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1. 发明申请

US20050186660A1 Human procalcitonin and the preparation and use thereof 有权
标题翻译：人类降钙素原及其制备和应用
公开(公告)号：US20050186660A1
公开(公告)日：2005-08-25
申请号：US11055622
申请日：2005-02-11
申请人： Harald Althaus , Hans-Peter Hauser
发明人： Harald Althaus , Hans-Peter Hauser
IPC分类号： C12N15/09 , A61K9/08 , A61K38/00 , A61K38/23 , A61K39/395 , A61K47/28 , A61K47/42 , A61P3/14 , A61P5/22 , A61P35/04 , C07J9/00 , C07K14/585 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/16 , C12P21/02 , C12P21/08 , C07H21/04
CPC分类号： C07K14/585 , A61K38/00 , C07K2319/00 , Y10S435/967
摘要： The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide comprising the amino acid sequence of human procalcitonin is inserted into a vector; a host organism is transformed with this gene-containing vector; and the polypeptide expressed by the host organism is isolated. Furthermore the use of the polypeptides according to the invention, in particular as medicaments and diagnostic agents is described.
摘要翻译：本发明涉及人类降钙素原及其制备和应用。具体地，描述了一种制备人降钙素原的方法，其中将编码包含人降钙素原的氨基酸序列的多肽的基因插入载体中; 用含该基因的载体转化宿主生物; 并分离由宿主生物表达的多肽。此外，描述了根据本发明的多肽，特别是作为药物和诊断剂的用途。

2. 发明授权

US07338770B2 Human procalcitonin and the preparation and use thereof 有权
标题翻译：人类降钙素原及其制备和应用
公开(公告)号：US07338770B2
公开(公告)日：2008-03-04
申请号：US11055622
申请日：2005-02-11
申请人： Harald Althaus , Hans-Peter Hauser
发明人： Harald Althaus , Hans-Peter Hauser
IPC分类号： G01N33/53 , G01N33/566 , C12N5/06 , C12N9/96 , A61K38/00
CPC分类号： C07K14/585 , A61K38/00 , C07K2319/00 , Y10S435/967
摘要： The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide comprising the amino acid sequence of human procalcitonin is inserted into a vector; a host organism is transformed with this gene-containing vector; and the polypeptide expressed by the host organism is isolated. Furthermore the use of the polypeptides according to the invention, in particular as medicaments and diagnostic agents is described.
摘要翻译：本发明涉及人类降钙素原及其制备和应用。具体地，描述了一种制备人降钙素原的方法，其中将编码包含人降钙素原的氨基酸序列的多肽的基因插入载体中; 用含该基因的载体转化宿主生物; 并分离由宿主生物表达的多肽。此外，描述了根据本发明的多肽，特别是作为药物和诊断剂的用途。

3. 发明授权

US06905687B2 Human procalcitonin and the preparation and use thereof 有权
公开(公告)号：US06905687B2
公开(公告)日：2005-06-14
申请号：US10394058
申请日：2003-03-24
申请人： Harald Althaus , Hans-Peter Hauser
发明人： Harald Althaus , Hans-Peter Hauser
IPC分类号： C12N15/09 , A61K9/08 , A61K38/00 , A61K38/23 , A61K39/395 , A61K47/28 , A61K47/42 , A61P3/14 , A61P5/22 , A61P35/04 , C07J9/00 , C07K14/585 , C07K16/26 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/16 , C12P21/02 , C12P21/08 , C07K14/435 , G01N33/53
CPC分类号： C07K14/585 , A61K38/00 , C07K2319/00 , Y10S435/967
摘要： The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide comprising the amino acid sequence of human procalcitonin is inserted into a vector; a host organism is transformed with this gene-containing vector; and the polypeptide expressed by the host organism is isolated. Furthermore the use of the polypeptides according to the invention, in particular as medicaments and diagnostic agents is described.

4. 发明授权

US06562946B2 Human procalcitonin and the preparation and use thereof 有权
公开(公告)号：US06562946B2
公开(公告)日：2003-05-13
申请号：US09742373
申请日：2000-12-22
申请人： Harald Althaus , Hans-Peter Hauser
发明人： Harald Althaus , Hans-Peter Hauser
IPC分类号： C07K14585
CPC分类号： C07K14/585 , A61K38/00 , C07K2319/00 , Y10S435/967
摘要： The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide comprising the amino acid sequence of human procalcitonin is inserted into a vector; a host organism is transformed with this gene-containing vector; and the polypeptide expressed by the host organism is isolated. Furthermore the use of the polypeptides according to the invention, in particular as medicaments and diagnostic agents is described.

