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1. 发明授权

US09045565B2 Water-soluble polysaccharide ethers and their use 有权
标题翻译：水溶性多糖醚及其用途
公开(公告)号：US09045565B2
公开(公告)日：2015-06-02
申请号：US13390733
申请日：2010-08-17
申请人： Helmut Ritter , Bernd Mueller , Dirk-Henning Menz
发明人： Helmut Ritter , Bernd Mueller , Dirk-Henning Menz
IPC分类号： C08B13/00 , A61L27/20 , C08B11/20 , C08L1/32 , C09K19/36 , C09K19/38 , C08B15/00 , A61K9/00
CPC分类号： C08B13/00 , A61K9/0051 , A61L27/20 , C08B11/20 , C08B15/00 , C08L1/32 , C09K19/36 , C09K19/3819 , C08L1/28
摘要： The invention relates to modified polysaccharide ethers having a weight-averaged molecular weight of 40,000 to 500,000 g/mole, zero shear viscosity of more than 10 Pa·s, and pseudo-plasticity of more than 20. These modified polysaccharide ethers are obtainable by reacting cellulose-based polysaccharide ether(s) with at least one mesogenic modification agent or modified polysaccharide ethers, obtainable by reacting polysaccharide ether(s) selected from hydroxypropylmethyl cellulose (HPMC), hydroxyethylmethyl cellulose (HEMC), methyl cellulose, and cellulose ethers with methyl and/or ethyl and/or propyl groups and mixtures thereof, with at least one mesogenic modification agent. These substances can be used to produce gel-like to stable aqueous preparations having viscoelastic flow properties, which are suited for use in the human body, particularly within the scope of ophthalmologic procedures.
摘要翻译：本发明涉及重均分子量为40,000至500,000g / mol，零剪切粘度大于10Pa·s，假塑性大于20的改性多糖醚。这些改性多糖醚可通过使通过使选自羟丙基甲基纤维素（HPMC），羟乙基甲基纤维素（HEMC），甲基纤维素和纤维素醚的多糖醚与甲基的纤维素醚反应获得的具有至少一种介晶改性剂或改性多糖醚的纤维素基多糖醚和/或乙基和/或丙基及其混合物与至少一种介晶改性剂。这些物质可以用于制备具有粘弹性流动性的稳定的水性制剂，其适用于人体，特别是在眼科手术范围内。

2. 发明申请

US20120238524A1 WATER-SOLUBLE POLYSACCHARIDE ETHERS AND THEIR USE 有权
标题翻译：水溶性多糖及其用途
公开(公告)号：US20120238524A1
公开(公告)日：2012-09-20
申请号：US13390733
申请日：2010-08-17
申请人： Helmut Ritter , Bernd Mueller , Dirk-Henning Menz
发明人： Helmut Ritter , Bernd Mueller , Dirk-Henning Menz
IPC分类号： A61K31/717 , A61P19/04 , A61P19/00 , A61P19/02 , C08B13/00 , A61P27/02
CPC分类号： C08B13/00 , A61K9/0051 , A61L27/20 , C08B11/20 , C08B15/00 , C08L1/32 , C09K19/36 , C09K19/3819 , C08L1/28
摘要： The invention relates to modified polysaccharide ethers having a weight-averaged molecular weight of 40000 to 50000 g/mole, zero shear viscosity of more than 10 Pas, and pseudoplasticity of more than 20, obtainable by reacting cellulose-based polysaccharide ether(s) with at least one mesogenic modification agent or modified polysaccharide ethers, obtainable by reacting polysaccharide ether(s) selected from the group consisting of hydroxypropylmethyl cellulose (HPMC), hydroxyethylmethyl cellulose (HEMC), methyl cellulose, and cellulose ethers with methyl and/or ethyl and/or propyl groups and mixtures thereof, with at least one mesogenic modification agent. Said substances can be used to produce gel-like to stable aqueous preparations having viscoelastic flow properties, which are suited for use in the human body, particularly within the scope of ophthalmologic procedures.
摘要翻译：本发明涉及重量平均分子量为40000-50000g / mol，零剪切粘度大于10Pa·s，假塑性大于20的改性多糖醚，其可通过使纤维素基多糖醚与通过使选自羟丙基甲基纤维素（HPMC），羟乙基甲基纤维素（HEMC），甲基纤维素和纤维素醚的多糖醚与甲基和/或乙基反应得到的至少一种介晶改性剂或改性多糖醚，以及 /或丙基及其混合物与至少一种介晶改性剂。所述物质可用于产生具有粘弹性流动性的稳定的具有粘弹性流动性的凝胶状的水性制剂，其适用于人体，特别是在眼科程序的范围内。

