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1. 发明授权

US08153663B2 3-amino-indazole or 3-amino-4,5,6,7-tetrahydro-indazole derivatives 失效
标题翻译： 3-氨基 - 吲唑或3-氨基-4,5,6,7-四氢 - 吲唑衍生物
公开(公告)号：US08153663B2
公开(公告)日：2012-04-10
申请号：US12563189
申请日：2009-09-21
申请人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Markus Rudolph , Sven Taylor
发明人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Markus Rudolph , Sven Taylor
IPC分类号： A61K31/44 , A61K31/415 , C07D401/02 , C07D231/56
CPC分类号： C07D231/56 , C07D401/12 , C07D407/12
摘要： This invention relates to novel indazole derivatives of formula I: wherein R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are FXR modulators and can be used as medicaments.
摘要翻译：本发明涉及式I的新型吲唑衍生物：其中R 1至R 7如说明书和权利要求书中所定义，以及其生理上可接受的盐。这些化合物是FXR调节剂，可用作药物。

2. 发明申请

US20110237628A1 CYCLOPENTYL- AND CYCLOHEPTYLPYRAZOLES 有权
标题翻译：环丙基和环己基四唑
公开(公告)号：US20110237628A1
公开(公告)日：2011-09-29
申请号：US13050031
申请日：2011-03-17
申请人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Bernd Kuhn , Hans Richter , Sven Taylor
发明人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Bernd Kuhn , Hans Richter , Sven Taylor
IPC分类号： A61K31/4439 , C07D231/54 , C07D257/04 , C07D401/12 , A61K31/416 , A61K31/41 , A61P43/00
CPC分类号： C07D231/54 , A61K9/0019 , A61K9/0095 , A61K9/1623 , A61K9/1652 , A61K9/2018 , A61K9/2866 , A61K9/4825 , A61K9/4858 , C07D401/12 , C07D403/12
摘要： This invention relates to novel cyclopentyl- and cycloheptylpyrazole derivatives of the formula I wherein A and R1 to R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. The invention relates also to compositions including these compounds and methods of using the compounds.
摘要翻译：本发明涉及式I的新的环戊基 - 和环庚基吡唑衍生物，其中A和R 1至R 4如说明书和权利要求书中所定义，以及其生理上可接受的盐。本发明还涉及包括这些化合物的组合物和使用该化合物的方法。

3. 发明申请

US20110210647A1 Electric universal drive 有权
标题翻译：电动万能驱动
公开(公告)号：US20110210647A1
公开(公告)日：2011-09-01
申请号：US13068203
申请日：2011-05-05
申请人： Hans Richter
发明人： Hans Richter
IPC分类号： H02N2/02 , H02N2/10
CPC分类号： H02N2/101 , F16D55/2245 , F16D65/54 , F16D2125/68 , H02N2/021
摘要： In a universal drive with a rotatable or linearly movable drive member and piezo actuators supported on a carrier for acting on a leg supported on the drive member and moving the leg in a high-frequency stepping sequence in a drive direction, wherein the carriers are jointly supported on a stator by a pretension member which biases them elastically toward the drive member via an elbow lever mechanism including a first elbow lever and at least a second elbow lever which are both connected to an actuator by a coupling member and this arrangement is such that, with the first elbow lever stretched, the second elbow lever is kinked and vice versa.
摘要翻译：在具有可旋转或可线性移动的驱动构件的通用驱动器和支撑在载体上的压电致动器用于作用在支撑在驱动构件上的腿上并以驱动方向的高频步进顺序移动腿，其中载体共同通过预紧构件支撑在定子上，该预紧构件通过包括第一肘杆和至少第二肘杆的肘杆机构朝向驱动构件弹性地偏压，所述肘杆机构都通过联接构件连接到致动器，并且这种布置使得第一肘杆拉伸，第二肘杆扭结，反之亦然。