5. 发明授权

US08828939B2 Modified vitamin K dependent polypeptides 有权
标题翻译：改良的维生素K依赖多肽
公开(公告)号：US08828939B2
公开(公告)日：2014-09-09
申请号：US11632552
申请日：2005-08-10
申请人： Thomas Weimer , Stefan Schulte , Kay Hofmann , Hans-Peter Hauser
发明人： Thomas Weimer , Stefan Schulte , Kay Hofmann , Hans-Peter Hauser
IPC分类号： A61K38/36 , C07K14/745 , C12N15/62 , C12N9/64
CPC分类号： C12N15/62 , C12N9/6424
摘要： The present invention relates to modified cDNA sequences coding for vitamin K-dependent polypeptides, in particular human Factor VII, human Factor VIIa, human Factor IX and human protein C and their derivatives with improved stability and extended plasma half life, recombinant expression vectors containing such cDNA sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having improved stability and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises such modified DNA sequences.
摘要翻译：本发明涉及编码维生素K依赖多肽，特别是人因子VII，人因子VIIa，人因子IX和人蛋白C及其衍生物的修饰cDNA序列，其具有改善的稳定性和延长的血浆半衰期，含有这样的重组表达载体 cDNA序列，用这种重组表达载体转化的宿主细胞，确实具有未修饰的野生型蛋白质的生物活性但具有改进的稳定性的生物活性的重组多肽和衍生物，以及制备这些重组蛋白及其衍生物的方法。本发明还涵盖用于人基因治疗的转移载体，其包含这种修饰的DNA序列。

6. 发明申请

US20090175828A1 Coagulation Factor X Polypeptides With Modified Activation Properties 有权
标题翻译：凝血因子X多肽具有改良的激活特性
公开(公告)号：US20090175828A1
公开(公告)日：2009-07-09
申请号：US12224182
申请日：2007-02-19
申请人： Stefan Schulte , Hans-Peter Hauser , Uwe Kalina , Thomas Weimer
发明人： Stefan Schulte , Hans-Peter Hauser , Uwe Kalina , Thomas Weimer
IPC分类号： A61K38/36 , C07K14/745 , C12N15/12 , C12N15/63 , C12N5/10 , C12P21/00 , A61P7/02
CPC分类号： C12N9/647 , A61K38/012 , A61K38/36 , C12N9/6432 , C12Y304/21006
摘要： The present invention relates to modified cDNA sequences coding for factor X polypeptides, in particular human factor X and its derivatives which can bypass the need for either factor VIIIa/factor IXa or factor VIIa/tissue factor for activation. The invention relates further to recombinant expression vectors containing such modified cDNA sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having altered activation properties, and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises such modified DNA sequences.
摘要翻译：本发明涉及编码因子X多肽，特别是人因子X及其衍生物的修饰的cDNA序列，其可以绕过对因子VIIIa /因子IXa或因子VIIa /组织因子进行活化的需要。本发明还涉及含有这种修饰的cDNA序列的重组表达载体，用这种重组表达载体转化的宿主细胞，确实具有未修饰的野生型蛋白的生物活性但具有改变的活化性质的重组多肽和衍生物，以及制备这些重组蛋白及其衍生物。本发明还涵盖用于人基因治疗的转移载体，其包含这种修饰的DNA序列。

7. 发明申请

US20090053185A1 Coagulation factor x polypeptides with modified activation properties 有权
标题翻译：凝血因子x多肽具有修饰的活化特性
公开(公告)号：US20090053185A1
公开(公告)日：2009-02-26
申请号：US11921399
申请日：2006-05-30
申请人： Stefan Schulte , Hans-Peter Hauser , Uwe Kalina , Thomas Weimer
发明人： Stefan Schulte , Hans-Peter Hauser , Uwe Kalina , Thomas Weimer
IPC分类号： A61K48/00 , C07K2/00 , C07H21/04 , C12N15/63 , C12N5/00 , C12P21/06 , A61K38/00 , A61K31/7088
CPC分类号： C12N9/6432 , C12Y304/21006
摘要： The present invention relates to modified cDNA sequences coding for human Factor X and their derivatives with improved stability and modified activation sequences, recombinant expression vectors containing such cDNA sequences, and host cells transformed with such recombinant expression vectors. The invention also relates to recombinant factor X polypeptides and derivatives which have biological activities of the unmodified wild type protein but with improved stability and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises such modified DNA.
摘要翻译：本发明涉及编码具有改善的稳定性和修饰的活化序列的人因子X及其衍生物的修饰的cDNA序列，含有此类cDNA序列的重组表达载体和用这些重组表达载体转化的宿主细胞。本发明还涉及具有未修饰的野生型蛋白的生物活性但具有改进的稳定性的重组因子X多肽和衍生物，以及用于制备这些重组蛋白及其衍生物的方法。本发明还涵盖用于人基因治疗的转移载体，其包含这种修饰的DNA。

