专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100222751A2 Transdermal Drug Delivery Patch 失效
标题翻译：透皮给药补片
公开(公告)号：US20100222751A2
公开(公告)日：2010-09-02
申请号：US12564808
申请日：2009-09-22
申请人： Hashem Heiati , Ludwig Weimann
发明人： Hashem Heiati , Ludwig Weimann
IPC分类号： A61K9/70 , A61F13/02 , A61M35/00
CPC分类号： A61K9/703 , A61K9/7084 , A61K9/7092 , A61M2025/0056 , A61M2025/0073
摘要： A transdermal drug delivery device is shown and described. The device includes an occlusive or non-occlusive backing, an adhesive, at least one drug delivery region, an adhesive, and a release liner. The device has an open configuration and a closed configuration. When the device is in the closed configuration, the adhesive, the at least one drug delivery region, and the release liner are disposed between first and second portions of the backing.
摘要翻译：显示和描述透皮药物递送装置。该装置包括闭塞性或非闭塞性背衬，粘合剂，至少一种药物递送区域，粘合剂和释放衬垫。该设备具有打开的配置和关闭的配置。当装置处于关闭构型时，将粘合剂，至少一种药物递送区域和释放衬垫设置在背衬的第一和第二部分之间。

2. 发明申请

US20100221313A1 TRANSDERMAL RESERVOIR PATCH 审中-公开
标题翻译：传感器储存器
公开(公告)号：US20100221313A1
公开(公告)日：2010-09-02
申请号：US12627924
申请日：2009-11-30
申请人： David J. Smith , Ludwig Weimann , Ollen Williams, Jr., III , Katherine Mary Evans , Mark John Badria
发明人： David J. Smith , Ludwig Weimann , Ollen Williams, Jr., III , Katherine Mary Evans , Mark John Badria
IPC分类号： A61F13/02 , A61K31/445 , B32B37/02 , B32B38/10 , B32B38/04
CPC分类号： A61K31/4468 , A61K9/7084 , B32B37/025 , B32B38/0004 , B32B2307/724 , B32B2309/105 , B32B2556/00 , Y10T156/10 , Y10T156/1052
摘要： A transdermal reservoir patch includes a first adhesive layer, a second adhesive layer and an occlusive backing layer configured to inhibit transport of a pharmaceutical agent from the first adhesive layer to the second adhesive layer. Methods of manufacturing the transdermal reservoir patch are disclosed.
摘要翻译：透皮储存器贴片包括第一粘合剂层，第二粘合剂层和闭塞背衬层，其被配置为抑制药剂从第一粘合剂层转运到第二粘合剂层。公开了制造透皮储存器贴片的方法。

3. 发明申请

US20070248657A1 Multi-compartment transdermal pain control device 审中-公开
标题翻译：多室经皮疼痛控制装置
公开(公告)号：US20070248657A1
公开(公告)日：2007-10-25
申请号：US11410745
申请日：2006-04-25
申请人： David Smith , Mark Badria , Ollen Williams , Ludwig Weimann
发明人： David Smith , Mark Badria , Ollen Williams , Ludwig Weimann
IPC分类号： A61K31/485 , A61K31/445 , A61K9/70
CPC分类号： A61K9/7092 , A61K9/7084 , A61K31/445 , A61K31/485 , A61K45/06
摘要： Multi-compartment patches containing skin-permeable forms of pharmaceutically effective amounts of an opioid agonist, an NMDA receptor antagonist and an anti-inflammatory are useful for the transdermal delivery of the active ingredients to alleviate pain.
摘要翻译：含有皮肤可渗透形式的药物有效量的阿片样物质激动剂，NMDA受体拮抗剂和抗炎剂的多隔层补片可用于透皮递送活性成分以缓解疼痛。

4. 发明申请

US20070202155A1 Low dose no donor-containing transdermal patch 审中-公开
标题翻译：低剂量无供体透皮贴剂
公开(公告)号：US20070202155A1
公开(公告)日：2007-08-30
申请号：US11701964
申请日：2007-02-01
申请人： Robert Ang , Ludwig Weimann , Sven Jacobson
发明人： Robert Ang , Ludwig Weimann , Sven Jacobson
IPC分类号： A61K9/70 , A61K31/21
CPC分类号： A61K9/7061 , A61K31/21 , A61K47/10
摘要： The present invention is drawn to a transdermal patch for the delivery of a nitroglycerin or other NO donor. The patch can comprise a backing layer, and a nitroglycerin-containing composition or other NO donor-containing composition which is supported at least in part by the backing layer. The transdermal patch can have a drug delivery zone defined by the area where the composition contacts an intact human skin site, and the transdermal patch can be formulated to deliver a nitric oxide donor, such as nitroglycerin, at from about 5 μg/hour to about 70 μg/hour. In one embodiment, the transdermal patch can provide a delivery rate at the drug delivery zone of from about 1 μg/cm2/day to about 600 μg/cm2/day. In another embodiment, the transdermal patch can contain from 6 wt % to 18 wt % of the nitric oxide donor, e.g., nitroglycerin. In each embodiment, the patch can contain at least 450 μg/cm2 of nitroglycerin.
摘要翻译：本发明涉及用于递送硝酸甘油或其他NO供体的透皮贴片。贴片可以包含背衬层和含硝酸甘油的组合物或其它含NO供体的组合物，其至少部分由背衬层支撑。透皮贴剂可以具有由组合物接触完整的人皮肤部位的区域限定的药物递送区，并且透皮贴剂可以配制成以约5mug /小时至约约5ug /小时递送一氧化氮供体，例如硝酸甘油 70杯/小时。在一个实施方案中，透皮贴剂可以在药物递送区域提供约1mug / cm 2 /天至约600mug / cm 2 /天的输送速率。在另一个实施方案中，透皮贴剂可含有6重量％至18重量％的一氧化氮供体，例如硝酸甘油。在每个实施方案中，贴片可以含有至少450杯/平方厘米的硝酸甘油。