3. 发明授权

US07026359B1 Utilization of a highly fluorinated oligomeric alkane in ophthalmology 失效
标题翻译：高度氟化的低聚烷烃在眼科学中的应用
公开(公告)号：US07026359B1
公开(公告)日：2006-04-11
申请号：US10018398
申请日：2000-04-27
申请人： Udo Gross , Dirk-Henning Menz , Erhard Kemnitz , Hans Hoerauf , Karin Kobuch
发明人： Udo Gross , Dirk-Henning Menz , Erhard Kemnitz , Hans Hoerauf , Karin Kobuch
IPC分类号： A01N29/00
CPC分类号： A61K9/0048 , A61K31/025 , Y10S514/912
摘要： The invention relates to the utilization of a highly fluorinated oligomeric alkane as a therapeutic agent in ophthalmology, the alkane having the general formula [—RF(CH2)nCR1—CR2—]x, wherein RF is a linear or branched perfluorinated alkyl chain C2F5 to C12F23, R1 and R2 are independently selected from the group consisting of H, CH3, C2H5 and C3H7, n is selected from the numbers 0, 1 and 2, and x is a number between 2 and 6, with a molar mass of at least 750. According to the invention, a pharmacological agent is provided that is used in ophthalmology and that causes little or no damage to the retina even when used over a long period.
摘要翻译：本发明涉及高度氟化的低聚烷烃作为眼科治疗剂的用途，具有通式[-R“ 其中R 1是直链或支链的，其中R 1是直链或支链的全氟化烷基链C 2 F 5到C 12 F 23，R 1，和R 2 2独立地选自H，CH 3，C 2 H 5和C 3是选自数字0,1和2，x是2和6之间的数字，摩尔质量至少为750。根据对于本发明，提供了用于眼科学的药理学试剂，即使在长时间使用时也对视网膜几乎没有或没有损伤。

4. 发明授权

US06372243B2 Low-oxygen fluorocarbon as an agent for ophthalmology 失效
标题翻译：低氧氟碳化合物作为眼科药物
公开(公告)号：US06372243B2
公开(公告)日：2002-04-16
申请号：US09270562
申请日：1999-03-16
申请人： Karin Kobuch , Veit-Peter Gabel , Joachim Dresp , Dirk-Henning Menz
发明人： Karin Kobuch , Veit-Peter Gabel , Joachim Dresp , Dirk-Henning Menz
IPC分类号： A61F202
CPC分类号： A61K31/025 , A61K9/0048
摘要： The present invention concerns fluorocarbons for use in ophthalmology. Fluorocarbons disclosed in the prior art can only be left in the eye for a limited period of time because they cause damage to the retina or intraocular structure. The present invention provides an oxygen-fluorocarbon mixture having a dissolved oxygen content of less than 6% by volume, which can be used as an ophthalmological agent for longer periods of time than conventional fluorocarbons, with little or no damage to the retina or intraocular structures. The invention also provides a process for preparing the oxygen-fluorocarbon mixture. In one embodiment, up to 20% by volume of a second gas, such as carbon dioxide or nitric oxide, is combined with the oxygen-fluorocarbon mixtures.
摘要翻译：本发明涉及用于眼科的碳氟化合物。现有技术中公开的氟碳化合物只能在有限的时间内留在眼睛中，因为它们对视网膜或眼内结构造成损害。本发明提供一种溶解氧含量小于6体积％的氧氟碳混合物，其可以比常规碳氟化合物更长时间地用作眼科剂，对视网膜或眼内结构几乎没有或没有损伤。本发明还提供了制备氧 - 碳氟化合物混合物的方法。在一个实施方案中，高达20体积％的第二气体，例如二氧化碳或一氧化氮，与氧 - 碳氟化合物混合物组合。

5. 发明授权

US07101564B1 Plastically deformable implant 失效
标题翻译：塑性变形植入物
公开(公告)号：US07101564B1
公开(公告)日：2006-09-05
申请号：US10018372
申请日：2000-06-07
申请人： Dirk-Henning Menz , Joachim Dresp
发明人： Dirk-Henning Menz , Joachim Dresp
IPC分类号： A61F2/02 , A61F2/14 , A61K31/74 , A61K47/30
CPC分类号： A61L27/52 , A61F2/02 , A61F2/12 , A61L27/16 , C08L27/12
摘要： The invention relates to a plastically deformable implant for inserting into bodily orifices of the human or animal body. Implants of this type are used, for example, in ophthalmology, in particular, as vitreous body or lens replacements and in dentistry, for example, for filling extraction cavities in jaw-bones. Known implants, however, are not suitable for long-term use. The invention aims to provide a deformable plastic implant which also has a long-term application. This is achieved by the fact that the implant consists of a gel which is not sealed, containing fluorocarbon and which is directly introduced into the natural, or artificially created bodily orifice.
摘要翻译：本发明涉及一种用于插入人体或动物体的身体孔中的塑性变形植入物。这种类型的植入物例如在眼科学中被使用，特别是作为玻璃体或晶状体替代物和牙科用途，例如用于在颚骨中填充提取腔。然而，已知的植入物不适合长期使用。本发明旨在提供一种也可长期应用的可变形塑料植入物。这是通过以下事实实现的：植入物由不密封的凝胶组成，包含碳氟化合物，并直接引入天然或人造创造的身体孔中。

