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1. 发明授权

US5976609A Process for recovering 2-hydroxy-4-methylthiobutyric acid (MHA), MHA and its use 失效
标题翻译： 2-羟基-4-甲硫基丁酸（MHA），MHA及其用途的回收方法
公开(公告)号：US5976609A
公开(公告)日：1999-11-02
申请号：US776217
申请日：1997-01-13
申请人： Hans-Albrecht Hasseberg , Klaus Huthmacher , Herbert Tanner , Volker Hafner , Harald Heinzel
发明人： Hans-Albrecht Hasseberg , Klaus Huthmacher , Herbert Tanner , Volker Hafner , Harald Heinzel
IPC分类号： A23K1/16 , C07C319/20 , C07C319/28 , C07C323/52 , C07C323/60 , A23L1/305 , A23L1/28 , C15C315/02 , C15C315/06
CPC分类号： C07C319/28 , A23K20/105 , C07C319/20 , Y10S426/807
摘要： It is known to isolate MHA from a reaction mixture obtained by the addition of hydrocyanic acid (HCN) to methyl mercaptopropionic aldehyde (MMP) and the hydrolysis of the methyl mercapto propionic aldehyde cyanohydrine (MMP-CH) obtained thereby with sulphuric acid, in which the reaction mixture is brought into contact with a substantially non-water-miscible organic solvent, in order to form an extraction solution having the solvent and MHA transferred from the reaction mixture, and the MHA is obtained as an extract from this extraction solution by concentration. The simplest and most economical process of the invention concerning the processing of the reaction product which facilitates the production of a highly concentrated product with an extremely low dimer, oligomer and by-product content, is characterised in that the concentration is conducted in such a way that the remaining extract contains less than 4 wt % and preferably less than 2 wt % of water. Animal feed supplement, mixtures for supplementing animal feed, e.g. with methionine or ammonium-MHA.
摘要翻译： PCT No.PCT / EP95 / 02515 Sec。 371日期1997年1月13日 102（e）日期1997年1月13日PCT提交1995年6月28日PCT公布。公开号WO96 / 01809 日本1996年1月25日已知通过将氢氰酸（HCN）加入到甲基巯基丙醛（MMP）中获得的反应混合物和由此获得的甲基巯基丙醛氰基氢醌（MMP-CH）的水解来分离MHA 硫酸，其中使反应混合物与基本上不与水混溶的有机溶剂接触，以形成从反应混合物中转移有溶剂和MHA的提取溶液，并且获得MHA作为该提取液通过浓缩。关于有助于生产具有极低二聚体，低聚物和副产物含量的高浓缩产物的反应产物的加工的本发明的最简单和最经济的方法的特征在于以这种方式进行浓缩剩余的提取物含有小于4重量％，优选小于2重量％的水。动物饲料补充剂，补充动物饲料的混合物。与甲硫氨酸或铵-MAA。

2. 发明授权

US6063968A Method for the production of trimethylhydroquinone 失效
标题翻译：生产三甲基氢醌的方法
公开(公告)号：US6063968A
公开(公告)日：2000-05-16
申请号：US855270
申请日：1997-05-14
申请人： Frank Hubner , Steffen Krill , Bernd Drapal , Hermann Schmitt , Klaus Huthmacher , Herbert Tanner
发明人： Frank Hubner , Steffen Krill , Bernd Drapal , Hermann Schmitt , Klaus Huthmacher , Herbert Tanner
IPC分类号： B01J31/02 , C07B61/00 , C07C27/02 , C07C37/055 , C07C37/07 , C07C39/08 , C07C67/00 , C07C37/00
CPC分类号： C07C37/0555 , C07C67/00 , C07C67/08
摘要： The invention relates to an improved method for the production of 2,3,5-trimethylhydroquinone by rearranging 4-oxo-isophorone (keto-isophorone, 3,5,5-trimethylcyclohex-2-en[e]-1,4-dione) to a trimethylhydroquinone diester and by its subsequent saponification. ##STR1##
摘要翻译：本发明涉及通过重新排列4-氧代 - 异佛尔酮（酮 - 异佛尔酮，3,5,5-三甲基环己-2-烯[e] -1,4-二酮）的生产2,3,5-三甲基氢醌的改进方法）到三甲基氢醌二酯并随后皂化。