5. 发明申请

US20070053966A1 Medicated orthopedic support structures for treatment of damaged musculoskeletal tissue 审中-公开
标题翻译：用于治疗损伤的肌肉骨骼组织的药物矫形支架结构
公开(公告)号：US20070053966A1
公开(公告)日：2007-03-08
申请号：US11511861
申请日：2006-08-28
申请人： Robert Ang , Ludwig Weimann , Anthony Murrell
发明人： Robert Ang , Ludwig Weimann , Anthony Murrell
IPC分类号： A61K9/70 , A61K31/21
CPC分类号： A61K9/7061 , A61K31/21
摘要： A system and method for treating damaged musculoskeletal tissue includes an orthopedic support structure and a nitroglycerin-containing composition. The orthopedic support structure provides mechanical support to the damaged tissue and maintains the nitroglycerin-containing composition in contact with the skin of a subject wearing using the system. The nitroglycerin-containing composition can be integrated into the orthopedic support structure or the support structure can be configured to contain removable doses of the nitroglycerin-containing composition. The system and method provides relief of pain and improved function of the musculoskeletal tissue.
摘要翻译：用于治疗损伤的肌肉骨骼组织的系统和方法包括矫形支撑结构和含硝酸甘油的组合物。矫形支撑结构为受损组织提供机械支撑，并使含硝酸甘油的组合物与使用该系统的受试者的皮肤接触。含硝酸甘油的组合物可以整合到整形外科支持结构中，或者支持结构可被配置成含有可除去剂量的含硝酸甘油的组合物。该系统和方法提供减轻疼痛和改善肌肉骨骼组织的功能。

6. 发明申请

US20060286158A1 Treatment of overuse tendinopathy using transdermal nitric oxide-generating agents 审中-公开
标题翻译：使用透皮一氧化氮发生剂治疗过度使用性腱鞘炎
公开(公告)号：US20060286158A1
公开(公告)日：2006-12-21
申请号：US11366204
申请日：2006-03-01
申请人： George Calvert Murrell , Robert Ang , Ludwig Weimann , Sven Jacobson
发明人： George Calvert Murrell , Robert Ang , Ludwig Weimann , Sven Jacobson
IPC分类号： A61K31/21 , A61K9/70
CPC分类号： A61K9/7023 , A61K31/21
摘要： The present invention provides methods for treating tendinopathy in the absence of inflammation by the transdermal administration of nitroglycerin. Such methods include methods for relieving pain associated with such tendinopathies, and the use of a transdermal patch configured to deliver glyceryl trinitrate at a rate of 5 mcg/hr to about 85 mcg/hr.
摘要翻译：本发明提供通过透皮给药硝酸甘油来治疗不存在炎症的腱鞘炎的方法。这样的方法包括减轻与这种腱病相关的疼痛的方法，以及使用经皮贴片，其配置为以5mcg / hr至约85mcg / hr的速率递送三硝酸甘油酯。

7. 发明申请

US20060034904A1 Transdermal delivery using emcapsulated agent activated by ultrasound and or heat 审中-公开
标题翻译：使用通过超声和/或热激活的封装剂进行透皮递送
公开(公告)号：US20060034904A1
公开(公告)日：2006-02-16
申请号：US10541001
申请日：2003-12-31
申请人： Ludwig Weimann
发明人： Ludwig Weimann
IPC分类号： A61N1/30 , A61K9/70
CPC分类号： A61K9/0009 , A61K9/0014 , A61K9/7084 , A61K9/7092 , A61M37/00 , A61M37/0092 , A61N1/30
摘要： A method for delivery of substance through at least one dermal layer, by providing a substance in microcapsules at a predetermined size, within a medium (150) for holding the microcapsules; placing the medium for holding the microcapsules on a surface of a patch (100) adjacent the skin (320) of a human or animal; and applying energy (200) to the patch, the energy having a characteristic of disturbing the integrity of the microcapsules, thereby resulting in release of the substance from the microcapsules. The energy may be selectively applied to release the substance at desired times. The substance may be a drug or other active agent.
摘要翻译：通过在用于保持微胶囊的介质（150）内通过在预定尺寸的微胶囊中提供物质来输送物质通过至少一个真皮层的方法; 将用于保持微胶囊的介质放置在与人或动物的皮肤（320）相邻的贴片（100）的表面上; 并且将能量（200）施加到贴剂上，该能量具有干扰微胶囊完整性的特征，从而导致物质从微胶囊中释放出来。可以选择性地施加能量以在期望的时间释放物质。该物质可以是药物或其它活性剂。

