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1. 发明授权

US08658102B2 Chemical analysis apparatus and chemical analysis method 有权
标题翻译：化学分析仪器和化学分析方法
公开(公告)号：US08658102B2
公开(公告)日：2014-02-25
申请号：US12785835
申请日：2010-05-24
申请人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
发明人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
IPC分类号： B06B1/06
CPC分类号： G01N35/1002 , B01F11/0283 , B01F2215/0037 , G01N35/025 , G01N2035/00554 , Y10S707/962 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
摘要： A chemical analysis apparatus comprising reaction containers containing therein a substance to be analyzed; an agitating mechanism spaced from the substance to be analyzed and agitating said substance to be analyzed with a liquid in said reaction container; and, a measuring portion for measuring physical properties of the substance to be analyzed, said agitating mechanism having a sound supply portion supplying sound waves to the substance to be analyzed, wherein said sound supply portion comprises a mechanism changing, in time, intensity of ultrasonic waves to be irradiated so as to apply pulsation to a swirl flow in the reaction container.
摘要翻译：一种化学分析装置，包括含有待分析物质的反应容器; 与待分析物质间隔开的搅拌机构，并在所述反应容器中用液体搅拌待分析物质; 以及用于测量被分析物质的物理性质的测量部分，所述搅拌机构具有向待分析物质供应声波的声音供给部分，其中所述声音供应部分包括时间上改变超声波强度的机构要被照射的波浪以便对反应容器中的涡流施加脉动。

2. 发明申请

US20070009387A1 Chemical analysis apparatus and chemical analysis method 有权
标题翻译：化学分析仪器和化学分析方法
公开(公告)号：US20070009387A1
公开(公告)日：2007-01-11
申请号：US11522379
申请日：2006-09-18
申请人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
发明人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
IPC分类号： G01N33/00
CPC分类号： G01N35/1002 , B01F11/0283 , B01F2215/0037 , G01N35/025 , G01N2035/00554 , Y10S707/962 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
摘要： A chemical analysis apparatus in which a sample to be analyzed and a reagent are placed into a reaction container, and sound waves are irradiated to said reaction container so as to agitate them, wherein said chemical analysis apparatus comprises a piezoelectric element producing said sound waves, and drivers for driving said piezoelectric element, said sound waves being intermittently irradiated into said reaction container.
摘要翻译：一种化学分析装置，其中将待分析样品和试剂置于反应容器中，并且将声波照射到所述反应容器以搅拌它们，其中所述化学分析装置包括产生所述声波的压电元件，以及用于驱动所述压电元件的驱动器，所述声波被间歇地照射到所述反应容器中。

3. 发明授权

US07722815B2 Chemical analysis apparatus and chemical analysis method 有权
标题翻译：化学分析仪器和化学分析方法
公开(公告)号：US07722815B2
公开(公告)日：2010-05-25
申请号：US10347384
申请日：2003-01-21
申请人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
发明人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
IPC分类号： G01N21/00
CPC分类号： G01N35/1002 , B01F11/0283 , B01F2215/0037 , G01N35/025 , G01N2035/00554 , Y10S707/962 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
摘要： Provided is a chemical analysis apparatus comprising a mechanism which can efficiently agitate a substance to be agitated so that a sample and a reagent are agitated and mixed together in a shorter time with a saved consumption power, incorporating a plurality of sound sources or reflecting plates, and a reaction container is located between one of the sound sources and another of the sound sources or one of the reflecting plates, whereby sound waves can be irradiated toward the reaction container in several directions in order to efficiently fluidize a solution in the reaction container.
摘要翻译：本发明提供一种化学分析装置，其特征在于，包括能够有效地搅拌待搅拌物质的机构，使得样品和试剂在节省的消耗功率的较短时间内被搅拌并混合在一起，结合有多个声源或反射板，并且反应容器位于一个声源和另一个声源或一个反射板之间，从而可以在几个方向上朝向反应容器照射声波，以便有效地使反应容器中的溶液流态化。

