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1. 发明授权

US4578400A Therapeutic composition and method for treatment of cardiovascular diseases 失效
标题翻译：用于治疗心血管疾病的治疗组合物和方法
公开(公告)号：US4578400A
公开(公告)日：1986-03-25
申请号：US680593
申请日：1984-12-11
申请人： Haruo Ohnishi , Kazuo Yamaguchi , Yasuo Suzuki , Nobuo Mochida
发明人： Haruo Ohnishi , Kazuo Yamaguchi , Yasuo Suzuki , Nobuo Mochida
IPC分类号： A61K31/325 , A61K31/20 , A61K31/23 , A61K31/335 , A61K31/365 , A61K31/366 , A61P3/06 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , C07C59/01 , C07D309/30 , C07D315/00 , A61K31/35
CPC分类号： C07D315/00 , C07C59/01
摘要： A therapeutic agent for the treatment of cardiovascular diseases which contains as the effective component at least one compound selected from the group consisting of 5-hydroxydecanoic acid, a salt thereof, an ester thereof and .delta.-decalactone, which is a lactone of 5-hydroxydecanoic acid.
摘要翻译：一种用于治疗心血管疾病的治疗剂，其包含作为有效成分的至少一种选自5-羟基癸酸，其盐，其酯和δ-癸内酯的化合物，其为5-羟基癸酸的内酯酸。

2. 发明授权

US4481137A Glycoproteins and processes for their production 失效
标题翻译：糖蛋白及其生产工艺
公开(公告)号：US4481137A
公开(公告)日：1984-11-06
申请号：US467840
申请日：1983-02-18
申请人： Haruo Ohnishi , Kazuo Yamaguchi , Yasuo Suzuki , Ei Mochida , Nobuo Mochida
发明人： Haruo Ohnishi , Kazuo Yamaguchi , Yasuo Suzuki , Ei Mochida , Nobuo Mochida
IPC分类号： A61K38/00 , C07K14/47 , C07K14/52 , C12P21/00 , C07G7/00
CPC分类号： C07K14/47 , C07K14/52 , A61K38/00 , Y10S514/908 , Y10S530/806 , Y10S530/809 , Y10S530/828 , Y10S530/829
摘要： A glycoprotein obtained from the cells of human or non-human warm-blooded animals having an anti-tumor effect and characterized by the following properties:(a) molecular weight: in the range from 7,000 to 90,000 by Sephadex gel filtration or SDS gel electrophoresis;(b) color reactions: it exhibits a color indicating proteins in the Lowry reaction, exhibits a color indicating peptide bonds and amino acids in the ninhydrin reaction after hydrolysis with hydrochloric acid, and exhibits a color indicating sugars in the phenol-sulfuric acid reaction, the anthrone-sulfuric acid reaction, the indole-sulfuric acid reaction and the tryptophane-sulfuric acid reaction;(c) appearance and solubility: white powder soluble in water, aqueous sodium chloride and phosphate buffer, and sparingly soluble in benzene, hexane and chloroform;(d) sugar content: sugar content is 8-45%, 6-28% of the total sugar being hexoses, 1-11% being hexosamines and 1-6% being sialic acids;(e) stability: stable in an aqueous solution of pH 2.0, pH 7.0 or pH 11.0 at 4.degree. C. for 24 hours or longer and in an aqueous solution of pH 7.0 at 60.degree. C. for 3 hours or longer; and(f) cytotoxicity: it selectively damages tumor cells without substantially damaging normal cells.
摘要翻译：从具有抗肿瘤作用的人或非人温血动物的细胞获得的糖蛋白，其特征在于以下性质：（a）分子量：通过Sephadex凝胶过滤或SDS凝胶电泳在7,000至90,000的范围内 ; （b）显色反应：在Lowry反应中表现出表示蛋白质的颜色，在用盐酸水解后，在茚三酮反应中表现出表示肽键和氨基酸的颜色，并表现出苯酚 - 硫酸反应中的糖的颜色，蒽酮 - 硫酸反应，吲哚 - 硫酸反应和色氨酸 - 硫酸反应; （c）外观和溶解性：白色粉末溶于水，氯化钠水溶液和磷酸盐缓冲液，微溶于苯，己烷和氯仿; （d）糖含量：糖含量为8-45％，总糖的6-28％为己糖，1-11％为己糖胺，1-6％为唾液酸; （e）稳定性：在pH2.0，pH7.0或pH11.0的水溶液中在4℃下稳定24小时以上，在pH7.0的水溶液中在60℃下稳定3小时以上; 和（f）细胞毒性：它选择性地损伤肿瘤细胞，而不会对正常细胞造成实质的损害。

3. 发明授权

US4379136A Solid stick of powder for cosmetic and toilet use and a method for preparing thereof 失效
标题翻译：化妆品和马桶用粉末的固体棒及其制备方法
公开(公告)号：US4379136A
公开(公告)日：1983-04-05
申请号：US967085
申请日：1978-12-06
申请人： Nobuo Mochida
发明人： Nobuo Mochida
IPC分类号： A61K8/02 , A61K8/00 , A61K8/81 , A61Q1/00 , A61Q1/12 , A61K7/32 , A61K31/745
CPC分类号： A61Q1/12 , A61K8/8111 , A61K2800/872 , Y10S424/05 , Y10S514/953
摘要： A solid stick of powder for cosmetic and toilet use prepared by compressing at an impact pressure of about 4.0 to 8.0 kg/cm.sup.2 a pulverulent blend of raw materials of powders and binding aids. Said stick can be applied to skin directly and has excellent properties of adhesion and feel.
摘要翻译：通过在约4.0至8.0kg / cm 2的冲击压力下压制粉末和粘合剂原料的粉末混合物制备的用于化妆品和厕所使用的固体粉末粉末。所述棒可以直接应用于皮肤，并且具有优异的粘附性和感觉性。

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