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1. 发明申请

US20080027038A1 N-Acylated lipophilic amino acid derivatives 审中-公开
标题翻译： N-酰化亲脂氨基酸衍生物
公开(公告)号：US20080027038A1
公开(公告)日：2008-01-31
申请号：US11892063
申请日：2007-08-20
申请人： HIdenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okumo , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
发明人： HIdenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okumo , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
IPC分类号： A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/554 , A61P17/02 , A61P19/10 , A61P5/00 , C07D243/10 , C07D267/14 , C07D281/10 , C07D403/12 , C07D417/12
CPC分类号： C07D223/16 , C07C237/22 , C07C2602/12 , C07D209/38 , C07D209/52 , C07D211/22 , C07D215/06 , C07D215/227 , C07D215/56 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/10 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D267/18 , C07D279/16 , C07D279/26 , C07D281/10 , C07D281/14 , C07D401/04 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Compounds of structural formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.
摘要翻译：结构式（I）的化合物，其中A是包含脂族桥基的亲脂基团，B是亲脂基团，D是具有至少一个氨基或取代的氨基的基团，R是氢，烷基或环烷基，以及药学上可接受的其盐和单独的异构体，其在人或动物中具有生长激素释放活性。

2. 发明申请

US20060142264A1 Novel amide derivatives 失效
标题翻译：新型酰胺衍生物
公开(公告)号：US20060142264A1
公开(公告)日：2006-06-29
申请号：US11359616
申请日：2006-02-23
申请人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
发明人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
IPC分类号： A61K31/554 , A61K31/553
CPC分类号： C07D223/16 , C07C237/22 , C07C2602/12 , C07D209/38 , C07D209/52 , C07D211/22 , C07D215/06 , C07D215/227 , C07D215/56 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/10 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D267/18 , C07D279/16 , C07D279/26 , C07D281/10 , C07D281/14 , C07D401/04 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.
摘要翻译：结构式（I）的化合物，其中A是包括脂族桥连基团的亲脂基团，B是亲脂基团，D是具有至少一个氨基或取代的氨基的基团，R是氢，烷基或环烷基，以及药学上可接受的其盐和单独的异构体，其在人或动物中具有生长激素释放活性。

3. 发明授权

US07279573B2 Amide derivatives 失效
标题翻译：酰胺衍生物
公开(公告)号：US07279573B2
公开(公告)日：2007-10-09
申请号：US11359616
申请日：2006-02-23
申请人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
发明人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
IPC分类号： A61P5/00 , A61K31/55 , C07D267/00
CPC分类号： C07D223/16 , C07C237/22 , C07C2602/12 , C07D209/38 , C07D209/52 , C07D211/22 , C07D215/06 , C07D215/227 , C07D215/56 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/10 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D267/18 , C07D279/16 , C07D279/26 , C07D281/10 , C07D281/14 , C07D401/04 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals
摘要翻译：结构式（I）的化合物，其中A是包括脂族桥连基团的亲脂基团，B是亲脂基团，D是具有至少一个氨基或取代的氨基的基团，R是氢，烷基或环烷基，以及药学上可接受的其盐和单独的异构体，其在人或动物中具有生长激素释放活性

4. 发明授权

US06864250B1 N-acylated lipophilic amino acid derivatives 失效
标题翻译： N-酰化亲脂性氨基酸衍生物
公开(公告)号：US06864250B1
公开(公告)日：2005-03-08
申请号：US09485845
申请日：1998-08-20
申请人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
发明人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
IPC分类号： C07D243/12 , A61K31/395 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/535 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5517 , A61K31/553 , A61K31/554 , A61K38/00 , A61P5/06 , A61P17/02 , A61P19/00 , A61P19/08 , A61P19/10 , A61P37/00 , A61P43/00 , C07D209/38 , C07D209/42 , C07D215/06 , C07D215/22 , C07D223/16 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/24 , C07D265/36 , C07D267/14 , C07D267/20 , C07D279/16 , C07D281/10 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04 , C07K5/06 , C07D267/02 , C07D281/02
CPC分类号： C07D223/16 , C07C237/22 , C07C2602/12 , C07D209/38 , C07D209/52 , C07D211/22 , C07D215/06 , C07D215/227 , C07D215/56 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/10 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D267/18 , C07D279/16 , C07D279/26 , C07D281/10 , C07D281/14 , C07D401/04 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals
摘要翻译：结构式（I）的化合物，其中A是包括脂族桥连基团的亲脂基团，B是亲脂基团，D是具有至少一个氨基或取代的氨基的基团，R是氢，烷基或环烷基，以及药学上可接受的其盐和单独的异构体，其在人或动物中具有生长激素释放活性

