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1. 发明授权

US5393774A Phenylethanolamines, pharmaceutical compositions containing these compounds and process for preparing them 失效
标题翻译：苯乙醇胺，含有这些化合物的药物组合物及其制备方法
公开(公告)号：US5393774A
公开(公告)日：1995-02-28
申请号：US187671
申请日：1994-01-27
申请人： Helmut Pieper , Gunther Engelhardt
发明人： Helmut Pieper , Gunther Engelhardt
IPC分类号： A23K1/16 , A61K31/275 , A61K31/277 , A61K31/36 , A61P3/06 , A61P11/00 , A61P11/08 , A61P13/02 , A61P15/00 , A61P21/02 , A61P25/02 , A61P25/04 , A61P29/00 , A61P43/00 , C07C255/59 , C07C271/28 , C07C255/50 , C07D317/54 , C07C28/58
CPC分类号： C07C255/59 , A23K20/111 , A61K31/275 , A61K31/36 , C07C271/28
摘要： The invention relates to phenylethanolamines of general formula ##STR1## wherein R.sub.1 and R.sub.2 are defined as in claim 1, the enantiomers and the acid addition salts thereof, which have valuable pharmacological properties, not only analgesic, antiphlogistic, broncholytic, uterus-spasmolytic, lipolytic effects and an antispastic effect on the cross-striped muscle, but also .beta..sub.2 -mimetic and/or .beta..sub.1 -blocking effects, the use thereof as pharmaceuticals and as performance enhancers and processes for preparing them.
摘要翻译：本发明涉及通式为“IMAGE”的苯乙醇胺，其中R 1和R 2如权利要求1所定义，其对映体及其酸加成盐具有有价值的药理学性质，不仅止痛，消炎，支气管分解，子宫解痉，脂肪分解效应和抗交叉效应，而且还具有β2-模拟和/或β1-阻断作用，其作为药物的用途以及用于制备它们的性能增强剂和方法。

2. 发明授权

US4214001A 1-(4-Acylamino-phenyl)-2-amino-ethanols and salts thereof 失效
标题翻译： 1-（4-酰基氨基 - 苯基）-2-氨基 - 乙醇及其盐
公开(公告)号：US4214001A
公开(公告)日：1980-07-22
申请号：US883814
申请日：1978-03-06
申请人： Gunther Engelhardt , Johannes Keck , Kruger , Klaus Noll , Helmut Pieper
发明人： Gunther Engelhardt , Johannes Keck , Kruger , Klaus Noll , Helmut Pieper
IPC分类号： A61K31/17 , A61K31/167 , A61K31/27 , A61P25/04 , A61P25/08 , C07C67/00 , C07C215/52 , C07C239/00 , C07C269/00 , C07C271/28 , C07C271/58 , C07C275/28 , C07C275/40 , A61K31/275 , C07C121/80 , C07C125/06
CPC分类号： C07C275/40
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or cyano;R.sub.2 is fluorine, cyano, trifluoromethyl, nitro or alkyl of 1 to 4 carbon atoms;R.sub.3 is alkoxy of 1 to 5 carbon atoms, alkenyloxy of 2 to 5 carbon atoms, aryloxy of 6 to 10 carbon atoms, aralkoxy of 7 to 11 carbon atoms, or --NR.sub.5 R.sub.6, where R.sub.5 and R.sub.6 are each hydrogen, alkyl of 1 to 5 carbon atoms, alkenyl of 2 to 5 carbon atoms, aryl of 6 to 10 carbon atoms or aralkyl of 7 to 11 carbon atoms; andR.sub.4 is cycloalkyl of 3 to 5 carbon atoms or alkyl of 3 to 5 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds as well as the salts are useful as analgesics, uterospasmolytics and antiasthmatics.
摘要翻译：其中R1是氢，卤素或氰基的式“IMAGE”的化合物; R2是氟，氰基，三氟甲基，硝基或1-4个碳原子的烷基; R3为1〜5个碳原子的烷氧基，2〜5个碳原子的烯氧基，6〜10个碳原子的芳氧基，7〜11个碳原子的芳烷氧基或-NR5R6，其中R5和R6分别为氢， 2至5个碳原子的烯基，6至10个碳原子的芳基或7至11个碳原子的芳烷基; R4为3〜5个碳原子的环烷基或3〜5个碳原子的烷基; 和无毒的，药学上可接受的酸加成盐。化合物以及盐可用作镇痛药，子宫内膜溶解药和止喘药。

