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1. 发明公开

US20240316367A1 HISTOTRIPSY EXCITATION SEQUENCES OPTIMIZED FOR BUBBLE CLOUD FORMATION USING SHOCK SCATTERING 审中-公开
公开(公告)号：US20240316367A1
公开(公告)日：2024-09-26
申请号：US18737746
申请日：2024-06-07
申请人： HISTOSONICS, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： Jonathan M. CANNATA , Timothy L. HALL , Adam D. MAXWELL , Dejan TEOFILOVIC
IPC分类号： A61N7/00 , A61B17/00 , A61B17/22 , A61B17/225
CPC分类号： A61N7/00 , A61B17/22004 , A61B2017/00176 , A61B2017/22008 , A61B2017/22028 , A61B17/225 , A61N2007/0039 , A61N2007/0078
摘要： Methods and devices for producing cavitation in tissue are provided. In one embodiment, a shock scattering method of Histotripsy therapy comprises delivering an initiation pressure waveform from an ultrasound therapy transducer into tissue, the initiation pressure waveform being configured to produce at least one bubble in the tissue, delivering a scattering pressure waveform from the ultrasound therapy transducer into the at least one bubble within a life-cycle of the at least one bubble, and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. The scattering pressure waveform can be delivered during the life-cycle of the at least one bubble. In some embodiments, the scattering pressure waveform is delivered within 5 μs to 1 s of the initiation pressure waveform. Systems for performing shock scattering Histotripsy therapy are also discussed.

2. 发明申请

US20190275353A1 HISTOTRIPSY EXCITATION SEQUENCES OPTIMIZED FOR BUBBLE CLOUD FORMATION USING SHOCK SCATTERING 审中-公开
公开(公告)号：US20190275353A1
公开(公告)日：2019-09-12
申请号：US16410821
申请日：2019-05-13
申请人： HISTOSONICS, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： Jonathan M. CANNATA , Timothy L. HALL , Adam D. MAXWELL , Dejan TEOFILOVIC
IPC分类号： A61N7/00 , A61B17/22
摘要： Methods and devices for producing cavitation in tissue are provided. In one embodiment, a shock scattering method of Histotripsy therapy comprises delivering an initiation pressure waveform from an ultrasound therapy transducer into tissue, the initiation pressure waveform being configured to produce at least one bubble in the tissue, delivering a scattering pressure waveform from the ultrasound therapy transducer into the at least one bubble within a life-cycle of the at least one bubble, and producing cavitation nuclei near the at least one bubble with the scattering pressure waveform. The scattering pressure waveform can be delivered during the life-cycle of the at least one bubble. In some embodiments, the scattering pressure waveform is delivered within 5 μs to 1 s of the initiation pressure waveform. Systems for performing shock scattering Histotripsy therapy are also discussed.

3. 发明公开

US20240001158A1 HISTOTRIPSY SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20240001158A1
公开(公告)日：2024-01-04
申请号：US18464877
申请日：2023-09-11
申请人： HistoSonics, Inc.
发明人： Jonathan M. CANNATA , Ryan MILLER , Alexander P. DURYEA , Dejan TEOFILOVIC , Zeljko MLADENOVIC , Aleksandra RAKIC , Joshua STOPEK
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/085
摘要： A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

4. 发明公开

US20240001157A1 HISTOTRIPSY SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20240001157A1
公开(公告)日：2024-01-04
申请号：US18464721
申请日：2023-09-11
申请人： HistoSonics, Inc.
发明人： Jonathan M. CANNATA , Ryan MILLER , Alexander P. DURYEA , Dejan TEOFILOVIC , Zeljko MLADENOVIC , Aleksandra RAKIC , Joshua STOPEK
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/085
摘要： A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

5. 发明公开

US20230310900A1 HISTOTRIPSY SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20230310900A1
公开(公告)日：2023-10-05
申请号：US18311045
申请日：2023-05-02
申请人： HistoSonics, Inc.
发明人： Jonathan M. CANNATA , Ryan M. MILLER , Alexander P. DURYEA , Dejan TEOFILOVIC , Zeljko MLADENOVIC , Aleksandra RAKIC , Joshua STOPEK
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/085
摘要： A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