8. 发明申请

US20080312143A1 Modified Cdna for High Expression Levels of Factor VIII and Its Derivatives 审中-公开
标题翻译：因子VIII及其衍生物的高表达水平的修饰的Cdna
公开(公告)号：US20080312143A1
公开(公告)日：2008-12-18
申请号：US10595401
申请日：2004-10-13
申请人： Hans-Peter Hauser , Jean-Luc Plantier , Cecille Ducasse , Claude Negrier
发明人： Hans-Peter Hauser , Jean-Luc Plantier , Cecille Ducasse , Claude Negrier
IPC分类号： A61K38/00 , C12N15/11 , C12N15/00 , C12N5/06 , A61P3/00 , A61K31/7088 , C12P21/04 , C07K14/00
CPC分类号： C07K14/755 , A61K48/00
摘要： The present invention relates to modified DNA sequences coding for biologically active recombinant human factor VIII and its derivatives, recombinant expression vectors containing such DNA sequences, host cells transformed with such recombinant expression vectors, and processes for the manufacture of the recombinant human factor VIII and its derivatives. The invention also covers a transfer vector for use in human gene therapy which comprises such modified DNA sequences. The present invention relates to modified DNA sequences coding for biologically active recombinant human factor VIII and its derivatives, recombinant expression vectors containing such DNA sequences, host cells transformed with such recombinant expression vectors, and processes for the manufacture of the recombinant human factor VIII and its derivatives. The invention also covers a transfer vector for use in human gene therapy which comprises such modified DNA sequences.
摘要翻译：本发明涉及编码生物活性重组人因子VIII及其衍生物的修饰DNA序列，含有这些DNA序列的重组表达载体，用这种重组表达载体转化的宿主细胞，以及重组人因子VIII及其制备方法衍生品本发明还涵盖用于人基因治疗的转移载体，其包含这种修饰的DNA序列。本发明涉及编码生物活性重组人因子VIII及其衍生物的修饰DNA序列，含有这些DNA序列的重组表达载体，用这种重组表达载体转化的宿主细胞，以及重组人因子VIII及其制备方法衍生品本发明还涵盖用于人基因治疗的转移载体，其包含这种修饰的DNA序列。

9. 发明授权

US06548635B1 Retrovirus from the HIV type O and its use (MVP-2901/94) 有权
标题翻译： HIV型O型逆转录病毒及其用途（MVP-2901/94）
公开(公告)号：US06548635B1
公开(公告)日：2003-04-15
申请号：US09610271
申请日：2000-07-06
申请人： Hans-Peter Hauser , Stefan Knapp , Stefan Brust , Lutz G. Gürtler , Josef Eberle , Lazare Kaptue , Léopold Achengui Zekeng
发明人： Hans-Peter Hauser , Stefan Knapp , Stefan Brust , Lutz G. Gürtler , Josef Eberle , Lazare Kaptue , Léopold Achengui Zekeng
IPC分类号： A61K3804
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , Y10S435/974 , Y10S435/975 , Y10S530/812
摘要： A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 950121601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.
摘要翻译：公开了一种新型HIV型O免疫缺陷病毒，其命名为MVP-2901/94，并已经在欧洲动物细胞培养物保藏中心（ECACC）VAL 950121601中保藏。可以从病毒获得的特征性抗原并且还可以用于检测与免疫缺陷病相关的抗逆转录病毒的抗体，以及病毒的部分DNA和氨基酸序列。

10. 发明授权

US06277561B1 Diagnostic assay for detection of HIV 失效
标题翻译：用于检测HIV的诊断测定
公开(公告)号：US06277561B1
公开(公告)日：2001-08-21
申请号：US09109916
申请日：1998-07-02
申请人： Lutz G. Guertler , Josef Eberle , Albrecht v. Brunn , Stefan Knapp , Hans-Peter Hauser
发明人： Lutz G. Guertler , Josef Eberle , Albrecht v. Brunn , Stefan Knapp , Hans-Peter Hauser
IPC分类号： C12Q170
CPC分类号： G01N33/56988 , A61K39/00 , C07K14/005 , C12N2740/16021 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12Q1/703
摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 92 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immuno-deficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.
摘要翻译：公开了一种新型免疫缺陷病毒，其具有命名为MVP-5180/91，并且已经保藏在欧洲动物细胞培养物库（ECACC）的第V 920 92 318号下。可从其中获得的特征性抗原，其中可以用于检测与免疫缺陷相关的逆转录病毒的抗体，还公开了病毒的DNA和氨基酸序列。

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