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    • 1. 发明申请
    • Polymeric compositions and dosage forms comprising the same
    • 聚合物组合物和包含其的剂型
    • US20050196442A1
    • 2005-09-08
    • US10794448
    • 2004-03-05
    • Hai HuangDer-Yang LeeShun Li
    • Hai HuangDer-Yang LeeShun Li
    • A61K9/22
    • A61K9/2031A61K9/2054
    • A dosage form comprises: (a) at least one active ingredient; (b) a core having an outer surface; and (c) a shell which resides upon at least a portion of the core outer surface, wherein at least a portion of the shell is semipermeable, such that the liquid medium diffuses through the semipermeable shell or shell portion to the core due to osmosis. The shell also provides for delivery of the active ingredient to a liquid medium outside the shell after contacting of the dosage form with the liquid medium. The dosage form delivers one or more active ingredients in a controlled manner upon contacting of the dosage form with a liquid medium. The dosage form may be employed to provide a burst release of the active ingredient, or to provide release of the active ingredient at an ascending release rate over an extended time period upon contacting of the dosage form with a liquid medium. At least a portion of the shell may be comprised of a polymeric composition containing film former, gelling agents, which can be dissolved in a multisolvent system comprised of water and an organic solvent.
    • 剂型包括:(a)至少一种活性成分; (b)具有外表面的芯; 和(c)位于所述芯外表面的至少一部分上的壳,其中所述壳的至少一部分是半透性的,使得所述液体介质由于渗透而扩散通过所述半透性壳或壳部分到所述芯。 壳体还提供了在剂型与液体介质接触之后将活性成分递送到壳外的液体介质。 剂型在剂型与液体培养基接触时以受控的方式递送一种或多种活性成分。 剂型可以用于提供活性成分的爆发释放,或者当剂型与液体介质接触时,在延长的释放速率下提供活性成分的释放。 壳的至少一部分可以由含有成膜剂,胶凝剂的聚合物组合物组成,其可以溶解在由水和有机溶剂组成的多溶剂体系中。