4. 发明授权

US07670558B2 Chemical analysis apparatus and chemical analysis method 有权
标题翻译：化学分析仪器和化学分析方法
公开(公告)号：US07670558B2
公开(公告)日：2010-03-02
申请号：US11522379
申请日：2006-09-18
申请人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
发明人： Hajime Katou , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
IPC分类号： G01N21/00
CPC分类号： G01N35/1002 , B01F11/0283 , B01F2215/0037 , G01N35/025 , G01N2035/00554 , Y10S707/962 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
摘要： A chemical analysis apparatus in which a sample to be analyzed and a reagent are placed into a reaction container, and sound waves are irradiated to said reaction container so as to agitate them, wherein said chemical analysis apparatus comprises a piezoelectric element producing said sound waves, and drivers for driving said piezoelectric element, said sound waves being intermittently irradiated into said reaction container.
摘要翻译：一种化学分析装置，其中将待分析样品和试剂置于反应容器中，并且将声波照射到所述反应容器以搅拌它们，其中所述化学分析装置包括产生所述声波的压电元件，以及用于驱动所述压电元件的驱动器，所述声波被间歇地照射到所述反应容器中。

5. 发明申请

US20100233027A1 CHEMICAL ANALYSIS APPARATUS AND CHEMICAL ANALYSIS METHOD 有权
标题翻译：化学分析装置和化学分析方法
公开(公告)号：US20100233027A1
公开(公告)日：2010-09-16
申请号：US12785835
申请日：2010-05-24
申请人： Hajime KATOU , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
发明人： Hajime KATOU , Ryo Miyake , Hiroyasu Uchida , Katsuhiro Kambara , Takenori Okusa , Shigenori Watari , Yoichiro Suzuki , Tomonori Mimura , Miki Taki , Akira Inagaki
IPC分类号： G01N29/00
CPC分类号： G01N35/1002 , B01F11/0283 , B01F2215/0037 , G01N35/025 , G01N2035/00554 , Y10S707/962 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99956
摘要： A chemical analysis apparatus comprising reaction containers containing therein a substance to be analyzed; an agitating mechanism spaced from the substance to be analyzed and agitating said substance to be analyzed with a liquid in said reaction container; and, a measuring portion for measuring physical properties of the substance to be analyzed, said agitating mechanism having a sound supply portion supplying sound waves to the substance to be analyzed, wherein said sound supply portion comprises a mechanism changing, in time, intensity of ultrasonic waves to be irradiated so as to apply pulsation to a swirl flow in the reaction container.
摘要翻译：一种化学分析装置，包括含有待分析物质的反应容器; 与待分析物质间隔开的搅拌机构，并在所述反应容器中用液体搅拌待分析物质; 以及用于测量被分析物质的物理性质的测量部分，所述搅拌机构具有向待分析物质供应声波的声音供给部分，其中所述声音供应部分包括时间上改变超声波强度的机构要被照射的波浪以便对反应容器中的涡流施加脉动。

6. 发明授权

US06737021B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US06737021B2
公开(公告)日：2004-05-18
申请号：US09789625
申请日：2001-02-22
申请人： Shigenori Watari , Hajime Katou , Katsuhiro Kambara , Hiroyasu Uchida , Takeshi Shibuya
发明人： Shigenori Watari , Hajime Katou , Katsuhiro Kambara , Hiroyasu Uchida , Takeshi Shibuya
IPC分类号： B32B500
CPC分类号： G01N35/025 , B01F11/0283 , G01N2035/00554 , Y10T436/11
摘要： Multiple piezoelectric elements 35 are arranged in a row along the top of liquid level in a reaction vessel 11. An ultrasonic reflecting material 38 is installed on the bottom of the portion of the heat insulating bath 12 where heat insulating medium 13 is stored. A lateral ultrasonic wave 9b is generated on the lower side by actuation of the piezoelectric element 35. Wave 9b is reflected by the ultrasonic reflecting material 38. As lower ultrasonic wave 8 advances along the wall surface of the reaction vessel, it collides with the specimen liquid, thereby causing a portion of the liquid level closer to the piezoelectric element 35 to be raised. When lateral ultrasonic wave 9a is applied to this portion, it reaches the inclined portion of the raised liquid level of the specimen. Swirling flow by agitation 36 is produced by acoustic radiation pressure of the ultrasonic wave. The specimen and reagent are mixed and agitated by this swirling flow.
摘要翻译：多个压电元件35沿着反应容器11中的液面顶部排列成一排。超声波反射材料38安装在绝热槽12的存储绝热介质13的部分的底部。通过压电元件35的驱动，在下侧产生横向超声波9b。波形9b被超声波反射材料38反射。随着低超声波8沿着反应容器的壁表面前进，它与样品液体，从而使更靠近压电元件35的液面的一部分升高。当横向超声波9a被施加到该部分时，其到达样本的升高的液面的倾斜部分。通过搅拌36产生的旋流由超声波的声辐射压力产生。样品和试剂通过这种旋流混合和搅拌。

