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1. 发明申请

US20070016037A1 Medical ultrasound pressure gradient measurement 有权
标题翻译：医学超声压力梯度测量
公开(公告)号：US20070016037A1
公开(公告)日：2007-01-18
申请号：US11147098
申请日：2005-06-06
申请人： Helene Houle , Liexiang Fan , Matthew Holladay , King Wong , Wayne Gueck
发明人： Helene Houle , Liexiang Fan , Matthew Holladay , King Wong , Wayne Gueck
IPC分类号： A61B8/00
CPC分类号： A61B8/06
摘要： Flow information (e.g., velocity and acceleration) and/or pressure gradient information are determined with ultrasound. Both velocity and acceleration are simultaneously estimated using a model and least squares analysis. Anti-aliasing of velocity information may be provided using the model and least squares analysis. Pressure gradient is calculated from velocity information automatically, more likely providing consistent measurements. Consistency may be increased further by automatically positioning a region of interest in either a multidimensional spatial image or a spatial-temporal image. A parametric image of pressure gradient for each spatial location within the image is generated as well as a delta pressure curve. Any single one or combinations of two or more of the features described above may be used.
摘要翻译：用超声波确定流量信息（例如，速度和加速度）和/或压力梯度信息。同时使用模型和最小二乘法分析速度和加速度。可以使用模型和最小二乘法分析来提供速度信息的抗锯齿。压力梯度由速度信息自动计算，更可能提供一致的测量。通过将感兴趣区域自动定位在多维空间图像或空间 - 时间图像中，可以进一步增加一致性。产生图像内每个空间位置的压力梯度的参数图像以及三角洲压力曲线。可以使用上述特征中的任何一个或两个或更多个特征的组合。

2. 发明申请

US20050041837A1 Flow representation method and system for medical imaging 有权
标题翻译：用于医学成像的流程表示方法和系统
公开(公告)号：US20050041837A1
公开(公告)日：2005-02-24
申请号：US10642914
申请日：2003-08-18
申请人： Liexiang Fan , Wayne Gueck , King Wong
发明人： Liexiang Fan , Wayne Gueck , King Wong
IPC分类号： G06K9/00 , G06T15/70
CPC分类号： G06T7/0012 , A61B8/483 , G06T13/80 , G06T2207/10132 , G06T2207/30104
摘要： Flow is represented by a synthesized or artificial pattern. Motion is visualized by apparent displacement of pixels from one frame to the next. An artificial pattern is introduced in order to present the flow. A changing parameter, such as velocity, is viewed as a function of multiple images or over time. The rate of change of the parameter is proportional to the perceived or actual motion. Humans perceive flow as a live stream, such as tap water pouring from a faucet or a stream in a creek. Flow associated with medical imaging is presented in a similar way, such that a pattern or other flow information persists over multiple images. The flow is synthesized by generating patterns and moving the generated patterns in the field of view. The direction and rate of motion of the pattern are a function of the direction and rate of the flow.
摘要翻译：流程由合成或人造图案表示。运动通过从一帧到下一帧的像素的明显位移可视化。引入人造模式以呈现流动。变化的参数（如速度）被视为多个图像或随着时间的推移的函数。参数的变化率与感知或实际运动成比例。人类将流动视为活流，例如从水龙头或溪流中涌出的自来水。与医学成像相关联的流程以类似的方式呈现，使得图案或其他流动信息保持在多个图像上。通过在视野中生成图案并移动生成的图案来合成流程。图案的方向和运动速度是流动方向和速度的函数。

