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    • 1. 发明授权
    • Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract
    • 消毒道下部可释放的涂层胶囊形式的药物制剂
    • US06309666B1
    • 2001-10-30
    • US08680753
    • 1996-07-15
    • Harumi HatanoTakahiro ItoTakashi IshibashiHiroyuki YoshinoMasakazu Mizobe
    • Harumi HatanoTakahiro ItoTakashi IshibashiHiroyuki YoshinoMasakazu Mizobe
    • A61K952
    • A61K9/4891
    • A pharmaceutical preparation in the form of a coated capsule which can release contents of a capsule at a lower part of the digestive tract comprising (a) a hard capsule containing at least an acidic substance, (b) a polymer film soluble at low pH which is formed on a surface of said hard capsule, and (c) an enteric coating film which is formed on a surface of said polymer film soluble at low pH. According to the pharmaceutical preparation of the present invention, any kind of a medicament can be delivered to any desired site between the upper part of the small intestine and the lower part of the large intestine in the digestive tract by controlling the amount of polymer(s) used for the polymer film soluble at low pH and/or by selecting the kind of the polymer film soluble at low pH and/or the acidic substance without any complicated requirements for each medicament.
    • 一种涂层胶囊形式的药物制剂,其能够释放消化道下部的胶囊内含物,其包含(a)含有至少一种酸性物质的硬胶囊,(b)在低pH下可溶的聚合物膜, 形成在所述硬胶囊的表面上,和(c)形成在所述聚合物膜的表面上的可溶于低pH的肠溶衣膜。 根据本发明的药物制剂,通过控制聚合物的量(s),可以将任何种类的药物递送到消化道的小肠上部和大肠的下部之间的任意位置 )和/或通过选择在低pH下可溶解的聚合物膜的种类和/或酸性物质,而对每种药物没有任何复杂的要求。