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1. 发明授权

US07909267B2 Hand triggered tissue sealant spray apparatus and system 有权
标题翻译：手触组织密封胶喷涂装置及系统
公开(公告)号：US07909267B2
公开(公告)日：2011-03-22
申请号：US12390014
申请日：2009-02-20
申请人： Heinz Redl , Zafar Khakpour , Scott R. Ariagno , Andreas Kellner , Lillian G. Zakarija
发明人： Heinz Redl , Zafar Khakpour , Scott R. Ariagno , Andreas Kellner , Lillian G. Zakarija
IPC分类号： A62C13/62 , A62C5/00 , B05B9/04 , B05B11/02 , F23D11/10 , B67D5/52
CPC分类号： B05B7/0408 , A61B17/00491 , A61B2017/00495 , B05B7/0483 , B05C17/00516 , B05C17/00553 , B05C17/015
摘要： An applicator includes a bore for containing a sealant component, a piston moveably positioned in the bore, a plunger member connected to the piston with a distal end disposed within the bore and a proximal end depending from the bore, a distal outlet communicating with the bore and connectable to a gas source, and an actuating member carried by the proximal end of the plunger member to move with the plunger member as the plunger member moves along the bore. The applicator may be used in a system with a gas source connected to the distal outlet, and a control unit connected to the actuating member and the gas source, the control unit adapted to supply gas to the distal outlet from the gas source essentially simultaneous with a force applied to the actuating member.
摘要翻译：施加器包括用于容纳密封剂部件的孔，可移动地定位在所述孔中的活塞，连接到所述活塞的柱塞构件，其远端设置在所述孔内以及从所述孔悬垂的近端，远端与所述孔连通并且可连接到气体源，以及由柱塞构件的近端承载的致动构件，随着柱塞构件沿着孔移动，与柱塞构件一起移动。施用器可以用在具有连接到远端出口的气源的系统中，以及连接到致动构件和气源的控制单元，所述控制单元适于从气源向远端出口提供气体，基本上与施加到致动构件的力。

2. 发明申请

US20110172703A1 TISSUE SEALANT APPLICATOR SYSTEM 有权
标题翻译：组织密封应用系统
公开(公告)号：US20110172703A1
公开(公告)日：2011-07-14
申请号：US13053201
申请日：2011-03-21
申请人： Heinz Redl , Zafar Khakpour , Scott R. Ariagno , Andreas Kellner , Lillian G. Zakarija
发明人： Heinz Redl , Zafar Khakpour , Scott R. Ariagno , Andreas Kellner , Lillian G. Zakarija
IPC分类号： A61B17/03
CPC分类号： B05B7/0408 , A61B17/00491 , A61B2017/00495 , B05B7/0483 , B05C17/00516 , B05C17/00553 , B05C17/015
摘要： A tissue sealant applicator system includes a tissue sealant applicator having an elongate body forming a bore containing a tissue sealant component, a piston, and a spray adaptor in fluid communication with the bore and forming a gas flow path. The system also includes a control unit adapted to be connected to a gas source, and a first gas passageway connecting the gas flow path and the control unit. The applicator includes an actuating member cooperatively associated with the piston to eject the tissue sealant from the bore upon user actuation. The control unit is adapted to supply gas from the gas source to the first gas passageway essentially simultaneously with user actuation of the actuating member, and to permit the supply of gas to the spray adaptor from the gas source to continue to flow for a predetermined time delay after the user stops actuating the actuating member.
摘要翻译：组织密封剂施加器系统包括组织密封剂施加器，其具有细长主体，所述细长主体形成包含与所述孔流体连通并形成气体流路的组织密封剂组件，活塞和喷雾适配器的孔。该系统还包括适于连接到气源的控制单元和连接气体流路和控制单元的第一气体通路。施加器包括与活塞协作地关联的致动构件，以在用户致动时将组织密封剂从孔中排出。控制单元适于在用户致动致动构件的同时基本同时将来自气体源的气体供应到第一气体通道，并且允许从气体源向喷雾适配器供应气体以继续流动预定时间在用户停止致动致动构件之后延迟。

