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1. 发明授权

US10167325B2 Plant-derived elastin binding protein ligands and methods of using the same 有权
公开(公告)号：US10167325B2
公开(公告)日：2019-01-01
申请号：US15186831
申请日：2016-06-20
申请人： HUMAN MATRIX SCIENCES, LLC , THE HOSPITAL FOR SICK CHILDREN
发明人： Felipe Jimenez , Thomas Mitts , Aleksander Hinek
IPC分类号： C07K14/00 , C07K14/415 , C07K7/06 , C07K7/08 , A61K8/19 , A61K8/64 , A61K9/00 , A61K33/26 , A61K33/32 , A61K33/34 , A61K38/16 , A61Q19/00 , A61K38/00
摘要： The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.

2. 发明授权

US10004779B2 Elastin protective polyphenolics and methods of using the same 有权
公开(公告)号：US10004779B2
公开(公告)日：2018-06-26
申请号：US14962592
申请日：2015-12-08
申请人： HUMAN MATRIX SCIENCES, LLC , THE HOSPITAL FOR SICK CHILDREN
发明人： Thomas Mitts , Felipe Jimenez , Aleksander Hinek
IPC分类号： A61K38/08 , A61K8/02 , A61K8/60 , A61K31/05 , A61Q19/08 , A61K31/352 , A61K31/7028 , A61K8/49 , A61K8/64 , A61K31/366 , A61K45/06
CPC分类号： A61K38/08 , A61K8/02 , A61K8/498 , A61K8/60 , A61K8/602 , A61K8/64 , A61K31/05 , A61K31/352 , A61K31/366 , A61K31/7028 , A61K45/06 , A61K2800/91 , A61Q19/08
摘要： Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.

3. 发明申请

US20130065835A1 PROGNOSTIC TESTS FOR DEVELOPMENT OF DERMAL STRETCH MARKS AND IMPLICATIONS FOR THE PREVENTATIVE TREATMENT THEREOF 审中-公开
标题翻译：用于发展标签的预防性试验及其预防性治疗的意义
公开(公告)号：US20130065835A1
公开(公告)日：2013-03-14
申请号：US13671531
申请日：2012-11-07
申请人： HUMAN MATRIX SCIENCES, LLC , The Hospital For Sick Children
发明人： Thomas Mitts , Felipe Jimenez , Aleksander Hinek
IPC分类号： A61K38/02 , A61P17/00 , C12Q1/68 , C12Q1/04 , G01N33/566
CPC分类号： G01N33/5091 , G01N33/5005 , G01N33/5082 , G01N33/6881 , G01N33/6887 , G01N2800/20 , Y10T436/143333
摘要： Various methods of assessing the regenerative potential of dermal tissue in a patient may be determined and methods to determine the potential development of stretch marks in a patient are provided. Through the analysis of a series of dermal tissue samples, a method of monitoring the aging process of the dermal tissue of a patient is possible. Damaged or stretched marked skin may also be used in the development of various diagnostic therapies relating to the inducement of the extracellular matrix components of the skin due to the loss of elastic fibers generally found in stretch marked skin.
摘要翻译：可以确定评估患者中真皮组织的再生潜力的各种方法，并且提供确定患者中妊娠纹潜在发展的方法。通过分析一系列真皮组织样品，可以监测患者皮肤组织的老化过程的方法。损伤或拉伸的标记皮肤也可用于开发与诱发皮肤细胞外基质成分有关的各种诊断疗法，这是由于通常在伸展性皮肤中发现的弹性纤维的损失。

4. 发明授权

US09422334B2 Plant-derived elastin binding protein ligands and methods of using the same 有权
公开(公告)号：US09422334B2
公开(公告)日：2016-08-23
申请号：US13975703
申请日：2013-08-26
申请人： HUMAN MATRIX SCIENCES, LLC , THE HOSPITAL FOR SICK CHILDREN
发明人： Felipe Jimenez , Thomas Mitts , Aleksander Hinek
IPC分类号： C07K14/00 , C07K7/06 , C07K7/08 , A61K38/00
CPC分类号： C07K14/415 , A61K8/19 , A61K8/645 , A61K9/0014 , A61K33/26 , A61K33/32 , A61K33/34 , A61K38/00 , A61K38/168 , A61K2800/74 , A61Q19/00 , C07K7/06 , C07K7/08
摘要： The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.

