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1. 发明申请

US20090318410A1 IMIDAZOPYRIDAZINES AS LIPID KINASE INHIBITORS 审中-公开
标题翻译：作为脂质激酶抑制剂的咪唑吡啶
公开(公告)号：US20090318410A1
公开(公告)日：2009-12-24
申请号：US12442418
申请日：2007-10-29
申请人： Hans-Georg Capraro , Pascal Furet , Patricia Imbach , Frédéric Stauffer
发明人： Hans-Georg Capraro , Pascal Furet , Patricia Imbach , Frédéric Stauffer
IPC分类号： A61K31/5025 , C07D487/04 , A61K31/5377
CPC分类号： C07D487/04
摘要： The invention relates to novel compounds of the formula I, as well as other invention embodiments related to these compounds. The compounds are e.g. useful in the treatment of the animal or human body in view of their ability to inhibit protein kinases such as especially PI3 kinase.
摘要翻译：本发明涉及式I的新化合物以及与这些化合物有关的其它发明实施方案。化合物是例如鉴于其抑制蛋白激酶（例如PI3激酶）的能力，可用于动物或人体的治疗。

2. 发明申请

US20100041662A1 Heterocyclic compounds as antiinflammatory agents 审中-公开
标题翻译：杂环化合物作为抗炎剂
公开(公告)号：US20100041662A1
公开(公告)日：2010-02-18
申请号：US12311393
申请日：2007-10-29
申请人： Sandrine Ferrand , Fraser Glickman , Catherine Leblanc , Cathy Ritchie , Duncan Shaw , Nikolaus Johannes Stiefl , Pascal Furet , Patricia Imbach , Frédéric Stauffer , Hans-Georg Capraro , François Gessier , Christoph Gaul , Pameia A. Albaugh , Greg Chopiuk
发明人： Sandrine Ferrand , Fraser Glickman , Catherine Leblanc , Cathy Ritchie , Duncan Shaw , Nikolaus Johannes Stiefl , Pascal Furet , Patricia Imbach , Frédéric Stauffer , Hans-Georg Capraro , François Gessier , Christoph Gaul , Pameia A. Albaugh , Greg Chopiuk
IPC分类号： A61K31/5025 , C07D487/00
CPC分类号： C07D487/04
摘要： A compound of Formula Ia or Ib in free or salt or solvate form, where R1, R2, R3, R4, R5 R20, R24, R25, X, Y and Z have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. These compounds are also useful for treating diseases mediated by the Pi3k receptor, the JAK-2 receptor and the TRK receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
摘要翻译：式Ia或Ib的游离或盐或溶剂合物形式的化合物，其中R1，R2，R3，R4，R5，R20，R24，R25，X，Y和Z具有说明书中指出的含义，可用于治疗疾病由ALK-5和/或ALK-4受体介导。这些化合物也可用于治疗由Pi3k受体，JAK-2受体和TRK受体介导的疾病。还描述了含有化合物的药物组合物和用于制备化合物的方法。

3. 发明申请

US20100311714A1 1H-IMIDAZO[4,5-c]QUINOLINONE COMPOUNDS 审中-公开
标题翻译： 1H-咪唑并[4,5-c]喹啉酮化合物
公开(公告)号：US20100311714A1
公开(公告)日：2010-12-09
申请号：US12792187
申请日：2010-06-02
申请人： Pascal Furet , Patricia Imbach , Robert Mah , Frédéric Stauffer
发明人： Pascal Furet , Patricia Imbach , Robert Mah , Frédéric Stauffer
IPC分类号： A61K31/437 , C07D471/04 , A61K31/506 , A61K31/497 , A61P35/04
CPC分类号： C07D471/04 , C07D471/14
摘要： The invention relates to the use of 1H-imidazo[4,5-c]quinolinone compounds and salts thereof in the treatment of protein and/or lipid kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases; 1H-imidazo[4,5-c]quinolinone compounds for use in the treatment of protein and/or lipid kinase dependent diseases; a method of treatment against said diseases, comprising administering the 1H-imidazo[4,5-c]quinolinone compounds to a warm-blooded animal, especially a human; pharmaceutical preparations comprising an 1H-imidazo[4,5-c]quinolinone compounds, especially for the treatment of a protein and/or lipid kinase dependent disease; novel 1H-imidazo[4,5-c]quinolinone compounds; and a process for the preparation of the novel 1H-imidazo[4,5-c]quinolinone compounds.
摘要翻译：本发明涉及1H-咪唑并[4,5-c]喹啉酮化合物及其盐在治疗蛋白质和/或脂质激酶依赖性疾病中的用途以及用于制备用于治疗所述疾病的药物制剂; 用于治疗蛋白质和/或脂质激酶依赖性疾病的1H-咪唑并[4,5-c]喹啉酮化合物; 一种治疗所述疾病的方法，包括将1H-咪唑并[4,5-c]喹啉酮化合物给予温血动物，特别是人; 包括1H-咪唑并[4,5-c]喹啉酮化合物的药物制剂，特别是用于治疗蛋白质和/或脂质激酶依赖性疾病; 新的1H-咪唑并[4,5-c]喹啉酮化合物; 以及制备新型1H-咪唑并[4,5-c]喹啉酮化合物的方法。

