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1. 发明授权

US09265824B2 Pharmaceutical product comprising mite allergen extract(s) and a method for the manufacture thereof 有权
标题翻译：包含螨变应原提取物的药物制品及其制造方法
公开(公告)号：US09265824B2
公开(公告)日：2016-02-23
申请号：US13701614
申请日：2011-06-03
申请人： Heather Michelle Webster , Jason Daniel Frey , Trena Larissa Repp , Craig T. Grass , David Rowles , Gary Steven Smith , Domingo Barber Hernandez , Fernando Juan Vidales , Carmen Arteaga Vazquez , Juan Carlos Moreno Segura , Maria Jose Chamorro Salillas
发明人： Heather Michelle Webster , Jason Daniel Frey , Trena Larissa Repp , Craig T. Grass , David Rowles , Gary Steven Smith , Domingo Barber Hernandez , Fernando Juan Vidales , Carmen Arteaga Vazquez , Juan Carlos Moreno Segura , Maria Jose Chamorro Salillas
IPC分类号： A23J1/00 , A61K35/12 , A61K35/64 , A61K39/35 , A61K39/36 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K9/00 , A61K9/20 , A61K35/646
CPC分类号： A61K39/35 , A61K9/0056 , A61K9/20 , A61K9/2063 , A61K9/2095 , A61K35/646 , A61K2039/515 , A61K2039/54
摘要： The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and/or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) An extract of Der p mite bodies, and b) An extract of Der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) An extract of Der p faecal particles, d) An extract of Der f faecal particles, e) An extract of Der f whole mite culture, f) An extract of an Der p whole mite culture, and g) a combination of extracts c) to f).
摘要翻译：本发明涉及一种包含变应原提取物或其变态反应蛋白的药物，用于治疗和/或预防由房尘螨引起的过敏和过敏性哮喘，该提取物包含至少一种选自以下组的螨体提取物：a） -b）：a）Der p mite体的提取物，和b）Der f mite体的提取物和至少一种选自以下组的螨培养物提取物：c）-g）：c）Der的提取物 p粪便颗粒，d）粪便颗粒的提取物，e）Der f全螨培养物的提取物，f）Der p全螨培养物的提取物，以及g）提取物c）至f）的组合。

2. 发明申请

US20130280302A1 PHARMACEUTICAL PRODUCT COMPRISING MITE ALLERGEN EXTRACT(S) AND A METHOD FOR THE MANUFACTURE THEREOF 有权
标题翻译：包含螨提取物的药物制品及其制造方法
公开(公告)号：US20130280302A1
公开(公告)日：2013-10-24
申请号：US13701614
申请日：2011-06-03
申请人： Heather Michelle Webster , Jason Daniel Frey , Trena Larissa Repp , Craig T. Grass , David Rowles , Gary Steven Smith , Domingo Barber Hernandez , Fernando Juan Vidales , Carmen Artega Vazquez , Juan Carlos Moreno Segura , Maria Jose Chamorro Salillas
发明人： Heather Michelle Webster , Jason Daniel Frey , Trena Larissa Repp , Craig T. Grass , David Rowles , Gary Steven Smith , Domingo Barber Hernandez , Fernando Juan Vidales , Carmen Artega Vazquez , Juan Carlos Moreno Segura , Maria Jose Chamorro Salillas
IPC分类号： A61K39/35
CPC分类号： A61K39/35 , A61K9/0056 , A61K9/20 , A61K9/2063 , A61K9/2095 , A61K35/646 , A61K2039/515 , A61K2039/54
摘要： The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and/or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) An extract of Der p mite bodies, and b) An extract of Der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) An extract of Der p faecal particles, d) An extract of Der f faecal particles, e) An extract of Der f whole mite culture, f) An extract of an Der p whole mite culture, and g) a combination of extracts c) to f).
摘要翻译：本发明涉及一种包含变应原提取物或其变态反应蛋白的药物，用于治疗和/或预防由房尘螨引起的过敏和过敏性哮喘，该提取物包含至少一种选自以下组的螨体提取物：a） -b）：a）Der p mite体的提取物，和b）Der f mite体的提取物和至少一种选自以下组的螨培养物提取物：c）-g）：c）Der的提取物 p粪便颗粒，d）粪便颗粒的提取物，e）Der f全螨培养物的提取物，f）Der p全螨培养物的提取物，和g）提取物c）至f）的组合。

3. 发明授权

US09259464B2 Pharmaceutical product comprising mite allergen extract(s) and a method for the manufacture thereof 有权
公开(公告)号：US09259464B2
公开(公告)日：2016-02-16
申请号：US13314024
申请日：2011-12-07
申请人： Heather M. Webster , Jason Daniel Frey , Trena L. Repp , Craig T. Grass , David Rowles , Gary Smith , Domingo Barber Hernandez , Fernando Juan Vidales , Carmen Arteaga Vazquez , Juan Carlos Moreno Segura , Maria Jose Chamorro Salillas
发明人： Heather M. Webster , Jason Daniel Frey , Trena L. Repp , Craig T. Grass , David Rowles , Gary Smith , Domingo Barber Hernandez , Fernando Juan Vidales , Carmen Arteaga Vazquez , Juan Carlos Moreno Segura , Maria Jose Chamorro Salillas
IPC分类号： A23J1/00 , A61K35/12 , A61K35/64 , A61K39/35 , A61K39/36 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K9/00 , A61K9/20 , A61K35/646
CPC分类号： A61K39/35 , A61K9/0056 , A61K9/20 , A61K9/2063 , A61K9/2095 , A61K35/646 , A61K2039/515 , A61K2039/54
摘要： The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and/or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) An extract of Der p mite bodies, and b) An extract of Der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) An extract of Der p faecal particles, d) An extract of Der f faecal particles, e) An extract of Der f whole mite culture, f) An extract of an Der p whole mite culture, and g) a combination of extracts c) to f).

