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1. 发明申请

US20130189771A1 CELL CULTURE DEVICE 审中-公开
标题翻译：细胞培养装置
公开(公告)号：US20130189771A1
公开(公告)日：2013-07-25
申请号：US13358014
申请日：2012-01-25
申请人： Hans Strandberg , Lars Enochson , Joakim Sandstedt
发明人： Hans Strandberg , Lars Enochson , Joakim Sandstedt
IPC分类号： C12M1/00
CPC分类号： C12M35/02
摘要： A cell culture device has a chamber bottom, a wall section and a lid that enclose a culture chamber. A first electrode in the chamber bottom extends over a cell culture area of the culture chamber onto which cells are to be cultured. A second electrode in the lid is aligned with the first electrode and extends over an area in the lid corresponding to the cell culture area. A stimulation pulse generator applies stimulation pulses over the electrodes to form an electric field with a homogenous current density in the cell culture area.
摘要翻译：细胞培养装置具有包围培养室的腔室底部，壁部分和盖子。腔室底部的第一个电极延伸到要培养细胞的培养室的细胞培养区域上。盖子中的第二电极与第一电极对准，并延伸到对应于细胞培养区域的盖子中的一个区域上。刺激脉冲发生器在电极上施加刺激脉冲，以在细胞培养区域中形成均匀电流密度的电场。

2. 发明授权

US08442647B2 Medical implantable lead and method for the manufacture thereof 有权
标题翻译：医用植入式铅及其制造方法
公开(公告)号：US08442647B2
公开(公告)日：2013-05-14
申请号：US13132125
申请日：2008-12-02
申请人： Hans Strandberg , Åke Sivard , Åsa Broomé , Kenneth Dahlberg , Gustav Pellijeff , Leda Henriquez
发明人： Hans Strandberg , Åke Sivard , Åsa Broomé , Kenneth Dahlberg , Gustav Pellijeff , Leda Henriquez
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/056 , A61N1/086 , A61N1/3718 , Y10T29/49002
摘要： A medical implantable lead adapted to be implanted into a human or animal body for monitoring and/or controlling of an organ inside the body has a fixation in a distal end, which is adapted to fix a distal end of the lead to the organ, an electrode member in the distal end adapted to be in contact with tissue of the organ and receive and/or transmit electrical signals from and/or to the organ, and at least one electrically conducting coil, which includes one or more electrically conducting helical wires and that is adapted to connect the electrode member in the distal end with a monitoring and/or controlling device in a proximal end of the lead. One or more of the individual wires of the coil has a wire core that is provided with a surrounding electrically insulating layer, which in turn is provided with a surrounding electrically conducting shield layer, and the coil is close lapped such that electrically conducting shield layers of adjacent loops of the coil are in electrical contact with each other.
摘要翻译：适于植入人体或动物体内的用于监测和/或控制体内器官的医用可植入引线具有在远端固定，其适于将引线的远端固定到器官，远端中的电极构件适于与器官的组织接触并且接收和/或传送来自器官和/或器官的电信号，以及至少一个导电线圈，其包括一个或多个导电螺旋线和其适于将远端中的电极构件与引线的近端中的监视和/或控制装置连接。线圈的一条或多条单独的线具有线芯，该芯线设置有环绕的电绝缘层，该电绝缘层又设置有环绕的导电屏蔽层，并且线圈被紧密地重叠，使得导电屏蔽层线圈的相邻环彼此电接触。

3. 发明授权

US08419716B2 Tissue stimulating device and method 有权
标题翻译：组织刺激装置及方法
公开(公告)号：US08419716B2
公开(公告)日：2013-04-16
申请号：US12445607
申请日：2006-10-31
申请人： Anna Weissenrieder-Norlin , Leda Henriquez , Hans Strandberg , Eva Harström , Mikael Sjögren , Annika Naeslund
发明人： Anna Weissenrieder-Norlin , Leda Henriquez , Hans Strandberg , Eva Harström , Mikael Sjögren , Annika Naeslund
IPC分类号： A61N1/44
CPC分类号： A61N1/44 , A61N1/32 , A61N1/362
摘要： A tissue stimulating device that provides biological stimulation of tissue has a release surface adapted for arrangement adjacent to a tissue to be stimulated. An agent reservoir of the device includes an ionic agent capable of causing a stimulation if present at sufficient high extracellular concentration close to the tissue. An agent releaser is provided in the device for releasing a selected amount of the ionic agent from the agent reservoir to an outside of the release surface at a stimulation occasion for stimulating the tissue. The ionic agent will cause a temporary change in ion permeability of the tissue cell membranes and a depolarization of the tissue cells.
摘要翻译：提供组织的生物刺激的组织刺激装置具有适于布置成邻近要刺激的组织的释放表面。该装置的药剂储存器包括能够在靠近组织足够高的细胞外浓度存在时引起刺激的离子试剂。在用于在用于刺激组织的刺激时刻将选定量的离子试剂从试剂储存器释放到释放表面外部的试剂释放剂。离子剂将导致组织细胞膜的离子渗透性的暂时变化和组织细胞的去极化。