5. 发明授权

US07064121B2 N-acylated lipophilic amino acid derivatives 失效
标题翻译： N-酰化亲脂性氨基酸衍生物
公开(公告)号：US07064121B2
公开(公告)日：2006-06-20
申请号：US10962598
申请日：2004-10-13
申请人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
发明人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
IPC分类号： A61P19/00 , A61K31/55 , C07D267/14 , C07D267/16 , C07D281/10
CPC分类号： C07D223/16 , C07C237/22 , C07C2602/12 , C07D209/38 , C07D209/52 , C07D211/22 , C07D215/06 , C07D215/227 , C07D215/56 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/10 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D267/18 , C07D279/16 , C07D279/26 , C07D281/10 , C07D281/14 , C07D401/04 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals
摘要翻译：结构式（I）的化合物，其中A是包括脂族桥连基团的亲脂基团，B是亲脂基团，D是具有至少一个氨基或取代的氨基的基团，R是氢，烷基或环烷基，以及药学上可接受的其盐和单独的异构体，其在人或动物中具有生长激素释放活性

6. 发明申请

US20050059699A1 N-acylated lipophilic amino acid derivatives 失效
标题翻译： N-酰化亲脂性氨基酸衍生物
公开(公告)号：US20050059699A1
公开(公告)日：2005-03-17
申请号：US10962598
申请日：2004-10-13
申请人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
发明人： Hidenori Funamizu , Nobuo Ishiyama , Satoru Ikegami , Tadashi Okuno , Kiyoshi Inoguchi , Ping Huang , Gilda Loew
IPC分类号： C07D243/12 , A61K31/395 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/535 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5517 , A61K31/553 , A61K31/554 , A61K38/00 , A61P5/06 , A61P17/02 , A61P19/00 , A61P19/08 , A61P19/10 , A61P37/00 , A61P43/00 , C07D209/38 , C07D209/42 , C07D215/06 , C07D215/22 , C07D223/16 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/24 , C07D265/36 , C07D267/14 , C07D267/20 , C07D279/16 , C07D281/10 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04 , C07K5/06 , C07D211/60 , A61K31/401 , A61K31/445
CPC分类号： C07D223/16 , C07C237/22 , C07C2602/12 , C07D209/38 , C07D209/52 , C07D211/22 , C07D215/06 , C07D215/227 , C07D215/56 , C07D223/20 , C07D225/06 , C07D225/08 , C07D243/10 , C07D243/12 , C07D243/14 , C07D265/36 , C07D267/14 , C07D267/18 , C07D279/16 , C07D279/26 , C07D281/10 , C07D281/14 , C07D401/04 , C07D403/12 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Compounds of structural Formula (I) where A is a lipophilic group including an aliphatic bridging group, B is a lipophilic group, D is a group having at least one amino or substituted amino group and R is hydrogen, alkyl or cycloalkyl, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.
摘要翻译：结构式（I）的化合物，其中A是包括脂族桥连基团的亲脂基团，B是亲脂基团，D是具有至少一个氨基或取代的氨基的基团，R是氢，烷基或环烷基，以及药学上可接受的其盐和单独的异构体，其在人或动物中具有生长激素释放活性。

