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1. 发明授权

US06671330B1 Power amplifier 有权
标题翻译：功率放大器
公开(公告)号：US06671330B1
公开(公告)日：2003-12-30
申请号：US09460120
申请日：1999-12-13
申请人： Helmut Lenz , Christian Schwingenschloegl
发明人： Helmut Lenz , Christian Schwingenschloegl
IPC分类号： H04K102
CPC分类号： H03F3/2173 , H03F3/2178 , H03F2200/331 , H03K7/08
摘要： A power amplifier, particularly a gradient amplifier of a nuclear magnetic resonance tomography apparatus, has at least one switched output stage containing a power bridge circuit formed by a number of switch elements, the bridge circuit being connected to a floating intermediate circuit voltage, as well as at least one digital pulse width modulator that generates pulse-width-modulated control signals for all switch elements of the power bridge circuit from digital input signals in order to generate at least one output stage voltage according to an output stage switching clock. The digital pulse width modulator has a modulator base element that contains a counter with an output for a counter reading, at least one comparator with an input for receiving the counter reading, a further input for receiving one of the digital input signals, an output binary signal representing a “smaller-than” comparison, and a further output for a further binary signal representing a “greater-than” comparison of the counter reading to the digital input signal. Circuitry follows the comparator for generating the control signals from the binary signals.
摘要翻译：功率放大器，特别是核磁共振断层摄影装置的梯度放大器，具有至少一个开关输出级，其包含由多个开关元件形成的功率桥式电路，桥式电路也连接到浮动中间电路电压作为至少一个数字脉宽调制器，其从数字输入信号产生用于电力电桥电路的所有开关元件的脉冲宽度调制控制信号，以便根据输出级切换时钟产生至少一个输出级电压。数字脉冲宽度调制器具有一个调制器基本元件，该调制器基本元件包含具有用于计数器读数的输出的计数器，至少一个具有用于接收计数器读数的输入的比较器，用于接收数字输入信号之一的另一输入端，表示“小于”比较的信号，以及表示“计数器读数”与数字输入信号的“大于”比较的另外的二进制信号的另一输出。电路跟随比较器，用于从二进制信号产生控制信号。

2. 发明授权

US10663538B2 Monitoring of a temporal change in a magnetic field in a magnetic resonance device 有权
公开(公告)号：US10663538B2
公开(公告)日：2020-05-26
申请号：US15700124
申请日：2017-09-09
申请人： Wolfgang Bielmeier , Gerhard Brinker , Swen Campagna , Nikolaus Demharter , Bernd Erbe , Matthias Gebhardt , Helmut Lenz , Jürgen Nistler , Dominik Paul , Carsten Prinz , Gudrun Ruyters , Stephan Stöcker , Markus Vester
发明人： Wolfgang Bielmeier , Gerhard Brinker , Swen Campagna , Nikolaus Demharter , Bernd Erbe , Matthias Gebhardt , Helmut Lenz , Jürgen Nistler , Dominik Paul , Carsten Prinz , Gudrun Ruyters , Stephan Stöcker , Markus Vester
IPC分类号： G01R33/24 , G01R33/385 , G01R33/28
摘要： A method for monitoring a temporal change in a magnetic field in a magnetic resonance device, as well as an evaluation unit, a magnetic resonance device, and a computer program product for performing the method are provided. The method provides that a position-dependent magnetic field distribution that is produced by the plurality of gradient coils is provided with a plurality of monitoring points. In addition, time-dependent gradient values of the plurality of gradient coils are ascertained. Based on position-dependent magnetic field distribution and the time-dependent gradient values, the temporal change in the magnetic field is ascertained. The temporal change in the magnetic field is monitored by comparing the temporal change in the magnetic field with at least one limit value.