4. 发明授权

US5814086A Perex respiratory system stimulation upon tachycardia detection 失效
标题翻译：佩雷克斯呼吸系统刺激对心动过速检测
公开(公告)号：US5814086A
公开(公告)日：1998-09-29
申请号：US950138
申请日：1997-10-14
申请人： Jakub Hirschberg , Hans Strandberg
发明人： Jakub Hirschberg , Hans Strandberg
IPC分类号： A61N1/365 , A61N1/36 , A61N1/372 , A61N1/38
CPC分类号： A61N1/3601
摘要： A tachycardia eliminating apparatus includes a heartbeat detector which detects heartbeats in an input heart activity signal which delivers an output heartbeat signal indicating each detected heartbeat, a tachycardia detector coupled to the output of the heartbeat detector which generates a tachycardia indication signal in response to a detected tachycardia status of a heart as reflected in the heartbeat signal, and a respiratory system stimulator coupled to the output of the tachycardia detector and generating an output respiratory system stimulation signal for stimulating a respiratory system to achieve a stimulated breathing rate, with the ratio of the detected heartbeat rate to the stimulated breathing rate corresponding to a predetermined value.
摘要翻译：心动过速消除装置包括心跳检测器，该心跳检测器检测输入心跳活动信号中的心跳，该信号传送指示每个检测到的心跳的输出心跳信号，耦合到心跳检测器的输出的心动过速检测器，其响应于检测到的心跳过程指示信号而产生心动过速指示信号在心跳信号中反映的心脏的心动过速状态，以及耦合到心动过速检测器的输出的呼吸系统刺激器，并且产生用于刺激呼吸系统以产生刺激呼吸频率的输出呼吸系统刺激信号，检测到对应于预定值的刺激呼吸频率的心跳速率。

5. 发明授权

US5697957A Adaptive method and apparatus for extracting an evoked response component from a sensed cardiac signal by suppressing electrode polarization components 失效
标题翻译：用于通过抑制电极偏振分量从感测的心脏信号中提取诱发反应分量的自适应方法和装置
公开(公告)号：US5697957A
公开(公告)日：1997-12-16
申请号：US705272
申请日：1996-08-29
申请人： Kjell Noren , Hans Strandberg
发明人： Kjell Noren , Hans Strandberg
IPC分类号： A61B5/0452 , A61N1/365 , A61N1/37
CPC分类号： A61N1/3704 , A61N1/3712 , A61N1/3716 , Y10S128/901
摘要： In a method and apparatus for suppressing electrode polarization components in a sensed cardiac signal, the sensed cardiac signal is added to either a differentiated or autocorrelated sensed cardiac signal and a difference is formed between the original sensed cardiac signal and the autocorrelated or differentiated signal, thereby extracting an evoked response component from the sensed cardiac signal, the evoked response component otherwise being overshadowed by the much higher-amplitude polarization component.
摘要翻译：在用于抑制检测到的心脏信号中的电极极化分量的方法和装置中，感测到的心脏信号被加到差分或自相关感测的心脏信号中，并且在原始感测心脏信号与自相关或微分信号之间形成差异，由此从所感测到的心脏信号中提取诱发反应分量，否则被高得多的振幅偏振分量遮蔽的诱发响应分量。

