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1. 发明申请

US20110091532A1 COMPOSITION FOR THE TREATMENT OF ARTHRITIS CONTAINING A DIBENZO-P-DIOXIN DERIVATIVE AS THE ACTIVE INGREDIENT 审中-公开
标题翻译：用于治疗含有作为活性成分的二苯并对二氧基衍生物的神经元的组合物
公开(公告)号：US20110091532A1
公开(公告)日：2011-04-21
申请号：US12996603
申请日：2009-04-17
申请人： Haeng Woo Lee , Hyeon Cheol Shin , Seoung Ho Kim , Yong Ju Park
发明人： Haeng Woo Lee , Hyeon Cheol Shin , Seoung Ho Kim , Yong Ju Park
IPC分类号： A61K31/357 , A61K9/127 , A61P19/02
CPC分类号： C07D493/04 , A61K9/127 , A61K31/357 , C07D319/24 , C07D407/12
摘要： Disclosed is a composition for treating arthritis containing a dibenzo-p-dioxin derivative as an active ingredient. This dibenzo-p-dioxin derivative is very effective in inhibiting NF-kB and AP-1 activity, alleviates the symptoms of degenerative arthritis and rheumatoid arthritis without irritating the skin or causing side effects, and can continue to exhibit improvement effects for a considerable period of time after discontinuation of treatment. Additionally, when the dibenzo-p-dioxin derivative is contained in liposomes, the composition of the invention exhibits much greater effects on treating arthritis by absorption through skin, and thus is useful for the treatment of degenerative arthritis and rheumatoid arthritis.
摘要翻译：公开了用于治疗含有二苯并对二恶英衍生物作为活性成分的关节炎的组合物。这种二苯并对二恶英衍生物在抑制NF-kB和AP-1活性方面非常有效，缓解了退行性关节炎和类风湿关节炎的症状，而不会刺激皮肤或引起副作用，并且可以在相当长的一段时间内继续表现出改善作用的时间停止治疗。此外，当二苯并对二恶英衍生物包含在脂质体中时，本发明的组合物通过皮肤吸收对治疗关节炎的影响更大，因此可用于治疗退行性关节炎和类风湿性关节炎。

2. 发明授权

US06221975B1 Process for preparing random copolymer functionalized at both terminals 有权
标题翻译：制备在两个末端官能化的无规共聚物的方法
公开(公告)号：US06221975B1
公开(公告)日：2001-04-24
申请号：US09377305
申请日：1999-08-19
申请人： Hyeon Cheol Shin , Chang Hwan Lee
发明人： Hyeon Cheol Shin , Chang Hwan Lee
IPC分类号： C08F837
CPC分类号： C08F8/32
摘要： This invention relates to a polymer having functional groups at both terminals comprising the steps of: preparing a difunctional initiator by recating divinyl aromatic material and an organo-lithium compound in the presence of a hydrocarbon solvent; synthesizing a random copolymer derived from an aromatic vinyl and conjugated diene monomer at only one terminal of two anionic terminals; adding a polar additive to activate both terminals of said copolymer, followed by the addition of an electrophilic material. The polymer material, so prepared, has an excellent combination of properties such as improved rolling resistance for use in making tire rubber treads, since it can enhance the polymer-filler interaction.
摘要翻译：本发明涉及在两端具有官能团的聚合物，其包括以下步骤：通过在烃溶剂存在下重新提取二乙烯基芳族物质和有机锂化合物来制备双官能引发剂; 合成来自芳族乙烯基和共轭二烯单体的无规共聚物仅在两个阴离子末端的一个末端; 加入极性添加剂以活化所述共聚物的两个末端，然后加入亲电材料。如此制备的聚合物材料具有优异的性能组合，例如用于制造轮胎橡胶胎面的改善的滚动阻力，因为它可以增强聚合物 - 填料相互作用。

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