7. 发明授权

US07955557B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US07955557B2
公开(公告)日：2011-06-07
申请号：US10681212
申请日：2003-10-09
申请人： Shigenori Watari , Hajime Katou , Katsuhiro Kambara , Hiroyasu Uchida , Takeshi Shibuya
发明人： Shigenori Watari , Hajime Katou , Katsuhiro Kambara , Hiroyasu Uchida , Takeshi Shibuya
IPC分类号： G01N15/06 , B06B1/00
CPC分类号： G01N35/025 , B01F11/0283 , G01N2035/00554 , Y10T436/11
摘要： Multiple piezoelectric elements 35 are arranged in a row along the top of liquid level in the reaction vessel 11. An ultrasonic reflecting material 38 is installed on the bottom of the portion of the heat insulating bath 12 where heat insulating medium 13 is stored. A lateral ultrasonic wave 9b is generated on the lower side is generated by actuation of the piezoelectric element 35. Wave 9b is reflected by the ultrasonic reflecting material 38. As a lower ultrasonic wave 8 advances along the wall surface of the reaction vessel, it collides with the specimen liquid level, thereby causing a portion of the liquid level closer to the piezoelectric element 35 to be raised. When the lateral ultrasonic wave 9a is applied to this portion, it reaches the inclined portion of the raised liquid level of the specimen. Swirling flow by agitation 36 is produced by the acoustic radiation pressure of the ultrasonic wave. The specimen and reagent are mixed and agitated by this swirling flow.
摘要翻译：多个压电元件35沿着反应容器11中的液面顶部排列成一排。超声波反射材料38安装在隔热介质13的储存部分的绝热槽12的底部。通过致动压电元件35产生下侧产生横向超声波9b。波形9b被超声波反射材料38反射。随着下部超声波8沿着反应容器的壁表面前进，它碰撞与试样液位一致，从而使液面的一部分更靠近压电元件35升高。当横向超声波9a被施加到该部分时，其到达样本的升高的液面的倾斜部分。通过搅拌36产生的流动通过超声波的声辐射压力产生。样品和试剂通过这种旋流混合和搅拌。

8. 发明授权

US08765474B2 Automatic analyzer and the analyzing method using the same 有权
标题翻译：自动分析仪及其分析方法
公开(公告)号：US08765474B2
公开(公告)日：2014-07-01
申请号：US12032339
申请日：2008-02-15
申请人： Katsuhiro Kambara , Shigenori Watari , Hidetoshi Sugiyama
发明人： Katsuhiro Kambara , Shigenori Watari , Hidetoshi Sugiyama
IPC分类号： G01N35/02
CPC分类号： G01N35/1002 , G01N35/1016 , G01N2035/00465 , G01N2035/00891 , G01N2035/1058
摘要： An automatic analyzer which assures uniformity in mixing effects regardless of sample quantity and test item and thus produces analysis results with high repeatability. The automatic analyzer includes a device for adding a conditioning liquid into a reaction chamber so that the quantity of liquid in the reaction chamber becomes a predetermined quantity prior to being mixed. The conditioning liquid may be a diluent or physiological saline as used for dilution of a sample or any other special liquid that adjusts the properties such as viscosity, surface tension, etc. of liquid to be mixed.
摘要翻译：一种自动分析仪，无论样品数量和检测项目如何，都能确保混合效果的均匀性，从而产生高重复性的分析结果。自动分析装置包括用于将调节液体添加到反应室中的装置，使得在混合之前反应室中的液体量变为预定量。调理液体可以是用于稀释样品或任何其它特殊液体的稀释剂或生理盐水，其调节待混合的液体的粘度，表面张力等性质。

