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    • 10. 发明授权
    • 2-substituted-1α,25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
    • 2-取代-1α,25-二羟基-19,26,27-三核维生素D类似物及其用途
    • US08404666B2
    • 2013-03-26
    • US11697434
    • 2007-04-06
    • Hector F. DeLucaLori A. PlumMargaret Clagett-DamePawel Grzywacz
    • Hector F. DeLucaLori A. PlumMargaret Clagett-DamePawel Grzywacz
    • A61K31/59C07C401/00
    • C07C401/00Y02P20/55
    • Compounds of formula I, II or III are provided where X1, X2 and X3 are independently selected from H and hydroxy protecting groups and R1 and R2 are independently selected from H or straight or branched chain alkyl groups having from 1 to 8 carbon atoms, straight or branched chain alkenyl groups having from 2 to 8 carbon atoms, straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms, or straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms; and R3 is independently selected from straight or branched chain alkyl groups having from 1 to 8 carbon atoms, straight or branched chain alkenyl groups having from 2 to 8 carbon atoms, straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms, or straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
    • 提供式I,II或III的化合物,其中X 1,X 2和X 3独立地选自H和羟基保护基,R 1和R 2独立地选自H或具有1至8个碳原子的直链或支链烷基,直链 或具有2至8个碳原子的支链烯基,具有1至8个碳原子的直链或支链羟基取代的烷基,或具有2至8个碳原子的直链和支链羟基取代的烯基; 并且R 3独立地选自具有1至8个碳原子的直链或支链烷基,具有2至8个碳原子的直链或支链烯基,具有1至8个碳原子的直链或支链羟基取代的烷基 或具有2至8个碳原子的直链和支链羟基取代的烯基。 这些化合物用于制备药物组合物,并且可用于治疗各种生物学条件。