专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4921856A Dihydropyridazinone derivatives, a process for their preparation and pharmaceutical preparations containing these compounds 失效
标题翻译：二氢哒嗪酮衍生物，其制备方法和含有这些化合物的药物制剂
公开(公告)号：US4921856A
公开(公告)日：1990-05-01
申请号：US176689
申请日：1988-04-01
申请人： Helmut Schickaneder , Peter Morsdorf , Volker Pfahlert , Heidrun Engler , Kurt H. Ahrens
发明人： Helmut Schickaneder , Peter Morsdorf , Volker Pfahlert , Heidrun Engler , Kurt H. Ahrens
IPC分类号： A61K31/50 , A61P9/04 , C07D237/04 , C07D403/10 , C07D403/12
CPC分类号： C07D403/10 , C07D237/04 , C07D403/12
摘要： New dihydropryidazinone derivatives corresponding to the following formula ##STR1## and a process for their preparation and pharmaceutical preparations containing these compounds are described. These compounds are effective positively inotropic substances with an improved therapeutic profile.
摘要翻译：描述了对应于下式（I）的新的二氢哒嗪酮衍生物及其制备方法和含有这些化合物的药物制剂。这些化合物是具有改善的治疗特征的有效的正性肌力物质。

2. 发明授权

US4957920A Benzimidazoles, and pharmaceutical preparations containing these compounds 失效
标题翻译：苯并咪唑和含有这些化合物的药物制剂
公开(公告)号：US4957920A
公开(公告)日：1990-09-18
申请号：US168273
申请日：1988-03-15
申请人： Peter Morsdorf , Helmut Schickaneder , Rolf Herter , Volker Pfahlert , Heidrun Engler , Kurt H. Ahrens
发明人： Peter Morsdorf , Helmut Schickaneder , Rolf Herter , Volker Pfahlert , Heidrun Engler , Kurt H. Ahrens
IPC分类号： A61K31/505 , A61P9/06 , C07D403/04 , C07D403/14
CPC分类号： C07D403/04
摘要： New benzimidazoles corresponding to the general formula I ##STR1## are described, in which the pyridazinone ring is attached in the 5- or 6- position of the benzimidazole ring and R.sup.1 denotes a hydrogen atom or a straight chained or branched C.sub.1 to C.sub.4 alkyl group, R.sup.2 denotes a hydrogen atom, a straight chained or branched C.sub.1 to C.sub.4 alkyl group, a C.sub.1 to C.sub.4 alkoxy group, a hydroxy group, a halogen atom, an amino group or a nitro group, A denotes a hydrogen atom, a group of the formula ##STR2## wherein R.sup.3 denotes a hydrogen atom, an optionally substituted C.sub.1 to C.sub.4 alkyl group or a C.sub.1 to C.sub.4 alkoxy group and B denotes a cyano group, a benzoyl group or a phenylsulphonyl group, or A denotes a group of the formula ##STR3## in which m has the value of 2 or 3 and n represents an integer from 1 to 6, and the physiologically acceptable salts thereof as well as processes for their preparation and pharmaceutical preparations containing these compounds. These compounds are new, effective, positive inotropic substances which do not act by the mechanism of phosphodiesterase inhibition.
摘要翻译：描述了对应于通式I（I）的新的苯并咪唑，其中哒嗪酮环连接在苯并咪唑环的5-或6-位，R1表示氢原子或直链或支链C1至 C4烷基，R2表示氢原子，直链或支链C1〜C4烷基，C1〜C4烷氧基，羟基，卤素原子，氨基或硝基，A表示氢原子，式中，R 3表示氢原子，可以具有取代基的C1〜C4烷基或C1〜C4烷氧基，B表示氰基，苯甲酰基或苯基磺酰基，A表示基团其中m具有2或3的数值，n表示1至6的整数，以及其生理上可接受的盐以及其制备方法和含有这些化合物的药物制剂。这些化合物是新的，有效的正性肌力物质，不受磷酸二酯酶抑制机制的作用。