3. 发明授权

US4244967A Antiphlogistic pharmaceutical compositions containing a phenylethanolamine and methods of use 失效
标题翻译：含有苯乙醇胺的消炎药物组合物及其使用方法
公开(公告)号：US4244967A
公开(公告)日：1981-01-13
申请号：US72553
申请日：1979-09-04
申请人： Gunther Engelhardt , Johannes Keck , Gerd Kruger , Klaus Noll , Helmut Pieper , Rainer Zimmermann
发明人： Gunther Engelhardt , Johannes Keck , Gerd Kruger , Klaus Noll , Helmut Pieper , Rainer Zimmermann
IPC分类号： A61K31/135 , A61K31/17 , A61K31/275 , A61K31/325 , A61P29/00 , A61P43/00 , A61K31/27
CPC分类号： A61K31/135 , A61K31/17 , A61K31/275 , A61K31/325
摘要： The method of using compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, iodine or cyano,R.sub.2 is fluorine, cyano, trifluoromethyl, nitro or alkyl of 1 to 4 carbon atoms,R.sub.3 is cycloalkyl or alkyl, each of 3 to 5 carbon atoms, andR.sub.4 is hydrogen or --CO--R.sub.5, whereR.sub.5 is alkoxy of 1 to 5 carbon atoms, alkenyloxy of 2 to 5 carbon atoms, aryloxy of 6 to 10 carbon atoms, aralkoxy of 7 to 11 carbon atoms, or amino which may be mono- or di-substituted by alkyl of 1 to 5 carbon atoms, alkenyl of 2 to 5 carbon atoms, aryl of 6 to 10 carbon atoms and/or aralkyl of 7 to 11 carbon atoms,and non-toxic, pharmacologically acceptable acid addition salts thereof as antirheumatics and antiphlogistics.
摘要翻译：使用下式化合物的方法其中R1是氢，氟，氯，溴，碘或氰基，R2是氟，氰基，三氟甲基，硝基或1-4个碳原子的烷基，R3是环烷基或烷基， 3〜5个碳原子，R4为氢或-CO-R5，R5为1〜5个碳原子的烷氧基，2〜5个碳原子的烯氧基，6〜10个碳原子的芳氧基，7〜11个芳氧基碳原子或可以被1至5个碳原子的烷基，2至5个碳原子的烯基，6至10个碳原子的芳基和/或7至11个碳原子的芳烷基单取代或二取代的氨基，以及无毒，药理学上可接受的酸加成盐作为抗风湿剂和消炎药。