6. 发明授权

US5683428A Atrial tachycardia-detecting heart stimulator comparing a plurality of P-P intervals with a threshold 失效
标题翻译：房性心动过速检测心脏刺激器将多个P-P间隔与阈值进行比较
公开(公告)号：US5683428A
公开(公告)日：1997-11-04
申请号：US571190
申请日：1995-12-12
申请人： Per Franberg , Anders Lindgren , Hans Strandberg
发明人： Per Franberg , Anders Lindgren , Hans Strandberg
IPC分类号： A61B5/0402 , A61B5/0452 , A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/3682
摘要： A heart stimulator for detecting atrial tachycardia, contains a control device to which are connected an atrial detector, having a blanking period, for detecting atrial events, a ventricular stimulation unit for delivering stimulation pulses in the ventricle, a counter for generating a variable PV interval between a detected atrial event and a stimulation pulse delivered in the ventricle, a time measurement unit for measuring time between two consecutive, detected atrial events and a calculation unit which, in a test mode for determining of whether atrial tachycardia is present, is arranged to cause the counter to generate a PV interval so the PV interval plus the atrial detector's blanking period is equal to half or less than half of an adjustable threshold level PP tachycardia. The time measurement unit sends a detection signal to the control device when a defined number of measured, consecutive PP intervals is less than a defined threshold value PP for the PP interval (threshold value PP tachycardia).
摘要翻译：用于检测房性心动过速的心脏刺激器包含控制装置，其连接有心房检测器，具有用于检测心房事件的消隐期，用于在心室中传送刺激脉冲的心室刺激单元，用于产生可变PV间隔的计数器在检测到的心房事件和在心室中传送的刺激脉冲之间的时间测量单元，用于测量两个连续的检测到的心房事件之间的时间的时间测量单元和在用于确定是否存在心房性心动过速的测试模式中的计算单元被布置为导致计数器产生PV间隔，因此PV间隔加上心房检测器的消隐周期等于可调节阈值水平PP心动过速的一半或者更少的一半。当定义数量的测量的连续PP间隔小于PP间隔（阈值PP心动过速）的定义阈值PP时，时间测量单元向控制装置发送检测信号。

7. 发明授权

US5602342A Method and device for measuring the flow of an electrolytic fluid 失效
标题翻译：用于测量电解液流动的方法和装置
公开(公告)号：US5602342A
公开(公告)日：1997-02-11
申请号：US677910
申请日：1996-07-10
申请人： Hans Strandberg
发明人： Hans Strandberg
IPC分类号： A61N1/365 , G01F1/64 , G01P5/00 , G01P5/08 , A61B5/00
CPC分类号： A61N1/36514 , G01F1/64 , G01P5/008 , G01P5/083
摘要： In a method for measuring the flow of an electrolytic fluid, the voltage or current is measured between two stationary electrodes immersed in the electrolytic fluid. A device for measuring the flow has at least two electrodes intended for immersion in the electrolyte. The electrodes are stationary, and a measurement unit is arranged to measure the voltage or current between the electrodes.
摘要翻译：在测量电解液流量的方法中，在浸入电解液中的两个固定电极之间测量电压或电流。用于测量流动的装置具有至少两个用于浸入电解质中的电极。电极是静止的，并且布置测量单元以测量电极之间的电压或电流。

8. 发明授权

US5476496A Implantable medical electrode system having an indifferent electrode formed as a part of the electrode insulator sleeve 失效
标题翻译：具有形成为电极绝缘体套筒的一部分的无差异电极的植入式医用电极系统
公开(公告)号：US5476496A
公开(公告)日：1995-12-19
申请号：US241397
申请日：1994-05-11
申请人： Hans Strandberg , Jakub Hirschberg
发明人： Hans Strandberg , Jakub Hirschberg
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： An implantable electrode system includes a connector for connecting a proximal end of the electrode to an implantable medical apparatus, such as for stimulating living tissue, and a distal end at which a tip electrode is located. The proximal end and the distal end are connected by a conductor which electrically connects the medical apparatus to the electrode tip, and which is surrounded by a flexible insulating sleeve. In order to provide an indifferent electrode having a large surface area relative to the size of the tip electrode, the insulating sleeve is provided with a section formed by an electrically conductive, flexible material, which serves as the indifferent electrode. The flexibility of the electrode system is retained, while providing an indifferent electrode of optional size.
摘要翻译：可植入电极系统包括用于将电极的近端连接到可植入医疗装置的连接器，例如用于刺激生物体组织和尖端电极所在的远端。近端和远端通过将医疗设备电连接到电极尖端并由柔性绝缘套管包围的导体连接。为了提供相对于尖端电极的尺寸具有大的表面积的无关电极，绝缘套管设置有由用作无差异电极的导电柔性材料形成的部分。保持电极系统的灵活性，同时提供任选尺寸的无关电极。