4. 发明申请

US20120076825A1 PHARMACEUTICAL PRODUCT COMPRISING MITE ALLERGEN EXTRACT(S) AND A METHOD FOR THE MANUFACTURE THEREOF 有权
标题翻译：包含螨提取物的药物制品及其制造方法
公开(公告)号：US20120076825A1
公开(公告)日：2012-03-29
申请号：US13314024
申请日：2011-12-07
申请人： Heather Michelle Webster , Jason Daniel Frey , Trena Larissa Repp , Craig T. Grass , David Rowles , Gary Smith , Domingo Barber Hernandez , Fernando Juan Vidales , Carmen Arteaga Vázquez , Juan Carlos Moreno Segura , Maria José Chamorro Salillas
发明人： Heather Michelle Webster , Jason Daniel Frey , Trena Larissa Repp , Craig T. Grass , David Rowles , Gary Smith , Domingo Barber Hernandez , Fernando Juan Vidales , Carmen Arteaga Vázquez , Juan Carlos Moreno Segura , Maria José Chamorro Salillas
IPC分类号： A61K39/35 , A61P11/06 , A61P37/08
CPC分类号： A61K39/35 , A61K9/0056 , A61K9/20 , A61K9/2063 , A61K9/2095 , A61K35/646 , A61K2039/515 , A61K2039/54
摘要： The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and/or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) An extract of Der p mite bodies, and b) An extract of Der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) An extract of Der p faecal particles, d) An extract of Der f faecal particles, e) An extract of Der f whole mite culture, f) An extract of an Der p whole mite culture, and g) a combination of extracts c) to f).
摘要翻译：本发明涉及一种包含变应原提取物或其变态反应蛋白的药物，用于治疗和/或预防由房尘螨引起的过敏和过敏性哮喘，该提取物包含至少一种选自以下组的螨体提取物：a） -b）：a）Der p mite体的提取物，和b）Der f mite体的提取物和至少一种选自以下组的螨培养物提取物：c）-g）：c）Der的提取物 p粪便颗粒，d）粪便颗粒的提取物，e）Der f全螨培养物的提取物，f）Der p全螨培养物的提取物，和g）提取物c）至f）的组合。

5. 发明申请

US20090297564A1 Use of a Liquid Allergy Vaccine Formulation for Oromucosal Administration 审中-公开
标题翻译：使用液体过敏疫苗配方用于青光眼管理
公开(公告)号：US20090297564A1
公开(公告)日：2009-12-03
申请号：US12084458
申请日：2006-11-03
申请人： Domingo Barber Hernandez , Fernando de la Torre Martínez , Pilar Rico Nieto
发明人： Domingo Barber Hernandez , Fernando de la Torre Martínez , Pilar Rico Nieto
IPC分类号： A61K39/35 , A61K39/36
CPC分类号： A61K39/35 , A61K39/36 , A61K2039/542 , A61K2039/545
摘要： The present invention relates to the use of an allergen for the manufacture of a liquid vaccine formulation for preventing or treating allergy in a subject by oromucosal administration in a dosage regimen comprising no up-dosing.
摘要翻译：本发明涉及变应原用于制备液体疫苗制剂的用途，所述液体疫苗制剂用于通过包括无剂量给药的剂量方案通过管粘膜给药预防或治疗受试者的过敏。

6. 发明申请

US20100240098A1 PROCESS FOR PRODUCING MATURE RECOMBINANT MITE GROUP I ALLERGEN 审中-公开
标题翻译：生产成熟重组蛭石组I过氧化物的方法
公开(公告)号：US20100240098A1
公开(公告)日：2010-09-23
申请号：US12681882
申请日：2008-10-07
申请人： Rafael Ignacio Monsalve Clemente , Domingo Barber Hernandez
发明人： Rafael Ignacio Monsalve Clemente , Domingo Barber Hernandez
IPC分类号： C12N15/09
CPC分类号： C07K14/43531
摘要： The present invention relates to a process for producing mature recombinant Mite Group I allergen comprising the steps of a) providing an allergen expression system in the form of a host cell selected from the group of yeasts containing a vector comprising cDNA encoding pro-allergen, b) cultivating the allergen expression system at a cultivation pH of between 5.5 and 7.5 for a cultivation period to express pro-allergen to obtain a cultivation mixture containing pro-allergen, c) adjusting the pH of the cultivation mixture to a maturation pH of between 3.5 and 5.0, d) maintaining the cultivation mixture at the maturation pH for a maturation period to convert the pro-allergen into mature allergen to obtain a product mixture, and e) subjecting the product mixture to a purification method to isolate mature allergen from the product mixture.
摘要翻译：本发明涉及一种生产成熟重组螨I组变应原的方法，包括以下步骤：a）提供宿主细胞形式的变应原表达系统，所述宿主细胞选自含有编码前变应原的cDNA的载体的酵母组，b ）培养变性体表达系统，培养pH为5.5至7.5，培养期间表达前变应原以获得含有前变应原的培养混合物，c）将培养混合物的pH调节至3.5的熟化pH 和5.0，d）将培养混合物保持在成熟pH下成熟期以将前变应原转化成成熟变应原以获得产物混合物，和e）使产物混合物经过纯化方法从产物中分离成熟变应原混合物。

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