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1. 发明申请

US20090099553A1 DEVICE FOR THE CONTROLLED RELEASE OF A SUBSTANCE AND METHOD OF RELEASING A SUBSTANCE 审中-公开
标题翻译：用于控制释放物质的装置和释放物质的方法
公开(公告)号：US20090099553A1
公开(公告)日：2009-04-16
申请号：US12298069
申请日：2007-04-17
申请人： Geert Langereis , Ventzeslav Petrov Iordanov , Michel Paul Barbara Van Bruggen , Hendrika Cecilia Krijnsen
发明人： Geert Langereis , Ventzeslav Petrov Iordanov , Michel Paul Barbara Van Bruggen , Hendrika Cecilia Krijnsen
IPC分类号： A61K9/22 , B05D1/36 , A61F7/00 , A61M31/00
CPC分类号： A61M37/00 , A61K9/0024 , A61K9/0097
摘要： This invention provides a device for the controlled release of a substance and a method of controllably releasing a substance from a compartment. The device comprises a plurality of compartments in a substrate, each compartment being closed by at least one release mechanism, wherein the release
摘要翻译：本发明提供了一种用于物质的受控释放的装置和可控地从隔室释放物质的方法。该装置包括在基板中的多个隔室，每个隔间由至少一个释放机构封闭，其中释放

2. 发明授权

US08062287B2 Device for controlled release of chemical molecules 有权
标题翻译：控制释放化学分子的装置
公开(公告)号：US08062287B2
公开(公告)日：2011-11-22
申请号：US12158059
申请日：2006-12-12
申请人： Hendrika Cecilia Krijnsen , Geert Langereis , Michel Paul Barbara Van Bruggen , Ventzeslav Petrov Iordanov
发明人： Hendrika Cecilia Krijnsen , Geert Langereis , Michel Paul Barbara Van Bruggen , Ventzeslav Petrov Iordanov
IPC分类号： A61K9/22
CPC分类号： A61M31/00 , A61B5/00 , A61B5/4839 , A61K9/48 , G06F19/00
摘要： The invention relates to a device comprising an ingestible capsule which measures at least one body parameter and starts a drug release program upon predefined changes in the body parameter.
摘要翻译：本发明涉及一种包含可摄入胶囊的装置，其测量至少一个身体参数，并且根据身体参数的预定变化来启动药物释放程序。

3. 发明申请

US20080262478A1 Device for Controlled Release of Chemical Molecules 有权
标题翻译：化学分子控制释放装置
公开(公告)号：US20080262478A1
公开(公告)日：2008-10-23
申请号：US12158059
申请日：2006-12-12
申请人： Hendrika Cecilia Krijnsen , Geert Langereis , Michel Paul Barbara Van Bruggen , Ventzeslav Petrov Iordanov
发明人： Hendrika Cecilia Krijnsen , Geert Langereis , Michel Paul Barbara Van Bruggen , Ventzeslav Petrov Iordanov
IPC分类号： A61K9/52 , A61B5/01
CPC分类号： A61M31/00 , A61B5/00 , A61B5/4839 , A61K9/48 , G06F19/00
摘要： The invention relates to a device comprising an ingestible capsule which measures at least one body parameter and starts a drug release program upon predefined changes in the body parameter.
摘要翻译：本发明涉及一种包含可摄入胶囊的装置，其测量至少一个身体参数，并且根据身体参数的预定变化来启动药物释放程序。

4. 发明申请

US20090264814A1 DEVICE FOR MEDICAL TREATMENT DECISION SUPPORT AND/OR MONITORING THE STATUS OF A PATIENT 审中-公开
标题翻译：医疗处理决定支持和/或监测患者状况的设备
公开(公告)号：US20090264814A1
公开(公告)日：2009-10-22
申请号：US12375743
申请日：2007-07-17
申请人： Hendrika Cecilia Krijnsen , Geert Langereis , Michel Paul Barbara Van Bruggen , Ventzeslav Petrov Iordanov
发明人： Hendrika Cecilia Krijnsen , Geert Langereis , Michel Paul Barbara Van Bruggen , Ventzeslav Petrov Iordanov
IPC分类号： A61M31/00 , A61B5/00
CPC分类号： G06F19/3456 , A61B5/01 , A61B5/4839 , G06F19/3481
摘要： The invention relates to a device for medical treatment decision support and/or monitoring the status of a patient, the device comprising a first measuring means at the ipsilateral side and a second measuring means at the contralateral side and a comparison means in order to find the optimal and/or suboptimal time for drug treatment and/or other medical treatment steps.
摘要翻译：本发明涉及一种用于医疗决策支持和/或监视患者状态的装置，该装置包括在同侧的第一测量装置和在对侧的第二测量装置，以及比较装置，以便找到药物治疗和/或其他医疗处理步骤的最佳和/或次优时间。

