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1. 发明授权

US4997927A Improved process for the purfication of synthetic oligonucleotides 失效
标题翻译：改进合成寡核苷酸的纯化方法
公开(公告)号：US4997927A
公开(公告)日：1991-03-05
申请号：US770295
申请日：1985-08-27
申请人： Helmut Blocker , Ronald Frank , Gudrun Heisterberg-Moutsis , Gisela Kurth , Andreas Meyerhans
发明人： Helmut Blocker , Ronald Frank , Gudrun Heisterberg-Moutsis , Gisela Kurth , Andreas Meyerhans
IPC分类号： C07H1/06 , C07H21/00 , C07H21/04
CPC分类号： C07H21/00 , Y02P20/55
摘要： A process for the purfication of synthetic oligonucleotides is described which drastically simplifies the hitherto very time consuming purification process. The deprotection solution is adsorbed without being concentrated on a carrier having reversed phase properties and optionally ion exchanger properties, the oligonuleotides without lipophilic protecting group are removed, their protecting group is cleaved off from the adsorbed oligonucleotides, the adsorbed oligonucleotides are washed and eluted from the carrier and then purified in a manner known per se.
摘要翻译：描述了合成寡核苷酸的纯化方法，其大大简化了迄今非常耗时的纯化过程。将脱保护溶液吸附而不被浓缩在具有反相特性和任选离子交换性质的载体上，除去没有亲脂性保护基团的寡核苷酸，将其保护基从吸附的寡核苷酸上切下，将吸附的寡核苷酸从载体，然后以本身已知的方式纯化。

2. 发明授权

US4863848A Double-stranded vector and process using it 失效
标题翻译：双链载体和使用它的过程
公开(公告)号：US4863848A
公开(公告)日：1989-09-05
申请号：US849031
申请日：1986-04-07
申请人： Helmut Blocker , Ronald Frank , Guido Volckaert
发明人： Helmut Blocker , Ronald Frank , Guido Volckaert
IPC分类号： C12N15/00 , C12Q1/68
CPC分类号： C12Q1/6869 , C12N15/00
摘要： The invention concerns a double-stranded recombinant DNA cloning vector comprising one single insertion site for foreign DNA and one or two labelling sites adjacent or approximate to said insertion site. In the instance of two labelling sites, said sites flank the insertion site. The labelling site(s) can be individually labelled in a fashion that results in the labelling of the 3' end of either strand. The use of the invention in a process affords the ability to individually label only one strand at the 3' end in a simplified method for base sequencing analysis.
摘要翻译：本发明涉及双链重组DNA克隆载体，其包含外源DNA的一个单一插入位点和与所述插入位点相邻或近似的一个或两个标记位点。在两个标记位点的情况下，所述位点位于插入位点的侧面。标记位点可以以导致任一链的3'末端的标记的方式单独标记。在一个方法中使用本发明提供了在3'末端单独标记一条链的能力，用于基本测序分析的简化方法。

3. 发明授权

US5126322A Pancreatic secretory tryspin inhibitor and variants thereof produced by a recombinant host therefore and pharmaceutical use thereof 失效
标题翻译：因此，由重组体宿主产生的胰腺分泌物转录抑制剂及其变体及其药物用途
公开(公告)号：US5126322A
公开(公告)日：1992-06-30
申请号：US685798
申请日：1991-04-16
申请人： John Collins , Helmut Blocker , Ronald Frank , Friedhelm Maywald , Hans Fritz , Wolfgang Bruns
发明人： John Collins , Helmut Blocker , Ronald Frank , Friedhelm Maywald , Hans Fritz , Wolfgang Bruns
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61P29/00 , A61P37/08 , C07K14/00 , C07K14/81 , C12N1/21 , C12P21/02 , C12R1/19
CPC分类号： C07K14/8135 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/036 , Y10S930/26 , Y10S930/27
摘要： The present invention relates to a peptide having essentially the amino acid sequence of pancreatic secretory trypsin inhibitor (PSTI). The present invention also relates to variants of such peptide wherein one or more of the amino acids in the original sequence are replaced by other amino acids. These peptides show an advantageously modified specificity in their inhibotory action. A method of preparation of the peptides and their pharmaceutical use is also described.
摘要翻译：本发明涉及基本上具有胰分泌型胰蛋白酶抑制剂（PSTI）的氨基酸序列的肽。本发明还涉及这种肽的变体，其中原始序列中的一个或多个氨基酸被其它氨基酸替代。这些肽在其抑制作用中表现出有利的修饰特异性。还描述了肽的制备方法及其药物用途。

