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    • 7. 发明授权
    • Process for treating tumors with cytotoxic substances
    • 用细胞毒性物质治疗肿瘤的方法
    • US06582690B1
    • 2003-06-24
    • US09273066
    • 1999-03-19
    • Ulrike SteinWolfgang WaltherPeter Schlag
    • Ulrike SteinWolfgang WaltherPeter Schlag
    • A61K3821
    • A61K38/191A61K38/2013
    • The invention concerns a cytotoxic, MDR-associated substance for producing a therapeutic agent for tumor therapy, which is characterized by a) the tumor cells of a tumor patient are chemosensitized with a cytokine, b) the scope of expression of one or more MDR-associate genes (e.g. mdrl, Mrp, Lrp) in the tumor tissues of the patient is determined according to the beginning of the cytokine treatment, c) the time domain is determined, in which the expression of one or more MDR-associate genes is substantially reduced by the cytokine treatment, d) the patient is treated in the determined time domain (“therapeutic window”) with a therapeutically effective amount of a cytotoxic, MDR-associated substance, the effectiveness of which is influenced (enhanced) by the expression of one or more MDR-associate genes. The use of said substance leads to an improved tumor therapy.
    • 本发明涉及用于产生用于肿瘤治疗的治疗剂的细胞毒性MDR相关物质,其特征在于:a)肿瘤患者的肿瘤细胞用细胞因子进行化学敏化,b)一种或多种MDR- 根据细胞因子治疗的开始确定患者肿瘤组织中的关联基因(例如mdr1,Mrp,Lrp),c)确定一个或多个MDR相关基因的表达基本上在时间域 通过细胞因子治疗减少d)在确定的时间域(“治疗窗口”)中用治疗有效量的细胞毒性MDR相关物质治疗患者,其效力受到(增强)的表达的影响 一个或多个MDR相关基因。 所述物质的使用导致改善的肿瘤治疗。