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1. 发明申请

US20140243705A1 FRICTIONAL TRANS-EPITHELIAL TISSUE DISRUPTION COLLECTION APPARATUS AND METHOD OF INDUCING AN IMMUNE RESPONSE 有权
标题翻译：摩擦上传组织破坏收集装置及诱导免疫应答的方法
公开(公告)号：US20140243705A1
公开(公告)日：2014-08-28
申请号：US14262179
申请日：2014-04-25
申请人： HISTOLOGICS LLC
发明人： NEAL MARC LONKY , MARTIN L. LONKY
IPC分类号： A61B10/02
CPC分类号： A61B10/0291 , A61B10/02 , A61B2010/0216 , A61B2017/320008
摘要： In an embodiment of the invention, a frictional tissue sampling device with a head designed to be rotated without rotating off the designated site can be used to obtain tissue biopsy samples. A frictional tissue sampling device with a head designed to be rotated without rotating off the designated site can be used to obtain an epithelial tissue biopsy sample from lesions. The device can be otherwise used to sample specific locations. In various embodiments, the head of the device is narrow and pointed with a hybrid pear shaped diamond facet. Abrasive material can be adhered to the facet.
摘要翻译：在本发明的一个实施例中，可以使用具有头部的摩擦组织取样装置，该头部设计为不转动指定位置而旋转，以获得组织活检样本。可以使用具有头部的摩擦组织采样装置，其被设计成不从指定位置旋转而旋转，从损伤获得上皮组织活组织检查样品。该设备可以用于采样特定位置。在各种实施例中，装置的头部是窄的并且具有杂交梨形金刚石刻面。研磨材料可以粘附到小面上。

2. 发明申请

US20140128773A1 FRICTIONAL TRANS-EPITHELIAL TISSUE DISRUPTION AND COLLECTION APPARATUS AND METHOD OF INDUCING AND/OR AUGMENTING AN IMMUNE RESPONSE 审中-公开
标题翻译：摩擦上皮组织破坏和收集装置及诱导和/或增强免疫应答的方法
公开(公告)号：US20140128773A1
公开(公告)日：2014-05-08
申请号：US14154447
申请日：2014-01-14
申请人： HISTOLOGICS, LLC
发明人： NEAL MARC LONKY , MARTIN L. LONKY
IPC分类号： A61B10/02
CPC分类号： A61M37/0015 , A61B10/02 , A61B10/0291 , A61B10/04 , A61B2010/0216 , A61B2017/320004 , A61B2017/320012 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061 , A61M2202/206 , A61M2202/30
摘要： The invention relates to trans-epithelial frictionally abrasive tissue sampling devices for performing biopsies and methods of inducing an immune response against a pathogen, wherein epithelial cells containing the pathogen are disrupted with the frictionally abrasive tissue sampling device to introduce the pathogen into the bloodstream of a patient.
摘要翻译：本发明涉及用于进行活组织检查的反式上皮摩擦磨擦组织取样装置和诱导针对病原体的免疫应答的方法，其中含有该病原体的上皮细胞被摩擦研磨组织取样装置破坏以将病原体引入到患者。

3. 发明申请

US20170021151A1 FRICTIONAL TRANS-EPITHELIAL TISSUE DISRUPTION AND COLLECTION APPARATUS AND METHOD OF INDUCING OR AUGMENTING AN IMMUNE RESPONSE 审中-公开
标题翻译：摩擦上皮组织破坏和收集装置及诱导或增强免疫应答的方法
公开(公告)号：US20170021151A1
公开(公告)日：2017-01-26
申请号：US15208603
申请日：2016-07-12
申请人： HISTOLOGICS, LLC
发明人： NEAL MARC LONKY , MARTIN L. LONKY
IPC分类号： A61M37/00 , A61B10/04 , A61B10/02
CPC分类号： A61M37/0015 , A61B10/02 , A61B10/0291 , A61B10/04 , A61B2010/0216 , A61B2017/320004 , A61B2017/320012 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061 , A61M2202/206 , A61M2202/30
摘要： The invention relates to trans-epithelial frictionally abrasive tissue sampling devices for performing biopsies and methods of inducing an immune response against a pathogen, wherein epithelial cells containing the pathogen are disrupted with the frictionally abrasive tissue sampling device to introduce the pathogen into the bloodstream of a patient.
摘要翻译：本发明涉及用于进行活组织检查的反式上皮摩擦磨擦组织取样装置和诱导针对病原体的免疫应答的方法，其中含有该病原体的上皮细胞被摩擦研磨组织取样装置破坏以将病原体引入到患者。

4. 发明申请

US20200093467A1 SCRAPE AND SWEEP FRICTIONAL TISSUE SAMPLING AND COLLECTION METHOD AND DEVICE 审中-公开
公开(公告)号：US20200093467A1
公开(公告)日：2020-03-26
申请号：US16573920
申请日：2019-09-17
申请人： Histologics LLC
发明人： NEAL MARC LONKY
IPC分类号： A61B10/02 , A61B17/32
摘要： In an embodiment of the invention, a frictional tissue sampling device with a head designed to be swept across or rotated without rotating off the designated site can be used to remove and obtain cell and tissue biopsy samples. A frictional tissue sampling device with a head designed to be applied to a designated site can be used to remove cells or debride tissue from, or obtain an epithelial or sub-epithelial tissue biopsy sample from lesions. The device can be otherwise used to sample specific locations. In various embodiments, the head of the device is coated with an abrasive frictional material on a platform applicator or gloved finger. The applicator tip may be trumpet shaped, propeller shaped, cone shaped, capsule shaped, narrow, or tapered, covered with a facet that can be round, diamond shaped, oval, or another geometric shape to match the device contour in contact with a tissue surface. The facet contour on applicator or finger can be concave, convex or flat. The abrasive material may exist coincidentally with a second absorptive material, which can be adherent anywhere on the applicator. The absorptive material is placed as to not oppose or contact the abrasive material. The abrasive material contacts the target tissue with the aim of scraping and dislodging tissue and cells, then sweeping and collecting the dislodged tissue and cells from the tissue surface, within the second absorptive material.

5. 发明申请

US20150157841A1 FRICTIONAL TRANS-EPITHELIAL TISSUE DISRUPTION AND COLLECTION APPARATUS AND METHOD OF INDUCING OR AUGMENTING AN IMMUNE RESPONSE 审中-公开
标题翻译：摩擦上皮组织破坏和收集装置及诱导或增强免疫应答的方法
公开(公告)号：US20150157841A1
公开(公告)日：2015-06-11
申请号：US14602002
申请日：2015-01-21
申请人： HISTOLOGICS, LLC
发明人： NEAL MARC LONKY , MARTIN L. LONKY
IPC分类号： A61M37/00 , A61B10/04
CPC分类号： A61M37/0015 , A61B10/02 , A61B10/0291 , A61B10/04 , A61B2010/0216 , A61B2017/320004 , A61B2017/320012 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061 , A61M2202/206 , A61M2202/30
摘要： The invention relates to trans-epithelial frictionally abrasive tissue sampling devices for performing biopsies and methods of inducing an immune response against a pathogen, wherein epithelial cells containing the pathogen are disrupted with the frictionally abrasive tissue sampling device to introduce the pathogen into the bloodstream of a patient.
摘要翻译：本发明涉及用于进行活组织检查的反式上皮摩擦磨擦组织取样装置和诱导针对病原体的免疫应答的方法，其中含有该病原体的上皮细胞被摩擦研磨组织取样装置破坏以将病原体引入到患者。

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