3. 发明申请

US20180074138A1 MONITORING OF A TEMPORAL CHANGE IN A MAGNETIC FIELD IN A MAGNETIC RESONANCE DEVICE 审中-公开
公开(公告)号：US20180074138A1
公开(公告)日：2018-03-15
申请号：US15700124
申请日：2017-09-09
申请人： Wolfgang Bielmeier , Gerhard Brinker , Swen Campagna , Nikolaus Demharter , Bernd Erbe , Matthias Gebhardt , Helmut Lenz , Jürgen Nistler , Dominik Paul , Carsten Prinz , Gudrun Ruyters , Stephan Stöcker , Markus Vester
发明人： Wolfgang Bielmeier , Gerhard Brinker , Swen Campagna , Nikolaus Demharter , Bernd Erbe , Matthias Gebhardt , Helmut Lenz , Jürgen Nistler , Dominik Paul , Carsten Prinz , Gudrun Ruyters , Stephan Stöcker , Markus Vester
IPC分类号： G01R33/24 , G01R33/385 , G01R33/28
CPC分类号： G01R33/24 , G01R33/288 , G01R33/385
摘要： A method for monitoring a temporal change in a magnetic field in a magnetic resonance device, as well as an evaluation unit, a magnetic resonance device, and a computer program product for performing the method are provided. The method provides that a position-dependent magnetic field distribution that is produced by the plurality of gradient coils is provided with a plurality of monitoring points. In addition, time-dependent gradient values of the plurality of gradient coils are ascertained. Based on position-dependent magnetic field distribution and the time-dependent gradient values, the temporal change in the magnetic field is ascertained. The temporal change in the magnetic field is monitored by comparing the temporal change in the magnetic field with at least one limit value.

4. 发明授权

US08664007B2 Immune complex-specific antibodies for increased sensitivity in immunoassay array tests 有权
标题翻译：免疫复合物特异性抗体，用于在免疫测定阵列测试中提高灵敏度
公开(公告)号：US08664007B2
公开(公告)日：2014-03-04
申请号：US11260938
申请日：2005-10-28
申请人： Ursula Klause , Helmut Lenz , Christine Markert-Hahn
发明人： Ursula Klause , Helmut Lenz , Christine Markert-Hahn
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , G01N33/6854
摘要： The invention concerns a method for determining antigen-specific antibodies of a particular immunoglobulin class in a sample by means of an immunoassay in an array format in which various binding partners Bnx are bound on different discrete areas on a support where Bnx in each case contain the various antigens that are able to specifically bind to the antibodies to be detected, by incubating the support with the sample and a binding partner B2 which carries a label and subsequently detecting the label on the respective discrete areas wherein B2 specifically binds antibodies of a certain immunoglobulin class that have been bound in an antigen-specific manner.
摘要翻译：本发明涉及通过以阵列格式的免疫测定来测定样品中特定免疫球蛋白类别的抗原特异性抗体的方法，其中各种结合配偶体Bnx结合在支架上的不同离散区域上，其中每种情况下Bnx包含能够通过将载体与样品一起孵育的各种抗原和携带标记的结合伴侣B2，随后检测各个离散区域上的标记，其中B2特异性结合某种免疫球蛋白的抗体已经以抗原特异性方式结合的类。

5. 发明申请

US20080012636A1 Electric Amplifier and Method for the Control Thereof 有权
标题翻译：电动放大器及其控制方法
公开(公告)号：US20080012636A1
公开(公告)日：2008-01-17
申请号：US11629442
申请日：2005-06-14
申请人： Helmut Lenz
发明人： Helmut Lenz
IPC分类号： H03F1/36
CPC分类号： G01R33/3852
摘要： A method for controlling an electric amplifier is provided. The method includes monitoring a closed-loop control signal of a regulator, which triggers an end stage of the amplifier; adjusting the closed-loop control signal as a function of an output signal of the end stage; comparing the closed-loop control signal with a reference signal; triggering the end stage when an amplitude limit value and a period length limit value are exceeded or undershot by the amplitude value and period length value, respectively, of the closed-loop control signal; and blocking an input side and/or the regulator when the end stage is triggered.
摘要翻译：提供了一种用于控制电放大器的方法。该方法包括监视调节器的闭环控制信号，其触发放大器的末级; 根据终端的输出信号调整闭环控制信号; 将闭环控制信号与参考信号进行比较; 当分别超过或低于闭环控制信号的振幅值和周期长度值的振幅限制值和周期长度限制值时，触发结束级; 并且当终端被触发时阻塞输入侧和/或调节器。

