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1. 发明申请

US20090143415A1 Tetrodotoxin And Its Derivatives For The Treatment Of Central-Nervously Derived Neuropathic Pain 审中-公开
标题翻译：河豚毒素及其衍生物治疗中枢神经性神经性疼痛
公开(公告)号：US20090143415A1
公开(公告)日：2009-06-04
申请号：US11663268
申请日：2005-09-21
申请人： Helmut Heinrich Buschmann , Frank Hay Kong Shum , Kim Noel Fisher , Anh Ho Ngoc , Michel Hamon
发明人： Helmut Heinrich Buschmann , Frank Hay Kong Shum , Kim Noel Fisher , Anh Ho Ngoc , Michel Hamon
IPC分类号： A61K31/519 , A61P25/00
CPC分类号： A61K31/519
摘要： The present invention refers to the use of a sodium channel blocker such as tetrodotoxin or saxitoxin, their analogues and derivatives as well as their physiologically acceptable salts, in medicinal products for human therapeutics for the treatment of central-nervously derived neuropathic pain.
摘要翻译：本发明涉及用于治疗中枢神经性神经性疼痛的人类治疗剂的药物中使用钠通道阻断剂如河豚毒素或类似物和衍生物以及其生理学上可接受的盐。

2. 发明申请

US20100075992A1 Tetrodotoxin and its derivatives for the treament of peripheral-nervously derived neuropathi pain 审中-公开
标题翻译：河豚毒素及其衍生物用于治疗周围神经性神经性疼痛
公开(公告)号：US20100075992A1
公开(公告)日：2010-03-25
申请号：US11663358
申请日：2005-09-20
申请人： Helmut Buschmann , Frank Hay Kong Shum , Kim Noel Fisher , Anh Ho Ngoc , Michel Hamon
发明人： Helmut Buschmann , Frank Hay Kong Shum , Kim Noel Fisher , Anh Ho Ngoc , Michel Hamon
IPC分类号： A61K31/519 , A61P25/00
CPC分类号： A61K31/519
摘要： The present invention refers to the use of a sodium channel blocker such as tetrodotoxin or saxitoxin, their analogues and derivatives as well as their physiologically acceptable salts, in medicinal products for human therapeutics for the treatment of peripheral-nervously derived neuropathic pain.
摘要翻译：本发明涉及用于治疗周围神经性神经性疼痛的人类治疗剂的药物中使用钠通道阻断剂如河豚毒素或类似物和衍生物及其生理学上可接受的盐。

3. 发明授权

US06407088B1 Method of analgesia 有权
标题翻译：镇痛方法
公开(公告)号：US06407088B1
公开(公告)日：2002-06-18
申请号：US09695053
申请日：2000-10-25
申请人： Qingbin Dong , Frank Hay Kong Shum
发明人： Qingbin Dong , Frank Hay Kong Shum
IPC分类号： A61K3133
CPC分类号： A61K31/519 , A61K31/506 , A61K31/517
摘要： This invention relates to a method of producing analgesia in a mammal experiencing pain by systemically administering an effective amount of a composition comprising essentially of a sodium channel blocking compound, in a suitable pharmaceutical vehicle, to alleviate the pain.
摘要翻译：本发明涉及通过在合适的药物载体中全面施用有效量的基本上由钠通道阻断化合物组成的组合物来减轻疼痛的方法，在经历疼痛的哺乳动物中产生止痛的方法。

4. 发明授权

US06562968B2 Method of purifying tetrodotoxin 有权
公开(公告)号：US06562968B2
公开(公告)日：2003-05-13
申请号：US09818863
申请日：2001-03-28
申请人： Maoqing Zhou , Frank Hay Kong Shum
发明人： Maoqing Zhou , Frank Hay Kong Shum
IPC分类号： C07D23900
CPC分类号： C07D491/22
摘要： The present invention relates to a new process of purifying tetrodotoxin using high performance liquid chromatograph technology.