3. 发明申请

US20050096543A1 Motion tracking for medical imaging 审中-公开
标题翻译：运动跟踪医学影像
公开(公告)号：US20050096543A1
公开(公告)日：2005-05-05
申请号：US10861268
申请日：2004-06-04
申请人： John Jackson , Liexiang Fan , Matthew Holladay , David Gustafson
发明人： John Jackson , Liexiang Fan , Matthew Holladay , David Gustafson
IPC分类号： A61B8/08 , G01S7/52 , G01S15/89 , G06T7/20 , A61B8/00
CPC分类号： G01S15/8981 , A61B6/503 , A61B6/504 , A61B8/0891 , A61B8/488 , A61B8/5276 , G01S7/52036 , G01S7/52066 , G01S7/52071 , G01S15/8988 , G06T7/248 , G06T2207/10132
摘要： Motion of a region of interest is tracked in medical imaging. For example, velocity information, such as colored Doppler velocity estimates independent of tracking from one image to another image, are used to indicate an amount of motion between the images. The velocity assisted tracking may be used for one dimensional tracking (e.g., for M-mode images), for tracking in two dimensional images, or for tracking between three dimensional representations. As an alternative or additional example, physiological signal information is used to assist in the tracking determination. A physiological signal may be used to model the likely movement of an organ being imaged to control or adjust matching search patterns and limits. The modeling may also be used to independently determine movement or for tracking. The independently determined tracking is then combined with tracking based on medical data or other techniques. The cost function or other metric for determining the sufficiency or a match may include information modeled from or selected as a function of the physiological cycle signal in addition to other matching calculations. The fusion of physiological signal information with image data tracking may improve the tracking.
摘要翻译：感兴趣的区域的运动在医学成像中被跟踪。例如，速度信息，例如独立于从一幅图像到另一幅图像的跟踪的彩色多普勒速度估计，用于指示图像之间的运动量。速度辅助跟踪可以用于一维跟踪（例如，用于M模式图像），用于在二维图像中跟踪或用于三维表示之间的跟踪。作为替代或附加示例，使用生理信号信息来辅助跟踪确定。可以使用生理信号来对被成像的器官的可能运动进行建模，以控制或调整匹配的搜索模式和限制。建模也可以用于独立地确定运动或跟踪。然后将独立确定的跟踪与基于医疗数据或其他技术的跟踪组合。用于确定足够或匹配的成本函数或其他度量可以包括除了其他匹配计算之外，根据生理周期信号建模或选择的信息。生理信号信息与图像数据跟踪的融合可以改善跟踪。

4. 发明授权

US08211024B2 Medical ultrasound pressure gradient measurement 有权
标题翻译：医学超声压力梯度测量
公开(公告)号：US08211024B2
公开(公告)日：2012-07-03
申请号：US11147098
申请日：2005-06-06
申请人： Helene C. Houle , Liexiang Fan , Matthew Holladay , King Yuen Wong , Wayne J. Gueck
发明人： Helene C. Houle , Liexiang Fan , Matthew Holladay , King Yuen Wong , Wayne J. Gueck
IPC分类号： A61B8/14
CPC分类号： A61B8/06
摘要： Flow information (e.g., velocity and acceleration) and/or pressure gradient information are determined with ultrasound. Both velocity and acceleration are simultaneously estimated using a model and least squares analysis. Anti-aliasing of velocity information may be provided using the model and least squares analysis. Pressure gradient is calculated from velocity information automatically, more likely providing consistent measurements. Consistency may be increased further by automatically positioning a region of interest in either a multidimensional spatial image or a spatial-temporal image. A parametric image of pressure gradient for each spatial location within the image is generated as well as a delta pressure curve. Any single one or combinations of two or more of the features described above may be used.
摘要翻译：用超声波确定流量信息（例如，速度和加速度）和/或压力梯度信息。同时使用模型和最小二乘法分析速度和加速度。可以使用模型和最小二乘法分析来提供速度信息的抗锯齿。压力梯度由速度信息自动计算，更有可能提供一致的测量。通过将感兴趣区域自动定位在多维空间图像或空间 - 时间图像中，可以进一步增加一致性。产生图像内每个空间位置的压力梯度的参数图像以及三角洲压力曲线。可以使用上述特征中的任何一个或两个或更多个特征的组合。

5. 发明授权

US10278671B2 Shear wave detection in medical ultrasound imaging 有权
公开(公告)号：US10278671B2
公开(公告)日：2019-05-07
申请号：US14042424
申请日：2013-09-30
申请人： Liexiang Fan , Seungsoo Kim , Nikolas Ivancevich
发明人： Liexiang Fan , Seungsoo Kim , Nikolas Ivancevich
IPC分类号： A61B5/00 , A61B8/00 , A61B8/08 , G01S7/52
摘要： Shear waves are detected with ultrasound. The detection of the shear wave is constrained using prior measurements in a more controlled environment (e.g., less noise). For example, shear waves measured in a phantom are used to constrain the detection of shear waves in a patient to avoid false positive detections.