4. 发明授权

US07534891B2 Quinoline derivatives as H3R inverse agonists 失效
标题翻译：喹啉衍生物作为H3R反向激动剂
公开(公告)号：US07534891B2
公开(公告)日：2009-05-19
申请号：US11251509
申请日：2005-10-14
申请人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Susanne Raab , Hans Richter , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
发明人： Silvia Gatti McArthur , Cornelia Hertel , Matthias Heinrich Nettekoven , Susanne Raab , Hans Richter , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Franz Schuler
IPC分类号： C07D215/38
CPC分类号： C07D401/14 , C07D215/48 , C07D401/12 , C07D405/14 , C07D417/12
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐以及包含这些化合物的药物组合物及其制备方法。该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。

5. 发明授权

US07534788B2 Benzofuran and benzothiophene-2-carboxylic acid amide derivatives 失效
标题翻译：苯并呋喃和苯并噻吩-2-羧酸酰胺衍生物
公开(公告)号：US07534788B2
公开(公告)日：2009-05-19
申请号：US12173888
申请日：2008-07-16
申请人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
发明人： Peter Mohr , Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Tadakatsu Takahashi , Sven Taylor
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4545 , C07D405/06 , C07D409/06
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formula I wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译：本发明涉及式I化合物，其中X，A和R 1至R 4如说明书和权利要求书中所定义，及其药学上可接受的盐。该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。

6. 发明授权

US07507736B2 Indol-2-yl-piperazin-1-yl-methanone derivatives 失效
标题翻译：吲哚-2-基 - 哌嗪-1-基 - 甲酮衍生物
公开(公告)号：US07507736B2
公开(公告)日：2009-03-24
申请号：US12019682
申请日：2008-01-25
申请人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Sven Taylor
发明人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Sven Taylor
IPC分类号： A61K31/454 , A61K31/496 , C07D401/12 , C07D451/06
CPC分类号： C07D401/12 , C07D401/02 , C07D401/14 , C07D451/06
摘要： The present invention relates to compounds of formula I wherein A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译：本发明涉及式I化合物，其中A和R 1至R 4如说明书和权利要求书中所定义，及其药学上可接受的盐。该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。

7. 发明授权

US07388095B2 5-substituted indole-2-carboxamide derivatives 失效
标题翻译： 5-取代的吲哚-2-甲酰胺衍生物
公开(公告)号：US07388095B2
公开(公告)日：2008-06-17
申请号：US11604563
申请日：2006-11-27
申请人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Sven Taylor
发明人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Sven Taylor
IPC分类号： C07D417/14 , C07D413/14 , C07D401/14
CPC分类号： C07D401/12 , C07D451/06
摘要： The present invention relates to compounds of formula I wherein R1 to R4 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译：本发明涉及式I化合物，其中R 1至R 4和G如说明书和权利要求及其药学上可接受的盐所定义。该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。

8. 发明申请

US20060178510A1 New morpholine derivatives as 5HT2C receptor agonists for the treatment of obesity 失效
标题翻译：新的吗啉衍生物作为治疗肥胖症的5HT2C受体激动剂
公开(公告)号：US20060178510A1
公开(公告)日：2006-08-10
申请号：US11332103
申请日：2006-01-13
申请人： Jonathan Bentley , Claire Dawson , Wolfgang Guba , Paul Hebeisen , Nathaniel Monck , Robert Pratt , Hans Richter , Stephan Roever , Vicki Ruston
发明人： Jonathan Bentley , Claire Dawson , Wolfgang Guba , Paul Hebeisen , Nathaniel Monck , Robert Pratt , Hans Richter , Stephan Roever , Vicki Ruston
IPC分类号： C07D265/30
CPC分类号： C07D265/30
摘要： The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in claim 1. These compounds can be used for the preparation of medicaments.
摘要翻译：本发明涉及式（I）的化合物及其药学上可接受的盐和酯，其中R 1至R 5具有权利要求1中给出的含义。这些化合物可用于制备药物。

