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1. 发明授权

US07115391B1 Production of recombinant AAV using adenovirus comprising AAV rep/cap genes 失效
标题翻译：使用包含AAV rep / cap基因的腺病毒生产重组AAV
公开(公告)号：US07115391B1
公开(公告)日：2006-10-03
申请号：US10089394
申请日：2000-09-29
申请人： Haifeng Chen , Gary Kurtzman
发明人： Haifeng Chen , Gary Kurtzman
IPC分类号： C12P21/06 , C12N15/63 , C12N15/64 , A61K39/12 , A01N63/00
CPC分类号： C12N15/86 , A61K2039/5256 , C12N2710/10344 , C12N2750/14143 , C12N2830/002 , C12N2830/42 , C12N2830/75 , C12N2840/20 , C12N2840/203
摘要： This invention relates to novel adenoviruses useful in the production of high titers of recombinant adeno-associated virus (rAAV) comprising a foreign DNA insert and methods of making these adenoviruses. The adenovirus comprises the AAV rep gene in which the p5 promoter is replaced by a minimal promoter or by no promoter. The invention also provides methods of producing high levels of rAAV as a substantially homogenous preparation and composition of rAAV.
摘要翻译：本发明涉及可用于生产包含外源DNA插入片段的重组腺相关病毒（rAAV）的高滴度的新型腺病毒和制备这些腺病毒的方法。腺病毒包含AAV rep基因，其中p5启动子被最小启动子或无启动子替代。本发明还提供了生产高水平rAAV作为rAAV的基本上均匀的制剂和组成的方法。

2. 发明申请

US20070065412A1 Production of recombinant AAV using adenovirus comprising AAV rep/cap genes 审中-公开
标题翻译：使用包含AAV rep / cap基因的腺病毒生产重组AAV
公开(公告)号：US20070065412A1
公开(公告)日：2007-03-22
申请号：US11509855
申请日：2006-08-25
申请人： Haifeng Chen , Gary Kurtzman
发明人： Haifeng Chen , Gary Kurtzman
IPC分类号： A61K48/00 , C12N15/861
CPC分类号： C12N15/86 , A61K2039/5256 , C12N2710/10344 , C12N2750/14143 , C12N2830/002 , C12N2830/42 , C12N2830/75 , C12N2840/20 , C12N2840/203
摘要： This invention relates to novel adenoviruses useful in the production of high titers of recombinant adeno-associated virus (rAAV) comprising a foreign DNA inert and methods of making these adenoviruses. The adenovirus comprises the AAV rep gene in which the p5 promoter of rep is replaced by a minimal promoter or by no promoter. The invention also provides methods of producing high levels of rAAV as a substantially homogeneous preparation and compositions of rAAV.
摘要翻译：本发明涉及可用于产生包含外源DNA惰性的重组腺相关病毒（rAAV）的高效价的新型腺病毒和制备这些腺病毒的方法。腺病毒包含AAV rep基因，其中rep的p5启动子被最小启动子或没有启动子替代。本发明还提供了生产高水平rAAV作为基本上均匀的制剂和rAAV的组合物的方法。

3. 发明申请

US20110320391A1 Method and Apparatus for Predicting Application Performance Across Machines with Different Hardware Configurations 有权
标题翻译：用于预测具有不同硬件配置的机器的应用性能的方法和装置
公开(公告)号：US20110320391A1
公开(公告)日：2011-12-29
申请号：US13171812
申请日：2011-06-29
申请人： Haifeng Chen , Hui Kang , Guofei Jiang , Kenji Yoshihira
发明人： Haifeng Chen , Hui Kang , Guofei Jiang , Kenji Yoshihira
IPC分类号： G06F15/18
CPC分类号： G06F11/3452 , G06F11/3409 , G06F11/3457 , G06F2201/815 , G06F2201/865
摘要： A method and system for predicting performance of an application on a machine of a predetermined hardware configuration simulates the performance of the application under a plurality of different simulated hardware configurations; builds a predictive model of the performance of the application based on the results of the simulations; obtains the performance of the application on a plurality of actual machines, each of the machines having a different hardware configuration; and Bayesian reinterprets the predictive model built from the results of the simulations using the performance of the application on the plurality of actual machines, to obtain a final predictive model of the performance of the application having an accuracy greater than the predictive model built from the results of the simulations.
摘要翻译：用于预测预定硬件配置的机器上的应用的性能的方法和系统在多种不同的模拟硬件配置下模拟应用的性能; 基于模拟结果构建应用程序性能的预测模型; 在多个实际机器上获得应用程序的性能，每个机器具有不同的硬件配置; 贝叶斯重新解释了使用多个实际机器上的应用性能的模拟结果构建的预测模型，以获得具有比从结果构建的预测模型更高的精度的应用的性能的最终预测模型的模拟。

