专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4826977A Photochromic spiropyran compounds 失效
标题翻译：光致变色螺吡喃化合物
公开(公告)号：US4826977A
公开(公告)日：1989-05-02
申请号：US50101
申请日：1987-05-15
申请人： Harry G. Heller , Stephen N. Oliver , John Whittall , Ian Tomlinson
发明人： Harry G. Heller , Stephen N. Oliver , John Whittall , Ian Tomlinson
IPC分类号： C07D311/96 , C07D491/107 , C08K5/1545 , C09K9/02 , C07D265/00 , G02B27/00 , G03C1/733
CPC分类号： C07D311/96 , C08K5/1545
摘要： A series of novel photochromic spiropyrans are disclosed in which a spiro-adamantane group is introduced into the 2-position of the benzopyran or naphthopyran ring. The spiropyran compounds of the invention exhibit heliochromic properties, i.e. they color in sunlight and fade rapidly at ambient temperatures in the absence of U.V. light, making them good candidates for use in the manufacture of sunglasses. The invention includes lenses which darken in sunlight and incorporate the novel spiropyrans and a process for the preparation of the spiropyran compounds.
摘要翻译：公开了一系列新颖的光致变色螺吡喃，其中螺金刚烷基被引入苯并吡喃或萘并吡喃环的2-位。本发明的螺吡喃化合物具有日光色性质，即它们在阳光下着色，并且在不存在U.V的情况下在环境温度下快速褪色。使他们成为制造太阳镜的良好候选人。本发明包括在阳光下变暗并掺入新型螺吡喃的透镜和制备螺吡喃化合物的方法。

2. 发明授权

US08070045B1 Curable amine flux composition and method of soldering 有权
标题翻译：可固化胺助焊剂组成及焊接方法
公开(公告)号：US08070045B1
公开(公告)日：2011-12-06
申请号：US12958487
申请日：2010-12-02
申请人： David D. Fleming , Mike K. Gallagher , Kim Sang Ho , Xiang-Qian Liu , Mark R. Winkle , Asghar Akber Peera , Glenn N. Robinson , Ian Tomlinson
发明人： David D. Fleming , Mike K. Gallagher , Kim Sang Ho , Xiang-Qian Liu , Mark R. Winkle , Asghar Akber Peera , Glenn N. Robinson , Ian Tomlinson
IPC分类号： B23K31/02 , B23K35/34
CPC分类号： B23K35/3615 , B23K1/0016 , B23K1/203 , B23K35/362 , B23K2101/38 , B23K2101/42
摘要： A curable amine flux composition is provided, comprising, as initial components: a resin component having at least two oxirane groups per molecule; an amine fluxing agent represented by formula I: wherein R1, R2, R3 and R4 are independently selected from a hydrogen, a substituted C1-80 alkyl group, an unsubstituted C1-80 alkyl group, a substituted C7-80 arylalkyl group and an unsubstituted C7-80 arylalkyl group; wherein R7 and R8 are independently selected from a C1-20 alkyl group, a substituted C1-20 alkyl group, a C6-20 aryl group and a substituted C6-20 aryl group or wherein R7 and R8, together with the carbon to which they are attached, form a C3-20 cycloalkyl ring optionally substituted with a C1-6 alkyl group; wherein R10 and R11 are independently selected from a C1-20 alkyl group, a substituted C1-20 alkyl group, a C6-20 aryl group and a substituted C6-20 aryl group or wherein R10 and R11, together with the carbon to which they are attached, form a C3-20 cycloalkyl ring optionally substituted with a C1-6 alkyl group; and, wherein R9 is selected from a hydrogen, a C1-30 alkyl group, a substituted C1-30 alkyl group, a C6-30 aryl group and a substituted C6-30 aryl group; and, optionally, a curing agent. Also provided is a method of soldering an electrical contact using the curable amine flux composition.
摘要翻译：提供了一种可固化胺助剂组合物，其包含作为初始组分的树脂组分：每分子具有至少两个环氧乙烷基团的树脂组分; 由式I表示的胺助熔剂：其中R 1，R 2，R 3和R 4独立地选自氢，取代的C 1-8烷基，未取代的C 1-80烷基，取代的C 7〜80芳烷基和未取代的 C7-80芳基烷基; 其中R 7和R 8独立地选自C 1-20烷基，取代的C 1-20烷基，C 6-20芳基和取代的C 6-20芳基，或者其中R 7和R 8与它们连接，形成任选被C 1-6烷基取代的C 3-20环烷基环; 其中R 10和R 11独立地选自C 1-20烷基，取代的C 1-20烷基，C 6-20芳基和取代的C 6-20芳基，或其中R 10和R 11与它们连接，形成任选被C 1-6烷基取代的C 3-20环烷基环; 并且其中R 9选自氢，C 1-30烷基，取代的C 1-30烷基，C 6-30芳基和取代的C 6-30芳基; 和任选的固化剂。还提供了使用可固化胺助剂组合物焊接电接触的方法。