9. 发明授权

US5314452A Protective arrangement for an implantable defibrillator 失效
标题翻译：可植入除颤器的保护装置
公开(公告)号：US5314452A
公开(公告)日：1994-05-24
申请号：US946599
申请日：1992-09-18
申请人： Jakub Hirschberg , Hans Strandberg
发明人： Jakub Hirschberg , Hans Strandberg
IPC分类号： A61N1/37 , A61N1/39 , A61N1/08
CPC分类号： A61N1/3931 , A61N1/37 , A61N1/3718 , Y10S128/908
摘要： In order to prevent a person handling a defibrillator during manufacture and in conjunction with implantation of the defibrillator from receiving an electrical shock due to a fault, a protective arrangement is provided for the defibrillator. This protective arrangement is in the form of a plug part detachably connectable to the defibrillator housing and having terminal pins engaging into the connecting sockets of the defibrillator which is present for receiving the electrode leads. The terminal pins produce an electrically conductive connection in the sockets and are directly connected to one another inside the plug part via an electrical resistor. In case of a fault, the high-voltage energy generated between the connecting sockets is harmlessly absorbed in the resistor.
摘要翻译：为了防止在制造过程中处理除颤器的人员以及除颤器的植入不会因故障而引起的电击，为除颤器提供保护装置。该保护装置是可拆卸地连接到去纤颤器壳体并且具有接合到用于接收电极引线的除颤器的连接插座中的端子销的插头部件的形式。端子引脚在插座中产生导电连接，并通过电阻器直接连接在插头部分内部。在发生故障的情况下，连接插座之间产生的高电压能量在电阻器中无害化吸收。

10. 发明授权

US08437863B2 Electrode lead 有权
标题翻译：电极铅
公开(公告)号：US08437863B2
公开(公告)日：2013-05-07
申请号：US13140729
申请日：2008-12-19
申请人： Åke Sivard , Gustav Pellijeff , Hans Strandberg , Leda Henriquez , Åsa Broomé , Kenneth Dahlberg
发明人： Åke Sivard , Gustav Pellijeff , Hans Strandberg , Leda Henriquez , Åsa Broomé , Kenneth Dahlberg
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/086 , A61N1/3688 , A61N1/3718
摘要： An implantable electrode lead for tissue stimulation adapted to be attached to an implantable tissue stimulator provided with a pulse generator, has at least two stimulation electrodes to apply stimulation pulses to said tissue and arranged close to the distal end of the electrode lead, and at least two electrical conductors to connect said electrodes to said pulse generator. The electrode lead further has a switching unit arranged close to the distal end of the electrode lead and adapted to switch the electrode lead between a local pacing mode and a normal pacing mode, the switching unit being controlled by a mode control signal. Further, a pacing module is arranged close to the distal end of the electrode lead and in relation to the switching unit and being connectable to said at least two stimulation electrodes, the pacing module includes a pulse generating unit to generate stimulating pulses to be applied to the tissue by the stimulation electrodes. When the electrode lead is in the local pacing mode the electrical conductors are disconnected from said stimulation electrodes which instead are connected to the pacing module, and when the electrode lead is in the normal pacing mode the electrical conductors are connected to the stimulation electrodes.
摘要翻译：一种用于组织刺激的可植入电极引线，其适用于连接到具有脉冲发生器的可植入组织刺激器，具有至少两个刺激电极，以将刺激脉冲施加到所述组织并且靠近电极引线的远端布置，并且至少两个电导体将所述电极连接到所述脉冲发生器。电极引线还具有靠近电极引线的远端布置的开关单元，并且适于在局部起搏模式和正常起搏模式之间切换电极引线，开关单元由模式控制信号控制。此外，起搏模块靠近电极引线的远端设置，并且相对于开关单元设置并且可连接到所述至少两个刺激电极，所述起搏模块包括脉冲产生单元，用于产生刺激脉冲以施加到由刺激电极组织。当电极引线处于局部起搏模式时，电导体与所述刺激电极断开，代替地连接到起搏模块，并且当电极引线处于正常起搏模式时，电导体连接到刺激电极。

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