5. 发明申请

US20090093691A1 DEVICE FOR MONITORING THE STATUS OF A PATIENT AND TREATMENT BASED THEREUPON 审中-公开
标题翻译：用于监测患者状况的设备和基于治疗的设备
公开(公告)号：US20090093691A1
公开(公告)日：2009-04-09
申请号：US12278978
申请日：2007-01-31
申请人： Hendrika Cecilia Krijnsen , Geert Langereis , Michel Paul Barbara Van Bruggen , Ventzeslav Petrov Iordanov
发明人： Hendrika Cecilia Krijnsen , Geert Langereis , Michel Paul Barbara Van Bruggen , Ventzeslav Petrov Iordanov
IPC分类号： A61M36/12 , A61B5/07 , A61B5/00
CPC分类号： A61B5/6848 , A61B5/01 , A61B5/02158 , A61N5/1027
摘要： The invention relates to a device for drug administration and/or monitoring the status of a patient, said device comprising at least one measuring means for measuring at least one body parameter of a patient for at least ≧1 measuring cycle, the measuring means being located in or in the vicinity of a bio-implantable and/or bio-implementable needle.
摘要翻译：本发明涉及一种用于药物施用和/或监测患者状态的装置，所述装置包括至少一个测量装置，用于至少测量至少一个测量周期的患者身体参数，所述测量装置是位于生物可植入和/或生物可实施针的附近或附近。

6. 发明申请

US20100114072A1 HYDROGEL BASED DEVICE FOR DETECTING AN ENVIRONMENTAL STATE 有权
标题翻译：用于检测环境状态的基于HYDROGEL的设备
公开(公告)号：US20100114072A1
公开(公告)日：2010-05-06
申请号：US12593305
申请日：2008-04-02
申请人： Ventzeslav Petrov Iordanov , Hendrika Cecilia Krijnsen , Michel Paul Barbara Van Bruggen , Anna-Maria Janner , Ralph Kurt
发明人： Ventzeslav Petrov Iordanov , Hendrika Cecilia Krijnsen , Michel Paul Barbara Van Bruggen , Anna-Maria Janner , Ralph Kurt
IPC分类号： A61M5/00 , G01F1/00 , G01N21/00
CPC分类号： A61B5/1459 , A61B5/0008 , A61B5/0031 , A61B5/4839
摘要： The invention relates to a transducer device (100,200,300,400) for detecting an environmental state or a change in the environmental state, in particular for detecting an environmental state within a biological material. The transducer device (100,200,300,400) comprises a channel (2,22,51) comprising a fluid, a hydrogel material (1,21,51), which is adapted to change its volume when getting into contact with an environmental material and/or when detecting an environmental change, and which is mechanically coupled to the channel (2,22,51) such that the volume of the channel (2,22,51) changes when the volume of the hydrogel material (1,21,51) changes. The transducer device (100,200,300,400) further comprises a sensor (11,12,25,35), which is adapted to generate a signal upon detection of the change of a physical property of the fluid that is induced by the volume change of the channel (2,22,51). By applying the transducer device (100,200,300,400) according to the invention within a bodily lumen, an accurate monitoring of physiological parameters, for which the hydrogel material (1,21,51) is sensitive, within the bodily lumen is possible. It is also possible to apply the transducer device (100,200,300,400) outside of the bodily lumen, for example to monitor the blood of a patient outside the bodily lumen.
摘要翻译：本发明涉及用于检测环境状态或环境状态变化的换能器装置（100,200,300,400），特别是用于检测生物材料内的环境状态。所述换能器装置（100,200,300,400）包括包含流体的通道（2,22,51），水凝胶材料（1,21,51），其适于在与环境材料接触时改变其体积，和/或检测环境变化，并且其机械耦合到通道（2,22,51），使得当水凝胶材料（1,21,51）的体积变化时，通道（2,22,51）的体积改变。传感器装置（100,200,300,400）还包括传感器（11,12,25,35），其适于在检测到由通道的体积变化引起的流体的物理特性的变化时产生信号（ 2,22,51）。通过将根据本发明的换能器装置（100,200,300,400）应用于体腔内，可以精确地监测身体内水凝胶材料（1,21,51）敏感的生理参数。也可以将换能器装置（100,200,300,400）应用于体腔外，例如监测患者体外的血液。