3. 发明授权

US4757080A 1,4-dihydropyridine derivatives 失效
标题翻译： 1,4-二氢吡啶衍生物
公开(公告)号：US4757080A
公开(公告)日：1988-07-12
申请号：US51300
申请日：1987-05-19
申请人： Helmut Schickaneder , Peter Morsdorf , Armin Buschauer , Walter Schunack , Heidrun Engler , Hartmut Vergin , Kurt H. Ahrens
发明人： Helmut Schickaneder , Peter Morsdorf , Armin Buschauer , Walter Schunack , Heidrun Engler , Hartmut Vergin , Kurt H. Ahrens
IPC分类号： A61K31/4427 , A61K31/455 , A61P9/10 , A61P9/12 , C07D211/90 , C07D401/12 , C07D413/14 , A61K31/44
CPC分类号： C07D401/12 , C07D211/90 , C07D413/14
摘要： New compounds which act on the cardiac circulation and correspond to the general formula ##STR1## and may be used for the treatment of cardiac diseases, in certain forms of hypertension and in diseases of arterial occlusion are described.Methods of preparation for these compounds and medicaments containing these compounds are also described.
摘要翻译：描述了作用于心脏循环并对应于通式并可用于治疗某些形式的高血压和动脉闭塞疾病的心脏疾病的新化合物。还描述了这些化合物的制备方法和含有这些化合物的药物。

4. 发明授权

US4968683A 6-oxo-pyridazine derivatives, a process for their preparation and medicaments containing these compounds 失效
标题翻译： 6-氧代 - 哒嗪衍生物，其制备方法和含有这些化合物的药物
公开(公告)号：US4968683A
公开(公告)日：1990-11-06
申请号：US337938
申请日：1989-04-14
申请人： Peter Morsdorf , Rolf Herter , Heidrun Engler , Volker Pfahlert , Reinhold Weidner , Kurt H. Ahrens
发明人： Peter Morsdorf , Rolf Herter , Heidrun Engler , Volker Pfahlert , Reinhold Weidner , Kurt H. Ahrens
IPC分类号： C07D403/00 , A61K31/50 , A61P9/00 , A61P9/04 , C07D401/14 , C07D403/12
CPC分类号： C07D401/14 , C07D403/12
摘要： New 6-oxo-pyridazine derivatives corresponding to the general formula I ##STR1## which represent new, positive inotropic compounds having a higher and more selective inotropy-increasing activity are described.A process of preparation and the medical use of these substances or of a medicament containing these substances are also described.
摘要翻译：描述了相应于通式I的新的6-氧代 - 哒嗪衍生物（I），其代表具有更高和更高选择性增强活性的新型正性肌力化合物。还描述了这些物质或含有这些物质的药物的制备和医疗用途的方法。

5. 发明授权

US4600721A Pharmaceutical preparation 失效
标题翻译：药物制剂
公开(公告)号：US4600721A
公开(公告)日：1986-07-15
申请号：US716408
申请日：1985-03-27
申请人： Peter Morsdorf , Helmut Schickaneder , Heidrun Engler , Istvan Szelenyi , Kurt H. Ahrens , Kay Brune
发明人： Peter Morsdorf , Helmut Schickaneder , Heidrun Engler , Istvan Szelenyi , Kurt H. Ahrens , Kay Brune
IPC分类号： A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61P11/00 , A61P17/00 , A61P27/02 , A61P27/14 , A61P29/00 , A61P37/08 , A61P43/00 , C07D263/58 , C07D277/82
CPC分类号： C07D263/58 , A61K31/42 , A61K31/425 , C07D277/82
摘要： Pharmaceutical preparations having an antiphlogistic action are described. The preparations contain, as active ingredient, a benzazole derivative corresponding to the general tautomeric formulae I ##STR1## wherein X represents a sulphur or oxygen atom and R.sup.1 represents a hydrogen atom and R.sup.2 a hydroxymethyl, formyl, lower carbalkoxy or lower acyl group or R.sup.1 and R.sup.2 together represent the group ##STR2## wherein R.sup.3 and R.sup.4 denote, independently of one another, a hydrogen atom or a C.sub.1 -C.sub.6 -alkyl group, or they contain a physiologically acceptable salt thereof. These pharmaceutical preparations are suitable in particular for the treatment of inflammatory conditions and for inhibiting the lipoxygenase and/or cyclooxygenase route of arachidonic acid metabolism.
摘要翻译：描述具有消炎作用的药物制剂。该制剂含有作为活性成分的对应于一般互变异构体I（I）的苯并唑衍生物，其中X表示硫或氧原子，R1表示氢原子，R2表示羟甲基，甲酰基，低级烷氧羰基或低级酰基基团或R 1和R 2一起表示基团，其中R 3和R 4彼此独立地表示氢原子或C 1 -C 6烷基，或它们含有其生理上可接受的盐。这些药物制剂特别适用于治疗炎性病症和抑制花生四烯酸代谢的脂氧合酶和/或环氧合酶途径。