6. 发明授权

US06211248B1 Fluorinated alkanes and their uses 失效
标题翻译：氟化烷烃及其用途
公开(公告)号：US06211248B1
公开(公告)日：2001-04-03
申请号：US09074252
申请日：1998-05-07
申请人： Dirk-Henning Menz
发明人： Dirk-Henning Menz
IPC分类号： A61K3102
CPC分类号： A61K9/0026 , A61L27/50 , A61L31/14 , C07C17/275 , C07C19/08 , C07C23/00 , C07C23/02 , C10M105/52 , C10M131/04 , C10M2211/022 , C10M2211/06
摘要： The invention concerns a partially fluorinated alkane with the general formula RF[CF2—CH2]RH, wherein RH is a substituent of the general formula CnHx selected from the group consisting of n-alkyl, sec-alkyl, tert-alkyl and cycloalkyl; RF is a substituent of the general formula CmFx selected from the group consisting of the perfluoro-n-alkyl, perfluoro-sec-alkyl, perfluoro-tert-alkyl, and perfluorocycloalkyls, with the proviso that only one of RF and RH can be linear, and that n>3, the sum of n+m
摘要翻译：本发明涉及具有通式RF [CF 2 -CH 2] RH的部分氟化烷烃，其中RH是选自正烷基，仲烷基，叔烷基和环烷基的通式CnHx的取代基; RF是选自全氟正烷基，全氟仲烷基，全氟叔烷基和全氟环烷基的通式CmF x的取代基，条件是RF和RH中只有一个可以是直链的，并且n> 3，n + m <18的和和仅RH或RF的和为正烷基或全氟化的正烷基。这些部分氟化的烷烃用作溶剂，特别是在其中烃溶剂的性质不可接受，在植入物中以及携带血液代用品的氧气的医疗应用中。

7. 发明授权

US07001607B1 Artificial tear replacement solution 失效
标题翻译：人造泪液更换溶液
公开(公告)号：US07001607B1
公开(公告)日：2006-02-21
申请号：US10049558
申请日：2000-06-30
申请人： Dirk-Henning Menz , Joachim Dresp , Martin Winter
发明人： Dirk-Henning Menz , Joachim Dresp , Martin Winter
IPC分类号： A61K31/74 , A61F2/00
CPC分类号： A61K9/0026 , A61K9/0048 , A61K31/02 , A61K31/03 , A61K31/08 , A61K31/16 , A61K31/18 , A61K31/185 , A61K31/19 , A61K31/215 , A61K31/495 , A61K31/661 , A61K31/695 , Y10S514/914 , Y10S514/944
摘要： A tear replacement solution that contains at least one water-soluble fluorosurfactant, water and a non-polar component, preferably in gel form, and a method for the external treatment for the eye of an mammal by applying the tear replacement solution to the eye, preferably by placing in the conjunctival sac.
摘要翻译：含有至少一种水溶性含氟表面活性剂，水和非极性组分，优选凝胶形式的泪液替代溶液，以及通过将眼泪替代溶液施用于眼睛来对哺乳动物的眼睛进行外部治疗的方法，优选通过放置在结膜囊中。

8. 发明授权

US06984394B2 Plastically deformable implant 失效
公开(公告)号：US06984394B2
公开(公告)日：2006-01-10
申请号：US10832516
申请日：2004-04-27
申请人： Dirk-Henning Menz , Joachim Dresp
发明人： Dirk-Henning Menz , Joachim Dresp
IPC分类号： A61F2/02 , A61F2/14 , A61K47/30
CPC分类号： A61L27/52 , A61F2/02 , A61F2/12 , A61L27/16 , C08L27/12
摘要： The invention relates to a plastically deformable implant for inserting into bodily orifices of the human or animal body. Implants of this type are used, for example, in ophthalmology, in particular, as vitreous body or lens replacements and in dentistry, for example, for filling extraction cavities in jaw-bones. Known implants, however, are not suitable for long-term use. The invention aims to provide a deformable plastic implant which also has a long-term application. This is achieved by the fact that the implant consists of a gel which is not sealed, containing fluorocarbon and which is directly introduced into the natural, or artificially created bodily orifice.

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