7. 发明申请

US20090317445A1 DRUG DELIVERY SYSTEM WITH THERMOSWITCHABLE MEMBRANES 审中-公开
标题翻译：具有热稳定膜的药物递送系统
公开(公告)号：US20090317445A1
公开(公告)日：2009-12-24
申请号：US12375036
申请日：2007-07-13
申请人： Michel Paul Barbara Van Bruggen , Hendrika Cecilia Krijnsen , Ventzeslav Petrov Iordanov , Anna-Maria Janner
发明人： Michel Paul Barbara Van Bruggen , Hendrika Cecilia Krijnsen , Ventzeslav Petrov Iordanov , Anna-Maria Janner
IPC分类号： A61K9/00
CPC分类号： A61M37/00 , A61M2037/0007
摘要： The present invention provides a device for controlled release of molecules. The device is particularly suitable for controlled release of therapeutic drugs to a patient. The device includes a housing with an opening for release of the molecules from the housing. The housing also comprises a reservoir for containing the molecules, in particular therapeutic drugs. The reservoir is arranged in the housing to allow release of the molecules through the opening. The device also comprises at least one thermoswitchable membrane and at least one heating element for at least partially heating the membrane. The device is configured for modulating the release of the molecules at the opening by heating the membrane, using the heating element. Optionally, the device further comprises a pressure element for providing pressurized release of the molecules from the device. In this way, the drug can be delivered to a patient in a pulsatile fashion. The present invention also provides a method for modulating the release of molecules, using such a device.
摘要翻译：本发明提供了用于分子控制释放的装置。该装置特别适用于向患者控制释放治疗药物。该装置包括具有用于从壳体释放分子的开口的壳体。壳体还包括用于容纳分子的储库，特别是治疗药物。储存器布置在壳体中以允许分子通过开口释放。该装置还包括至少一个可热转换膜和至少一个用于至少部分地加热膜的加热元件。该装置被配置为使用加热元件通过加热膜来调节开口处分子的释放。可选地，所述装置还包括用于从所述装置提供所述分子的加压释放的压力元件。以这种方式，药物可以以脉动方式递送给患者。本发明还提供了使用这种装置调节分子释放的方法。

8. 发明申请

US20100042042A1 ENVIRONMENTAL STATE DETECTION WITH HYDROGEL BASED FULLY INTEGRATED TRANSDUCER DEVICE 审中-公开
标题翻译：基于氢化物的全集成传感器设备的环境状态检测
公开(公告)号：US20100042042A1
公开(公告)日：2010-02-18
申请号：US12444722
申请日：2007-10-08
申请人： Ventzeslav Petrov Iordanov , Michel Paul Barbara Van Bruggen , Hendrika Cecilia Krijnsen , Anna-Maria Janner
发明人： Ventzeslav Petrov Iordanov , Michel Paul Barbara Van Bruggen , Hendrika Cecilia Krijnsen , Anna-Maria Janner
IPC分类号： A61M37/00 , G01J1/44 , H01L31/12 , G01N21/00
CPC分类号： G01N21/77 , A61B5/0031 , A61B5/0071 , A61B5/0084 , A61B5/01 , A61B5/14539 , G01N2021/7723
摘要： It is described a hydrogel based transducer device for detecting an environmental state, in particular for detecting an environmental state within a biological material. The transducer device (300) comprises a base element (302), a radiation source (305), which is formed at the base element (302) and which is adapted to emit electromagnetic radiation (306), an optical element (325), which is arranged at the base element (302) and which is adapted to interact with the electromagnetic radiation (306). The transducer device (300) further comprises a radiation detector (350), which is adapted to receive the electromagnetic radiation (326) having interacted with the optical element (325), and a hydrogel material (340), which is mechanically coupled to the optical element (325) and which is adapted to change its volume when getting into contact with an environmental material of the transducer device (300) such that the spatial position of the optical element (325) is changed. The base element (302), the radiation source (305) and the radiation detector (350) are formed integrally from an electronic substrate material.
摘要翻译：描述了用于检测环境状态的基于水凝胶的换能器装置，特别是用于检测生物材料内的环境状态。换能器装置（300）包括基座元件（302），辐射源（305），其形成在基座元件（302）处并适于发射电磁辐射（306），光学元件（325）其布置在基座元件（302）处并且适于与电磁辐射（306）相互作用。换能器装置（300）还包括辐射检测器（350），其适于接收与光学元件（325）相互作用的电磁辐射（326），以及水凝胶材料（340），其被机械耦合到光学元件（325），并且适于在与所述换能器装置（300）的环境材料接触时改变其体积，使得所述光学元件（325）的空间位置改变。基底元件（302），辐射源（305）和辐射检测器（350）由电子基底材料一体地形成。