4. 发明授权

US09458177B2 Oxazolidin-2-one compounds and uses thereof 有权
标题翻译：恶唑烷-2-酮化合物及其用途
公开(公告)号：US09458177B2
公开(公告)日：2016-10-04
申请号：US14478523
申请日：2014-09-05
申请人： Giorgio Caravatti , Robin Alec Fairhurst , Pascal Furet , Clive McCarthy , Heinrich Rueeger , Frank Hans Seiler , Frédéric Stauffer
发明人： Giorgio Caravatti , Robin Alec Fairhurst , Pascal Furet , Clive McCarthy , Heinrich Rueeger , Frank Hans Seiler , Frédéric Stauffer
IPC分类号： C07D403/04 , C07D498/04 , C07D413/14 , A61K31/5377 , A61K45/06
CPC分类号： C07D498/04 , A61K31/5377 , A61K45/06 , C07D413/14
摘要： The present invention relates to oxazolidin-2-one substituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.
摘要翻译：本发明涉及作为PI3K（磷脂酰肌醇-3-激酶）抑制剂的恶唑烷-2-酮取代的嘧啶化合物及其药物组合物，其制备方法和用于治疗依赖于 PI3K。

5. 发明授权

US08476294B2 1H-imidazo[4,5-c]quinolinone derivatives 失效
标题翻译： 1H-咪唑并[4,5-c]喹啉酮衍生物
公开(公告)号：US08476294B2
公开(公告)日：2013-07-02
申请号：US12792471
申请日：2010-06-02
申请人： Pascal Furet , Frank Stephan Kalthoff , Robert Mah , Christian Ragot , Frédéric Stauffer
发明人： Pascal Furet , Frank Stephan Kalthoff , Robert Mah , Christian Ragot , Frédéric Stauffer
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , C07D471/14 , C07D498/04
摘要： The invention relates to the use of 1H-imidazo[4,5-c]quinolinone derivatives and salts thereof in the treatment of protein and/or lipid kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases; 1H-imidazo[4,5-c]quinolinone derivatives for use in the treatment of protein and/or lipid kinase dependent diseases; a method of treatment against said diseases, comprising administering the 1H-imidazo[4,5-c]quinolinone derivatives to a warm-blooded animal, especially a human; pharmaceutical preparations comprising an 1H-imidazo[4,5-c]quinolinone derivative, especially for the treatment of a protein and/or lipid kinase dependent disease; novel 1H-imidazo[4,5-c]quinolinone derivatives; and a process for the preparation of the novel 1H-imidazo[4,5-c]quinolinone derivatives.
摘要翻译：本发明涉及1H-咪唑并[4,5-c]喹啉酮衍生物及其盐在治疗蛋白质和/或脂质激酶依赖性疾病中的用途以及用于制备用于治疗所述疾病的药物制剂; 用于治疗蛋白质和/或脂质激酶依赖性疾病的1H-咪唑并[4,5-c]喹啉酮衍生物; 一种治疗所述疾病的方法，包括将1H-咪唑并[4,5-c]喹啉酮衍生物给予温血动物，特别是人; 包含1H-咪唑并[4,5-c]喹啉酮衍生物的药物制剂，特别是用于治疗蛋白质和/或脂质激酶依赖性疾病; 新型1H-咪唑并[4,5-c]喹啉酮衍生物; 以及制备新的1H-咪唑并[4,5-c]喹啉酮衍生物的方法。