4. 发明申请

US20110200555A1 CONJUGATES OF HYDROXYALKYL STARCH AND A PROTEIN 有权
标题翻译：羟丙基淀粉和蛋白质的结合
公开(公告)号：US20110200555A1
公开(公告)日：2011-08-18
申请号：US13018648
申请日：2011-02-01
申请人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
发明人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
IPC分类号： A61K38/21 , C07K14/565 , C07K14/535 , C12N9/96 , C07K14/81 , C07K14/755 , C07K1/107 , C12P21/00 , A61K38/19 , A61K38/48 , A61K38/57 , A61K38/37 , A61P25/00 , A61P7/00 , A61P7/02 , A61P9/10 , A61P11/00 , A61P17/00 , A61P7/04
CPC分类号： A61K47/61 , A61K47/50
摘要： Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
摘要翻译：本文提供羟烷基淀粉和蛋白质的缀合物。缀合物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价连接形成。本文还提供了产生缀合物的方法和缀合物的用途。

5. 发明授权

US07739836B2 Vehicle door with selective full open positions 有权
标题翻译：车门有选择性的全开位置
公开(公告)号：US07739836B2
公开(公告)日：2010-06-22
申请号：US11146796
申请日：2005-06-07
申请人： John V Keane , Ronald Frank
发明人： John V Keane , Ronald Frank
IPC分类号： E05C17/22
CPC分类号： E05C17/203 , E05D5/062 , E05Y2900/531 , Y10T16/6295
摘要： An apparatus is provided for establishing at least two open access door positions relative to an opening of a compartment. The apparatus includes a position defining member having at least one engagement element, and a stop member. The position defining member is adapted to be coupled to the compartment. A housing member is adapted to be coupled to the access door for movement therewith, and has an opening for translatable receipt of the position defining member. The housing member further includes an engagement element operable to engage the at least one engagement element of the position defining member to establish a first open access door position. The stop member contacting the housing member establishes a second open access door position approximately perpendicular to the compartment.
摘要翻译：提供了一种用于建立相对于隔室的开口的至少两个开放通道门位置的装置。该装置包括具有至少一个接合元件的位置限定件和止动件。位置限定构件适于联接到隔间。壳体构件适于联接到检修门以与其一起运动，并且具有用于可平移地接收位置限定构件的开口。壳体构件还包括接合元件，其可操作以接合所述位置限定构件的至少一个接合元件以建立第一开放进入门位置。接触壳体构件的止动构件建立大致垂直于隔室的第二开放通道门位置。

6. 发明申请

US20100144822A1 Use of Inhibitors of the Degradation of P27, in Particular Argyrin and Derivatives Thereof, for the Treatment of Proliferative Diseases 有权
标题翻译：使用抑制剂降低P27，特别是Argyrin及其衍生物，用于治疗增殖性疾病
公开(公告)号：US20100144822A1
公开(公告)日：2010-06-10
申请号：US12527428
申请日：2008-02-27
申请人： Nisar Malek , Florenz Sasse , Irina Nickeleit , Ronald Frank , Bettina Hinkelmann , Heinrich Steinmetz
发明人： Nisar Malek , Florenz Sasse , Irina Nickeleit , Ronald Frank , Bettina Hinkelmann , Heinrich Steinmetz
IPC分类号： A61K31/404 , G01N33/567 , G01N33/574 , C12Q1/68 , A61P35/00
CPC分类号： A61K31/4045 , A61K31/405 , A61K38/00 , C07D519/04 , C07K7/56 , G01N33/5011
摘要： The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular Argyrin and derivatives thereof, preferably Argyrin A, for the treatment of proliferative diseases, such as cancer, as well as the derivatization of said macrocycles.
摘要翻译：本发明涉及作为p27蛋白酶体降解抑制剂的特别大环化合物的用途，特别是Argyrin及其衍生物，优选Argyrin A，用于治疗增殖性疾病如癌症，以及所述大环化合物的衍生化。