6. 发明申请

US20070262892A1 Method for generating a modulator input signal and premodulator 失效
标题翻译：用于产生调制器输入信号和预调制器的方法
公开(公告)号：US20070262892A1
公开(公告)日：2007-11-15
申请号：US11784047
申请日：2007-04-05
申请人： Helmut Lenz
发明人： Helmut Lenz
IPC分类号： H03M3/00
CPC分类号： H03F3/2173
摘要： A method for generating at least one modulator input signal from at least one regulator signal is provided. The method comprising: generating at least one dither signal based on the periodic output of elements of a discrete dither sequence of the basic form DF=0, 1, 2 . . . 2(m−n)−1; and adding the at least one dither signal to the regulator signal. The regulator signal comprises a digital regulator signal with a length of m bits, and the modulator input signal comprises a digital modulator input signal with a length of n bits, where m>n.
摘要翻译：提供了一种用于从至少一个调节器信号产生至少一个调制器输入信号的方法。该方法包括：基于基本形式DF = 0,1,2的离散抖动序列的元素的周期性输出来产生至少一个抖动信号。。。 2（m-n）-1; 以及将所述至少一个抖动信号添加到所述调节器信号。调节器信号包括长度为m位的数字调节器信号，并且调制器输入信号包括长度为n位的数字调制器输入信号，其中m> n。

7. 发明授权

US07091632B2 Stabilization circuit for compensating fluctuations in a voltage at a user 失效
公开(公告)号：US07091632B2
公开(公告)日：2006-08-15
申请号：US10266293
申请日：2002-10-08
申请人： Helmut Lenz
发明人： Helmut Lenz
IPC分类号： H02J3/24
CPC分类号： H02J3/1814 , H02J9/06 , Y02E40/18
摘要： A stabilization circuit wherein voltages of the secondary winding of a transformer are stabilized with respect to mains voltage fluctuations and load fluctuations, an auxiliary voltage is derived either from a secondary winding of the transformer or an auxiliary transformer. Together with the mains voltage portion of this auxiliary voltage acquired by pulse-width modulation forms the primary voltage of the transformer such that the desired stabilization is achieved.

8. 发明授权

US6060285A Process for the production of hetero-bispecific antibodies 失效
标题翻译：异源双特异性抗体的制备方法
公开(公告)号：US6060285A
公开(公告)日：2000-05-09
申请号：US500596
申请日：1990-03-22
申请人： Helmut Lenz , Ulrich Weidle
发明人： Helmut Lenz , Ulrich Weidle
IPC分类号： C07K16/46 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , C12R1/19 , C12R1/91 , C07H15/12 , C12N5/00 , C12N15/00 , C12P21/06
CPC分类号： C07K16/468 , Y10S435/972
摘要： For the production of hetero-bispecific monoclonal antibodies at least the genes for the light chain and for the variable part of the heavy chain are isolated from a hybridoma cell line which secretes an antibody with a desired specificity and they are inserted into a eukaryotic plasmid vector which contains a marker capable of selection together with a strong promoter, this expression vector is transfected into a hybridoma cell line which secretes antibodies with a second desired specificity, the cell line is cultured, the antibodies are obtained and the bispecific antibody is isolated.
摘要翻译：为了生产异双特异性单克隆抗体，至少将轻链基因和重链可变部分从杂交瘤细胞系中分离出来，所述杂交瘤细胞系将具有所需特异性的抗体分泌，并将其插入真核质粒载体其包含能够与强启动子一起选择的标记，将该表达载体转染到以第二所需特异性分泌抗体的杂交瘤细胞系中，培养细胞系，获得抗体并分离双特异性抗体。