3. 发明授权

US08469289B2 Tissue sealant applicator system 有权
标题翻译：组织密封胶涂布系统
公开(公告)号：US08469289B2
公开(公告)日：2013-06-25
申请号：US13053201
申请日：2011-03-21
申请人： Heinz Redl , Zafar Khakpour , Scott R. Ariagno , Andreas Kellner , Lillian G. Zakarija
发明人： Heinz Redl , Zafar Khakpour , Scott R. Ariagno , Andreas Kellner , Lillian G. Zakarija
IPC分类号： A62C13/62 , A62C5/00 , B05B9/04 , B05B11/02 , F23D11/10
CPC分类号： B05B7/0408 , A61B17/00491 , A61B2017/00495 , B05B7/0483 , B05C17/00516 , B05C17/00553 , B05C17/015
摘要： A tissue sealant applicator system includes a tissue sealant applicator having an elongate body forming a bore containing a tissue sealant component, a piston, and a spray adaptor in fluid communication with the bore and forming a gas flow path. The system also includes a control unit adapted to be connected to a gas source, and a first gas passageway connecting the gas flow path and the control unit. The applicator includes an actuating member cooperatively associated with the piston to eject the tissue sealant from the bore upon user actuation. The control unit is adapted to supply gas from the gas source to the first gas passageway essentially simultaneously with user actuation of the actuating member, and to permit the supply of gas to the spray adaptor from the gas source to continue to flow for a predetermined time delay after the user stops actuating the actuating member.
摘要翻译：组织密封剂施加器系统包括组织密封剂施加器，其具有细长主体，所述细长主体形成包含与所述孔流体连通并形成气体流路的组织密封剂组件，活塞和喷雾适配器的孔。该系统还包括适于连接到气源的控制单元和连接气体流路和控制单元的第一气体通路。施加器包括与活塞协作地关联的致动构件，以在用户致动时将组织密封剂从孔中排出。控制单元适于在用户致动致动构件的同时基本同时将来自气体源的气体供应到第一气体通道，并且允许从气体源向喷雾适配器供应气体以继续流动预定时间在用户停止致动致动构件之后延迟。

4. 发明授权

US07537174B2 Hand triggered tissue sealant spray apparatus and system 有权
标题翻译：手触组织密封胶喷涂装置及系统
公开(公告)号：US07537174B2
公开(公告)日：2009-05-26
申请号：US11331243
申请日：2006-01-12
申请人： Heinz Redl , Zafar Khakpour , Scott R. Ariagno , Andreas Kellner , Lillian G. Zakarija
发明人： Heinz Redl , Zafar Khakpour , Scott R. Ariagno , Andreas Kellner , Lillian G. Zakarija
IPC分类号： A62C13/62 , A62C5/00 , B05B9/04 , B05B11/02 , F23D11/10 , B67D5/52
CPC分类号： B05B7/0408 , A61B17/00491 , A61B2017/00495 , B05B7/0483 , B05C17/00516 , B05C17/00553 , B05C17/015
摘要： The present invention is generally directed to various structures for applying a sealant to a work surface. In one aspect of the invention, a sealant applicator assembly is provided for use with an apparatus of the type having an elongated body defining an interior bore and having a piston movably positioned in the bore and a pusher member operatively associated with the piston. The assembly comprises a spray adaptor adapted to communicate with the bore of the body and defining a distal outlet. A first gas passageway is cooperatively associated with the distal outlet and configured to direct gas to create a spray discharge of the sealant. An actuating member is adapted to be cooperative associated with a pusher member to eject sealant through the distal outlet and is operative to simultaneously actuate a supply of gas to the first gas passageway for creating a spray discharge of sealant.
摘要翻译：本发明一般涉及用于向工作表面施加密封剂的各种结构。在本发明的一个方面，提供密封剂施加器组件，用于具有限定内孔的细长主体并具有可移动地定位在孔中的活塞的类型的装置，以及与活塞可操作地相关联的推动构件。组件包括适于与主体的孔连通并限定远侧出口的喷雾适配器。第一气体通道与远端出口协作地相关联并且构造成引导气体以产生密封剂的喷射排出。致动构件适于与推动器构件协作关联以通过远端出口喷射密封剂，并且可操作以同时致动向第一气体通道供应气体，以产生密封剂的喷射排放。