7. 发明申请

US20100062973A1 Production of bioactive glycoproteins from inactive starting material 审中-公开
标题翻译：从无活性原料生产生物活性糖蛋白
公开(公告)号：US20100062973A1
公开(公告)日：2010-03-11
申请号：US11908325
申请日：2006-03-09
申请人： Ronald Frank , Harald S. Conradt , Eckart Grabenhorst , Norbert Zander
发明人： Ronald Frank , Harald S. Conradt , Eckart Grabenhorst , Norbert Zander
IPC分类号： A61K47/48 , C07K14/00 , C12P21/00
CPC分类号： A61K47/61
摘要： A method for preparing a conjugate comprising a glycoprotein and a polymer or a derivative of said polymer, wherein the polymer is a hydroxyalkylstarch (HAS), the method comprising the steps a) reacting said glycoprotein with a modified polyol carrying attached thereto, by a covalent linkage, a functional group Z, in the presence of a transferase capable of catalysing formation of a covalent linkage between the glycoprotein and said modified polyol, yielding a glycoprotein covalently linked to a polyol carrying attached thereto, by a covalent linkage, at least one functional group Z, and b) reacting at least one functional group A of the polymer or the derivative thereof with the at least one functional group Z of the glycoprotein added to said glycoprotein during step a), and thereby forming a covalent linkage.
摘要翻译：一种制备包含糖蛋白和所述聚合物的聚合物或衍生物的缀合物的方法，其中所述聚合物是羟烷基淀粉（HAS），所述方法包括以下步骤：a）使所述糖蛋白与载体连接的改性多元醇通过共价连接，官能团Z，在存在能够催化糖蛋白和所述修饰的多元醇之间的共价键的转移酶的存在下，通过共价连接产生与携带与其连接的多元醇共价连接的糖蛋白，至少一种功能性组Z，和b）在步骤a）期间使聚合物或其衍生物的至少一个官能团A与加入到所述糖蛋白的糖蛋白的至少一个官能团Z反应，从而形成共价键。

8. 发明授权

US07119671B2 Seat buckle sensor 失效
标题翻译：座扣传感器
公开(公告)号：US07119671B2
公开(公告)日：2006-10-10
申请号：US10761129
申请日：2004-01-20
申请人： Ronald Frank , Matthew De Remer , Adam Young
发明人： Ronald Frank , Matthew De Remer , Adam Young
IPC分类号： B60Q1/00
CPC分类号： B60R22/48 , B60R21/01546 , B60R2021/01265 , B60R2022/4816 , H05K3/284
摘要： A seat buckle sensor system is provided that provides an output representative of a lock condition of a seat belt buckle. The system includes a magnet on an end of a seat buckle lock pin and a Hall device. The lock pin, and magnet on the end thereof, move between a locked position and an unlocked position relative to the Hall device. The magnet imparts a first magnetic flux on the Hall device in the locked position causing the Hall device to produce a first output. The magnet imparts a second magnetic flux on the Hall device in the unlocked position causing the Hall device to produce a second output.
摘要翻译：提供了一种座椅扣式传感器系统，其提供代表安全带扣的锁定状态的输出。该系统包括在座扣扣销和霍尔装置的一端的磁体。锁定销和其端部上的磁体相对于霍尔装置在锁定位置和解锁位置之间移动。磁体在锁定位置的霍尔器件上施加第一磁通，使霍尔器件产生第一输出。磁体在解锁位置的霍尔器件上施加第二磁通量，从而使霍尔元件产生第二输出。

9. 发明授权

US06720161B1 Immobilized substrate, separation gels and method for detecting enzymatic activity 失效
标题翻译：固定底物，分离凝胶和检测酶活性的方法
公开(公告)号：US06720161B1
公开(公告)日：2004-04-13
申请号：US09673337
申请日：2000-12-26
申请人： Ronald Frank , Werner Tegge
发明人： Ronald Frank , Werner Tegge
IPC分类号： C12Q148
CPC分类号： G01N33/561 , C12Q1/00 , G01N30/90 , G01N2650/00
摘要： The present invention refers to a method for attaching substrate molecules to gel matrices, characterized in that a substrate is covalently bound to a monomeric or oligomeric constitutional unit of a gel and the resultant product is polymerized. The present invention further refers to gels obtainable by this process.
摘要翻译：本发明涉及一种将底物分子附着在凝胶基质上的方法，其特征在于底物与凝胶的单体或低聚结构单元共价结合，所得产物聚合。本发明还涉及可通过该方法获得的凝胶。

10. 发明授权

US08017739B2 Conjugates of hydroxyalkyl starch and a protein 失效
标题翻译：羟烷基淀粉和蛋白质的共轭物
公开(公告)号：US08017739B2
公开(公告)日：2011-09-13
申请号：US11518558
申请日：2006-09-08
申请人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
发明人： Wolfram Eichner , Martin Schimmel , Frank Hacket , Elmar Kraus , Norbert Zander , Ronald Frank , Harald Conradt , Klaus Langer , Michele Orlando , Klaus Sommermeyer
IPC分类号： C12N9/00 , C12N9/96 , A61K31/715 , A61K38/43 , A61K47/36 , A61K38/16
CPC分类号： A61K47/61 , A61K47/50
摘要： Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.
摘要翻译：本文提供羟烷基淀粉和蛋白质的缀合物。缀合物通过羟烷基淀粉或羟烷基淀粉和蛋白质的衍生物之间的共价连接形成。本文还提供了产生缀合物的方法和缀合物的用途。

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