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1. 发明授权

US08642533B2 Methods of nourishing animals 失效
标题翻译：滋养动物的方法
公开(公告)号：US08642533B2
公开(公告)日：2014-02-04
申请号：US12993783
申请日：2009-05-22
申请人： H. William Harris, Jr. , Marlies Betka , Chris Frederick Holm , Steven Harold Jury
发明人： H. William Harris, Jr. , Marlies Betka , Chris Frederick Holm , Steven Harold Jury
IPC分类号： A61K38/00 , A61K31/315 , A61K31/20
CPC分类号： A61K33/34 , A23K10/18 , A23K20/10 , A23K20/111 , A23K20/142 , A23K20/147 , A23K20/174 , A23K20/24 , A23K20/30 , A23K50/30 , A23K50/70 , A23K50/75 , A61K31/137 , A61K31/138 , A61K31/19 , A61K31/198 , A61K31/28 , A61K31/315 , A61K31/59 , A61K31/593 , A61K33/06 , A61K33/30 , A61K33/32 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of maintaining, and methods of restoring, a desired calcium homeostasis in a non-human terrestrial animal by administering an effective amount of one or more Calcium-Sensing Receptor modulators (CaSRs) to the animal. The invention further provides methods of reducing foot lesions in chickens. The invention also relates to food compositions useful in the methods of the invention.
摘要翻译：本发明涉及通过向动物施用有效量的一种或多种钙感受器调节剂（CaSR）来维持和恢复非人类陆地动物中期望的钙稳态的方法和方法。本发明还提供了减少鸡中足部损伤的方法。本发明还涉及可用于本发明方法的食品组合物。

2. 发明申请

US20130196958A1 METHODS OF NOURISHING ANIMALS 失效
标题翻译：免疫动物的方法
公开(公告)号：US20130196958A1
公开(公告)日：2013-08-01
申请号：US12993783
申请日：2009-05-22
申请人： H. William Harris, JR. , Marlies Betka , Chris Frederick Holm , Steven Harold Jury
发明人： H. William Harris, JR. , Marlies Betka , Chris Frederick Holm , Steven Harold Jury
IPC分类号： A23K1/16 , A61K31/59 , A61K31/137
CPC分类号： A61K33/34 , A23K10/18 , A23K20/10 , A23K20/111 , A23K20/142 , A23K20/147 , A23K20/174 , A23K20/24 , A23K20/30 , A23K50/30 , A23K50/70 , A23K50/75 , A61K31/137 , A61K31/138 , A61K31/19 , A61K31/198 , A61K31/28 , A61K31/315 , A61K31/59 , A61K31/593 , A61K33/06 , A61K33/30 , A61K33/32 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of maintaining, and methods of restoring, a desired calcium homeostasis in a non-human terrestrial animal by administering an effective amount of one or more Calcium-Sensing Receptor modulators (CaSRs) to the animal. The invention further provides methods of reducing foot lesions in chickens. The invention also relates to food compositions useful in the methods of the invention.
摘要翻译：本发明涉及通过向动物施用有效量的一种或多种钙感受器调节剂（CaSR）来维持和恢复非人类陆地动物中期望的钙稳态的方法和方法。本发明还提供了减少鸡中足部损伤的方法。本发明还涉及可用于本发明方法的食品组合物。

3. 发明申请

US20100162962A1 METHODS OF RAISING CRUSTACEANS IN LOW SALINITY WATER 有权
标题翻译：提高低盐度水质的方法
公开(公告)号：US20100162962A1
公开(公告)日：2010-07-01
申请号：US12612518
申请日：2009-11-04
申请人： Steven H. Jury , H. William Harris, JR. , Chris F. Holm , Marlies Betka
发明人： Steven H. Jury , H. William Harris, JR. , Chris F. Holm , Marlies Betka
IPC分类号： A01K61/00 , A01K61/02
CPC分类号： C09D5/1625 , A01K61/59 , Y02A40/824
摘要： The present invention relates to methods of raising crustaceans, comprising maintaining crustaceans in low salinity water having a Calcium-sensing Receptor (CaSR) modulator(s), and adding feed that contains an agent that contributes to modulation of a crustacean CaSR to the water.
摘要翻译：本发明涉及提供甲壳类动物的方法，包括保持具有钙感受受体（CaSR）调节剂的低盐度水中的甲壳动物，并将含有有助于调节甲壳类动物CaSR的药剂的饲料加入到水中。