4. 发明授权

US06793926B1 Methods for production of a recombinant adeno-associated virus 失效
标题翻译：生产重组腺相关病毒的方法
公开(公告)号：US06793926B1
公开(公告)日：2004-09-21
申请号：US09578561
申请日：2000-05-25
申请人： Siyamak Rasty , Matthew A. Gonda , Haifeng Chen
发明人： Siyamak Rasty , Matthew A. Gonda , Haifeng Chen
IPC分类号： A61K3912
CPC分类号： C12N15/86 , C12N2710/14043 , C12N2710/14143 , C12N2750/14143 , C12N2800/108 , C12N2830/42 , C12N2840/20 , C12N2840/203
摘要： This invention relates to novel nonmammalian carrier vectors and viruses useful in the production of high titers of recombinant viruses which may contain foreign DNA inserts or which may be point-mutated or deleted viruses, and methods of producing those viruses. The nonmammalian carrier vector (“carrier vector”) is a chimeric vector which includes those portions of a nonmammalian virus backbone which allow replication in a nonmammalian host cell. The carrier vector includes various nucleic acid cassettes, which may include an embedded recombinant viral genome containing a desired transgene, components necessary for production of a replication-defective recombinant virus containing the transgene, and domains that permit the carrier vector to bind to mammalian cells. The invention also provides methods of producing high concentrations of recombinant virus as a substantially homogeneous preparation, compositions to produce the recombinant virus, and novel recombinant viruses.
摘要翻译：本发明涉及可用于产生可能含有外来DNA插入片段或可能是点突变或缺失病毒的重组病毒的高滴度的新型非哺乳动物载体载体和病毒，以及产生这些病毒的方法。非哺乳动物载体载体（“载体载体”）是嵌合载体，其包括允许在非哺乳动物宿主细胞中复制的非哺乳动物病毒骨架的那些部分。载体载体包括各种核酸盒，其可以包含含有所需转基因的嵌入式重组病毒基因组，用于产生含有转基因的复制缺陷型重组病毒所必需的组分和允许载体载体结合哺乳动物细胞的结构域。本发明还提供了生产高浓度重组病毒作为基本上均匀的制剂，产生重组病毒的组合物和新的重组病毒的方法。