5. 发明申请

US20090152305A1 HAND TRIGGERED TISSUE SEALANT SPRAY APPARATUS AND SYSTEM 有权
标题翻译：手触式组织密封喷雾装置和系统
公开(公告)号：US20090152305A1
公开(公告)日：2009-06-18
申请号：US12390014
申请日：2009-02-20
申请人： Heinz Redl , Zafar Khakpour , Scott R. Ariagno , Andreas Kellner , Lillian G. Zakarija
发明人： Heinz Redl , Zafar Khakpour , Scott R. Ariagno , Andreas Kellner , Lillian G. Zakarija
IPC分类号： B67D5/42
CPC分类号： B05B7/0408 , A61B17/00491 , A61B2017/00495 , B05B7/0483 , B05C17/00516 , B05C17/00553 , B05C17/015
摘要： An applicator includes a bore for containing a sealant component, a piston moveably positioned in the bore, a plunger member connected to the piston with a distal end disposed within the bore and a proximal end depending from the bore, a distal outlet communicating with the bore and connectable to a gas source, and an actuating member carried by the proximal end of the plunger member to move with the plunger member as the plunger member moves along the bore. The applicator may be used in a system with a gas source connected to the distal outlet, and a control unit connected to the actuating member and the gas source, the control unit adapted to supply gas to the distal outlet from the gas source essentially simultaneous with a force applied to the actuating member.
摘要翻译：施加器包括用于容纳密封剂部件的孔，可移动地定位在所述孔中的活塞，连接到所述活塞的柱塞构件，其远端设置在所述孔内以及从所述孔悬垂的近端，远端与所述孔连通并且可连接到气体源，以及由柱塞构件的近端承载的致动构件，随着柱塞构件沿着孔移动，与柱塞构件一起移动。施用器可以用在具有连接到远端出口的气源的系统中，以及连接到致动构件和气源的控制单元，所述控制单元适于从气源向远端出口提供气体，基本上与施加到致动构件的力。

6. 发明申请

US20060191962A1 Hand triggered tissue sealant spray apparatus and system 有权
公开(公告)号：US20060191962A1
公开(公告)日：2006-08-31
申请号：US11331243
申请日：2006-01-12
申请人： Heinz Redl , Zafar Khakpour , Scott Ariagno , Andreas Kellner , Lillian Zakarija
发明人： Heinz Redl , Zafar Khakpour , Scott Ariagno , Andreas Kellner , Lillian Zakarija
IPC分类号： G01F11/00
CPC分类号： B05B7/0408 , A61B17/00491 , A61B2017/00495 , B05B7/0483 , B05C17/00516 , B05C17/00553 , B05C17/015
摘要： The present invention is generally directed to various structures for applying a sealant to a work surface. In one aspect of the invention, a sealant applicator assembly is provided for use with an apparatus of the type having an elongated body defining an interior bore and having a piston movably positioned in the bore and a pusher member operatively associated with the piston. The assembly comprises a spray adaptor adapted to communicate with the bore of the body and defining a distal outlet. A first gas passageway is cooperatively associated with the distal outlet and configured to direct gas to create a spray discharge of the sealant. An actuating member is adapted to be cooperative associated with a pusher member to eject sealant through the distal outlet and is operative to simultaneously actuate a supply of gas to the first gas passageway for creating a spray discharge of sealant.

7. 发明申请

US20100168779A1 TISSUE SEALING SYSTEM AND APPARATUS 有权
标题翻译：组织密封系统和装置
公开(公告)号：US20100168779A1
公开(公告)日：2010-07-01
申请号：US12650185
申请日：2009-12-30
申请人： Heinz Redl , Zafar Khakpour , Rene Fortelny
发明人： Heinz Redl , Zafar Khakpour , Rene Fortelny
IPC分类号： A61B17/03 , A61B17/34
CPC分类号： A61B17/00491 , A61B17/3474 , A61B2017/00495 , A61B2017/00522
摘要： A laparoscopic tissue sealant spray apparatus and system having a laparoscopic tissue sealant spray assembly combined with a trocar assembly, the tissue sealant spray assembly having an elongate delivery tube. A spray outlet at a distal end of the elongate delivery tube may be rounded or angled. A ring member provided at the distal end of the elongate delivery tube directs a spray cone toward a portion of a target tissue site, and the spray cone may be repositioned to a different portion of the target tissue site by rotation of the elongate delivery tube. The trocar assembly includes a vent opening that connects to a venting valve member that provides a vent path which passively opens upon operation of the tissue sealant spray assembly, avoiding excessive pressure build-up within a body cavity.
摘要翻译：一种腹腔镜组织密封剂喷雾装置和系统，其具有与套管针组件结合的腹腔镜组织密封剂喷涂组件，所述组织密封剂喷涂组件具有细长的输送管。在细长输送管的远端处的喷雾出口可以是圆形的或成角度的。设置在细长输送管的远端处的环形构件将喷雾锥体朝向目标组织部位的一部分引导，并且可以通过细长输送管的旋转将喷雾锥体重新定位到目标组织部位的不同部分。套管针组件包括连接到通气阀构件的通气口，该通气孔构件提供在组织密封剂喷涂组件的操作时被动打开的通气路径，从而避免体腔内过度的压力积聚。