5. 发明授权

US06478966B2 System for extracting tetrodotoxin 失效
公开(公告)号：US06478966B2
公开(公告)日：2002-11-12
申请号：US09818775
申请日：2001-03-28
申请人： Maoqing Zhou , Frank Hay Kong Shum
发明人： Maoqing Zhou , Frank Hay Kong Shum
IPC分类号： C07D49100
CPC分类号： B01J20/14 , B01D15/00 , B01J20/20 , B01J39/00
摘要： The invention relates to a system for extracting toxins from biological tissues. The system comprises a lixiviator, an ion-exchange column, a diatomaceous silica-active carbon column, and a vacuum concentrator. Twenty to one hundred kilograms of raw material can be processed at one time when puffer fish ovaries are used as the starting material.

6. 发明授权

US06780866B2 Analgesic composition and method 失效
公开(公告)号：US06780866B2
公开(公告)日：2004-08-24
申请号：US10062483
申请日：2002-02-05
申请人： Baoshan Ku , Frank Hay Kong Shum
发明人： Baoshan Ku , Frank Hay Kong Shum
IPC分类号： A61K31505
CPC分类号： A61K45/06 , A61K31/485 , A61K31/517 , A61K31/519 , A61K31/52 , A61K2300/00
摘要： A pharmaceutical analgesic composition comprising an opioid analgesic agent and a compound that binds to the SS1 or SS2 subunit of a sodium channel, such as tetrodotoxin and saxitoxin, and analogs thereof. Administration of an opioid analgesic agent and a compound that binds to the SS1 or SS2 subunit of a sodium channel, such as tetrodotoxin and saxitoxin, and analogs thereof, produces analgesia in the treatment of pain in mammals.

7. 发明授权

US06559154B2 Composition of sodium channel blocking compound 失效
公开(公告)号：US06559154B2
公开(公告)日：2003-05-06
申请号：US09819796
申请日：2001-03-29
申请人： Yuhong Kang , Frank Hay Kong Shum
发明人： Yuhong Kang , Frank Hay Kong Shum
IPC分类号： A61K31505
CPC分类号： A61K9/0019 , A61K31/4995 , A61K31/519 , A61K45/06 , A61K47/10 , A61K47/12
摘要： The composition of the present invention comprises a sodium channel blocking compound which is capable of specifically binding to a site, either on an SS1 region or an SS2 region, on an extracellular region of a sodium channel alpha subunit, and a pharmaceutically acceptable carrier.

8. 发明授权

US06552191B1 Method of extracting tetrodotoxin 失效
标题翻译：提取河豚毒素的方法
公开(公告)号：US06552191B1
公开(公告)日：2003-04-22
申请号：US09695711
申请日：2000-10-25
申请人： Maoqing Zhou , Frank Hay Kong Shum
发明人： Maoqing Zhou , Frank Hay Kong Shum
IPC分类号： C07D49120
CPC分类号： C07D491/18
摘要： The present invention relates to a new process of extracting tetrodotoxin from the tissues of an organism. The invention provides increased yield of tetrodotoxin from animal tissues. In the invention, a lixiviated solution is obtained by soaking the tissues with water and a weak organic acid. Soluble proteins are removed by heating the lixiviated solution at a temperature below the boiling point. After pH adjustment, the solution is passed through a cation exchange column. Inorganic salts and alkaline amino acids are removed, and then the tetrodotoxin is adsorbed and eluted from activated carbon. The tetrodotoxin is crystallized by adjusting the pH to 8-10.
摘要翻译：本发明涉及从生物体的组织中提取河豚毒素的新方法。本发明提供了来自动物组织的河豚毒素的增加的产量。在本发明中，通过用水和弱有机酸浸泡组织来获得浸渍溶液。通过在低于沸点的温度下加热浸渍溶液来除去可溶性蛋白质。 pH调节后，溶液通过阳离子交换柱。去除无机盐和碱性氨基酸，然后从活性炭吸附和洗脱河豚毒素。通过将pH调节至8-10，使河豚毒素结晶。

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