8. 发明授权

US06842641B2 Method and apparatus for in-vivo transdermal and/or intradermal delivery of drugs by sonoporation 有权
标题翻译：用于通过超音波进行药物体内透皮和/或皮内递送的方法和装置
公开(公告)号：US06842641B2
公开(公告)日：2005-01-11
申请号：US10303283
申请日：2002-11-25
申请人： Ludwig Weimann , Richard Childs
发明人： Ludwig Weimann , Richard Childs
IPC分类号： A61B17/20 , A61M37/00 , A61N1/30
CPC分类号： A61M37/0092 , A61B17/205 , A61M2037/0007
摘要： An apparatus for performing in-vivo sonoporation of a skin area and transdermal and/or intradermal delivery of a drug solution includes a container having an end adjacent the skin area and containing the drug solution. The container further includes an ultrasound horn having a tip submerged in the drug solution for applying ultrasound radiation to the drug solution. The ultrasound radiation has a frequency in the range of 15 KHz and 1 MHz and is applied at an intensity, for a period of time and at a distance from said skin area effective to generate cavitation bubbles. The cavitation bubbles collapse and transfer their energy into the skin area, thus causing the formation of pores in the skin area. The ultrasound radiation intensity and distance from the skin area are also effective in generating ultrasonic jets, which ultrasonic jets then drive the drug solution through the end adjacent the skin area and the formed pores into the skin.
摘要翻译：用于进行皮肤区域的体内超声和药物溶液的透皮和/或皮内递送的装置包括具有与皮肤区域相邻的端部并且容纳药物溶液的容器。容器还包括具有浸没在药液中的尖端的超声波喇叭，用于向药物溶液施加超声辐射。超声波辐射具有在15KHz和1MHz范围内的频率，并且以与产生空化气泡有效的一段时间和距离所述皮肤区域的强度一起施加。空化气泡塌陷并将能量转移到皮肤区域，从而导致皮肤区域形成毛孔。超声波辐射强度和与皮肤区域的距离在产生超声波射流方面也是有效的，超声波射流然后将药液通过邻近皮肤区域的端部和形成的孔驱动到皮肤中。

9. 发明授权

US06487447B1 Method and apparatus for in-vivo transdermal and/or intradermal delivery of drugs by sonoporation 有权
标题翻译：用于通过超音波进行药物体内透皮和/或皮内递送的方法和装置
公开(公告)号：US06487447B1
公开(公告)日：2002-11-26
申请号：US09690604
申请日：2000-10-17
申请人： Ludwig Weimann , Richard Childs
发明人： Ludwig Weimann , Richard Childs
IPC分类号： A61N130
CPC分类号： A61M37/0092 , A61B17/205 , A61M2037/0007
摘要： An apparatus for performing in-vivo sonoporation of a skin area and transdermal and/or intradermal delivery of a drug solution includes a container having an end covered with a porous membrane and containing the drug solution and an ultrasound horn having a tip submerged in the drug solution. The ultrasound horn applies ultrasound radiation to the drug solution. The ultrasound radiation has a frequency in the range of 15 KHz and 1 MHz and is applied at an intensity, for a period of time and at a distance from said skin area effective to generate cavitation bubbles. The cavitation bubbles collapse and transfer their energy into the skin area thus causing the formation of pores in the skin area. The ultrasound radiation intensity and distance from the skin area are also effective in generating ultrasonic jets, which ultrasonic jets then drive the drug solution through the porous membrane and the formed pores into the skin.
摘要翻译：用于进行皮肤区域的体内超声检查和药物溶液的透皮和/或皮内递送的装置包括具有覆盖有多孔膜并且包含药物溶液的端部的容器和具有浸没在药物中的尖端的超声波喇叭解。超声波喇叭将超声辐射应用于药物溶液。超声波辐射具有在15KHz和1MHz范围内的频率，并且以与产生空化气泡有效的一段时间和距离所述皮肤区域的强度一起施加。气蚀泡沫破裂并将其能量转移到皮肤区域，从而导致皮肤区域中形成毛孔。超声波辐射强度和距离皮肤区域的距离在产生超声波射流方面也是有效的，超声波射流然后将药物溶液通过多孔膜和形成的孔驱动到皮肤中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式