3. 发明授权

US6005147A Method of producing 3, 5, 5-trimethylcyclohexa-3-ene-1-one(.beta.-isophorone) by the isomerization of 3, 5, 5-trimethylcyclohexa-2-ene-1-(.alpha.-isophorone) 失效
标题翻译：通过异构化3,5,5-三甲基环己-2-烯-1-酮（α-异佛尔酮）制备3,5,5-三甲基环己-3-烯-1-酮（β-异构体）的方法，
公开(公告)号：US6005147A
公开(公告)日：1999-12-21
申请号：US938822
申请日：1997-09-26
申请人： Steffen Krill , Gunes Giray , Klaus Huthmacher , Frank Hubner , Herbert Tanner
发明人： Steffen Krill , Gunes Giray , Klaus Huthmacher , Frank Hubner , Herbert Tanner
IPC分类号： B01J23/78 , B01J27/138 , B01J27/232 , C07B61/00 , C07C45/67 , C07C49/603
CPC分类号： C07C45/67
摘要： A method of producing 3,5,5-trimethylcyclohexa-3-ene-1-one (.beta.-isophorone) including a catalyst of an oxide or mixed oxide of at least one element of the groups IIa, VIII, Ib, IIIa and Va of the periodic system. Isomerization is carried out without the addition of an organic base. The space-time yield in the production of .beta.-isophorone by the isomerization of .alpha.-isophorone is at a level suitable for an industrial application. .beta.-isophorone is especially suitable as an intermediate product for producing ketoisophorone.
摘要翻译：制备3,5,5,3-三甲基环己-3-烯-1-酮（β-异丙酮）的方法，其包括IIa，VIII，Ib，IIIa和Vaa族组合中的至少一种元素的氧化物或混合氧化物的催化剂的周期性系统。不加入有机碱进行异构化。通过α-异佛尔酮异构化生产β-异佛尔酮的时空产率处于适合工业应用的水平。 β-异佛尔酮特别适合作为生产酮异佛尔酮的中间产物。

4. 发明授权

US5990349A Process for the preparation of D,L-methionine or the salt thereof 失效
标题翻译：制备D，L-甲硫氨酸或其盐的方法
公开(公告)号：US5990349A
公开(公告)日：1999-11-23
申请号：US37020
申请日：1998-03-09
申请人： Friedhelm Geiger , Baudouin Halsberghe , Hans-Joachim Hasselbach , Klaus Hentschel , Klaus Huthmacher , Martin Korfer , Sven-Peter Mannsfeld , Herbert Tanner , Ferdinand Theissen , Jose Vanrobaeys , Klaus Willigerodt
发明人： Friedhelm Geiger , Baudouin Halsberghe , Hans-Joachim Hasselbach , Klaus Hentschel , Klaus Huthmacher , Martin Korfer , Sven-Peter Mannsfeld , Herbert Tanner , Ferdinand Theissen , Jose Vanrobaeys , Klaus Willigerodt
IPC分类号： C07C319/20 , C07C319/28 , C07C323/58 , C07D233/76 , C07C321/00 , C07C315/00
CPC分类号： C07C319/20 , C07C319/28 , C07D233/76
摘要： A process for the preparation of methionine or a salt of methionine by reaction of the components 3-methylmercaptopropionaldhyde, hydrogen cyanide, ammonia and carbon dioxide or components from which the above-mentioned components can be prepared, optionally in the presence of water, to 5-(2-methylmercaptoethyl)-hydantoin and further reaction thereof to methionine or the salt thereof, characterised in that the reaction of the components is initiated by means of at least one premixture in such a way that a first mixture is formed containing at least the predominant proportion (at least 5/10) of the 3-methylmercaptopropionaldeyde and at least 1/10 of the hydrogen cyanide component or corresponding quantities of components from which these components can be prepared, and less than 5/10 of one of the components ammonia, carbon dioxide or of the components from which ammonia or carbon dioxide can be prepared, and in that this first mixture is combined with the other component(s) for the reactive conversion to 5-(2-methylmercaptoethyl)-hydantoin, wherein this (these) latter component(s) may be premixed in one or more other mixtures.
摘要翻译：通过将3-甲基巯基丙酸，氰化氢，氨和二氧化碳或可由其制备上述组分的组分，任选地在水存在下，将组分3-甲基巯基丙酸，氰化氢，氨和二氧化碳或组分反应制备甲硫氨酸或甲硫氨酸的方法， - （2-甲基巯基乙基） - 乙内酰脲及其与甲硫氨酸或其盐的反应，其特征在于，组分的反应通过至少一种预混物引发，使得形成第一混合物至少含有 3-甲基巯基丙酸的主要比例（至少+ E，fra 5/10 + EE）和氰化氢组分的至少+ E，fra 1/10 + EE或可以制备这些组分的相应量的组分，并且可以制备氨，二氧化碳或其中可以制备氨或二氧化碳的组分之一的小于+ E，fra 5/10 + EE，并且因为该第一混合物与反应转化成5-（2-甲基巯基乙基） - 乙内酰脲的其它组分，其中这些（这些）后一种组分可以在一种或多种其它混合物中预混合。