5. 发明授权

US09175312B2 Vectors harboring toxic genes, methods and uses therefor 有权
标题翻译：含有毒性基因的载体，其方法和用途
公开(公告)号：US09175312B2
公开(公告)日：2015-11-03
申请号：US13982530
申请日：2012-10-16
申请人： Haifeng Chen
发明人： Haifeng Chen
IPC分类号： C07H21/00 , C12N15/86 , A61K31/7088 , C07K14/34 , C07K14/21 , C12N9/22 , C12N9/24 , A61K48/00
CPC分类号： C12N15/86 , A61K31/7088 , A61K48/00 , C07K14/21 , C07K14/34 , C12N9/22 , C12N9/2497 , C12N2710/14043 , C12N2710/14052 , C12N2750/14143 , C12N2750/14152 , C12N2799/026 , C12N2830/42 , C12N2840/005 , C12N2840/102 , C12N2840/44 , C12N2840/85
摘要： The present disclosure describes nucleic acids, and viruses comprising such nucleic acids, for growing a toxic gene in an insect cell. These nucleic acids comprise a sequence encoding a toxic polypeptide, and an intron that interrupts the sequence, whereby the intron is spliced in mammalian cells but not in insect cells. Infection of mammalian cells but not insect cells with the nucleic acids or viruses can lead to expression of toxic levels of the toxic polypeptide in mammalian cells but not in insect cells. Viruses, such as an AAV or a baculovirus comprising a nucleic acid can be grown in insect cell lines in vitro and can be administered to a subject in need of therapy, such as a subject in need of cancer therapy.
摘要翻译：本公开描述了用于在昆虫细胞中生长毒性基因的核酸和包含此类核酸的病毒。这些核酸包含编码毒性多肽的序列和中断该序列的内含子，由此内含子在哺乳动物细胞中剪接而不在昆虫细胞中剪接。哺乳动物细胞而不是昆虫细胞与核酸或病毒的感染可导致在哺乳动物细胞中毒性水平的毒性水平的表达，但不能在昆虫细胞中表达。病毒如AAV或包含核酸的杆状病毒可以在昆虫细胞系中体外生长，并且可以施用于需要治疗的受试者，例如需要癌症治疗的受试者。

6. 发明申请

US20140329313A1 EXPRESSION IN INSECT CELLS OF GENES WITH OVERLAPPING OPEN READING FRAMES, METHODS AND COMPOSITIONS THEREFOR 审中-公开
标题翻译：具有重叠开放阅读框架的基因的表达细胞中的表达，其方法和组合物
公开(公告)号：US20140329313A1
公开(公告)日：2014-11-06
申请号：US14297165
申请日：2014-06-05
申请人： Haifeng Chen
发明人： Haifeng Chen
IPC分类号： C12N15/85 , C07K14/005
CPC分类号： C12N15/86 , C07K14/005 , C12N7/00 , C12N15/85 , C12N2750/00043 , C12N2750/00051 , C12N2750/14151 , C12N2750/14152 , C12N2800/105 , C12N2800/50 , C12N2830/42 , C12N2840/20
摘要： The present teachings disclose nucleic acid cassettes for expressing in an insect cell a plurality of polypeptides encoded by a gene comprising overlapping open reading frames (ORFs). A cassette comprises, in 5′ to 3′ order, a) a first insect cell-operable promoter, b) a 5′ portion of a gene comprising a first ORF of the gene, c) an intron comprising a second insect cell-operable promoter, and d) a 3′ portion of the gene comprising at least one additional ORF. Vectors and insect cells comprising the cassettes are also disclosed, as well as methods for production of recombinant adeno-associated virus in insect cells using the cassettes.
摘要翻译：本教导公开了用于在昆虫细胞中表达由包含重叠开放阅读框（ORFs）的基因编码的多个多肽的核酸盒。一个盒子以5'至3'的顺序包括a）第一个昆虫细胞可操作的启动子，b）包含该基因的第一个ORF的基因的5'部分，c）包含第二个昆虫细胞可操作的启动子启动子，和d）包含至少一个额外ORF的基因的3'部分。还公开了包含盒的载体和昆虫细胞，以及在使用盒的昆虫细胞中产生重组腺相关病毒的方法。

7. 发明授权

US08200797B2 Systems and methods for automatic profiling of network event sequences 有权
标题翻译：网络事件序列自动分析的系统和方法
公开(公告)号：US08200797B2
公开(公告)日：2012-06-12
申请号：US11941759
申请日：2007-11-16
申请人： Xiaoqiao Meng , Guofei Jiang , Hui Zhang , Haifeng Chen , Kenji Yoshihira
发明人： Xiaoqiao Meng , Guofei Jiang , Hui Zhang , Haifeng Chen , Kenji Yoshihira
IPC分类号： G06F15/173 , G10L15/14
CPC分类号： H04L41/0613 , H04L41/145 , H04L41/22
摘要： Systems and methods are disclosed that profile event sequences by creating a mixture model from the event sequences; estimating parameters for the mixture model; and applying the mixture model to profile the event sequences.
摘要翻译：公开了通过从事件序列创建混合模型来描述事件序列的系统和方法; 估计混合模型的参数; 并应用混合模型来描述事件序列。