5. 发明申请

US20190153045A1 PLANT-DERIVED ELASTIN BINDING PROTEIN LIGANDS AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：US20190153045A1
公开(公告)日：2019-05-23
申请号：US16201243
申请日：2018-11-27
申请人： HUMAN MATRIX SCIENCES, LLC , THE HOSPITAL FOR SICK CHILDREN
发明人： Felipe Jimenez , Thomas Mitts , Aleksander Hinek
IPC分类号： C07K14/415 , C07K7/08 , A61K33/26 , A61K8/19 , A61K33/34 , A61K8/64 , A61K9/00 , C07K7/06 , A61K33/32 , A61K38/16 , A61Q19/00
摘要： The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.

6. 发明授权

US09254300B2 Elastin protective polyphenolics and methods of using the same 有权
公开(公告)号：US09254300B2
公开(公告)日：2016-02-09
申请号：US14150742
申请日：2014-01-08
申请人： HUMAN MATRIX SCIENCES, LLC , THE HOSPITAL FOR SICK CHILDREN
发明人： Thomas Mitts , Felipe Jimenez , Aleksander Hinek
IPC分类号： A61K9/00 , A61K31/05 , A61P9/00 , A61K31/7028 , A61K8/02 , A61K8/60 , A61Q19/08 , A61K31/352
CPC分类号： A61K38/08 , A61K8/02 , A61K8/498 , A61K8/60 , A61K8/602 , A61K8/64 , A61K31/05 , A61K31/352 , A61K31/366 , A61K31/7028 , A61K45/06 , A61K2800/91 , A61Q19/08
摘要： Dermal fibroblasts permanently loose their ability to synthesize elastin, the major component of elastic fibers, shortly after puberty. This progressive loss of elastic fibers cannot be replaced, resulting in the physical signs of aging. The present invention provides methods and compositions containing the polyphenols ellagic acid and/or tannic acid for protection against degradation of cutaneous elastic fibers by the elastolytic enzymes. The use of ellagic acid and/or tannic acid increased the overall deposition of elastic fibers in healthy and damaged skin cells. The protection of both intra-tropoelastin and extra-cellular mature elastic fibers from proteolytic enzymes by ellagic acid and tannic acid caused an increase in the net deposition of elastic fibers. Therefore, embodiments of the present invention provide methods and composition for the treatment of skin and prevention and treatment of degradation of dermal elastic fibers.

7. 发明授权

US10844101B2 Plant-derived elastin binding protein ligands and methods of using the same 有权
公开(公告)号：US10844101B2
公开(公告)日：2020-11-24
申请号：US16201243
申请日：2018-11-27
申请人： ELASTOGENESIS, LLC , THE HOSPITAL FOR SICK CHILDREN
发明人： Felipe Jimenez , Thomas Mitts , Aleksander Hinek
IPC分类号： C07K14/415 , C07K7/08 , C07K7/06 , A61K8/19 , A61K8/64 , A61K9/00 , A61K33/26 , A61K33/32 , A61K33/34 , A61K38/16 , A61Q19/00 , A61K38/00
CPC分类号： C07K14/415 , A61K8/19 , A61K8/645 , A61K9/0014 , A61K33/26 , A61K33/32 , A61K33/34 , A61K38/168 , A61Q19/00 , C07K7/06 , C07K7/08 , A61K38/00 , A61K2800/74
摘要： The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.