9. 发明授权

US5644053A Penam derivatives 失效
公开(公告)号：US5644053A
公开(公告)日：1997-07-01
申请号：US559104
申请日：1995-11-16
申请人： Christian Hubschwerlen , Hans Richter , Jean-Luc Specklin
发明人： Christian Hubschwerlen , Hans Richter , Jean-Luc Specklin
IPC分类号： A61K31/40 , A61K31/425 , A61K31/43 , A61K31/431 , A61K31/435 , A61K31/495 , A61K31/545 , A61P31/04 , A61P43/00 , C07D499/00 , C07D499/86 , C07D499/87 , C07D499/897
CPC分类号： C07D499/00
摘要： The present invention discloses compounds having the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is --COR.sup.4, --CN, --CH.sub.2 R.sup.5, halogen, --CH.dbd.CHR.sup.6 or Q and the other is hydrogen or lower alkyl or both R.sup.1 and R.sup.2 together form a .gamma.-lactam ring,R.sup.3 is hydrogen, lower alkyl, aryl-alkyl, allyl or a residue which is cleavable in vivo,R.sup.4 is hydrogen, lower alkyl, lower alkoxy, benzyloxy, amino, lower alkylamino or lower alkyl-lower alkoxyamino,R.sup.5 is hydroxy, --OCONHR.sup.7, --OCONH.sub.2 or a five- or six-membered hetero-aromatic ring which contains N,S and/or O and which is linked via a nitrogen atom,R.sup.6 is --CN or CHO,R.sup.7 is --COCH.sub.2 Cl,Q is a five- or six-membered hetero-aromatic ring which contains N, S and/or O andn is 0, 1 or 2,and the pharmaceutically compatible salts thereof.These compounds are good .beta.-lactamase inhibitors. They can be used for the prevention or treatment of bacterial infections, optionally together with a .beta.-lactam antibiotic.

10. 发明授权

US4950106A Method and apparatus for installation of an underground seal beneath a garbage dump 失效
标题翻译：在垃圾场下方安装地下密封的方法和装置
公开(公告)号：US4950106A
公开(公告)日：1990-08-21
申请号：US347779
申请日：1989-04-27
申请人： Hans Richter
发明人： Hans Richter
IPC分类号： B09B1/00 , E02D31/00 , E21C41/00 , E21D9/06
CPC分类号： E21C41/00 , E02D31/006
摘要： A method and apparatus for installing an underground seal beneath a garbage dump in a strip-like manner. The earth is worked in strips under the garbage dump by the front end of a driving shield. The earth is transported to the rear end of the driving shield, and is compressed at the rear end. A strip-like layer of a waterproof material is inserted, under the protection of a cover of the driving shield. A supply tunnel pipe is constructed and subsequently dismantled, comprised of individual tunnel pipe sections, under the protection of the cover while the driving shield is moved forward. The dismantled tunnel pipe sections of the tunnel pipe are used to erect an additional tunnel pipe which is laterally displaced in a direction toward the next strip-like layer opposite the first one tunnel pipe behind the driving shield. By stabilizing the dismantled pipe sections they need not be dragged along or transported out of the remaining tunnel pipe.
摘要翻译： PCT No.PCT / EP88 / 00721 Sec。 371日期：1989年4月27日 102（e）日期1989年4月27日PCT提交1988年8月12日PCT公布。公开号WO89 / 02009 日期：1989年3月9日。一种以条状方式在垃圾场下方安装地下密封的方法和装置。地面在垃圾场的下方由驾驶护罩的前端处理。地面被运送到驱动屏蔽的后端，并在后端被压缩。在驱动屏蔽罩的保护下，插入防水材料的带状层。供应隧道管被构造并随后拆除，包括单独的隧道管段，在保护盖的同时驱动屏蔽向前移动。隧道管的拆除的隧道管段用于竖立一个额外的隧道管，该隧道管朝着与驱动屏蔽的后面的第一个隧道管相对的下一条带状层的方向横向移位。通过稳定拆卸的管道段，它们不需要沿着或者从剩余的隧道管道中被拖出或运出。

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