4. 发明授权

US4362738A Esters and amides containing the 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl moiety 失效
标题翻译：含有1-（4-氯苯甲酰基）-5-甲氧基-2-甲基-1H-吲哚-3-乙酰基部分的酯和酰胺
公开(公告)号：US4362738A
公开(公告)日：1982-12-07
申请号：US158587
申请日：1980-06-11
申请人： Johannes Keck , Gerd Kruger , Helmut Pieper , Klaus Noll , Gunther Engelhardt , Norbert Promberger , Rainer Zimmermann
发明人： Johannes Keck , Gerd Kruger , Helmut Pieper , Klaus Noll , Gunther Engelhardt , Norbert Promberger , Rainer Zimmermann
IPC分类号： C07D209/08 , A61K31/495 , A61P29/00 , C07C67/00 , C07C227/00 , C07C227/16 , C07C227/18 , C07C229/54 , C07C237/32 , C07C237/38 , C07C313/00 , C07C323/12 , C07C323/65 , C07D209/28 , C07D213/74 , C07D295/088 , C07D295/155 , C07D401/12 , C07H13/08 , C07D279/18 , A61K27/00
CPC分类号： C07D213/74 , C07D209/28 , C07D295/088 , C07D295/155
摘要： Compounds of the formula ##STR1## wherein each X, which may be identical or different from the other X, is oxygen or imino;R.sub.1 is hydrogen, fluorine, chlorine or bromine;R.sub.2 and R.sub.3, which may be identical or different from each other, are each hydrogen; unsubstituted or mono-substituted alkyl of 1 to 6 carbon atoms, where the substituent is phenyl or dialkylamino with 1 to 3 carbon atoms in each alkyl moiety; pyridyl; or cycloalkyl of 5 to 7 carbon atoms;R.sub.2 and R.sub.3, together with each other and the nitrogen atoms to which they are attached, are pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-aryl-piperazino or N-(alkyl of 1 to 3 carbon atoms)-piperazino;A is cycloalkylene of 5 to 7 carbon atoms; unsubstituted or substituted alkylene of 2 to 10 carbon atoms, where the substituents are one to two alkyls of 1 to 3 carbon atoms each, one to two carbalkoxys of 2 to 4 carbon atoms each, one to two phenyls, one to four hydroxyls, one halomethyl, one hydroxymethyl, one alkanoyloxy of 1 to 18 carbon atoms, one alkanoyloxymethyl of 1 to 18 carbon atoms in the alkanoyl moiety or one ##STR2## where R.sub.1, R.sub.2 and R.sub.3 have the meanings previously defined; or alkylene of 2 to 10 carbon atoms interrupted by oxygen, sulfur, sulfoxide, sulfonyl, phenyl, cyclohexyl, pyridyl, piperazino or unsubstituted or substituted imino, where the substituent on the imino group is alkyl of 1 to 6 carbon atoms, phenyl or phenylalkyl of 1 to 3 carbon atoms in the alkyl moiety;B is the acyl residue of an antiphlogistic carboxylic acid;and their non-toxic, pharmacologically acceptable acid addition salts. The compounds as well as their salts are useful as anti-inflammatories.
摘要翻译：其中每个X可以相同或不同于另一个X的式“IMAGE”的化合物是氧或亚氨基; R1是氢，氟，氯或溴; R2和R3可以相同或不同，分别为氢; 未取代或单取代的1至6个碳原子的烷基，其中取代基为苯基或每个烷基部分具有1至3个碳原子的二烷基氨基; 吡啶基或5至7个碳原子的环烷基; 吡咯烷基，哌啶子基，六亚甲基亚氨基，吗啉代，N-芳基 - 哌嗪子基或N-（1至3个碳原子的烷基） - 哌嗪基; R 2和R 3彼此连接并连接的氮原子。 A是5至7个碳原子的亚环烷基; 2至10个碳原子的未取代或取代的亚烷基，其中取代基为1至2个碳原子数为1至2个的烷基，每个为2至4个碳原子的1至2个碳烷氧基，1至2个苯基，1至4个羟基，1至2个卤代甲基，一个羟甲基，一个1至18个碳原子的烷酰氧基，一个在烷酰基部分中具有1至18个碳原子的烷酰氧基甲基或一个，其中R1，R2和R3具有以前定义的含义; 或由氧，硫，亚砜，磺酰基，苯基，环己基，吡啶基，哌嗪子基或未取代或取代的亚氨基所取代的2至10个碳原子的亚烷基，其中亚氨基上的取代基是1至6个碳原子的烷基，苯基或苯基烷基在烷基部分中具有1至3个碳原子; B是消炎性羧酸的酰基残基; 及其无毒，药理学上可接受的酸加成盐。化合物及其盐可用作抗炎剂。

