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1. 发明授权

US08137425B2 Intake system for vehicle internal combustion engine 有权
标题翻译：汽车内燃机进气系统
公开(公告)号：US08137425B2
公开(公告)日：2012-03-20
申请号：US12524621
申请日：2008-01-29
申请人： Haruhiko Saito , Tatsuya Oyama
发明人： Haruhiko Saito , Tatsuya Oyama
IPC分类号： B01D46/00
CPC分类号： F02M35/10321 , F02B27/005 , F02M35/02 , F02M35/10013 , F02M35/108 , F02M35/161 , Y02T10/146
摘要： An intake system (10, 20) for a vehicle internal combustion engine is provided in which a first air intake duct (16), having an air intake inlet (16a) to inhale external air, is connected to an air cleaner box (14). A second air intake duct (17, 27) is also connected to the air cleaner box. The air intake inlet is closer to the air cleaner box than the second air intake duct is. The cross section area of a second air intake duct is greater than the cross section area of the first air intake duct. The center axis of the second air intake duct at an end on the side of a second air intake opening (12, 22) intersects with the center axis of the first air intake duct at an end on the side of a first air intake opening (11).
摘要翻译：提供了一种用于车辆内燃机的进气系统（10,20），其中具有吸入外部空气的进气口（16a）的第一进气管道（16）连接到空气滤清器箱（14）。第二进气管道（17,27）也连接到空气滤清器箱。进气口比第二进气管更靠近空气滤清器箱。第二进气管道的横截面面积大于第一进气管道的横截面面积。在第二进气口（12,22）侧的端部处的第二进气管道的中心轴线与第一进气口侧的端部处的第一进气管道的中心轴线相交 11）。

2. 发明授权

US07758678B2 Fuel adsorption filter and air cleaner 有权
标题翻译：燃油吸附过滤器和空气净化器
公开(公告)号：US07758678B2
公开(公告)日：2010-07-20
申请号：US12103896
申请日：2008-04-16
申请人： Tomohiro Yoshida , Tatsuya Oyama , Haruhiko Saito , Tohru Ohba , Shinichi Kamiya , Masaki Aihara , Yoichi Ishihara
发明人： Tomohiro Yoshida , Tatsuya Oyama , Haruhiko Saito , Tohru Ohba , Shinichi Kamiya , Masaki Aihara , Yoichi Ishihara
IPC分类号： B01D53/02
CPC分类号： B01D53/0407 , B01D46/0036 , B01D46/10 , B01D2253/102 , B01D2259/4516 , F02M25/08 , F02M33/04 , F02M35/02 , F02M35/024 , F02M35/10013
摘要： A housing of an air cleaner has an air inlet port and an air outlet port, and incorporates an air filter. In the housing, a fuel adsorption filter is arranged downstream of the air filter in such manner as to intersect an air passage. An open portion and a sheet-like adsorption portion are vertically defined in an outer frame of the fuel adsorption filter. The adsorption portion has a fuel adsorbing function. A weir is provided in a boundary between the open portion and the adsorption portion. The weir limits air flow from the upstream side of the adsorption portion to the upstream side of the open portion. A flow straightening plate having a flow straightening function is provided in the open portion.
摘要翻译：空气净化器的壳体具有空气入口和空气出口，并且包括空气过滤器。在壳体中，燃料吸附过滤器以与空气通道相交的方式设置在空气过滤器的下游。在燃料吸附过滤器的外框架中垂直地限定开放部分和片状吸附部分。吸附部具有燃料吸附功能。在开口部和吸附部之间的边界设置有堰。堰限制从吸附部的上游侧到开口部的上游侧的空气流。在开放部分设有具有流动矫直功能的流动矫直板。

3. 发明申请

US20100083928A1 INTAKE SYSTEM FOR VEHICLE INTERNAL COMBUSTION ENGINE 有权
标题翻译：用于车辆内燃机的吸入系统
公开(公告)号：US20100083928A1
公开(公告)日：2010-04-08
申请号：US12524621
申请日：2008-01-29
申请人： Haruhiko Saito , Tatsuya Oyama
发明人： Haruhiko Saito , Tatsuya Oyama
IPC分类号： F02M35/10 , F02M35/02
CPC分类号： F02M35/10321 , F02B27/005 , F02M35/02 , F02M35/10013 , F02M35/108 , F02M35/161 , Y02T10/146
摘要： An intake system (10, 20) for a vehicle internal combustion engine is provided in which a first air intake duct (16), having an air intake inlet (16a) to inhale external air, is connected to an air cleaner box (14). A second air intake duct (17, 27) is also connected to the air cleaner box. The air intake inlet is closer to the air cleaner box than the second air intake duct is. The cross section area of a second air intake duct is greater than the cross section area of the first air intake duct. The center axis of the second air intake duct at an end on the side of a second air intake opening (12, 22) intersects with the center axis of the first air intake duct at an end on the side of a first air intake opening (11).
摘要翻译：提供了一种用于车辆内燃机的进气系统（10,20），其中具有吸入外部空气的进气口（16a）的第一进气管道（16）连接到空气滤清器箱（14）。第二进气管道（17,27）也连接到空气滤清器箱。进气口比第二进气管更靠近空气滤清器箱。第二进气管道的横截面面积大于第一进气管道的横截面面积。在第二进气口（12,22）侧的端部处的第二进气管道的中心轴线与第一进气口侧的端部处的第一进气管道的中心轴线相交 11）。