3. 发明申请

US20110223168A1 LIGAND THAT HAS BINDING SPECIFICITY FOR IL-4 AND/OR IL-13 审中-公开
标题翻译：对IL-4和/或IL-13具有结合特异性的配体
公开(公告)号：US20110223168A1
公开(公告)日：2011-09-15
申请号：US13111516
申请日：2011-05-19
申请人： Greg Winter , Ian Tomlinson , Olga Ignatovich , Lucy Holt , Elena De Angelis
发明人： Greg Winter , Ian Tomlinson , Olga Ignatovich , Lucy Holt , Elena De Angelis
IPC分类号： A61K39/395 , C07K16/44 , A61P11/06 , A61P37/08
CPC分类号： C07K16/18 , A61K47/60 , A61K2039/505 , C07K16/241 , C07K16/2866 , C07K16/2878 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C12N2799/021
摘要： The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.
摘要翻译：本发明提供了包含具有第一结合特异性的第一免疫球蛋白可变结构域和具有第二结合特异性的互补或非互补免疫球蛋白可变结构域的双重特异性配体。

4. 发明申请

US20100266616A1 POLYPEPTIDES, ANTIBODY VARIABLE DOMAINS AND ANTAGONISTS 有权
标题翻译：多肽，抗体可变域和拮抗剂
公开(公告)号：US20100266616A1
公开(公告)日：2010-10-21
申请号：US12663502
申请日：2008-06-04
申请人： Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
发明人： Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C12N15/63 , C12N5/10 , C07K14/00 , A61P35/00 , A61P29/00
CPC分类号： C07K16/005 , A61K9/0078 , A61K2039/544 , C07K16/22 , C07K16/2866 , C07K16/2878 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The invention relates to anti-TNFR1 polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for as therapeutics and/or prophylactics that are likely to encounter proteases when administered to a patient, for example for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating inflammatory disease, such as arthritis or COPD.
摘要翻译：本发明涉及抗TNFR1多肽和抗蛋白酶降解的抗体单可变结构域（dAb），以及包含它们的拮抗剂。多肽，dAb和拮抗剂可用作当被施用于患者时可能遇到蛋白酶的治疗剂和/或预防剂，例如用于肺部给药，口服给药，递送至肺部并递送至患者的胃肠道，以及用于治疗炎性疾病，例如关节炎或COPD。

5. 发明申请

US20100254972A1 METHODS FOR SELECTING PROTEASE RESISTANT POLYPEPTIDES 审中-公开
标题翻译：选择抗病毒多肽的方法
公开(公告)号：US20100254972A1
公开(公告)日：2010-10-07
申请号：US12663491
申请日：2008-06-03
申请人： Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
发明人： Laurent Jespers , Malgorzata Pupecka , Ian Tomlinson , Carolyn Enever
IPC分类号： A61K39/395 , C12N9/64 , C12N9/76 , C12N9/74 , C07K16/00 , A61P27/02 , A61P1/00 , A61P11/00
CPC分类号： C07K16/2878 , A61K9/007 , A61K9/0078 , A61K9/1623 , A61K9/1641 , A61K39/3955 , A61K2039/544 , A61M11/005 , A61M15/08 , A61M16/14 , C07K16/00 , C07K16/005 , C07K16/22 , C07K16/2866 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： The invention relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the GI tract or pulmonary tissue of a human. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, combining the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, eg for treating disease or conditions of GI tract or pulmonary tissue in humans.
摘要翻译：本发明涉及一种用于从文库或肽和多肽（例如显示系统）的文库或组合库中选择，分离和/或回收肽或多肽的方法，所述多肽和多肽（例如，显示系统）可通过蛋白酶如蛋白酶胃肠道或人体的肺组织。通常，该方法包括提供肽或多肽的文库或库，在适用于蛋白酶活性的条件下将文库或库与蛋白酶组合，以及选择，分离和/或回收抗蛋白酶降解的肽或多肽并具有所需的生物活性。所选择的肽和多肽可用作治疗剂，例如用于治疗人类胃肠道或肺组织的疾病或病症。

