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1. 发明申请

US20140127240A1 Novel Binder-Drug Conjugates (ADCs) and Use of Same 审中-公开
标题翻译：新型粘合剂 - 药物共轭物（ADC）及其使用
公开(公告)号：US20140127240A1
公开(公告)日：2014-05-08
申请号：US14113070
申请日：2012-04-20
申请人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte C. Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörißen , Sandra Brokowski
发明人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte C. Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörißen , Sandra Brokowski
IPC分类号： A61K47/48 , C07K5/06 , A61K45/06
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , C07K5/0205 , C07K5/0207 , C07K5/06 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present patent application relates to novel binder-drug conjugates (ADCs) of N,N-dialkylauristatins directed against the target epidermal growth factor receptor (EGFR, gene ID 1956), effective metabolites of these ADCs, methods for producing these ADCs, use of these ADCs for treatment and or prevention of diseases as well as the use of these ADCs to produce pharmaceutical drugs for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic diseases such as cancer, for example. Such treatments may be administered as monotherapy or in combination with other pharmaceutical drugs or other therapeutic measures.
摘要翻译：本专利申请涉及针对靶表皮生长因子受体（EGFR，基因ID 1956）的N，N-二烷基硫酸锡的新型粘合剂 - 药物共轭物（ADC），这些ADC的有效代谢物，制备这些ADC的方法，这些ADC用于治疗和/或预防疾病，以及使用这些ADC来制备用于治疗和/或预防疾病，特别是过度增生和/或血管发生疾病例如癌症的药物。这样的治疗可以作为单一疗法或与其它药物或其他治疗措施组合施用。

2. 发明申请

US20130066055A1 NEW BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF 审中-公开
标题翻译：新的联合药物联合会（ADCS）及其使用
公开(公告)号：US20130066055A1
公开(公告)日：2013-03-14
申请号：US13451950
申请日：2012-04-20
申请人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte Christine Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörissen , Sandra Borkowski
发明人： Hans-Georg Lerchen , Lars Linden , Sherif El Sheikh , Jörg Willuda , Charlotte Christine Kopitz , Joachim Schuhmacher , Simone Greven , Christoph Mahlert , Beatrix Stelte-Ludwig , Sven Golfier , Rudolf Beier , Iring Heisler , Axel Harrenga , Karl-Heinz Thierauch , Sandra Bruder , Heike Petrul , Hannah Jörissen , Sandra Borkowski
IPC分类号： C07K17/02
CPC分类号： A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/422 , A61K31/4245 , A61K31/5355 , A61K31/536 , A61K31/537 , A61K31/5377 , A61K39/3955 , A61K45/06 , A61K47/542 , A61K47/6803 , A61K47/6851 , A61K47/6859 , A61K47/6869 , A61K47/6889 , C07K5/0205 , C07K5/0207 , C07K5/06 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K7/02 , C07K7/06 , C07K16/18 , C07K16/28 , C07K16/2812 , C07K16/2863 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
摘要翻译：本申请涉及针对目标C4.4a的N，N-二烷基硫酸钠的新粘合剂 - 药物共轭物（ADC），这些ADC的活性代谢物，制备这些ADC的方法，使用这些ADC 治疗和/或预防疾病，以及使用这些ADC用于制备用于治疗和/或预防疾病的药物，更特别是过度增殖和/或血管生成疾病，例如癌症疾病。这样的治疗可以作为单一疗法来实施，或者与其它药物组合或进一步的治疗措施。

3. 发明授权

US4784441A Protective boot supporting sleeve for universal joint in wheel assembly 失效
标题翻译：保护套支撑套，用于万向节车轮组装
公开(公告)号：US4784441A
公开(公告)日：1988-11-15
申请号：US2867
申请日：1987-01-13
申请人： Hans-Heinrich Welschof , Rudolf Beier
发明人： Hans-Heinrich Welschof , Rudolf Beier
IPC分类号： F16C19/00 , B60B27/00 , B60B35/14 , B60B35/16 , B60B35/18 , B60B27/02
CPC分类号： B60B27/0005 , Y10S464/906
摘要： In a wheel assembly for a vehicle wheel, a supportive sleeve is provided mounted in rotatably fixed engagement with a hub of the wheel assembly with one side of a protective boot for the universal joint being attached thereto. The supportive sleeve is constructed as a shaped sheet metal part shaped which, during installation, is permanently plastically deformed in press-fitted engagement with a groove in the hub of the wheel assembly and is formed with a radially extending annular region which is pressed into abutting engagement with an inner bearing ring of the wheel bearing assembly.
摘要翻译：在用于车轮的车轮组件中，提供安装成与车轮组件的轮毂可旋转地固定接合的支撑套筒，其一侧用于万向接头的保护罩。支撑套筒被构造为成形的金属片状件，其在安装期间被永久塑性地变形，与轮组件的轮毂中的槽压配合，并形成有径向延伸的环形区域，该环形区域被压入邻接与车轮轴承组件的内轴承环接合。