5. 发明授权

US5907065A Method of producing .beta.-isophorone by the isomerization of .alpha.-isophorone 失效
标题翻译：通过α-异佛尔酮异构化生产β-异佛尔酮的方法
公开(公告)号：US5907065A
公开(公告)日：1999-05-25
申请号：US938821
申请日：1997-09-26
申请人： Steffen Krill , Gunes Giray , Frank Hubner , Rainer Hahn , Klaus Huthmacher , Herbert Tanner
发明人： Steffen Krill , Gunes Giray , Frank Hubner , Rainer Hahn , Klaus Huthmacher , Herbert Tanner
IPC分类号： B01J23/02 , B01J23/75 , B01J23/755 , C07B61/00 , C07C45/67 , C07C45/82 , C07C45/83 , C07C49/603
CPC分类号： C07C45/67 , C07C45/82
摘要： A method of producing 3,5,5-trimethylcyclohexa-3-ene-1-one (.beta.-isophorone) by isomerization of 3,5,5-trimethylcyclohexa-2-ene-1-one (.alpha.-isophorone) in a liquid phase in the presence of a homogeneous or heterogeneous catalyst in which a mixture with a relatively low concentration of .beta.-isophorone is drawn off from the reaction container and the .beta.-isophorone isolated by vacuum distillation. .beta.-isophorone is an important synthetic structural element for the production of carotinoids, vitamins and pharmaceutical products.
摘要翻译：通过在液体中异构化3,5,5-三甲基环己-2-烯-1-酮（α-异佛尔酮）制备3,5,5-三甲基环己-3-烯-1-酮（β-异构体）的方法在均相或非均相催化剂的存在下，从反应容器中抽出具有较低浓度的β-异佛尔酮的混合物和通过真空蒸馏分离的β-异佛尔酮。 β-异佛尔酮是生产类胡萝卜素，维生素和药物的重要合成结构元素。

6. 发明授权

US5770769A Process for the preparation of D,L-methionine or the salt thereof 失效
公开(公告)号：US5770769A
公开(公告)日：1998-06-23
申请号：US768624
申请日：1996-12-18
申请人： Friedhelm Geiger , Baudouin Halsberghe , Hans-Joachim Hasselbach , Klaus Hentschel , Klaus Huthmacher , Martin Korfer , Sven-Peter Mannsfeld , Herbert Tanner , Ferdinand Theissen , Jose Vanrobaeys , Klaus Willigerodt
发明人： Friedhelm Geiger , Baudouin Halsberghe , Hans-Joachim Hasselbach , Klaus Hentschel , Klaus Huthmacher , Martin Korfer , Sven-Peter Mannsfeld , Herbert Tanner , Ferdinand Theissen , Jose Vanrobaeys , Klaus Willigerodt
IPC分类号： C07C319/20 , C07C319/28 , C07C323/58 , C07D233/76 , C07C321/00
CPC分类号： C07C319/20 , C07C319/28 , C07D233/76
摘要： A process for the preparation of methionine or a salt of methionine by reaction of the components 3-methylmercaptopropionaldhyde, hydrogen cyanide, ammonia and carbon dioxide or components from which the above-mentioned components can be prepared, optionally in the presence of water, to 5-(2-methylmercaptoethyl)-hydantoin and further reaction thereof to methionine or the salt thereof, characterised in that the reaction of the components is initiated by means of at least one premixture in such a way that a first mixture is formed containing at least the predominant proportion (at least 5/10) of the 3-methylmercaptopropionaldeyde and at least 1/10 of the hydrogen cyanide component or corresponding quantities of components from which these components can be prepared, and less than 5/10 of one of the components ammonia, carbon dioxide or of the components from which ammonia or carbon dioxide can be prepared, and in that this first mixture is combined with the other component(s) for the reactive conversion to 5-(2-methylmercaptoethyl)-hydantoin, wherein this (these) latter component(s) may be premixed in one or more other mixtures.