6. 发明授权

US08961418B2 Solving for shear wave information in medical ultrasound imaging 有权
标题翻译：解决医学超声成像中的剪切波信息
公开(公告)号：US08961418B2
公开(公告)日：2015-02-24
申请号：US12898957
申请日：2010-10-06
申请人： Liexiang Fan
发明人： Liexiang Fan
IPC分类号： A61B8/00 , A61B8/08 , G01S7/52 , G01S15/89 , A61B8/14
CPC分类号： A61B8/485 , A61B8/14 , A61B8/488 , G01S7/52042 , G01S15/8906 , G06F19/00
摘要： A shear wave velocity solution is provided for medical ultrasound imaging. Rather than determining shear wave information for each location based on distance from the origin of the shear wave and time to peak displacement for the location, displacement profiles resulting from different combinations of origin and detection locations are correlated. Shear information is detected using displacements from a diverse spatial combination of transmission locations and detection locations. The correlation combination is used in a same function for simultaneously solving for the delays for multiple lateral locations. Spatial diversity and layered correlation may provide for more accurate shear wave estimation.
摘要翻译：提供用于医学超声成像的剪切波速度解决方案。与根据距离原始的剪切波的距离以及位置的时间到峰值位移的距离确定每个位置的剪切波信息而不是根据不同原点和检测位置的组合产生的位移曲线相关。使用来自传输位置和检测位置的不同空间组合的位移来检测剪切信息。相关组合用于相同的功能，用于同时求解多个横向位置的延迟。空间分集和分层相关可以提供更准确的剪切波估计。

7. 发明申请

US20130345545A1 Ultrasound Enhanced Magnetic Resonance Imaging 审中-公开
标题翻译：超声增强磁共振成像
公开(公告)号：US20130345545A1
公开(公告)日：2013-12-26
申请号：US13529746
申请日：2012-06-21
申请人： Patrick Gross , Chi-Yin Lee , Stephen R. Barnes , Liexiang Fan , Caroline Maleke , Kevin Michael Sekins
发明人： Patrick Gross , Chi-Yin Lee , Stephen R. Barnes , Liexiang Fan , Caroline Maleke , Kevin Michael Sekins
IPC分类号： A61B8/13 , A61B5/055
CPC分类号： A61B5/055
摘要： Magnetic resonance imaging frame rate is increased using ultrasound information. Magnetic resonance (MR) images may be provided at an increased frame rate relative to the MR acquisition. For times between acquisition of MR data, MR data may be created. To account for any change in position of tissue over time, ultrasound is used to track the location of tissue or other imaged structure. The ultrasound-based location information is used to indicate the position of intensities or values of the created MR data. MR images at a higher frame rate than the MR acquisition are generated, but with accuracy of relative position based on the ultrasound data.
摘要翻译：使用超声信息增加磁共振成像帧率。可以以相对于MR采集的增加的帧速率提供磁共振（MR）图像。对于获取MR数据之间的时间，可能会创建MR数据。为了考虑组织随时间的位置的任何变化，使用超声波来跟踪组织或其他成像结构的位置。基于超声的位置信息用于指示所创建的MR数据的强度或值的位置。产生比MR获取更高的帧速率的MR图像，但是基于超声数据的相对位置的精度。