7. 发明申请

US20060014701A1 Novel amide derivatives as growth hormone secretagogues 审中-公开
标题翻译：新型酰胺衍生物作为生长激素促分泌素
公开(公告)号：US20060014701A1
公开(公告)日：2006-01-19
申请号：US11218562
申请日：2005-09-06
申请人： Nobuo Ishiyama , Hirohide Ishige , Mitsuo Mimura , Tadashi Okuno , Kiyoharu Ukai , Takeshi Kiyofuji , Shinji Tauchi , Kiyoshi Inoguchi , Ping Huang , Gilda Loew , Linda Maki
发明人： Nobuo Ishiyama , Hirohide Ishige , Mitsuo Mimura , Tadashi Okuno , Kiyoharu Ukai , Takeshi Kiyofuji , Shinji Tauchi , Kiyoshi Inoguchi , Ping Huang , Gilda Loew , Linda Maki
IPC分类号： A61K38/04 , C07K5/04
CPC分类号： C07K5/06165 , A61K38/00 , C07K5/0202 , C07K5/0205 , C07K5/06026 , C07K5/06034 , C07K5/06078 , C07K5/06139
摘要： Disclosed are the novel compounds as growth hormone secretagogues represented by the structural Formula I: wherein R1 is, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryl, or substituted or unsubstituted amino, X is —CO— or —SO2—, Y is: wherein n is an integer from 0-4, R4 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, R5 and R6 are independently selected from hydrogen, substituted or unsubstituted alkyl, or R5 and R6 or R4 and R5 are taken together to form substituted or unsubstituted alkylene, R2 is hydrogen, or substituted or unsubstituted alkyl, R3 is substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, D is substituted or unsubstituted amino, substituted or unsubstituted alkoxy, or substituted or unsubstituted alkylthio, * represents an asymmetric center, and pharmaceutically acceptable salts and individual isomers thereof, which have growth hormone releasing activity in humans or animals.
摘要翻译：公开了由结构式I表示的生长激素促分泌素的新化合物：其中R 1是取代或未取代的烷基，取代或未取代的环烷基，取代或未取代的烷氧基，取代或未取代的芳基或取代的或未取代的氨基，X是-CO-或-SO 2 - ，Y是：其中n是0-4的整数，R 4是氢，取代或未取代的烷基，取代或未取代的环烷基，取代或未取代的芳基，R 5和R 6独立地选自氢，取代或未取代的烷基或R 5， R S和R 6或R 4和R 5一起形成取代或未取代的亚烷基，R 2 O， >是氢或取代或未取代的烷基，R 3是取代或未取代的烷基，取代或未取代的环烷基，取代或未取代的芳基，D是取代或未取代的取代或未取代的烷氧基，或取代或未取代的烷硫基，*表示在人或动物中具有生长激素释放活性的不对称中心及其药学上可接受的盐和各异构体。

8. 发明授权

US08161630B2 Rotor attachment apparatus and rotor attachment method 有权
标题翻译：转子连接装置及转子安装方法
公开(公告)号：US08161630B2
公开(公告)日：2012-04-24
申请号：US12666233
申请日：2009-03-03
申请人： Yoshiaki Takehara , Kiyoshi Inoguchi
发明人： Yoshiaki Takehara , Kiyoshi Inoguchi
IPC分类号： B23P19/00
CPC分类号： H02K15/02 , Y10T29/49009 , Y10T29/49011 , Y10T29/49012 , Y10T29/53143 , Y10T29/53161
摘要： A rotor attachment apparatus for attaching a rotor of a motor coaxially to a crankshaft by inserting the rotor into a rotor housing that is attached to an engine, including: a rotor support member; rotor positioning members that engage some of a plurality of bolt insertion holes provided in the rotor, to thereby position the rotor; a temporary fixation bolt that temporarily fixes the rotor on the rotor support member; a drive shaft a tip portion of which is engaged with a shaft end portion of the crankshaft, and which supports the rotor support member movably in an axis direction via a screw mechanism; a base member that moves the rotor support member toward and away from the rotor while rotatably supporting a base end of the drive shaft; base positioning members that engage the rotor housing; and a fastening mechanism which engages a head of a coupling bolt inserted into at least one of the bolt insertion holes, and which is supported by the rotor support member so as to bias the coupling bolt toward the rotor.
摘要翻译：一种转子附接装置，其通过将转子插入到发动机附接的转子壳体中而将马达的转子同轴地附接到曲轴，转子附接装置包括：转子支撑构件; 转子定位构件，其接合设置在转子中的多个螺栓插入孔中的一些，从而定位转子; 临时固定螺栓，其将转子临时固定在转子支撑构件上; 驱动轴，其末端部与曲轴的轴端部接合，并且通过螺纹机构沿轴向方向可移动地支撑转子支撑部件; 基部构件，其使所述转子支撑构件朝向和远离所述转子移动，同时可旋转地支撑所述驱动轴的基端; 接合转子壳体的基座定位构件; 以及紧固机构，其接合插入到至少一个所述螺栓插入孔中的联接螺栓的头部，并且由所述转子支撑构件支撑，以将所述联接螺栓朝向所述转子偏置。