5. 发明授权

US4119710A Bronchospasmolytic 1-(p-amino-phenyl)-2-amino-ethanols-(1) and salts 失效
标题翻译：支气管解痉剂1-（对氨基 - 苯基）-2-氨基 - 乙醇 - （1）和盐
公开(公告)号：US4119710A
公开(公告)日：1978-10-10
申请号：US754981
申请日：1976-12-28
申请人： Gunther Engelhardt , Johannes Keck , Gerd Kruger , Klaus-Reinhold Noll , Helmut Pieper
发明人： Gunther Engelhardt , Johannes Keck , Gerd Kruger , Klaus-Reinhold Noll , Helmut Pieper
IPC分类号： C07D263/04 , C07D317/58 , A61K31/04 , A61K31/135 , A61K31/275 , A61K31/36
CPC分类号： C07D263/04 , C07D317/58
摘要： Racemic and optically active compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, iodine or cyano,R.sub.2 is fluorine, trifluoromethyl, nitro or cyano, andR.sub.3 is alkyl of 3 to 5 carbon atoms, hydroxy(alkyl of 3 to 5 carbon atoms), cycloalkyl of 3 to 5 carbon atoms, 1-(3,4-methylenedioxy-phenyl)-2-propyl or 1-(p-hydroxy-phenyl)-2-propyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics, uterospasmolytics, bronchospasmolytics and antispastics for the skeletal musculature, and especially as .beta..sub.2 -receptor mimetics and .beta..sub.1 -receptor blockers.
摘要翻译：其中R 1为氢，氟，氯，溴，碘或氰基的外消旋和旋光活性化合物，R 2为氟，三氟甲基，硝基或氰基，R 3为3至5个碳原子的烷基，羟基（烷基 3至5个碳原子的环烷基，3至5个碳原子的环烷基，1-（3,4-亚甲二氧基 - 苯基）-2-丙基或1-（对羟基 - 苯基）-2-丙基，和非毒性其药理学可接受的酸添加剂; 这些化合物作为其作为骨质疏松症，骨质疏松症，骨质疏松症和骨质疏松症的抗生素有用的化合物，特别适用于β2受体的MIME和β受体阻断剂。

6. 发明授权

US5880284A Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them 失效
标题翻译：环状脲衍生物，含有这些化合物的药物组合物及其制备方法
公开(公告)号：US5880284A
公开(公告)日：1999-03-09
申请号：US864528
申请日：1997-05-28
申请人： Frank Himmelsbach , Volkhard Austel , Gunter Linz , Helmut Pieper , Brian Guth , Thomas Muller , Johannes Weisenberger
发明人： Frank Himmelsbach , Volkhard Austel , Gunter Linz , Helmut Pieper , Brian Guth , Thomas Muller , Johannes Weisenberger
IPC分类号： A61K31/41 , A61K31/395 , A61K31/415 , A61K31/4166 , A61K31/435 , A61K31/4427 , A61K31/445 , A61P7/02 , A61P9/10 , A61P35/00 , A61P43/00 , C07C281/06 , C07D233/02 , C07D233/32 , C07D233/36 , C07D233/44 , C07D233/70 , C07D233/72 , C07D235/26 , C07D239/10 , C07D249/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D417/06 , C07D453/02 , C07D487/08
CPC分类号： C07D401/04 , C07D233/36 , C07D233/44 , C07D233/70 , C07D233/72 , C07D235/26 , C07D239/10 , C07D249/12 , C07D401/06 , C07D401/10 , C07D417/06 , C07D453/02
摘要： The invention relates to cyclic urea derivatives of general formula I ##STR1## wherein R.sub.a, R.sub.b, X and Y are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation inhibiting effects, and to drugs containing the compounds and processes for preparing them.
摘要翻译：本发明涉及通式I（I）的环脲衍生物，其中Ra，Rb，X和Y如权利要求1所定义，其互变异构体，立体异构体和盐，特别是其与无机或有机物的生理上可接受的盐具有有价值的药理学性质，优选聚集抑制作用的酸或碱，以及含有这些化合物的药物及其制备方法。