4. 发明授权

US07069876B2 Methods for raising pre-adult anadromous fish 有权
标题翻译：提高成年鱼类的方法
公开(公告)号：US07069876B2
公开(公告)日：2006-07-04
申请号：US10410872
申请日：2003-04-09
申请人： H. William Harris, Jr. , David R. Russell , Jacqueline Nearing , Marlies Betka
发明人： H. William Harris, Jr. , David R. Russell , Jacqueline Nearing , Marlies Betka
IPC分类号： A01K61/00
CPC分类号： A01K61/10 , A23K50/80 , Y02A40/81
摘要： Methods, compositions and kits for improving the raising of pre-adult anadromous fish, or preparing pre-adult anadromous fish for transfer to seawater. The methods involve adding at least one Polyvalent Cation Sensing Receptor (PVCR) modulator to the freshwater in an amount sufficient to increase expression and/or sensitivity of at least one PVCR; and adding feed for fish consumption to the freshwater, wherein the feed comprises an amount of NaCl sufficient to contribute to a significantly increased level of the PVCR modulator in serum of the pre-adult anadromous fish.
摘要翻译：用于改善成年前成鱼的饲养的方法，组合物和试剂盒，或制备用于转运到海水的成年前成鱼。所述方法包括以足以增加至少一个PVCR的表达和/或敏感性的量向淡水中加入至少一种多价阳离子感应受体（PVCR）调节剂; 并向淡水添加鱼类消费的饲料，其中饲料包含一定量的NaCl，足以有助于在成年前成鱼的血清中PVCR调节剂的水平显着增加。

5. 发明申请

US20090078212A1 Growing marine fish in fresh water 失效
公开(公告)号：US20090078212A1
公开(公告)日：2009-03-26
申请号：US12229186
申请日：2008-08-20
申请人： H. William Harris, JR. , David R. Russell , Jacqueline Nearing , Marlies Betka
发明人： H. William Harris, JR. , David R. Russell , Jacqueline Nearing , Marlies Betka
IPC分类号： A01K61/00
CPC分类号： A01K63/04 , A01K61/10 , A01K61/80 , A01K61/85 , A23K20/142 , A23K20/147 , A23K20/20 , A23K20/22 , A23K50/80 , Y02A40/81 , Y02A40/845
摘要： The invention relates to methods for raising marine fish in freshwater. The methods involve transferring fish to freshwater containing at least one Polyvalent Cation Sensing Receptor (PVCR) modulator in an amount sufficient to increase expression and/or sensitivity of at least one PVCR; and adding feed for fish consumption to the freshwater, wherein the feed comprises an amount of NaCl sufficient to contribute to a significant increased level of the PVCR modulator in serum of the marine fish.

6. 发明授权

US06979559B2 Polyvalent cation-sensing receptor in atlantic salmon 失效
公开(公告)号：US06979559B2
公开(公告)日：2005-12-27
申请号：US10125792
申请日：2002-04-18
申请人： H. William Harris, Jr. , Jacqueline Nearing , Marlies Betka
发明人： H. William Harris, Jr. , Jacqueline Nearing , Marlies Betka
IPC分类号： A61K38/00 , C07K14/705 , C12N15/63 , C07H21/04 , C07K14/00 , C12N15/85 , C12N15/86
CPC分类号： C07K14/705 , A01K2227/40 , A61K38/00 , C07K2319/00
摘要： The present invention encompasses three full length nucleic acid and amino acid sequences for PolyValent Cation-Sensing Receptors (PVCR) in Atlantic Salmon. These PVCR have been named SalmoKCaR#1, SalmoKCaR#2, and SalmoKCaR#3. The present invention includes homologs thereof, antibodies thereto, and methods for assessing SalmoKCaR nucleic acid molecules and polypeptides. The present invention further includes plasmids, vectors, host cells containing the nucleic acid sequences of SalmoKCaR #1,2 and/or 3.