9. 发明申请

US20110041321A1 ROTOR ATTACHMENT APPARATUS AND ROTOR ATTACHMENT METHOD 有权
标题翻译：转子附件装置和转子附件方法
公开(公告)号：US20110041321A1
公开(公告)日：2011-02-24
申请号：US12666233
申请日：2009-03-03
申请人： Yoshiaki Takehara , Kiyoshi Inoguchi
发明人： Yoshiaki Takehara , Kiyoshi Inoguchi
IPC分类号： H02K15/02
CPC分类号： H02K15/02 , Y10T29/49009 , Y10T29/49011 , Y10T29/49012 , Y10T29/53143 , Y10T29/53161
摘要： A rotor attachment apparatus for attaching a rotor of a motor coaxially to a crankshaft by inserting the rotor into a rotor housing that is attached to an engine, including: a rotor support member; rotor positioning members that engage some of a plurality of bolt insertion holes provided in the rotor, to thereby position the rotor; a temporary fixation bolt that temporarily fixes the rotor on the rotor support member; a drive shaft a tip portion of which is engaged with a shaft end portion of the crankshaft, and which supports the rotor support member movably in an axis direction via a screw mechanism; a base member that moves the rotor support member toward and away from the rotor while rotatably supporting a base end of the drive shaft; base positioning members that engage the rotor housing; and a fastening mechanism which engages a head of a coupling bolt inserted into at least one of the bolt insertion holes, and which is supported by the rotor support member so as to bias the coupling bolt toward the rotor.
摘要翻译：一种转子附接装置，其通过将转子插入到发动机附接的转子壳体中而将马达的转子同轴地附接到曲轴，转子附接装置包括：转子支撑构件; 转子定位构件，其接合设置在转子中的多个螺栓插入孔中的一些，从而定位转子; 临时固定螺栓，其将转子临时固定在转子支撑构件上; 驱动轴，其末端部与曲轴的轴端部接合，并且通过螺纹机构沿轴向方向可移动地支撑转子支撑部件; 基部构件，其使所述转子支撑构件朝向和远离所述转子移动，同时可旋转地支撑所述驱动轴的基端; 接合转子壳体的基座定位构件; 以及紧固机构，其接合插入到至少一个所述螺栓插入孔中的联接螺栓的头部，并且由所述转子支撑构件支撑，以将所述联接螺栓朝向所述转子偏置。

10. 发明授权

US07037919B1 Tetrahydroquinoline derivatives 失效
标题翻译：四氢喹啉衍生物
公开(公告)号：US07037919B1
公开(公告)日：2006-05-02
申请号：US10110636
申请日：2000-10-06
申请人： Keigo Hanada , Kazuyuki Furuya , Kiyoshi Inoguchi , Motonori Miyakawa , Naoya Nagata
发明人： Keigo Hanada , Kazuyuki Furuya , Kiyoshi Inoguchi , Motonori Miyakawa , Naoya Nagata
IPC分类号： A61K31/473 , A61K31/4741 , A61K31/4745 , C07D221/06 , C07D491/048
CPC分类号： C07D221/16
摘要： Tetrahydroquinoline derivatives of general formula (I) or salts thereof, having a specific and strong binding affinity for AR and exhibiting AR agonism or antagonism; and pharmaceutical compositions containing the derivatives or the salts.
摘要翻译：通式（I）的四氢喹啉衍生物或其盐对AR具有特异性和强结合亲和力并表现出AR激动作用或拮抗作用; 和含有衍生物或盐的药物组合物。

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