6. 发明申请

US20160135916A1 ARTICULATING ARM LIMITER FOR CAVITATIONAL ULTRASOUND THERAPY SYSTEM 审中-公开
标题翻译：用于CAVITATIONAL超声治疗系统的ARM LIMITER
公开(公告)号：US20160135916A1
公开(公告)日：2016-05-19
申请号：US14899139
申请日：2014-07-03
申请人： HISTOSONICS, INC.
发明人： Aleksandra RAKIC , Dejan TEOFILOVIC
IPC分类号： A61B90/50 , F16C11/04 , F16M13/02 , A61N7/00
摘要： Methods and devices for manipulating an articulating arm of an ultrasound therapy system are provided. In one embodiment an articulating arm comprises a first articulating arm link, a second articulating arm link, a rotating joint configured to rotationally connect the first articulating arm link to the second articulating arm link so that the first and second articulating arm links are substantially perpendicular, and an arm limiter attached to the second articulating arm link, the arm limiter being configured to limit rotation of the second articulating arm link along the rotating joint with respect to the first articulating arm link. An ultrasound therapy transducer and imaging system can be mounted on the articulating arm. Methods for performing manipulating the arm and system are also provided.
摘要翻译：提供了用于操纵超声治疗系统的关节臂的方法和装置。在一个实施例中，铰接臂包括第一铰接臂连杆，第二铰接臂连杆，旋转接头，其构造成将第一铰接臂连杆旋转地连接到第二铰接臂连杆，使得第一和第二铰接臂连杆基本垂直，以及臂限制器，其附接到所述第二铰接臂连杆，所述臂限制器构造成限制所述第二铰接臂连杆相对于所述第一铰接臂连杆沿着所述旋转接头的旋转。超声波治疗传感器和成像系统可以安装在关节臂上。还提供了用于执行操纵臂和系统的方法。

7. 发明公开

US20240307708A1 HISTOTRIPSY SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20240307708A1
公开(公告)日：2024-09-19
申请号：US18594843
申请日：2024-03-04
申请人： HistoSonics, Inc.
发明人： Jonathan M. CANNATA , Ryan M. MILLER , Alexander P. DURYEA , Dejan TEOFILOVIC , Zeljko MLADENOVIC , Aleksandra RAKIC , Joshua STOPEK
IPC分类号： A61N7/00 , A61B8/08 , A61B17/22
CPC分类号： A61N7/00 , A61B8/085 , A61B2017/22008 , A61N2007/0039 , A61N2007/0052
摘要： A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

8. 发明公开

US20230310901A1 HISTOTRIPSY SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20230310901A1
公开(公告)日：2023-10-05
申请号：US18311050
申请日：2023-05-02
申请人： HistoSonics, Inc.
发明人： Jonathan M. CANNATA , Ryan M. MILLER , Alexander P. DURYEA , Dejan TEOFILOVIC , Zeljko MLADENOVIC , Aleksandra RAKIC , Joshua STOPEK
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B8/085
摘要： A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

9. 发明公开

US20230240792A1 ARTICULATING ARM LIMITER FOR CAVITATIONAL ULTRASOUND THERAPY SYSTEM 审中-公开
公开(公告)号：US20230240792A1
公开(公告)日：2023-08-03
申请号：US17929951
申请日：2022-09-06
申请人： HISTOSONICS, INC.
发明人： Aleksandra RAKIC , Dejan TEOFILOVIC
IPC分类号： A61B90/50 , A61N7/02 , A61B8/00 , A61B90/80 , A61N7/00 , F16C11/04 , F16M13/02
CPC分类号： A61B90/50 , A61N7/02 , A61B8/4218 , A61B8/4405 , A61B90/80 , A61N7/00 , F16C11/04 , F16M13/02 , A61B2090/378
摘要： Methods and devices for manipulating an articulating arm of an ultrasound therapy system are provided. In one embodiment an articulating arm comprises a first articulating arm link, a second articulating arm link, a rotating joint configured to rotationally connect the first articulating arm link to the second articulating arm link so that the first and second articulating arm links are substantially perpendicular, and an arm limiter attached to the second articulating arm link, the arm limiter being configured to limit rotation of the second articulating arm link along the rotating joint with respect to the first articulating arm link. An ultrasound therapy transducer and imaging system can be mounted on the articulating arm. Methods for performing manipulating the arm and system are also provided.

10. 发明申请

US20200346046A1 HISTOTRIPSY SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20200346046A1
公开(公告)日：2020-11-05
申请号：US16930181
申请日：2020-07-15
申请人： HISTOSONICS, INC.
发明人： Jonathan M. CANNATA , Ryan MILLER , Alexander P. DURYEA , Dejan TEOFILOVIC , Zeljko MLADENOVIC , Aleksandra RAKIC , Joshua STOPEK
IPC分类号： A61N7/00
摘要： A histotripsy therapy system configured for the treatment of tissue is provided, which may include any number of features. Provided herein are systems and methods that provide efficacious non-invasive and minimally invasive therapeutic, diagnostic and research procedures. In particular, provided herein are optimized systems and methods that provide targeted, efficacious histotripsy in a variety of different regions and under a variety of different conditions without causing undesired tissue damage to intervening/non-target tissues or structures.

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