7. 发明授权

US5607944A Bicyclic heterocyclic compounds, pharmaceutical preparations containing these compounds and processes for their preparations 失效
标题翻译：双环杂环化合物，含有这些化合物的药物制剂及其制备方法
公开(公告)号：US5607944A
公开(公告)日：1997-03-04
申请号：US509248
申请日：1995-07-31
申请人： G unter Linz , Frank Himmelsbach , Helmut Pieper , Volkhard Austel , Thomas M uller , Johannes Weisenberger , Brian Guth
发明人： G unter Linz , Frank Himmelsbach , Helmut Pieper , Volkhard Austel , Thomas M uller , Johannes Weisenberger , Brian Guth
IPC分类号： A61K31/435 , A61K31/445 , A61K31/535 , A61K31/55 , A61P3/08 , A61P7/02 , A61P9/00 , A61P9/10 , A61P17/00 , A61P35/00 , A61P43/00 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention relates to bicyclic heterocyclic compounds of general formula ##STR1## wherein A to F, Y.sub.1 and Y.sub.2 are defined as in claim 1, the tautomers thereof, the stereoisomers thereof including their mixtures, and salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing the compounds and processes for preparing them as well as new intermediate products of general formula Ia.
摘要翻译：本发明涉及通式为（I）的双环杂环化合物，其中A至F，Y 1和Y 2如权利要求1所定义，其互变异构体，其立体异构体包括其混合物及其盐，特别是生理上可接受的其盐与具有有价值的药理学性质，优选聚集抑制作用的有机或无机酸或碱形成，含有该化合物的药物组合物及其制备方法以及通式Ia的新中间产物。

8. 发明授权

US5597825A Biphenyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them 失效
标题翻译：联苯衍生物，含有这些化合物的药物组合物及其制备方法
公开(公告)号：US5597825A
公开(公告)日：1997-01-28
申请号：US257759
申请日：1994-05-16
申请人： Frank Himmelsbach , Helmut Pieper , Volkhard Austel , G unter Linz , Thomas M uller , Wolfgang Eisert , Johannes Weisenberger
发明人： Frank Himmelsbach , Helmut Pieper , Volkhard Austel , G unter Linz , Thomas M uller , Wolfgang Eisert , Johannes Weisenberger
IPC分类号： C07C211/44 , A61K38/00 , C07C211/48 , C07C211/50 , C07C211/53 , C07C233/65 , C07C237/36 , C07C237/38 , C07C243/22 , C07C255/54 , C07C255/56 , C07C255/57 , C07C255/58 , C07C255/59 , C07C255/60 , C07C257/18 , C07C271/64 , C07C275/28 , C07C275/32 , C07C275/38 , C07C275/42 , C07C279/18 , C07C307/10 , C07C309/11 , C07C311/04 , C07C311/06 , C07C311/08 , C07C311/11 , C07C311/16 , C07C311/19 , C07C311/21 , C07C311/29 , C07C317/14 , C07C317/44 , C07C317/46 , C07C321/24 , C07C323/60 , C07C323/62 , C07D207/08 , C07D207/26 , C07D211/34 , C07D211/60 , C07D211/62 , C07D211/70 , C07D257/04 , C07D295/192 , C07F9/40 , C07K5/06 , A61K31/495 , A61K31/40 , A61K31/445 , C07D295/185
CPC分类号： C07D295/192 , C07C237/36 , C07C237/38 , C07C243/22 , C07C255/56 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/18 , C07C271/64 , C07C275/42 , C07C307/10 , C07C309/11 , C07C311/04 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C311/29 , C07C317/44 , C07C317/46 , C07C323/60 , C07C323/62 , C07D211/34 , C07D211/60 , C07D211/62 , C07D211/70 , C07K5/06026 , A61K38/00 , C07C2101/14
摘要： The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties, preferably aggregation-inhibiting effects, pharmaceutical compositions containing these compounds and processes for preparing them.
摘要翻译：本发明涉及通式为（I）的联苯衍生物，其中A至E和X如权利要求1所定义，其立体异构体包括它们的混合物及其盐，特别是其与无机或有机物的生理上可接受的盐酸或碱，其具有有价值的性质，优选聚集抑制作用，含有这些化合物的药物组合物及其制备方法。

