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1. 发明申请

US20160008483A1 NOVEL INSULIN ANALOG AND USE THEREOF 审中-公开
标题翻译：新型胰岛素模拟及其使用
公开(公告)号：US20160008483A1
公开(公告)日：2016-01-14
申请号：US14769495
申请日：2014-02-26
申请人： HANMI PHARM. CO., LTD
发明人： Sang Youn HWANG , Yong Ho HUH , Jin Young KIM , Sung Hee HONG , In Young CHOI , Sung Youb JUNG , Se Chang KWON , Dae Jin KIM , Hyun Uk KIM , Myung Hyun JANG , Seung Su KIM
IPC分类号： A61K47/48 , C07K14/62
摘要： The present invention relates to an insulin analog that has a reduced insulin titer and a reduced insulin receptor binding affinity compared to the native form for the purpose of increasing the blood half-life of insulin, a conjugate prepared by linking the insulin analog and a carrier, a long-acting formulation including the conjugate, and a method for preparing the conjugate.
摘要翻译：本发明涉及胰岛素类似物，其与天然形式相比具有降低的胰岛素滴度和降低的胰岛素受体结合亲和力，以增加胰岛素的血液半衰期，通过连接胰岛素类似物和载体，包含缀合物的长效制剂，以及制备该缀合物的方法。

2. 发明申请

US20160000931A1 SITE-SPECIFIC INSULIN CONJUGATE 审中-公开
标题翻译：特异性胰岛素联合
公开(公告)号：US20160000931A1
公开(公告)日：2016-01-07
申请号：US14770214
申请日：2014-02-26
申请人： HANMI PHARM. CO., LTD.
发明人： Myung Hyun JANG , Dae Jin KIM , Sang Youn HWANG , Hyun Uk KIM , Sung Youb JUNG , Se Chang KWON
IPC分类号： A61K47/48 , A61K38/28
CPC分类号： A61K47/6849 , A61K38/28 , A61K47/68 , A61K47/6811 , A61K47/6889 , C07K14/62 , C07K17/08 , C07K2319/30
摘要： Provided are an insulin conjugate having improved insulin receptor binding affinity and increased activity, in which a non-peptidyl polymer and an immunoglobulin Fc region are site-specifically linked to an amino acid residue of the insulin beta chain excluding the N-terminus thereof via a covalent bond, a long-acting formulation including the same, and a preparation method thereof. The insulin conjugate of the present invention is used to provide an insulin formulation which exhibits a remarkably increased in vivo activity of the peptide.
摘要翻译：提供了具有改善的胰岛素受体结合亲和力和增加的活性的胰岛素缀合物，其中非肽基聚合物和免疫球蛋白Fc区通过经由以下步骤经由其N-末端与胰岛素β链的氨基酸残基进行位点特异性连接共价键，包含它们的长效制剂及其制备方法。本发明的胰岛素缀合物用于提供表现出肽显着增加的体内活性的胰岛素制剂。

3. 发明申请

US20160199451A1 COMPOSITION FOR TREATING HYPERLIPIDEMIA COMPRISING OXYNTOMODULIN DERIVATIVE 审中-公开
公开(公告)号：US20160199451A1
公开(公告)日：2016-07-14
申请号：US15086499
申请日：2016-03-31
申请人： HANMI PHARM. CO., LTD.
发明人： Sung Youb JUNG , Jin-Sun KIM , Myung Hyun JANG , Sang Hyun LEE , In Young CHOI , Se Chang KWON
IPC分类号： A61K38/22 , A61K45/06 , A61K47/48
CPC分类号： A61K38/26 , A61K38/22 , A61K45/06 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/643 , A61K47/6435 , A61K47/68 , A61K47/6811 , C07K14/605 , C07K14/76 , C07K14/78
摘要： The present invention relates to a composition for preventing or treating hyperlipidemia, fatty liver disease or arteriosclerosis, comprising an oxyntomodulin derivative as an active ingredient. The oxyntomodulin derivative has a high ability to activate GLP-1 receptor and glucagon receptor compared to native oxyntomodulin and has the effects of reducing the blood total cholesterol, low-density cholesterol and triglyceride levels that were increased by high-fat diet, and increasing high-density cholesterol levels and the high-density cholesterol/low-density cholesterol ratio. Thus, the oxyntomodulin derivative can be effectively used for the treatment of hyperlipidemia and related diseases.

4. 发明申请

US20160008484A1 IMPROVED PREPARATION METHOD FOR HIGH-YIELD PRODUCTION OF PHYSIOLOGICALLY ACTIVE POLYPEPTIDE CONJUGATE 审中-公开
标题翻译：生物活性多肽共聚物高效生产的改进制备方法
公开(公告)号：US20160008484A1
公开(公告)日：2016-01-14
申请号：US14772493
申请日：2014-03-05
申请人： HANMI PHARM. CO., LTD.
发明人： Myung Hyun JANG , Min Young KIM , Dae Jin KIM , Sung Youb JUNG , Se Chang KWON
IPC分类号： A61K47/48 , A61K38/28
摘要： Provided is a method for preparing a conjugate by linking a physiologically active polypeptide, a non-peptidyl polymer linker, and an immunoglobulin constant region via a covalent bond. The method for efficiently preparing the physiologically active polypeptide conjugate uses a salt in a coupling reaction to solve the problem of low production yield during preparation of the physiologically active polypeptide conjugate. The conjugate of physiologically active polypeptide-non-peptidyl polymer-immunoglobulin constant region can be produced with high purity and yield by the subject method. Due to the method for preparing the physiologically active polypeptide conjugate, production costs can be reduced. Therefore, the method can be used to develop long-acting formulations of physiologically active polypeptides, which have improved industrial applicability and drug regulation compliance.
摘要翻译：提供通过共价键连接生理活性多肽，非肽基聚合物接头和免疫球蛋白恒定区来制备缀合物的方法。用于有效制备生理活性多肽缀合物的方法使用耦合反应中的盐来解决制备生理活性多肽缀合物期间产量低的问题。生理活性多肽 - 非肽基聚合物 - 免疫球蛋白恒定区的缀合物可以通过本发明方法以高纯度和产率产生。由于制备生理活性多肽缀合物的方法，可以降低生产成本。因此，该方法可用于开发具有改善的工业适用性和药物调节依从性的生理活性多肽的长效制剂。

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