逆转录病毒或慢病毒感染。

10. 发明申请

US20070185062A1 Phosponate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production 有权
标题翻译：用作治疗病毒感染的药物组合物中的活性成分的磷酸核苷，以及用于其生产的中间体
公开(公告)号：US20070185062A1
公开(公告)日：2007-08-09
申请号：US10598535
申请日：2005-03-04
申请人： Piet Herdewijn , Christophe Pannecouque , Tongfei Wu , Erik De clercq
发明人： Piet Herdewijn , Christophe Pannecouque , Tongfei Wu , Erik De clercq
IPC分类号： A61K31/675 , C07F9/6512
CPC分类号： C07H19/20 , C07F7/0812 , C07H1/00 , C07H15/04 , C07H17/02 , C07H19/00 , C07H19/06 , C07H19/10 , C07H19/16
摘要： The present invention relates to novel phosponate nucleosides, more specifically to novel phosponalkoxy substituted nucleosides. The invention further relates to compounds having HIV (Human Immunodeficiency Virus) replication inhibiting properties and to compounds having antiviral activities with respect to other viruses. The invention also relates to methods for preparation of all such compounds and pharmaceutical compositions comprising them. The invention further relates to the use of said compounds as a medicine and in the manufacture of a medicament useful for the treatment of subjects suffering from HIV infection, as well as for treatment of other viral, retroviral or lentiviral infections and to the treatment of animals suffering from FIV, viral, retroviral or lentiviral infections.
摘要翻译：本发明涉及新的磷酸核苷，更具体地涉及新的磷酰烷氧基取代的核苷。本发明还涉及具有HIV（人类免疫缺陷病毒）复制抑制性质的化合物和对其它病毒具有抗病毒活性的化合物。本发明还涉及制备所有这些化合物的方法和包含它们的药物组合物。本发明还涉及所述化合物作为药物和制备用于治疗患有HIV感染的受试者以及用于治疗其它病毒，逆转录病毒或慢病毒感染和治疗动物的药物的用途患有FIV，病毒，逆转录病毒或慢病毒感染。

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