4. 发明授权

US08442371B2 Tight-buffered optical fibers and optical fiber cables 有权
标题翻译：紧密光纤和光纤电缆
公开(公告)号：US08442371B2
公开(公告)日：2013-05-14
申请号：US12566736
申请日：2009-09-25
申请人： Tatsuya Oyama , Toshiaki Ozawa
发明人： Tatsuya Oyama , Toshiaki Ozawa
IPC分类号： G02B6/44
CPC分类号： C03C25/1065 , G02B6/02395 , G02B6/4402 , G02B6/443 , G02B6/4433
摘要： An optical fiber cable and a tight-buffered optical fiber which suppress an increase in transmission loss in a humid and hot environment and have good manufacturability are disclosed. The tight-buffered optical fiber of the present invention comprises a glass fiber surrounded by a first coating layer and a second coating layer, the second coating layer comprising two or more layers; wherein a pull-out force is 15 N/20 mm or less in at least one pair of layers between the first coating layer and the second coating layer, or between any two layers of the second coating layer.
摘要翻译：公开了一种光纤电缆和紧密缓冲光纤，其抑制在潮湿和高温环境中的传输损耗的增加并且具有良好的可制造性。本发明的缓冲缓冲光纤包括被第一涂层和第二涂层包围的玻璃纤维，第二涂层包括两层或更多层; 其中在第一涂层和第二涂层之间或第二涂层的任何两层之间的至少一对层中的拉拔力为15N / 20mm或更小。

5. 发明授权

US08217031B2 Heteroaryl derivatives 失效
标题翻译：杂芳基衍生物
公开(公告)号：US08217031B2
公开(公告)日：2012-07-10
申请号：US12593566
申请日：2008-03-28
申请人： Masato Matsuoka , Tatsuya Oyama
发明人： Masato Matsuoka , Tatsuya Oyama
IPC分类号： A61K31/55 , C07D223/16
CPC分类号： C07D491/048 , C07D495/04
摘要： The present invention relates to a compound represented by formula [1] or a pharmaceutically acceptable salt thereof: In formula [1], one of X and Y is CH and the other is oxygen or sulfur; R is hydrogen, etc.; Z is hydrogen, etc.; Ar is phenyl, etc.; and n is 1 or 2 and or m is 1 or 2, excluding compounds where n is 2 and m is 2 simultaneously. Also provided is a pharmaceutical composition comprising a compound of formula [1] or a pharmaceutically acceptable salt thereof as an active ingredient. The composition is usable as an agent for the prevention or treatment of depression, panic disorder, anxiety, obsessive-compulsive disorder, chronic pain, fibromyalgia, obesity, stress urinary incontinence, and overactive bladder.
摘要翻译：本发明涉及由式[1]表示的化合物或其药学上可接受的盐：在式[1]中，X和Y之一是CH，另一个是氧或硫; R是氢等; Z是氢等; Ar是苯基等; n为1或2，m为1或2，不包括n为2，m为2的化合物。还提供了包含式[1]化合物或其药学上可接受的盐作为活性成分的药物组合物。该组合物可用作预防或治疗抑郁症，恐慌症，焦虑症，强迫症，慢性疼痛，纤维肌痛，肥胖，压力性尿失禁和膀胱过动症的药剂。