8. 发明授权

US06852099B2 Device for controllably applying liquids to body surfaces 失效
标题翻译：用于可控地将液体施加到身体表面的装置
公开(公告)号：US06852099B2
公开(公告)日：2005-02-08
申请号：US10163201
申请日：2002-06-04
申请人： Heinz Redl , Zafar Khakpour
发明人： Heinz Redl , Zafar Khakpour
IPC分类号： A61B17/00 , A61B17/12 , A61M25/00 , A61M35/00 , A61M25/01
CPC分类号： A61B17/00491 , A61B2017/00022 , A61B2017/00495 , A61B2017/00544
摘要： A system and method for controllably applying the fluids to a body surface or cavity is disclosed. These fluids can include tissue adhesives, hemostats, sealants, anti-adhesives, or any other fluid capable of being applied to a body surface or cavity. In one embodiment, the system and method is used to apply components of a tissue adhesive with the aid of pressurized gas. This system comprises a tube having a proximal end and a distal end, at least one component lumen and a gas lumen which open at the distal end of the tube, a component source connected to the component lumen, a source of pressurized gas connected to the gas lumen, a sensor capable of delivering a sensor signal, a switch connected to the source of pressurized gas, and a control system programmed to switch off the pressurized gas supply when the sensor signal corresponds to a predetermined limit value.
摘要翻译：公开了一种用于将流体可控地施加到体表或腔的系统和方法。这些流体可以包括组织粘合剂，止血剂，密封剂，抗粘合剂或能够施加到体表或空腔的任何其它流体。在一个实施例中，系统和方法用于借助于加压气体来施加组织粘合剂的部件。该系统包括具有近端和远端的管，在管的远端开口的至少一个部件腔和气体腔，连接到部件内腔的部件源，连接到组件腔的加压气体源气体管腔，能够传递传感器信号的传感器，连接到加压气体源的开关，以及被编程为当传感器信号对应于预定极限值时关闭加压气体供应的控制系统。

9. 发明授权

US09179898B2 Tissue sealing system and apparatus 有权
标题翻译：组织密封系统和装置
公开(公告)号：US09179898B2
公开(公告)日：2015-11-10
申请号：US12650185
申请日：2009-12-30
申请人： Heinz Redl , Zafar Khakpour , Rene Fortelny
发明人： Heinz Redl , Zafar Khakpour , Rene Fortelny
IPC分类号： A61B17/34 , A61B17/00
CPC分类号： A61B17/00491 , A61B17/3474 , A61B2017/00495 , A61B2017/00522
摘要： A laparoscopic tissue sealant spray apparatus and system having a laparoscopic tissue sealant spray assembly combined with a trocar assembly, the tissue sealant spray assembly having an elongate delivery tube. A spray outlet at a distal end of the elongate delivery tube may be rounded or angled. A ring member provided at the distal end of the elongate delivery tube directs a spray cone toward a portion of a target tissue site, and the spray cone may be repositioned to a different portion of the target tissue site by rotation of the elongate delivery tube. The trocar assembly includes a vent opening that connects to a venting valve member that provides a vent path which passively opens upon operation of the tissue sealant spray assembly, avoiding excessive pressure build-up within a body cavity.
摘要翻译：一种腹腔镜组织密封剂喷雾装置和系统，其具有与套管针组件结合的腹腔镜组织密封剂喷涂组件，所述组织密封剂喷涂组件具有细长的输送管。在细长输送管的远端处的喷雾出口可以是圆形的或成角度的。设置在细长输送管的远端处的环形构件将喷雾锥体朝向目标组织部位的一部分引导，并且可以通过细长输送管的旋转将喷雾锥体重新定位到目标组织部位的不同部分。套管针组件包括连接到通气阀构件的通气口，该通气孔构件提供在组织密封剂喷涂组件的操作时被动打开的通气路径，从而避免体腔内过度的压力积聚。

10. 发明申请

US20120316113A1 FGF BASED FIBRIN BINDING PEPTIDES 审中-公开
标题翻译：基于FGF的FIBRIN结合肽
公开(公告)号：US20120316113A1
公开(公告)日：2012-12-13
申请号：US13462624
申请日：2012-05-02
申请人： Heinz Redl , Tatjana Morton
发明人： Heinz Redl , Tatjana Morton
IPC分类号： A61K38/18 , C07K7/08 , A61P43/00 , C07K14/50
CPC分类号： C07K14/503 , A61K38/1825 , C07K2319/21 , C07K2319/23 , C07K2319/50
摘要： The present invention relates to a polypeptide fragments of Fibroblast Growth Factor 2, wherein said fragments are adapted to bind to fibrinogen or to fibrin and/or increase cell proliferation, differentiation or migration. These fragments are suitable for promoting wound healing and/or hemostasis.
摘要翻译：本发明涉及成纤维细胞生长因子2的多肽片段，其中所述片段适于结合纤维蛋白原或纤维蛋白和/或增加细胞增殖，分化或迁移。这些片段适用于促进伤口愈合和/或止血。

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