8. 发明授权

US09458197B2 Elastin digest compositions and methods utilizing same 有权
公开(公告)号：US09458197B2
公开(公告)日：2016-10-04
申请号：US14480277
申请日：2014-09-08
申请人： HUMAN MATRIX SCIENCES, LLC
发明人： Thomas Mitts , Felipe Jimenez
IPC分类号： C07K7/06 , A61K38/05 , A61K39/00 , A61K8/64 , A61K38/39 , A61Q7/00 , A61Q11/00 , A61Q19/00 , A61Q19/08 , A61K38/18 , A61K45/06 , A61K38/08 , A61K38/19
CPC分类号： C07K7/06 , A61K8/64 , A61K38/05 , A61K38/08 , A61K38/18 , A61K38/19 , A61K38/39 , A61K39/00 , A61K39/0005 , A61K45/06 , A61Q7/00 , A61Q11/00 , A61Q19/00 , A61Q19/08
摘要： The present invention provides compositions for the therapeutic and/or cosmetic treatment of Elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate the endogenous production of Elastin and appear to enhance the elasticity of the skin and provide an external supply of peptide precursors of Elastin that penetrate into the tissue to which it is applied. The present invention describes compositions containing an elastin digest derived from proteolytic digestion of insoluble elastin derived from mammalian ligaments with a protein digesting composition, such as proteinase K. The elastin digest is a mixture of elastin peptides wherein the elastin peptide mixture comprises peptides of the sequence GXXPG, wherein X represents one of the natural amino acids. The elastin digest of the present invention may also comprise epitopes of cytokines, growth factors and di-peptides. Methods of using these elastin digest comprising compositions for treating tissues in need of increased elasticity and or Elastin are described.

9. 发明授权

US08828927B2 Elastin digest compositions and methods utilizing same 有权
标题翻译：弹性蛋白酶消化组合物和利用其的方法
公开(公告)号：US08828927B2
公开(公告)日：2014-09-09
申请号：US13914615
申请日：2013-06-10
申请人： Human Matrix Sciences, LLC
发明人： Thomas Mitts , Felipe Jimenez
IPC分类号： A61K38/00 , C07K14/00 , A61K38/39 , A61Q19/00 , A61Q19/08 , A61Q11/00 , A61K8/64 , A61K39/00 , A61K38/18 , A61K45/06 , A61Q7/00
CPC分类号： C07K7/06 , A61K8/64 , A61K38/05 , A61K38/08 , A61K38/18 , A61K38/19 , A61K38/39 , A61K39/00 , A61K39/0005 , A61K45/06 , A61Q7/00 , A61Q11/00 , A61Q19/00 , A61Q19/08
摘要： The present invention provides compositions for the therapeutic and/or cosmetic treatment of Elastin comprising tissues. Therapeutic and cosmetic compositions comprising an elastin digest stimulate the endogenous production of Elastin and appear to enhance the elasticity of the skin and provide an external supply of peptide precursors of Elastin that penetrate into the tissue to which it is applied. The present invention describes compositions containing an elastin digest derived from proteolytic digestion of insoluble elastin derived from mammalian ligaments with a protein digesting composition, such as proteinase K. The elastin digest is a mixture of elastin peptides wherein the elastin peptide mixture comprises peptides of the sequence GXXPG, wherein X represents one of the natural amino acids. The elastin digest of the present invention may also comprise epitopes of cytokines, growth factors and di-peptides. Methods of using these elastin digest comprising compositions for treating tissues in need of increased elasticity and or Elastin are described.
摘要翻译：本发明提供了用于治疗和/或美容治疗包含组织的弹性蛋白酶的组合物。包含弹性蛋白消化物的治疗和化妆品组合物刺激弹性蛋白酶的内源性产生，并且看起来增强皮肤的弹性，并提供穿透其施用于组织的弹性蛋白的肽前体的外部供应。本发明描述了包含衍生自蛋白质消化组合物如蛋白酶K的从哺乳动物韧带蛋白水解消化的弹性蛋白消化物的组合物。弹性蛋白消化物是弹性蛋白肽的混合物，其中弹性蛋白肽混合物包含序列的肽 GXXPG，其中X表示天然氨基酸之一。本发明的弹性蛋白消化物还可以包含细胞因子，生长因子和二肽的表位。描述了使用包含组合物的这些弹性蛋白消化剂来治疗需要增加弹性的组织或Elastin的方法。

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