6. 发明申请

US20090259026A1 Ligand 有权
标题翻译：配体
公开(公告)号：US20090259026A1
公开(公告)日：2009-10-15
申请号：US11704832
申请日：2007-02-08
申请人： Ian Tomlinson , Laurent Jespers , Jasper Clube , Lucy J. Holt , Oliver Schon
发明人： Ian Tomlinson , Laurent Jespers , Jasper Clube , Lucy J. Holt , Oliver Schon
IPC分类号： C12P21/08 , C07K16/18
CPC分类号： C07K16/18 , A61K47/6843 , C07K16/241 , C07K16/2878 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/53 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/624 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/00 , C07K2319/01 , C07K2319/31
摘要： The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.
摘要翻译：本发明提供了包含具有第一结合特异性的第一免疫球蛋白可变结构域和具有第二结合特异性的互补或非互补免疫球蛋白可变结构域的双重特异性配体。

7. 发明申请

US20070104710A1 Ligand that has binding specificity for IL-4 and/or IL-13 审中-公开
标题翻译：对IL-4和/或IL-13具有结合特异性的配体
公开(公告)号：US20070104710A1
公开(公告)日：2007-05-10
申请号：US11338863
申请日：2006-01-24
申请人： Ian Tomlinson , Steve Holmes , Kevin Moulder
发明人： Ian Tomlinson , Steve Holmes , Kevin Moulder
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/18 , A61K47/60 , A61K2039/505 , C07K16/241 , C07K16/2866 , C07K16/2878 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C12N2799/021
摘要： The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity.
摘要翻译：本发明提供了包含具有第一结合特异性的第一免疫球蛋白可变结构域和具有第二结合特异性的互补或非互补免疫球蛋白可变结构域的双重特异性配体。

8. 发明申请

US20060257406A1 Ligand 审中-公开
标题翻译：配体
公开(公告)号：US20060257406A1
公开(公告)日：2006-11-16
申请号：US11141661
申请日：2005-05-31
申请人： Greg Winter , Ian Tomlinson , Olga Ignatovich , Ben Woolven , Philip Jones
发明人： Greg Winter , Ian Tomlinson , Olga Ignatovich , Ben Woolven , Philip Jones
IPC分类号： A61K39/395 , C07H21/04
CPC分类号： C07K16/18 , A61K47/60 , A61K2039/505 , C07K16/241 , C07K16/2866 , C07K16/2878 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C12N2799/021
摘要： The invention provides a dual-specific ligand comprising a first immunoglobulin variable domain having a first binding specificity for a target ligand and a complementary or non-complementary immunoglobulin variable domain having a second binding specificity for a receptor of the target ligand.
摘要翻译：本发明提供了双特异性配体，其包含对靶配体具有第一结合特异性的第一免疫球蛋白可变结构域和对靶配体的受体具有第二结合特异性的互补或非互补免疫球蛋白可变结构域。

9. 发明申请

US20050010051A1 Novel processes for the preparation of (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol 失效
公开(公告)号：US20050010051A1
公开(公告)日：2005-01-13
申请号：US10840586
申请日：2004-05-06
申请人： Jonathan Evans , Sandra Stolz-Dunn , Ian Tomlinson
发明人： Jonathan Evans , Sandra Stolz-Dunn , Ian Tomlinson
IPC分类号： A61K31/445 , C07D211/20 , C07D211/22 , C07D211/32
CPC分类号： C07D211/32 , C07D211/22
摘要： The present invention provides various processes for the preparation of (R)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. These processes may be characterized by the following scheme:

10. 发明申请

US20110152407A1 Novel diamino-alcohol compounds, their manufacture and use in epoxy resins 有权
标题翻译：新型二氨基醇化合物，其制造和用于环氧树脂
公开(公告)号：US20110152407A1
公开(公告)日：2011-06-23
申请号：US12928600
申请日：2010-12-15
申请人： Asghar Akber Peera , Ian Tomlinson
发明人： Asghar Akber Peera , Ian Tomlinson
IPC分类号： C08L63/00 , C08L63/02 , C08L63/04
CPC分类号： C08G59/64 , C08L63/00 , C08L2205/02
摘要： A new class of compounds, namely diamino alcohols, is described, along with a process for their production and their use as hardeners, or curing agents, for epoxy resin systems, some of which have high glass transition temperatures, Tgs, such as greater than about 120° C.
摘要翻译：描述了一类新的化合物，即二氨基醇，以及它们的生产方法和用作环氧树脂体系的硬化剂或固化剂的方法，其中一些化合物具有高的玻璃化转变温度，例如大于约120℃

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式