4. 发明授权

US4747805A Protective boot assembly for constant velocity universal joint 失效
标题翻译：恒速万向节保护罩组件
公开(公告)号：US4747805A
公开(公告)日：1988-05-31
申请号：US10398
申请日：1987-02-03
申请人： Hans-Heinrich Welschof , Rudolf Beier
发明人： Hans-Heinrich Welschof , Rudolf Beier
IPC分类号： B60T8/171 , F16D3/16 , F16D3/84 , F16J3/04 , F16J15/52 , G01P3/488 , F16C1/26
CPC分类号： G01P3/488 , F16D3/845 , Y10S464/906 , Y10T403/31 , Y10T403/52
摘要： A protective boot for sealing the free space between the driving and driven parts of a constant velocity universal joint formed of a material which is suitable for injection molding, wherein the boot is formed with a larger outer diameter part mounted on an outer joint member of the joint and attached thereto by a relative thin-walled metal cap which, due to its resilience, is capable of sealingly pressing radial and axial sealing faces provided at the outer diameter part of the boot against an outer circumference and an end face of the outer joint member while securingly embracing them. The boot is formed with a smaller diameter part which is provided with an inwardly directed end facing the outer joint member and resting in sealing engagement against a driving shaft connected to an inner joint member of a universal joint over a defined distance. For improving production characteristics, the inwardly directed end of the boot may have a relatively short length and a resulting free space up to the axial limit of the joint inner member is bridged by a sleeve which may be of cardboard or plastic and which may have elongate slots to facilitate assembly.
摘要翻译：一种用于密封由适于注射成型的材料形成的等速万向接头的驱动部分和被驱动部分之间的自由空间的保护套，其中，所述护罩形成有安装在所述外部接头构件上的较大外径部分通过相对的薄壁金属盖接合并附接到其上，该金属盖由于其弹性而能够密封地将设置在护罩的外径部分处的径向和轴向密封面抵靠外部接头的外周和端面成员，同时确保拥抱他们。靴子形成有较小的直径部分，其具有面向外部接头部件的向内指向的端部，并且与限定距离上连接到万向接头的内部接头部件的驱动轴线密封接合。为了改善生产特性，靴子的向内指向的端部可以具有相对短的长度，并且通过可以是纸板或塑料的套筒桥接直到接头内部构件的轴向极限的所产生的自由空间，并且可以具有细长的槽以方便装配。

5. 发明授权

US4793212A Differential gear assembly for motor vehicles 失效
公开(公告)号：US4793212A
公开(公告)日：1988-12-27
申请号：US85456
申请日：1987-08-14
申请人： Hans-Heinrich Welschof , Rudolf Beier
发明人： Hans-Heinrich Welschof , Rudolf Beier
IPC分类号： B60K17/16 , F16D3/20 , F16D3/227 , F16H48/08 , F16H48/10 , F16H1/40
CPC分类号： F16D3/227 , B60K17/165 , F16H48/08 , F16D2003/22326 , F16H2048/082 , F16H2048/085 , F16H2048/087
摘要： A differential gear assembly particularly for motor vehicles having a rotatably supported differential housing, a driving gear attached to the differential housing, at least two rotatably supported differential bevel gears and a pair of output bevel gears which engage into the differential bevel gears with a constant velocity universal joint being integrated into each of the output bevel gears. The differential bevel gears are connected in a form-fitting manner to the driving gear by means of radial and/or axial recesses, apertures or the like, with the differential housing, which may be formed of two parts, being connected to the driving gear. The differential housing is formed with an aperture or is divided in the region of each differential bevel gear to form a compact structure.