9. 发明授权

US5541343A Cyclic imino derivatives and pharmaceutical compositions containing them 失效
标题翻译：环状亚胺衍生物和含有它们的药物组合物
公开(公告)号：US5541343A
公开(公告)日：1996-07-30
申请号：US365336
申请日：1994-12-28
申请人： Frank Himmelsbach , Volkhard Austel , Helmut Pieper , Wolfgang Eisert , Thomas Mueller , Johannes Weisenberger , Guenter Linz , Gerd Krueger
发明人： Frank Himmelsbach , Volkhard Austel , Helmut Pieper , Wolfgang Eisert , Thomas Mueller , Johannes Weisenberger , Guenter Linz , Gerd Krueger
IPC分类号： A61K31/40 , A61K31/00 , A61K31/395 , A61K31/397 , A61K31/401 , A61K31/4015 , A61K31/402 , A61P7/00 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P35/00 , C07D205/08 , C07D207/00 , C07D207/04 , C07D207/08 , C07D207/12 , C07D207/26 , C07D207/267 , C07D207/27 , C07D207/273 , C07D207/277 , C07D211/76 , C07D223/10 , C07F9/572
CPC分类号： C07D207/26 , C07D207/273 , C07D207/277 , C07F9/5722
摘要： The invention relates to cyclic imino compounds which have, inter alia, valuable pharmacological properties, especially inhibitory effects on cell aggregation, pharmaceutical compositions which contain these compounds and processes for preparing them.
摘要翻译：本发明涉及具有有价值的药理学性质，特别是对细胞聚集的抑制作用的环状亚氨基化合物，其含有这些化合物的药物组合物及其制备方法。

10. 发明授权

US5478942A Cyclic urea derivatives and pharmaceutical compositions containing these compounds 失效
标题翻译：环状尿素衍生物和含有这些化合物的药物组合物
公开(公告)号：US5478942A
公开(公告)日：1995-12-26
申请号：US144909
申请日：1993-10-28
申请人： Frank Himmelsbach , Helmut Pieper , Volkhard Austel , Guenter Linz , Thomas Mueller , Johannes Weisenberger , Wolfgang Eisert
发明人： Frank Himmelsbach , Helmut Pieper , Volkhard Austel , Guenter Linz , Thomas Mueller , Johannes Weisenberger , Wolfgang Eisert
IPC分类号： A61K31/41 , A61K31/415 , A61K31/4166 , A61K31/4184 , A61K31/433 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/5355 , A61K31/54 , A61K31/541 , A61K31/675 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P29/00 , A61P35/00 , C07D211/58 , C07D233/30 , C07D233/32 , C07D233/36 , C07D233/70 , C07D233/72 , C07D233/74 , C07D233/76 , C07D235/26 , C07D239/10 , C07D239/36 , C07D249/12 , C07D285/10 , C07D309/12 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D471/04 , C07F9/6506 , C07D249/04 , C07D249/06
CPC分类号： C07D285/10 , C07D211/58 , C07D233/32 , C07D233/70 , C07D233/72 , C07D235/26 , C07D239/10 , C07D239/36 , C07D249/12 , C07D309/12 , C07D401/04 , C07D403/04 , C07D471/04 , C07F9/65061
摘要： The invention relates to cyclic urea derivatives of general formula ##STR1## wherein R.sub.a, R.sub.b, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.
摘要翻译：本发明涉及通式为（I）的环脲衍生物，其中Ra，Rb，X和Y如本文所定义，含有衍生物的药物组合物及其制备方法。

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