9. 发明申请

US20100087795A1 SELF-LEARNING DRUG DELIVERY SYSTEM 审中-公开
标题翻译：自学药物递送系统
公开(公告)号：US20100087795A1
公开(公告)日：2010-04-08
申请号：US12519803
申请日：2007-12-19
申请人： Hendrika Cecilia Krijnsen , Ventzeslav Petrov Iordanov , Anna-Maria Janner , Michel Paul Barbara Van Bruggen
发明人： Hendrika Cecilia Krijnsen , Ventzeslav Petrov Iordanov , Anna-Maria Janner , Michel Paul Barbara Van Bruggen
IPC分类号： A61M37/00 , A61K31/485 , A61K31/445 , A61K31/164 , A61P25/04
CPC分类号： A61M5/1723 , A61M2005/1405 , A61M2005/14208 , A61M2205/52
摘要： Self-learning process for automatically adjusting a dosage of a substance administered to a person by a drug delivery device, a drug delivery device, wherein a dosage of a substance is adjusted by such a self-learning process and a drug delivery system comprising such a drug delivery device. Pain is experienced differently at certain times of day due to the origin causing the symptoms. Therefore, the medication providing pain relief should also be adjusted accordingly. The invention is to anticipate the pain experience and to deliver pain relief medication in such a way that Quality of Life is improved by appropriate timing of the right amount of medication and by appropriate timing of turning off the medication to reduce side effects.
摘要翻译：用于通过药物递送装置自动调整施用于人的物质的剂量的自学习过程，药物递送装置，其中通过这种自学习过程调节物质的剂量，以及药物递送系统，药物输送装置。由于原因导致症状，疼痛在一天的某些时间有不同的体验。因此，提供疼痛缓解的药物也应相应调整。本发明旨在预测疼痛经验并提供止痛药物，使得通过合适的药物量的适当时机以及关闭药物的适当时机来改善生命质量以减少副作用。

10. 发明申请

US20100042043A1 AUTOMATIC DRUG ADMINISTRATION WITH REDUCED POWER CONSUMPTION 审中-公开
标题翻译：具有降低功耗的自动药物管理
公开(公告)号：US20100042043A1
公开(公告)日：2010-02-18
申请号：US12593026
申请日：2008-03-20
申请人： Hendrika Cecilia Krijnsen , Ventzeslav Petrov Iordanov , Anna M. Janner , Michel Paul Barbara Van Bruggen
发明人： Hendrika Cecilia Krijnsen , Ventzeslav Petrov Iordanov , Anna M. Janner , Michel Paul Barbara Van Bruggen
IPC分类号： A61M5/168 , A61K9/22 , G06F1/32
CPC分类号： A61M5/1723 , A61M5/142 , A61M2205/8212 , A61M2230/63
摘要： It is described a drug delivery system (100) that is adapted to infuse at least one drug in a profile related to the status of a patient. The system comprises sensors (110), dedicated electronics (140) and software to monitor the patient's activity and maintain control over the drug-release profile. A control unit (120) of the system (100) is adapted to temporarily set at least one component (110, 120, 150) of the system (100) in an idle mode (265). This will result in particular in a reduction of power required by the system (100). The described system (100) enables a personalized treatment of patients by monitoring their individual activity status and coupling this information to a drug delivery following appropriate delivery profiles. The system (100) may be provided with a memory in order to store a time dependence of activity data. This time dependence may be used by physicians to monitor, support and adapt their therapy for the patients. The system (100) may be realized as a closed-loop system for monitoring and treatment of various diseases such as hemophilia A and Parkinson.
摘要翻译：描述了适于在与患者的状态相关的轮廓中注入至少一种药物的药物递送系统（100）。该系统包括传感器（110），专用电子设备（140）和用于监视患者活动并维持对药物释放特征的控制的软件。系统（100）的控制单元（120）适于将系统（100）的至少一个组件（110,120,150）临时设置为空闲模式（265）。这将特别导致系统（100）所需的功率的降低。所描述的系统（100）能够通过监测患者的个体活动状态来对患者进行个性化治疗，并将该信息与适当的递送概况相关联地传递给药物递送。系统（100）可以设置有存储器，以便存储活动数据的时间依赖性。这种时间依赖可以由医生使用来监测，支持和适应患者的治疗。系统（100）可以实现为用于监测和治疗各种疾病如血友病A和帕金森病的闭环系统。

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