7. 发明授权

US06748900B2 Methods for growing and imprinting fish using an odorant 有权
标题翻译：使用气味剂生长和印迹鱼的方法
公开(公告)号：US06748900B2
公开(公告)日：2004-06-15
申请号：US10268051
申请日：2002-10-08
申请人： H. William Harris, Jr. , Steven Jury , David R. Russell , Jacqueline Nearing , Marlies Betka , Timothy Linley , Edward M. Brown
发明人： H. William Harris, Jr. , Steven Jury , David R. Russell , Jacqueline Nearing , Marlies Betka , Timothy Linley , Edward M. Brown
IPC分类号： A01K6100
CPC分类号： C07K14/461 , A01K79/00 , A01K79/02 , A23K50/80
摘要： The present invention relates to methods of imprinting fish in freshwater with at least one odorant for the fish and causing the imprinted fish to react to the odorant in seawater, wherein the fish are maintained in freshwater prior to transfer to seawater. The method includes: adding at least one Polyvalent Cation Sensing Receptor (PVCR) modulator to the freshwater in an amount sufficient to modulate expression and/or sensitivity of at least one PVCR, the PVCR modulator being one which alters olfactory sensing of the fish to the odorant; adding feed for fish consumption to the freshwater, the feed containing the odorant and an amount of NaCl sufficient to contribute to a significantly increased level of the PVCR modulator in serum of the fish upon consumption of the feed, whereby the fish are imprinted with the odorant; transferring the imprinted fish to seawater; and providing a source of said odorant in the seawater to which the imprinted fish are transferred, thereby causing the imprinted fish to react to said odorant. The present invention also includes methods of homing or attracting fish, as well as methods for repelling fish by modulating the expression and/or sensitivity of the PVCR in the olfactory apparatus of the fish.
摘要翻译：本发明涉及将鱼类在淡水中印迹至少一种用于鱼类的气味剂并使印迹鱼与海水中的气味剂反应的方法，其中在转移到海水之前将鱼保持在淡水中。该方法包括：将至少一种多价阳离子感应受体（PVCR）调节剂以足以调节至少一个PVCR的表达和/或敏感性的量添加到淡水中，PVCR调节剂是将鱼的嗅觉感测改变为气味; 向淡水添加饲料，含有气味剂的饲料和一定量的NaCl足以有助于在饲料消耗时鱼血清中PVCR调节剂的水平显着提高，由此将鱼加上加味剂 ; 将印迹鱼转移到海水中; 并在所述海水中提供所述加臭剂的来源，所述海水中转印有所述印迹鱼，从而使所述印迹鱼与所述加臭剂反应。本发明还包括归巢或吸引鱼的方法，以及通过调节鱼的嗅觉装置中PVCR的表达和/或敏感性来排斥鱼的方法。

8. 发明授权

US06481379B1 Methods for raising pre-adult anadromous fish 有权
标题翻译：提高成年鱼类的方法
公开(公告)号：US06481379B1
公开(公告)日：2002-11-19
申请号：US09687372
申请日：2000-10-12
申请人： H. William Harris, Jr. , David R. Russell , Jacqueline Nearing , Marlies Betka
发明人： H. William Harris, Jr. , David R. Russell , Jacqueline Nearing , Marlies Betka
IPC分类号： A01K6100
CPC分类号： A01K61/10 , A23K50/80 , Y02A40/81
摘要： The invention relates to methods, compositions and kits for improving the raising of pre-adult anadromous fish, or preparing pre-adult anadromous fish for transfer to seawater. The methods involve adding PVCR modulators (e.g., calcium and/or magnesium) to the freshwater in an amount sufficient to increase expression and/or sensitivity of at least one PVCR; and adding feed for fish consumption to the freshwater, wherein the feed contains an amount of NaCl sufficient to contribute to a significantly increased level of the PVCR modulator in serum of the pre-adult anadromous fish.
摘要翻译：本发明涉及用于改善成年前成鱼的饲养的方法，组合物和试剂盒，或者用于制备用于转运至海水的成年前成鱼。所述方法包括以足以增加至少一种PVCR的表达和/或敏感性的量向淡水中加入PVCR调节剂（例如钙和/或镁）并向淡水添加鱼类消费的饲料，其中饲料含有足以有助于在成年前成鱼的血清中PVCR调节剂水平显着提高的量的NaCl。

