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    • 8. 发明申请
    • Radioactive bone cement for treatment of tumors in bone
    • 放射性骨水泥治疗骨肿瘤
    • US20060216230A1
    • 2006-09-28
    • US11388630
    • 2006-03-24
    • Joyce KeyakHarry Skinner
    • Joyce KeyakHarry Skinner
    • A61K51/00
    • A61K51/12A61L24/0015A61L24/0052A61L2300/44A61L2430/02
    • Conventional internal radiation therapy has used implants, such as granules or seeds, each of which includes a radiation source for implantation within the patient. In contrast to conventional internal radiation therapy, disclosed herein is a radioactive flowable cement capable of curing to form radioactive cured cement, such that the radioactive cured cement may simultaneously provide radiation therapy, bone repair and pain management. Radioactive cement may allow for the convenient introduction of a suitable volume of radioactive material to a target site within the patient's body in a single minimally invasive procedure, as compared with the conventional need for precise implantation locations of numerous radioactive granules. In further contrast to conventional methods, radioactive cement may provide a distributed radioactive source, such that the radioactive dose rate across the target tissue (e.g., bone) can be more constant. In still further contrast to conventional methods, radioactive cement can penetrate into trabecular bone tissue prior to curing to a solid phase, thereby treating a larger volume of tissue as compared with conventional immobilized solid granules. In contrast to conventional external (beam) radiation therapy, radioactive cement may allow greater doses to the tissue to be treated, for example, by avoiding irradiation of dose-limiting structures, and enables treatment to be completed in a single procedure as opposed to multiple out-patient visits for external radiation therapy.
    • 常规的内部放射治疗已经使用植入物,例如颗粒或种子,其中每一种都包括用于植入患者体内的辐射源。 与传统的内部放射治疗相反,本文公开了一种能够固化以形成放射性固化的水泥的放射性可流动的水泥,使得放射性固化的水泥可以同时提供放射治疗,骨修复和疼痛管理。 与常规对许多放射性颗粒的精确植入位置的传统需求相比,放射性水泥可以允许在单个微创程序中方便地将合适体积的放射性材料引入患者体内的靶位点。 与常规方法的进一步对比,放射性水泥可以提供分布式放射源,使得穿过靶组织(例如骨)的放射性剂量率可以更加恒定。 与常规方法进一步对比,放射性水泥在固化至固相之前可以渗透入小梁骨组织,从而与传统的固定固体颗粒相比处理较大体积的组织。 与传统的外部(束)放射治疗相比,放射性水泥可以允许例如通过避免剂量限制结构的照射来治疗组织的更大剂量,并且使得治疗能够以单个程序而不是多个 门诊外部放射治疗。