9. 发明授权

US07027935B2 Sample dispensing apparatus and automatic analyzer using the same 有权
标题翻译：样品分配装置和使用其的自动分析仪
公开(公告)号：US07027935B2
公开(公告)日：2006-04-11
申请号：US10634775
申请日：2003-08-06
申请人： Akihiro Shimase , Hiroyasu Uchida , Katsuhiro Kambara , Tomoyuki Tobita
发明人： Akihiro Shimase , Hiroyasu Uchida , Katsuhiro Kambara , Tomoyuki Tobita
IPC分类号： G01F1/00 , G01F7/00
CPC分类号： G01N35/1016 , G01N35/1004
摘要： A sample dispensing apparatus is realized which can detect a dispensing abnormality occurred during the sample dispensing operation regardless of the type and the extent of the abnormality. A pressure sensor is connected to a dispensing flow passage system, including a sample probe and a dispensing syringe, and a plurality of output values of the pressure sensor during the sample dispensing operation are taken in. A multi-item analysis (based on the Mahalanobis distance) is carried out by using, as items, the plurality of taken-in output values of the pressure sensor. Whether the dispensing is normally performed or not is determined by comparing an analysis result with a threshold. A highly reliable determination result is obtained in spite of variations of sensitivity of the pressure sensor.
摘要翻译：实现了一种样品分配装置，其可以检测在样品分配操作期间发生的分配异常，而不管异常的类型和程度如何。压力传感器连接到分配流路系统，包括样品探针和分注注射器，并且在样品分配操作期间采用压力传感器的多个输出值。多项目分析（基于马哈拉诺比斯距离）通过使用压力传感器的多个取入输出值作为项目进行。通过将分析结果与阈值进行比较来确定分配是否正常执行。尽管压力传感器的灵敏度变化，但获得了高度可靠的测定结果。

10. 发明授权

US07771656B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US07771656B2
公开(公告)日：2010-08-10
申请号：US10466839
申请日：2001-01-23
申请人： Takeshi Shibuya , Hiroyasu Uchida , Katsuhiro Kambara
发明人： Takeshi Shibuya , Hiroyasu Uchida , Katsuhiro Kambara
IPC分类号： G01N21/00 , G01N31/00 , G01N15/06
CPC分类号： G01N35/109 , G01N35/025 , G01N35/1002 , G01N2035/0443 , G01N2035/0455
摘要： A reagent dispensing mechanism (15), first and second dispensing-mechanism transfer means (26, 27), and a second reagent vessel (reagent cassette) carrying-in/out mechanism (24), which are constructed by employing an XY-mechanism, are arranged so as to travel above a reagent table (25) to carry in/out a reagent cassette (22). As compared with the case where the reagent cassette carrying-in/out mechanism (24) is installed radially of the reagent table (25), the area of an automatic analyzer in the horizontal direction can be reduced and a reagent vessel (16) can be moved to a predetermined position in a shorter time by combining the rotation of the reagent table (25) with the movement of the XY-mechanism. Further, as compared the case of dispensing reagents from reagent vessels in a matrix pattern by using the reagent dispensing/transferring mechanism, the travel distance of the transferring mechanism can be shortened and so can be the travel time. Thus, an analyzer adaptable as a machine of high processing capability with a shorter cycle time can be constructed.
摘要翻译：一种试剂分配机构（15），第一和第二分配机构转移装置（26,27）和第二试剂容器（试剂盒）进/出机构（24），它们通过采用XY机构被布置成在试剂台（25）的上方行进以携带/取出试剂盒（22）。与在试剂台（25）的径向安装有试剂盒搬入机构（24）的情况相比，自动分析装置的水平方向的面积减少，试剂容器（16）能够通过组合试剂台（25）的旋转与XY机构的运动，在更短的时间内将其移动到预定位置。此外，与通过使用试剂分配/转移机构以矩阵图案分配试剂的情况相比，可以缩短传送机构的移动距离，从而可以缩短行进时间。因此，可以构建适合作为具有较短循环时间的高处理能力的机器的分析器。

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