9. 发明授权

US06475792B1 Methods for raising pre-adult anadromous fish 有权
标题翻译：提高成年鱼类的方法
公开(公告)号：US06475792B1
公开(公告)日：2002-11-05
申请号：US09687476
申请日：2000-10-12
申请人： H. William Harris, Jr. , David R. Russell , Jacqueline Nearing , Marlies Betka
发明人： H. William Harris, Jr. , David R. Russell , Jacqueline Nearing , Marlies Betka
IPC分类号： C12N500
CPC分类号： A01K61/13 , A23K50/80 , Y02A40/81 , Y10S530/857
摘要： The invention relates to methods, compositions and kits for improving the raising of pre-adult anadromous fish, or preparing pre-adult anadromous fish for transfer to seawater. The methods involve adding PVCR modulators (e.g., calcium and/or magnesium) to the freshwater in an amount sufficient to increase expression and/or sensitivity of at least one PVCR; and adding feed for fish consumption to the freshwater, wherein the feed comprises amounts of NaCl and an amino acid sufficient to contribute to a significantly increased level of the PVCR modulator in serum of the pre-adult anadromous fish.
摘要翻译：本发明涉及用于改善成年前成鱼的饲养的方法，组合物和试剂盒，或者用于制备用于转运至海水的成年前成鱼。所述方法包括以足以增加至少一种PVCR的表达和/或敏感性的量向淡水中加入PVCR调节剂（例如钙和/或镁）并向淡水添加鱼类消费的饲料，其中饲料包含NaCl和氨基酸的量，其足以有助于在成年前成鱼的血清中PVCR调节剂的水平显着增加。

10. 发明授权

US07421975B2 Growing marine fish in fresh water 有权
标题翻译：在淡水中种植海鱼
公开(公告)号：US07421975B2
公开(公告)日：2008-09-09
申请号：US11702482
申请日：2007-02-05
申请人： H. William Harris, Jr. , David R. Russell , Jacqueline Nearing , Marlies Betka
发明人： H. William Harris, Jr. , David R. Russell , Jacqueline Nearing , Marlies Betka
IPC分类号： A01K61/00
CPC分类号： A01K63/04 , A01K61/10 , A01K61/80 , A01K61/85 , A23K20/142 , A23K20/147 , A23K20/20 , A23K20/22 , A23K50/80 , Y02A40/81 , Y02A40/845
摘要： The invention relates to methods, compositions and kits for raising marine fish in freshwater. The methods involve adding at least one Polyvalent Cation Sensing Receptor (PVCR) modulator to the freshwater in an amount sufficient to increase expression and/or sensitivity of at least one PVCR; and adding feed for fish consumption to the freshwater, wherein the feed comprises an amount of NaCl sufficient to contribute to a significant increased level of the PVCR modulator in serum of the marine fish.
摘要翻译：本发明涉及用于在淡水中养殖海鱼的方法，组合物和试剂盒。所述方法包括以足以增加至少一个PVCR的表达和/或敏感性的量向淡水中加入至少一种多价阳离子感应受体（PVCR）调节剂; 并向淡水添加鱼类消费的饲料，其中饲料包含一定量的NaCl，足以有助于海鱼血清中PVCR调节剂的显着提高。

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