6. 发明授权

US4723464A Differential gear assembly for motor vehicles 失效
标题翻译：机动车用差速齿轮总成
公开(公告)号：US4723464A
公开(公告)日：1988-02-09
申请号：US757689
申请日：1985-07-22
申请人： Hans-Heinrich Welschof , Rudolf Beier
发明人： Hans-Heinrich Welschof , Rudolf Beier
IPC分类号： B60K17/16 , F16D3/20 , F16D3/227 , F16H48/08 , F16H48/10 , F16H1/40
CPC分类号： F16D3/227 , B60K17/165 , F16H48/08 , F16D2003/22326 , F16H2048/082 , F16H2048/085 , F16H2048/087
摘要： A differential gear assembly particularly for motor vehicles having a rotatably supported differential housing, a driving gear attached to the differential housing, at least two rotatably supported differential bevel gears and a pair of output bevel gears which engage into the differential bevel gears with a constant velocity universal joint being integrated into each of the output bevel gears. The differential bevel gears are connected in a form-fitting manner to the driving gear by means of radial and/or axial recesses, apertures or the like, with the differential housing, which may be formed of two parts, being connected to the driving gear. The differential housing is formed with an aperture or is divided in the region of each differential bevel gear to form a compact structure.
摘要翻译：一种特别用于机动车辆的差速齿轮组件，其具有可旋转地支撑的差速器壳体，附接到差速器壳体的驱动齿轮，至少两个可旋转支撑的差速锥齿轮和一对输出锥齿轮，其以恒定速度接合到差速锥齿轮万向节被整合到每个输出锥齿轮中。差速器锥齿轮通过径向和/或轴向凹槽，孔或类似物以形状配合方式连接到驱动齿轮，差速器壳体可以由两部分组成，连接到驱动齿轮。差速器壳体形成有孔或者在每个差速锥齿轮的区域中分开以形成紧凑的结构。

7. 发明申请

US20090208495A1 ANTI-TUMOR EFFECTIVE PARAMYXOVIRUS 审中-公开
标题翻译：抗肿瘤有效的寄生虫病
公开(公告)号：US20090208495A1
公开(公告)日：2009-08-20
申请号：US12368330
申请日：2009-02-10
申请人： Rudolf Beier , Florian Puehler
发明人： Rudolf Beier , Florian Puehler
IPC分类号： A61K39/395 , A61K35/76
CPC分类号： A61K35/768 , A61K38/00 , C12N2760/18032
摘要： Paramyxovirus from the group APMV3, APMV4, APMV5, APMV6, APMV7, APMV8, APMV9, Mapueravirus and Fer-de-Lance virus are described, which can be used for the production of a medicament for the treatment of tumors. The virus has a selectivity to kill human tumor cells but not human normal differentiated and human normal proliferating cells at the same dose. By genetic engineering the virus can be modified in such a way that one or more genes are added or are replaced by the homologous genes of a related paramyxovirus. By that method the anti-tumor activity of the resulting chimeric virus is enhanced compared to the parental virus.
摘要翻译：描述了可用于制备用于治疗肿瘤的药物的来自APMV3，APMV4，APMV5，APMV6，APMV7，APMV8，APMV9，马普兰病毒和Fer-de-Lance病毒的副粘病毒。该病毒具有杀死人类肿瘤细胞但不具有相同剂量的人正常分化和人正常增殖细胞的选择性。通过基因工程，病毒可以以一种或多种基因被添加或被相关副粘病毒的同源基因替代的方式进行修饰。通过该方法，与亲本病毒相比，所得嵌合病毒的抗肿瘤活性得到增强。

8. 发明授权

US4995853A Plunging constant velocity ratio universal joint 失效
标题翻译：倾角恒速比万向节
公开(公告)号：US4995853A
公开(公告)日：1991-02-26
申请号：US363152
申请日：1989-06-08
申请人： Peter Schwarzler , Hans Wormsbacher , Rudolf Beier
发明人： Peter Schwarzler , Hans Wormsbacher , Rudolf Beier
IPC分类号： F16D3/227
CPC分类号： F16D3/227 , F16D2003/22303 , F16D2003/22313 , Y10S464/906
摘要： A constant velocity ratio universal joint of plunging type, comprising an outer joint member (1), an inner joint member (2), facing pairs of tracks (3, 4) in the joint members receiving balls (5) for torque transmission, and a cage (6) constraining the balls and having first and second control surfaces (7, 9) with centers of curvature unequally off-set from the ball center plane I, in order to guide the balls to the bisect or plane, wherein the first control surface of the cage comprises two portions (7.sub.1, 7.sub.2). The first portion (7.sub.1) is part-spherical, and the second portion (7.sub.2) is a surface of revolution about the axis of the cage of an arc of radius of curvature less than the radius of curvature of the part-spherical portion (7.sub.1). The effect of the unequal off-set of the control surfaces of the cage is to compensate for axial thrusts on the balls when the joint is articulated, and the provision of the two portions of the first control surface has the effect of reducing such compensation with increasing articulation, thereby preventing possible jamming of the balls.
摘要翻译：一种用于扭矩传递的接头构件接收球（5）中的一对轨道（3,4）的外接头构件（1），内接头构件（2），其包括外接头构件（1），内接头构件（2）限制球的保持架（6），并且具有与球中心平面I不均匀偏离的曲率中心的第一和第二控制表面（7,9），以便将球引导到二等分或平面，其中第一保持架的控制面包括两部分（71,72）。第一部分（71）是部分球形的，并且第二部分（72）是围绕保持架的轴线的旋转曲面的曲面半径小于部分球形部分（71）的曲率半径）。保持架的控制表面的不相等偏移的作用是补偿当关节铰接时球上的轴向推力，并且提供第一控制表面的两个部分具有减少这种补偿的效果增加关节，从而防止可能的球堵塞。