8. 发明申请

US20130296743A1 Ultrasound for Therapy Control or Monitoring 审中-公开
标题翻译：超声治疗控制或监测
公开(公告)号：US20130296743A1
公开(公告)日：2013-11-07
申请号：US13462715
申请日：2012-05-02
申请人： Chi-Yin Lee , Liexiang Fan , Jerry Hopple , Stephen J. Hsu , Xiaozheng Zeng , Caroline Maleke , Christophe Duong , Kevin Michael Sekins , John Kook , Stephen R. Barnes
发明人： Chi-Yin Lee , Liexiang Fan , Jerry Hopple , Stephen J. Hsu , Xiaozheng Zeng , Caroline Maleke , Christophe Duong , Kevin Michael Sekins , John Kook , Stephen R. Barnes
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B5/01 , A61B5/4836 , A61B8/5223 , A61B2018/00791 , A61B2034/101 , A61B2090/378 , A61N2007/0052
摘要： Therapy control and/or monitoring is performed with an ultrasound scanner. The ultrasound scanner detects temperature to monitor therapy, and perform HIFU beam location refocusing of the therapy system based on the temperature. The monitoring is synchronized with the therapy using a trigger output of the ultrasound scanner. The trigger output responds to a scan sequence of the ultrasound scanner. To meet a given therapy plan, the scan sequence is customized, resulting in the customized trigger sequence. Three dimensional or multi-planar reconstruction rendering is used to represent temperature for monitoring feedback. The temperature at locations not being treated may be monitored. If the temperature has an undesired characteristic (e.g., too high), then the therapy is controlled by ceasing, at least temporarily.
摘要翻译：用超声波扫描器进行治疗控制和/或监视。超声波扫描仪检测温度以监测治疗，并且基于温度执行治疗系统的HIFU束位置重新聚焦。监测与使用超声波扫描仪的触发输出的治疗同步。触发输出响应超声扫描仪的扫描序列。为了满足给定的治疗计划，扫描序列是定制的，导致定制的触发序列。三维或多平面重建渲染用于表示监视反馈的温度。可以监测未被处理的位置处的温度。如果温度具有不期望的特征（例如太高），则至少暂时停止治疗。

9. 发明授权

US08469891B2 Viscoelasticity measurement using amplitude-phase modulated ultrasound wave 有权
标题翻译：使用振幅相位调制超声波的粘弹性测量
公开(公告)号：US08469891B2
公开(公告)日：2013-06-25
申请号：US13029369
申请日：2011-02-17
申请人： Caroline Maleke , Liexiang Fan , Kevin Michael Sekins , Roee Lazebnik , John Benson
发明人： Caroline Maleke , Liexiang Fan , Kevin Michael Sekins , Roee Lazebnik , John Benson
IPC分类号： A61B8/00 , G01N11/10 , G01N29/00
CPC分类号： A61B8/485 , A61B5/055 , A61B8/08 , A61B8/5261
摘要： A viscoelastic property of tissue is measured in vivo. To collect more information and/or estimate viscosity, shear modulus, and/or other shear characteristics, an amplitude and phase modulated waveform is transmitted to the tissue. The displacement caused by the waveform over time includes displacements associated with response to different frequencies. By examining the displacement in the frequency domain, one or more viscoelastic properties may be calculated for different frequencies. The frequency response may indicate the health of the tissue.
摘要翻译：在体内测量组织的粘弹性。为了收集更多信息和/或估计粘度，剪切模量和/或其他剪切特性，幅度和相位调制波形被传送到组织。由波形随时间引起的位移包括与响应于不同频率相关联的位移。通过检查频域中的位移，可以针对不同的频率计算一个或多个粘弹性质。频率响应可能表示组织的健康。

10. 发明申请

US20100286516A1 HIGH PULSE REPETITION FREQUENCY FOR DETECTION OF TISSUE MECHANICAL PROPERTY WITH ULTRASOUND 有权
标题翻译：用于检测超声波组织机械性能的高脉冲重复频率
公开(公告)号：US20100286516A1
公开(公告)日：2010-11-11
申请号：US12240044
申请日：2008-09-29
申请人： Liexiang Fan , Richard Chiao
发明人： Liexiang Fan , Richard Chiao
IPC分类号： A61B8/00
CPC分类号： A61B8/08 , A61B8/485 , G01S7/52036 , G01S15/8959
摘要： Detection of tissue response is provided with a high pulse repetition frequency. A sequence of separable signals is transmitted in one event. For example, pulses at different frequencies are transmitted as separate waveforms, but in rapid succession. As another example, coded transmit pulses are used. After transmission of the pulses, signals are received. Based on the different frequencies or coding, tissue response is measured at different times based on the receive event. Instead of one measure, a plurality of measures are provided for a given transmit and receive event pair, increasing the effective pulse repetition frequency for shear or elasticity imaging.
摘要翻译：组织反应的检测具有高脉冲重复频率。在一个事件中发送可分离信号的序列。例如，不同频率的脉冲作为单独的波形传输，但是以快速连续的方式传输。作为另一示例，使用编码的发送脉冲。在发送脉冲之后，接收信号。基于不同的频率或编码，基于接收事件在不同时间测量组织响应。代替一种措施，为给定的发射和接收事件对提供多个测量，增加用于剪切或弹性成像的有效脉冲重复频率。

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