6. 发明授权

US4954501A Piperazine substituted 6-phenyldihydro-3(2H)-pyridazinones, and pharmaceutical preparations containing these 失效
标题翻译：哌嗪取代的6-苯基二氢-3（2H） - 哒嗪酮，以及含有它们的药物制剂
公开(公告)号：US4954501A
公开(公告)日：1990-09-04
申请号：US247868
申请日：1988-09-21
申请人： Rolf Herter , Peter Morsdorf , Volker Pfahlert , Heidrun Engler , Helmut Schickaneder , Kurt-Henning Ahrens
发明人： Rolf Herter , Peter Morsdorf , Volker Pfahlert , Heidrun Engler , Helmut Schickaneder , Kurt-Henning Ahrens
IPC分类号： A61K31/50 , A61K31/505 , A61P9/04 , A61P9/12 , C07D237/04 , C07D401/10 , C07D403/12 , C07D417/12
CPC分类号： C07D401/10 , C07D237/04 , C07D403/12 , C07D417/12
摘要： New 6-phenyldihydro-3(2H)-pyridazinones corresponding to the following general formula ##STR1## are described. These compounds are readily prepared in a form suitable for oral administration and are distinguished by a high positive inotropic action and have only a slight effect on blood pressure and cardiac frequency. A process for their preparation and pharmaceutical preparations containing these compounds are also described.
摘要翻译：描述对应于以下通式的新的6-苯基二氢-3（2H） - 哒嗪酮。这些化合物容易地以适于口服给药的形式制备，并且通过高的正性肌力作用区分，并且对血压和心脏频率仅具有轻微的影响。还描述了其制备方法和含有这些化合物的药物制剂。

7. 发明授权

US4948802A Guanidine carboxylic acid esters and pharmaceutical preparations containing these compounds 失效
标题翻译：胍胺羧酸酯和含有这些化合物的药物制剂
公开(公告)号：US4948802A
公开(公告)日：1990-08-14
申请号：US180135
申请日：1988-04-11
申请人： Peter Morsdorf , Helmut Schickaneder , Volker Pfahlert , Heidrun Engler , Armin Buschauer , Walter Schunack
发明人： Peter Morsdorf , Helmut Schickaneder , Volker Pfahlert , Heidrun Engler , Armin Buschauer , Walter Schunack
IPC分类号： A61K31/415 , A61K31/44 , A61K31/4427 , A61P43/00 , C07D233/54 , C07D233/64 , C07D401/12 , C07D417/06 , C07D417/12
CPC分类号： C07D233/64 , C07D401/12 , C07D417/12
摘要： New guanidine carboxylic acid esters corresponding to the general formula I ##STR1## and a process for the preparation of these compounds are described. The compounds according to the invention are H.sub.2 -agonists optionally having an additional H.sub.1 -antagonistic component. They are distinguished by their improved oral activity. The use of the above-mentioned guanidine carboxylic acid esters and of pharmaceutical preparations containing these esters is also described.
摘要翻译：描述了对应于通式I（I）的新的胍胺羧酸酯及其制备方法。根据本发明的化合物是任选具有另外的H1-拮抗组分的H 2 - 激动剂。他们的口头活动有所改善。还描述了使用上述胍羧酸酯和含有这些酯的药物制剂。

8. 发明授权

US4732986A Benzothiazole derivatives, processes for their preparation and pharmaceutical compositions containing these compounds 失效
标题翻译：苯并噻唑衍生物，其制备方法和含有这些化合物的药物组合物
公开(公告)号：US4732986A
公开(公告)日：1988-03-22
申请号：US51214
申请日：1987-05-12
申请人： Kay Brune , Heidrun Engler , Istvan Szelenyi , Peter Morsdorf , Helmut Schickaneder , Kurt H. Ahrens
发明人： Kay Brune , Heidrun Engler , Istvan Szelenyi , Peter Morsdorf , Helmut Schickaneder , Kurt H. Ahrens
IPC分类号： A61K31/425 , A61K31/428 , A61P11/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07D277/82 , C12N9/99
CPC分类号： C07D277/82
摘要： Benzothiazole derivatives corresponding to the general formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 represent, independently of one another, a hydrogen atom, a halogen atom, a linear C.sub.1 -C.sub.3 -alkyl group or a linear C.sub.1 -C.sub.3 -alkoxy group, R.sup.5 represents a hydrogen atom or a linear C.sub.1 -C.sub.3 -alkyl group, R.sup.6 represents a hydrogen atom, and R.sup.7 represents a formyl group, a carbalkoxy group of the formula ##STR2## wherein R.sup.8 denotes a linear or branch chained C.sub.1 -C.sub.4 -alkyl group, or it represents an acyl group of the formula ##STR3## wherein R.sup.9 denotes a linear C.sub.1 -C.sub.3 -alkyl group, or R.sup.6 and R.sup.7 together represent the group ##STR4## wherein R.sup.10 and R.sup.11 represent, independently of one another, a hydrogen atom or a linear C.sub.1 -C.sub.6 -alkyl group or R.sup.6 and R.sup.7 represent the group ##STR5## wherein R.sup.12 and R.sup.13 represent, independently of one another, a linear C.sub.1 -C.sub.3 -alkyl group or a linear C.sub.1 -C.sub.3 -alkoxy group or R.sup.6 and R.sup.7 represent the group ##STR6## wherein R.sup.14 denotes a linear C.sub.1 -C.sub.3 -alkyl group, as well as the physiologically acceptable salts thereof, a process for the preparation of these compounds, and a pharmaceutical preparation containing them, are described.
摘要翻译：对应于通式I（I）的苯并噻唑衍生物，其中R 1，R 2，R 3和R 4彼此独立地表示氢原子，卤素原子，直链C 1 -C 3 - 烷基或直链C 1 -C 3 - C 3 - 烷氧基，R 5表示氢原子或直链C 1 -C 3 - 烷基，R 6表示氢原子，R 7表示甲酰基，式◎的烷氧基，其中，R 8表示直链或支链或者它表示下式的酰基，其中R 9表示直链C 1 -C 3 - 烷基，或者R 6和R 7一起表示基团，其中R 10和R 11独立地表示另一方面，氢原子或直链C 1 -C 6 - 烷基或R 6和R 7表示基团，其中R 12和R 13彼此独立地表示直链C 1 -C 3 - 烷基或直链C 1 -C 3 - 烷氧基或R6和R7表示基团，其中R14表示直链C1-C3-烷基，以及生理记录描述了其可接受的盐，制备这些化合物的方法和含有它们的药物制剂。