9. 发明授权

US4858998A Wheel supporting assembly 失效
标题翻译：车轮支撑组件
公开(公告)号：US4858998A
公开(公告)日：1989-08-22
申请号：US142506
申请日：1988-01-11
申请人： Hans-Heinrich Welschof , Rudolf Beier
发明人： Hans-Heinrich Welschof , Rudolf Beier
IPC分类号： B60B35/18 , B60B27/00 , B60B35/14
CPC分类号： B60B27/0005 , Y10S464/906
摘要： A wheel supporting assembly for a motor vehicle, comprising a wheel carrier member (1) with means for attachment to at least one suspension component, and a unit of hub member (16), universal joint member (21), and bearing with outer race (15) integral with or received in a bearing housing (3), secured to the wheel carrier member. The wheel carrier member affords a formation (2) open and undercut-free in a direction transversely of the rotational axis of the hub member, so that the hub member-bearing unit can be fitted radially to the wheel carrier member. The bearing housing of the unit is then held to the wheel carrier member by at least two fixing elements, particularly bolts, spaced from one another by a distance greater than an outer diameter of the bearing, which distance is preferably less than the size of a flange on the hub member to which a wheel is to be attached.
摘要翻译：一种用于机动车辆的车轮支撑组件，包括具有用于附接到至少一个悬挂部件的装置的轮承载构件（1）和轮毂构件（16），万向节构件（21）和具有外圈的轴承的单元（15）与轴承壳体（3）成一体或被接纳在轴承壳体（3）中，固定到车轮承载构件上。车轮承载构件沿横向于轮毂构件的旋转轴线的方向提供打开和无切削的构造（2），使得轮毂构件承载单元可径向地配合到车轮承载构件。然后，单元的轴承壳体通过至少两个彼此间隔开的距离大于轴承的外径的固定元件（特别是螺栓）而保持在车轮承载构件上，该距离优选地小于轴承的尺寸轮毂部件上要安装轮缘的法兰。

10. 发明授权

US4835829A Hub assembly 失效
标题翻译：轮毂总成
公开(公告)号：US4835829A
公开(公告)日：1989-06-06
申请号：US57278
申请日：1987-05-29
申请人： Hans-Heinrich Welschof , Rudolf Beier , Norbert Hofmann
发明人： Hans-Heinrich Welschof , Rudolf Beier , Norbert Hofmann
IPC分类号： F16D3/20 , B60B27/00 , B60B35/14 , B60B35/18 , F16C19/18 , F16C33/60 , F16C35/04 , F16C35/063 , F16D1/068 , F16D3/224
CPC分类号： F16D1/068 , B60B27/0005 , F16C19/186 , F16C33/60 , F16C35/063 , F16C2326/02 , Y10S464/906 , Y10T29/49535
摘要： A hub assembly comprising a hub member (10), a flange (4) for wheel attachment, a double row bearing (2), and a constant velocity ratio universal joint (3), wherein the bearing has at least one inner bearing ring (13, 14) which is a separate component received on the hub member, and a connection between the hub member and a further part of the assembly is established by a welding and upsetting operation, and the inner bearing ring is engaged to hold it in position and to set the bearing as a result of such welding and upsetting operation. The welded and upset connection may be provided between the hub member and an outer member (15) of the constant velocity ratio universal joint, or between the hub member and flange. A weld bead formed by the welding and upsetting operation may engage the inner bearing ring either directly or indirectly, or a projection extending from the part welded to the hub member may engage the inner bearing ring.
摘要翻译：一种轮毂组件，包括轮毂构件（10），用于车轮附接的凸缘（4），双列轴承（2）和恒速比万向接头（3），其中所述轴承具有至少一个内轴承环 13，14），其是容纳在轮毂构件上的单独部件，并且通过焊接和镦锻操作建立轮毂构件与组件的另一部分之间的连接，并且内轴承环接合以将其保持在适当位置并且由于这种焊接和镦锻操作而设置轴承。焊接和镦粗连接可以设置在轮毂构件和恒速比万向接头的外部构件（15）之间，或者在轮毂构件和凸缘之间。通过焊接和镦锻操作形成的焊道可以直接或间接地接合内轴承环，或者从焊接到轮毂构件的部件延伸的突起可以接合内轴承环。

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