6. 发明申请

US20080103162A1 Antipruritics 审中-公开
标题翻译：止痒药
公开(公告)号：US20080103162A1
公开(公告)日：2008-05-01
申请号：US11981315
申请日：2007-10-30
申请人： Tatsuya Oyama , Kyoko Sakana
发明人： Tatsuya Oyama , Kyoko Sakana
IPC分类号： A61K31/517 , A61P17/04
CPC分类号： C07D401/06 , A61K31/00 , A61K31/517 , C07D239/94
摘要： The present invention relates to an antipruritic agent comprising a nociceptine antagonist as an active ingredient. The nociceptine antagonist can be used as a preventive or remedy for diseases associated with itching (for example, atopic dermatitis and urticaria), local pruritus cutaneous caused by insect excretion and secretion, nodular prurigo, kidney dialysis, diabetes, blood disease, liver disease, kidney disease, incretion and metabolic disorder, viscera malignant tumor, hyperthyroidism, autoimmune disease, multiple sclerosis, neurologic disease, psychoneurosis, allergic conjunctivitis, spring catarrh, atopic keratoconjunctivitis, or itching caused by excess use of laxuries and drugs because it has excellent scratching behavior suppressing effect, that is, antiitching effect and antipruritic effect.
摘要翻译：本发明涉及含有止痛剂拮抗剂作为活性成分的止痒剂。伤害性疼痛拮抗剂可用作与瘙痒相关疾病（例如特应性皮炎和荨麻疹）的预防或治疗，由昆虫排泄和分泌引起的皮肤局部瘙痒，结节性瘙痒，肾透析，糖尿病，血液病，肝脏疾病，肾脏疾病，增生和代谢紊乱，内脏恶性肿瘤，甲状腺功能亢进，自身免疫性疾病，多发性硬化，神经系统疾病，精神病，过敏性结膜炎，春季卡他症，特应性角膜结膜炎，或过度使用松弛症和药物引起的瘙痒，因为它具有优异的划痕行为抑制作用，即防止止痛作用和止痒作用。

7. 发明申请

US20100022566A1 QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF 有权
标题翻译：喹诺酮衍生物及其药物组合物
公开(公告)号：US20100022566A1
公开(公告)日：2010-01-28
申请号：US12089087
申请日：2006-10-03
申请人： Masahiko Okano , Tatsuya Oyama
发明人： Masahiko Okano , Tatsuya Oyama
IPC分类号： A61K31/517 , C07D239/72 , A61P17/02 , A61P17/06
CPC分类号： C07D239/94 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14
摘要： The present invention relates to novel quinazoline derivatives with less skin irritation and an excellent action of strongly suppressing scratching behavior, and pharmaceutical compositions containing a quinazoline derivative as an active ingredient. The present invention is directed to the quinazoline derivatives represented by the general formula [1] or pharmaceutically acceptable salts thereof. In the general formula [1], R1 represents hydrogen or the like; R2 represents hydrogen or the like; R3 and R4 are the same or different and represent hydrogen, alkyl, alkoxy or halogen; R5 is combined with R6 to represent alkylene or represents hydrogen, hydroxy, alkyl, phenyl or alkoxy; R6 represents alkyl, cycloalkyl, phenyl, a 5- to 10-membered aromatic heterocyclic group containing one to three heteroatoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, or —N(R6-1)(R6-2).
摘要翻译：本发明涉及具有较少皮肤刺激性和强烈抑制划伤行为的优异作用的新型喹唑啉衍生物以及含有喹唑啉衍生物作为活性成分的药物组合物。本发明涉及由通式[1]表示的喹唑啉衍生物或其药学上可接受的盐。在通式[1]中，R 1表示氢等; R2表示氢等; R3和R4相同或不同，代表氢，烷基，烷氧基或卤素; R5与R6结合表示亚烷基或代表氢，羟基，烷基，苯基或烷氧基; R6表示烷基，环烷基，苯基，含有1至3个选自氮原子，氧原子和硫原子的杂原子的5至10元芳族杂环基或-N（R 6-1）（ R6-2）。

8. 发明授权

US07163921B1 Peptide derivatives and medicinal compositions 有权
标题翻译：肽衍生物和药物组合物
公开(公告)号：US07163921B1
公开(公告)日：2007-01-16
申请号：US10257238
申请日：2001-04-16
申请人： Kouichi Ishiyama , Tomohiro Terada , Tatsuya Oyama , Tadaaki Ohgi
发明人： Kouichi Ishiyama , Tomohiro Terada , Tatsuya Oyama , Tadaaki Ohgi
IPC分类号： A61K38/07 , A61K38/05 , A61K38/06 , C07K5/08 , C07K7/04
CPC分类号： C07K5/1016 , A61K38/00 , C07K5/0812 , C07K5/1027 , C07K7/56
摘要： The present invention to novel nociceptin receptor agonists which are peptide derivatives represented by the following general formula (1): (in which A is alkylene, —CH2)nCO— or a group expressed by the following formula (2) or (3): wherein n represents an integer of 1 to 8; X and Y are same or different and each represents —CONH— or —CH2NH—; R1, R2 and R3 are same or different and each represents alkyl, aryl or heteroaryl; Z represents —CON(R4)R5 or —CH2N(R4)R5; R4 and R5 are same or different and each represents hydrogen, alkyl, aryl or heteroaryl) or a pharmaceutically acceptable salt thereof. A pharmaceutical composition according to the present invention is useful as a nociceptin receptor agonist.
摘要翻译：本发明涉及由以下通式（1）表示的肽衍生物的新的伤害感受激素受体激动剂：（其中A为亚烷基，-CH 2 O 2）n CO- 或由下式（2）或（3）表示的基团：其中n表示1至8的整数; X和Y相同或不同，各自表示-CONH-或-CH 2 NH-; R 1，R 2和R 3相同或不同，各自表示烷基，芳基或杂芳基; Z表示-CON（R 4）R 5或-CH 2 N（R 4）R SUP > 5 ; R 4和R 5相同或不同，各自表示氢，烷基，芳基或杂芳基）或其药学上可接受的盐。根据本发明的药物组合物可用作伤害感受肽受体激动剂。