9. 发明授权

US5039675A Benzimidazoles and pharmaceutical preparations containing these compounds 失效
标题翻译：苯并咪唑和含有这些化合物的药物制剂
公开(公告)号：US5039675A
公开(公告)日：1991-08-13
申请号：US497223
申请日：1990-03-22
申请人： Peter Morsdorf , Helmut Schickaneder , Rolf Herter , Volker Pfanhlert , Geidrun Engler , Kurt H. Ahrens
发明人： Peter Morsdorf , Helmut Schickaneder , Rolf Herter , Volker Pfanhlert , Geidrun Engler , Kurt H. Ahrens
IPC分类号： A61K31/505 , A61P9/06 , C07D403/04 , C07D403/14
CPC分类号： C07D403/04
摘要： New benzimidazoles correponding to the general formula I ##STR1## are described, in which the pyridazinone ring is attached in the 5- or 6- position of the benzimidazole ring and R.sup.1 denotes a hydrogen atom or a straight chained or branched C.sub.1 to C.sub.4 alkyl group, R.sup.2 denotes a hydrogen atom, a straight chained or branched C.sub.1 to C.sub.4 alkyl group, a C.sub.1 to C.sub.4 alkoxy group, a hydroxy group, a halogen atom, an amino group or a nitro group, A denotes a hydrogen atom, a group of the formula ##STR2## wherein R.sup.3 denotes a hydrogen atom, an optionally substituted C.sub.1 to C.sub.4 alkyl group or a C.sub.1 to C.sub.4 alkoxy group and B denotes a cyano group, a benzoyl group or a phenylsulphonyl group, or A denotes a group of the formula ##STR3## in which m has the value 2 or 3 and n represents an integer from 1 to 6, and the physiologically acceptable salts thereof as well as processes for their preparation and pharmaceutical preparations. containing these compounds These compounds are new, effective, positive inotropic substances which do not act by the mechanism of phosphodiesterase inhibition.

10. 发明授权

US5182294A Imidazolyl propyl guanidine derivative and a pharmaceutical composition containing this compound 失效
标题翻译：咪唑基丙基胍衍生物和含有该化合物的药物组合物
公开(公告)号：US5182294A
公开(公告)日：1993-01-26
申请号：US639511
申请日：1991-01-10
申请人： Peter Morsdorf , Heidrun Engler , Helmut Schickaneder , Kurt-Henning Ahrens
发明人： Peter Morsdorf , Heidrun Engler , Helmut Schickaneder , Kurt-Henning Ahrens
IPC分类号： A61K31/44 , A61K31/4427 , A61P9/00 , A61P9/04 , C07D401/12
CPC分类号： C07D401/12
摘要： A new imidazolyl propyl guanidine derivative corresponding to formula I ##STR1## is described, which is distinguished by a combination of particularly advantageous properties for the treatment of diseases of the heart and circulation.
摘要翻译：描述了对应于式I的新的咪唑基丙基胍衍生物（I），其特征在于用于治疗心脏和循环疾病的特别有利的性质的组合。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式