6. 发明授权

US07994170B2 1,3-dihydro-imidazo[4,5-C]quinolin-2-ones as lipid kinase inhibitors 有权
标题翻译： 1,3-二氢 - 咪唑并[4,5-C]喹啉-2-酮作为脂质激酶抑制剂
公开(公告)号：US07994170B2
公开(公告)日：2011-08-09
申请号：US12577268
申请日：2009-10-12
申请人： Carlos Garcia-Echeverria , Frédéric Stauffer , Pascal Furet
发明人： Carlos Garcia-Echeverria , Frédéric Stauffer , Pascal Furet
IPC分类号： C07D471/04 , A61K31/4188
CPC分类号： C07D471/04
摘要： The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.
摘要翻译：本发明涉及式（I）的新型有机化合物，其制备方法，其在治疗人或动物体的方法中的应用，其用途单独或与一种或多种其它药学活性化合物用于治疗炎性或阻塞性气道疾病，例如哮喘，通常与移植相关的疾病，或增生性疾病如肿瘤疾病。

7. 发明申请

US20120207751A1 Imidazoquinolines as lipid kinase inhibitors 审中-公开
标题翻译：咪唑喹啉作为脂质激酶抑制剂
公开(公告)号：US20120207751A1
公开(公告)日：2012-08-16
申请号：US13453225
申请日：2012-04-23
申请人： Carlos Garcia-Echeverria , Frédéric Stauffer , Pascal Furet
发明人： Carlos Garcia-Echeverria , Frédéric Stauffer , Pascal Furet
IPC分类号： A61K31/4745 , A61K31/506 , A61K31/496 , A61K31/5685 , A61K31/565 , A61K31/4375 , A61K31/704 , A61K31/513 , A61K31/7068 , A61K31/519 , A61K33/24 , A61K39/395 , A61K31/5377 , A61K31/517 , A61K38/08 , A61P35/00 , A61K31/69 , A61K31/498
CPC分类号： C07D471/04
摘要： The invention relates to a combination comprising compounds of formula (I) and one or more other antiproliferative compounds, hormones or radiation, pharmaceutical preparations comprising the combination thereof, and the application thereof in a process for the treatment of tumors.
摘要翻译：本发明涉及包含式（I）化合物和一种或多种其它抗增殖化合物，激素或辐射的组合，包含其组合的药物制剂及其在治疗肿瘤的方法中的应用。

8. 发明申请

US20100056558A1 1,3-DIHYDRO-IMIDAZO[4,5-C]QUINOLIN-2-ONES AS LIPID KINASE INHIBITORS 有权
标题翻译： 1,3-二氢-1H-咪唑并[4,5-C]喹啉-2-酮作为脂质激酶抑制剂
公开(公告)号：US20100056558A1
公开(公告)日：2010-03-04
申请号：US12577268
申请日：2009-10-12
申请人： Carlos Garcia-Echeverria , Frédéric Stauffer , Pascal Furet
发明人： Carlos Garcia-Echeverria , Frédéric Stauffer , Pascal Furet
IPC分类号： A61K31/437 , C07D471/04 , A61P11/00 , A61P35/00 , A61P29/00
CPC分类号： C07D471/04
摘要： The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.
摘要翻译：本发明涉及式（I）的新型有机化合物，其制备方法，其在治疗人或动物体的方法中的应用，其用途单独或与一种或多种其它药学活性化合物用于治疗炎性或阻塞性气道疾病，例如哮喘，通常与移植相关的疾病，或增生性疾病如肿瘤疾病。

9. 发明授权

US07667039B2 1,3-dihydro-imidazo [4,5-C] quinolin-2-ones as lipid kinase inhibitors 有权
标题翻译： 1,3-二氢 - 咪唑并[4,5-C]喹啉-2-酮作为脂质激酶抑制剂
公开(公告)号：US07667039B2
公开(公告)日：2010-02-23
申请号：US11913788
申请日：2006-05-18
申请人： Carlos Garcia-Echeverria , Frédéric Stauffer , Pascal Furet
发明人： Carlos Garcia-Echeverria , Frédéric Stauffer , Pascal Furet
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof—alone or in combination with one or more other pharmaceutically active compounds—for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.
摘要翻译：本发明涉及式（I）的新型有机化合物，其制备方法，其在治疗人或动物体的方法中的应用，其用途单独或与一种或多种其它药学活性化合物用于治疗炎性或阻塞性气道疾病，例如哮喘，通常与移植相关的疾病，或增生性疾病如肿瘤疾病。

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