9. 发明授权

US08431586B2 Quinazoline derivatives and pharmaceutical compositions thereof 有权
标题翻译：喹唑啉衍生物及其药物组合物
公开(公告)号：US08431586B2
公开(公告)日：2013-04-30
申请号：US12089087
申请日：2006-10-03
申请人： Masahiko Okano , Tatsuya Oyama
发明人： Masahiko Okano , Tatsuya Oyama
IPC分类号： A61K31/517
CPC分类号： C07D239/94 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14
摘要： The present invention relates to novel quinazoline derivatives with less skin irritation and an excellent action of strongly suppressing scratching behavior, and pharmaceutical compositions containing a quinazoline derivative as an active ingredient. The present invention is directed to the quinazoline derivatives represented by the general formula [1] or pharmaceutically acceptable salts thereof. In the general formula [1], R1 represents hydrogen or the like; R2 represents hydrogen or the like; R3 and R4 are the same or different and represent hydrogen, alkyl, alkoxy or halogen; R5 is combined with R6 to represent alkylene or represents hydrogen, hydroxy, alkyl, phenyl or alkoxy; R6 represents alkyl, cycloalkyl, phenyl, a 5- to 10-membered aromatic heterocyclic group containing one to three heteroatoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, or —N(R6-1)(R6-2).
摘要翻译：本发明涉及具有较少皮肤刺激性和强烈抑制划伤行为的优异作用的新型喹唑啉衍生物以及含有喹唑啉衍生物作为活性成分的药物组合物。本发明涉及由通式[1]表示的喹唑啉衍生物或其药学上可接受的盐。在通式[1]中，R 1表示氢等; R2表示氢等; R3和R4相同或不同，代表氢，烷基，烷氧基或卤素; R5与R6结合表示亚烷基或代表氢，羟基，烷基，苯基或烷氧基; R6表示烷基，环烷基，苯基，含有1至3个选自氮原子，氧原子和硫原子的杂原子的5至10元芳族杂环基或-N（R 6-1）（ R6-2）。

10. 发明授权

US07718663B2 Quinazoline derivatives and medicaments 失效
标题翻译：喹唑啉衍生物和药物
公开(公告)号：US07718663B2
公开(公告)日：2010-05-18
申请号：US10512954
申请日：2003-04-28
申请人： Masahiko Okano , Tatsuya Oyama
发明人： Masahiko Okano , Tatsuya Oyama
IPC分类号： A61K31/517 , C07D239/94
CPC分类号： A61K31/517 , A61K31/357 , A61K31/5377 , A61K31/541 , C07D239/84 , C07D239/95
摘要： An object of the present invention is to provide an antipruritic agent having a novel action mechanism.The present invention provides an antipruritic agent comprising a compound represented by the following general formula (1): wherein R1 represents a hydrogen atom or alkyl; the ring Q represents a cyclohexylene group or a phenylene group; A1 and A2 represent a single bond or an alkylene group; E represents —NHCO—; A3 represents a single bond or a divalent saturated or unsaturated aliphatic hydrocarbon group; R3 represents a non-cyclic aliphatic hydrocarbon group; and R4 and R5 are the same or different and each represents a hydrogen atom or alkyl, or a pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明的目的是提供具有新颖作用机理的止痒剂。本发明提供含有由以下通式（1）表示的化合物的止痒剂：其中R1表示氢原子或烷基; 环Q表示亚环己基或亚苯基; A1和A2表示单键或亚烷基; E表示-NHCO-; A3表示单键或二价饱和或不饱和脂族烃基; R3表示非环状脂族烃基; R 4和R 5相同或不同，各自表示氢原子或烷基，或其药学上可接受的盐作为活性成分。

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