7. 发明授权

US5981767A Method of producing dry thioctic acid 失效
标题翻译：干硫辛酸生产方法
公开(公告)号：US5981767A
公开(公告)日：1999-11-09
申请号：US102758
申请日：1998-06-23
申请人： Herbert Tanner , Karlheinz Drauz , Gerhard Sator , Horst Bethge , Roland Moller , Frank Hubner , Thomas Tacke , Claus Rehren
发明人： Herbert Tanner , Karlheinz Drauz , Gerhard Sator , Horst Bethge , Roland Moller , Frank Hubner , Thomas Tacke , Claus Rehren
IPC分类号： A61K31/385 , A61P25/00 , A61P25/04 , A61P29/00 , C07D339/04 , C07D333/24
CPC分类号： C07D339/04 , Y02P20/544
摘要： The present invention is relative to a method of producing dry thioctic acid in which a raw material in which concentrated thioctic acid is present is treated with liquid or supercritical CO.sub.2, thus yielding thioctic acid with low residual solvent contents in a simple industrial method.
摘要翻译：本发明涉及一种生产干硫辛酸的方法，其中存在浓硫硫酸的原料用液体或超临界CO 2处理，从而以简单的工业方法产生具有低残留溶剂含量的硫辛酸。

8. 发明授权

US4065510A Production of an alkenol from an alkene oxide 失效
标题翻译：从烯烃生产烯醇
公开(公告)号：US4065510A
公开(公告)日：1977-12-27
申请号：US640210
申请日：1975-12-12
申请人： Gerd Schreyer , Herbert Tanner , Wolfgang Weigert , Ullrich Gora
发明人： Gerd Schreyer , Herbert Tanner , Wolfgang Weigert , Ullrich Gora
IPC分类号： B01J27/18 , C07C29/00
CPC分类号： B01J27/1806
摘要： Lithium phosphate catalysts for the rearrangement of alkene oxides to the corresponding alkenols are prepared as overcoats on inert carriers. The catalysts are prepared for example by overcoating the inert carrier with the lithium phosphate in the presence of moisture.
摘要翻译：将用于将烯烃氧化物重排为相应链烯醇的磷酸锂催化剂制备为惰性载体上的外涂层。催化剂例如通过在水分存在下用磷酸锂覆盖惰性载体来制备。

9. 发明授权

US3968253A Feed additive for ruminants 失效
标题翻译：反刍动物饲料添加剂
公开(公告)号：US3968253A
公开(公告)日：1976-07-06
申请号：US441983
申请日：1974-02-13
申请人： Heidrun Bertram , Rudolf Fahnenstich , Herbert Tanner
发明人： Heidrun Bertram , Rudolf Fahnenstich , Herbert Tanner
IPC分类号： A23K1/16 , A23K1/22
CPC分类号： A23K20/142 , Y10S426/807
摘要： N-hydroxymethyl methionine is incorporated in feeds for ruminants.
摘要翻译：将N-羟甲基甲硫氨酸掺入反刍动物饲料中。

10. 发明授权

US5279832A Active-substance preparation for oral administration, especially to ruminants 失效
标题翻译：用于口服给药的活性物质制剂，特别是反刍动物
公开(公告)号：US5279832A
公开(公告)日：1994-01-18
申请号：US820777
申请日：1992-01-15
申请人： Dieter Greissinger , Heidermarie Kniesel , Winfried Heimbeck , Herbert Tanner
发明人： Dieter Greissinger , Heidermarie Kniesel , Winfried Heimbeck , Herbert Tanner
IPC分类号： A23K40/35 , A61K9/22 , A61K9/36 , A61K9/50 , A61K9/52 , A61K45/08 , A61P3/00 , A61K9/44
CPC分类号： A61K9/5073 , A23K40/35
摘要： A dosage form for administering physiologically active substances to animals, especially ruminant animals. The dosage unit includes a core which contains the active substance and a coating. The coating has selected areas which are thinner than the average thickness of the coating and/or areas which are predetermined rupture sites. These thin areas or predetermined rupture sites are constructed and arranged so as to detach and/or rupture under the conditions which are present after oral administration of the dosage form. As a result, the delayed release of the physiologically-active substance is accelerated. For example, the coating may be formulated to not be affected in the first stomach of a ruminant but to rapidly disintegrate in the animal's second stomach.
摘要翻译： 2.1饲料添加剂和药物等活性成分通常以延迟方式释放，或者经口给药缓慢释放。特别是在反刍动物的情况下，在瘤胃中应该释放很少或没有。适当的封装是昂贵的，并且特别是对于相对大量的产品的管理而言是不合适的并且太昂贵。这种类型的已知包封也具有可疑的生理可接受性和/或不允许的缺点。 2.2新型封装包含相对薄的区域和/或预定的断裂点，与基本上均匀的涂层相比，其加速了释放。诸如颗粒的角度细节优选地被包封，所述包封以这样的方式形成，使得在口服给药之后胶囊可以在边缘断裂。封装优选由两层组成，内层含有填料加成膜剂，外层仅含有成膜剂。 2.3包封适用于营养目的的活性剂的保护管理，例如甲硫氨酸，或用于医疗，特别是兽医，特别是反刍动物的治疗。

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