9. 发明授权

US5965378A Antibody class-specific interference eliminating reagent 失效
标题翻译：抗体类特异性干扰消除试剂
公开(公告)号：US5965378A
公开(公告)日：1999-10-12
申请号：US809412
申请日：1997-04-24
申请人： Dittmar Schlieper , Helmut Lenz , Urban Schmitt , Volker Klemt
发明人： Dittmar Schlieper , Helmut Lenz , Urban Schmitt , Volker Klemt
IPC分类号： C07K16/06 , C07K16/42 , G01N33/53 , G01N33/531 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6854 , C07K16/065 , C07K16/4283 , G01N33/5306 , G01N33/54393 , C07K2317/55 , Y10S435/962 , Y10S435/965 , Y10S436/825 , Y10S530/829 , Y10S530/861 , Y10S530/862 , Y10S530/863 , Y10S530/864 , Y10S530/865 , Y10S530/866
摘要： The invention concerns a composition composed of several different antibodies or/and antibody fragments which is suitable as a reagent to reduce interferences in an immunological method for the class-specific detection of antibodies from one or several of the immunoglobulin classes G, M, A, D and E.
摘要翻译： PCT No.PCT / EP95 / 04307 Sec。 371日期1997年04月24日 102（e）日期1997年4月24日PCT提交1995年11月2日PCT公布。公开号WO96 / 14337 日期1996年5月17日本发明涉及由几种不同的抗体或/和抗体片段组成的组合物，其适合作为用于减少免疫学方法中针对来自一种或几种免疫球蛋白类别G的抗体类别特异性检测的干扰的试剂， M，A，D和E.

10. 发明授权

US4543325A Process and reagent for the determination of creatinine 失效
标题翻译：用于测定肌酐的方法和试剂
公开(公告)号：US4543325A
公开(公告)日：1985-09-24
申请号：US449925
申请日：1982-12-15
申请人： Winfried Albert , Joachim Ziegenhorn , Joachim Siedel , Hans-Georg Batz , Helmut Lenz , Brigitte Pautz
发明人： Winfried Albert , Joachim Ziegenhorn , Joachim Siedel , Hans-Georg Batz , Helmut Lenz , Brigitte Pautz
IPC分类号： G01N33/53 , G01N33/70 , C12N9/96 , C12Q1/34
CPC分类号： G01N33/70 , Y10S435/81 , Y10S435/961 , Y10S436/822
摘要： The present invention provides a process for the immunological determination of creatinine, wherein creatinine is converted into 1-methylhydantoin, the 1-methylhydantoin formed is incubated in an aqueous medium with antibodies which are directed against a conjugate of a first hydantoin derivative of the general formula: ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which can be the same or different, are hydrogen atoms, alkyl radicals containing up to 3 carbon atoms or phenyl radicals, with a first hapten carrier substance suitable for antibody formation, reacted with a conjugate of a second hydantoin derivative of general formula (I) with a second hapten carrier substance, one of the components antibody and conjugate being present in the solid phase or in dissolved form and the other component being present in dissolved form, and the inhibition of the binding reaction between the antibodies and the hydantoin conjugate with the second hapten carrier substance is measured.The present invention also provides a reagent for the immunological determination of creatinine, wherein it contains creatinine iminohydrolase, antibodies against a conjugate of a hydantoin of the general formula: ##STR2## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which can be the same or different, are hydrogen atoms, alkyl radicals containing up to 3 carbon atoms or phenyl radicals, with a first hapten carrier substance, a conjugate of a hydantoin of general formula (I) with a second hapten carrier substance which does not cross-react substantially with the first hapten carrier substance and a buffer substance.
摘要翻译：本发明提供了一种免疫学测定肌酐的方法，其中将肌酐转化为1-甲基乙内酰脲，所形成的1-甲基乙内酰脲在水性介质中与针对通式：其中可以相同或不同的R 1，R 2，R 3和R 4为氢原子，含有至多3个碳原子的烷基或苯基，其中第一半抗原载体物质适用于抗体与通式（I）的第二乙内酰脲衍生物与第二半抗原载体物质的缀合物反应，抗体和缀合物之一是固相或溶解形式存在，另一种成分以溶解形式存在并且测量了与第二半抗原载体物质的抗体和乙内酰脲缀合物之间的结合反应的抑制。本发明还提供了一种用于免疫测定肌酐的试剂，其中含有肌酐亚氨基水解酶，针对通式如下的乙内酰脲的缀合物的抗体：其中R1，R2，R3和R4可以相同或不同的是氢原子，含有至多3个碳原子的烷基或苯基，具有第一半抗原载体物质，通式（I）的乙内酰脲与不会基本上交叉反应的第二半抗原载体物质的缀合物具有第一半抗原载体物质和缓冲物质。

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