8. 发明申请

US20110173327A1 Virtualization and Consolidation Analysis Engine for Enterprise Data Centers 有权
标题翻译：企业数据中心的虚拟化和整合分析引擎
公开(公告)号：US20110173327A1
公开(公告)日：2011-07-14
申请号：US12940134
申请日：2010-11-05
申请人： Haifeng Chen , Guofei Jiang , Kenji Yoshihira , Akhilesh Saxena
发明人： Haifeng Chen , Guofei Jiang , Kenji Yoshihira , Akhilesh Saxena
IPC分类号： G06F15/173
CPC分类号： G06F9/5066 , Y02D10/22 , Y02D10/36
摘要： A method and apparatus for consolidating a plurality of applications into one or more servers. The method and apparatus organizes consolidation constraints representing preferences about placing applications into the one or more servers, and allocates the applications into the one or more servers in a manner that maximally satisfies the consolidation constraints.
摘要翻译：一种用于将多个应用程序合并到一个或多个服务器中的方法和装置。方法和装置组织表示将应用放置到一个或多个服务器中的偏好的合并约束，并且以最大程度地满足合并约束的方式将应用分配给一个或多个服务器。

9. 发明申请

US20100262858A1 Invariants-Based Learning Method and System for Failure Diagnosis in Large Scale Computing Systems 有权
标题翻译：基于不变量的大规模计算系统故障诊断学习方法与系统
公开(公告)号：US20100262858A1
公开(公告)日：2010-10-14
申请号：US12754572
申请日：2010-04-05
申请人： Haifeng Chen , Guofei Jiang , Kenji Yoshihira , Akhilesh Saxena
发明人： Haifeng Chen , Guofei Jiang , Kenji Yoshihira , Akhilesh Saxena
IPC分类号： G06F11/07 , G06F17/30
CPC分类号： G06N99/005 , G06F11/0709 , G06F11/079 , G06F11/0793
摘要： A method system for diagnosing a detected failure in a computer system, compares a failure signature of the detected failure to an archived failure signature contained in a database to determine if the archived failure signature matches the failure signature of the detected failure. If the archived failure signature matches the failure signature of the detected failure, an archived solution is applied to the computer system that resolves the detected failure, the archived solution corresponding to a solution used to resolve a previously detected computer system failure corresponding to the archived failure signature in the database that matches the detected failure.
摘要翻译：一种用于诊断计算机系统中检测到的故障的方法系统，将检测到的故障的故障签名与包含在数据库中的存档故障签名进行比较，以确定归档故障签名是否与检测到的故障的故障签名相匹配。如果归档故障签名与检测到的故障的故障签名相匹配，则归档解决方案应用于解决检测到的故障的计算机系统，归档解决方案对应于用于解决先前检测到的与归档故障相对应的计算机系统故障的解决方案数据库中的签名与检测到的故障相匹配。

10. 发明授权

US07590513B2 Automated modeling and tracking of transaction flow dynamics for fault detection in complex systems 有权
标题翻译：自动建模和跟踪复杂系统中故障检测的事务流动态
公开(公告)号：US07590513B2
公开(公告)日：2009-09-15
申请号：US11275796
申请日：2006-01-30
申请人： Guofei Jiang , Haifeng Chen , Cristian Ungureanu , Kenji Yoshihira
发明人： Guofei Jiang , Haifeng Chen , Cristian Ungureanu , Kenji Yoshihira
IPC分类号： G06F17/10
CPC分类号： G06F11/008
摘要： A method and system that automatically derives models between monitored quantities under non-faulty conditions so that subsequent faults can be detected as deviations from the derived models. The invention identifies unusual conditions for fault detection and isolation that is absent in rule-based systems.
摘要翻译：在非故障条件下，在监测量之间自动导出模型的方法和系统，以便随后的故障可以被检测为与衍生模型的偏差。本发明确定了在基于规则的系统中不存在的用于故障检测和隔离的异常情况。

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